Mode of action of OB protein (leptin) on feeding

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 275, Issue 1 44-1, 1998, Pages

  Flynn, Mark C ^a   Scott, Thomas R ^a   Pritchard, Thomas C ^b   Plata Salamán, Carlos R ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Anorexia; Behavior; Cerebrospinal fluid; Cytokine; Food intake; Intracerebroventricular administration; Meal; Nervous system; Obesity; Rat; Satiety

Indexed keywords

INTERLEUKIN RECEPTOR; LEPTIN;

ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; CEREBROSPINAL FLUID; COMPUTER ANALYSIS; FEEDING; FOOD INTAKE; IMMUNOMODULATION; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SATIETY; TEST MEAL;

EID: 0031817698     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.275.1.r174     Document Type: Article

References (35)

1. Barrachina, M. D., V. Martinez, L. X. Wang, J. Y. Wei, and Y. Tache. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc. Natl. Acad. Sci. USA 94: 10455-10460, 1997.
2. Campfield, L. A., F. J. Smith, and P. Burn. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm. Metab. Res. 28: 619-632, 1996.
3. Campfield, L. A., F. J. Smith, Y. Guisez, R. Devos, and P. Burn. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549, 1995.
4. Cheung, C. C., D. K. Clifton, and R. A. Steiner. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138: 4489-4492, 1997.
5. Crawley, J. N., and R. L. Corwin. Biological actions of cholecystokinin. Peptides 15: 731-755, 1994.
6. Cusin, I., F. Rohner-Jeanrenaud, A. Stricker-Krongrad, and B. Jeanrenaud. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes 45: 1446-1450, 1996.
7. Elmquist, J. K., R. S. Ahima, E. Maratos-Flier, J. S. Flier, and C. B. Saper. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138: 839-842, 1997.
8. Fan, W., B. A. Boston, R. A., Kesterson, V. J. Hruby, and R. D. Cone. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997.
9. Goldstone, A. P., J. G. Mercer, I. Gunn, K. M. Moar, C. M. B. Edwards, M. Rossi, J. K. Howard, S. Rasheed, M. D. Turton, C. Small, M. M. Heath, D. Oshea, J. Steere, K. Meeran, M. A. Ghatei, N. Hoggard, and S. R. Bloom. Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents. FEBS Lett. 415: 134-138, 1997.
10. Halaas, J. L., K. S. Gajiwala, M. Maffei, S. L. Cohen, B. T. Chait, D. Rabinowitz, R. L. Lallone, S. K. Burley, and J. M. Friedman. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546, 1995.
11. Jacob, R. J., J. Dziura, M. B. Medwick, P. Leone, S. Caprio, M. During, G. I. Shulman, and R. S. Sherwin. The effect of leptin is enhanced by macroinjection into the ventromedial hypothalamus. Diabetes 46: 150-152, 1997.
12. Kaiyala, K. J., S. C. Woods, and M. W. Schwartz. New model for the regulation of energy balance and adiposity by the central nervous system. Am. J. Clin. Nutr. 62: 1123S-1134S, 1995.
13. 2 receptor effects on natural meal patterns. Peptides 12: 1251-1260, 1991.
14. Mercer, J. G., N. Hoggard, L. M. Williams, C. B. Lawrence, L. T. Hannah, P. J. Morgan, and P. Trayhurn. Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8: 733-735, 1996.
15. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543, 1995.
16. Plata-Salamán, C. R. Interferons and central regulation of feeding. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1222-R1227, 1992.
17. Plata-Salamán, C. R. Meal patterns in response to the intracerebroventricular administration of interleukin-1β in rats. Physiol. Behav. 55: 727-733, 1994.
18. Plata-Salamán, C. R. Anorexia during acute and chronic disease. Nutrition 12: 69-78, 1996.
19. Plata-Salamán, C. R. Leptin (OB protein), neuropeptide Y, and interleukin-1 interactions as interface mechanisms for the regulation of feeding in health and disease. Nutrition 12: 718-719, 1996.
20. Plata-Salamán, C. R. Anorexia during acute and chronic disease: relevance of neurotransmitter-peptide-cytokine interactions. Nutrition 13: 159-160, 1997.
21. Plata-Salamán, C. R., and J. P. Borkoski. Interleukin-8 modulates feeding by direct action in the central nervous system. Am. J. Physiol. 265 (Regulatory Integrative Comp. Physiol. 34): R877-R882, 1993.
22. 2-microglobulin, a marker of immune activation. Am. J. Physiol. 268 (Regulatory Integrative Comp. Physiol. 37): R1513-R1519, 1995.
23. Raber, J., S. Z. Chen, L. Mucke, and L. L. Feng. Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. J. Biol. Chem. 272: 15057-15060, 1997.
24. Riedy, C. A., M. Chavez, D. P. Figlewicz, and S. C. Woods. Central insulin enhances sensitivity to cholecystokinin. Physiol. Behav. 58: 755-760, 1995.
25. Schwartz, M. W., D. G. Baskin, T. R. Bukowski, J. L. Kuijper, D. Foster, G. Lasser, D. E. Prunkard, D. Porte, S. C. Woods, R. J. Seeley, and D. S. Weigle. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
26. Schwartz, M. W., R. J. Seeley, L. A. Campfield, P. Burn, and D. G. Baskin. Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98: 1101-1106, 1996.
27. Sivitz, W. I., S. A. Walsh, D. A. Morgan, M. J. Thomas, and W. G. Haynes. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138: 3395-3401, 1997.
28. Smith, F. J., L. A. Campfield, J. A. Moschera, P. S. Bailon, and P. Burn. Feeding inhibition by neuropeptide Y. Nature 382: 307, 1996.
29. Smith, G. P. The direct and indirect controls of meal size. Neurosci. Biobehav. Rev. 20: 41-46, 1996.
30. Smith, G. P., and J. Gibbs. Satiating effect of cholecystokinin. Ann. NY Acad. Sci. 713: 236-241, 1994.
31. Sonti, G., S. E. Ilyin, and C. R. Plata-Salamán. Neuropeptide Y blocks and reverses interleukin-1β-induced anorexia in rats. Peptides 17: 517-520, 1996.
32. Stephens, T. W., M. Basinski, P. K. Bristow, J. M. Bue-Valleskey, S. G. Burgett, L. Craft, J. Hale, J. Hoffmann, H. M. Hsiung, A. Kriauciunas, W. MacKellar, P. R. Rosteck, Jr., B. Schoner, D. Smith, F. C. Tinsley, X.-Y. Zhang, and M. Heiman. The role of neuropeptide Y in antiobesity action of the obese gene product. Nature 377: 530-532, 1995.
33. Tempel, D. L., and, S. F. Leibowitz. Diurnal variations in the feeding responses to norepinephrine, neuropeptide Y and galanin in the PVN. Brain Res. Bull. 25: 821-825, 1990.
34. Vanderweele, D. A. Insulin is a prandial satiety hormone. Physiol. Behav. 56: 619-622, 1994.
35. Wang, Q., C. Bing, K. Albarazanji, D. E. Mossakowaska, X. M. Wang, D. L. Mcbay, W. A. Neville, M. Taddayon, L. Pickavance, S. Dryden, M. E. A. Thomas, M. T. Mchale, I. S. Gloyer, S. Wilson, R. Buckingham, J. R. S. Arch, P. Trayhurn, and G. Williams. Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 46: 335-341, 1997.