A leptin dose-response study in obese (ob/ob) and lean (+/?) mice

Endocrinology

Volumn 139, Issue 1, 1998, Pages 8-19

  Harris, Ruth B S ^a   Zhou, Jun ^b   Redmann, Stephen M ^a   Smagin, Gennady N ^a   Smith, Steven R ^a   Rodgers, Erin ^a   Zachwieja, Jeffrey J ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85011486581     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.139.1.5675     Document Type: Article

References (51)

1. BrayGA, YorkDA1979Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev59:719-809
2. Coleman DL 1973 Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9:294-298
3. ZhangY, ProencaR, MaffeiM, BaroneM, LeopoldL, FriedmanJM1994Positional cloning of the mouse obese gene and its human homologue. Nature372:425-432
4. ZhangF, BasinskiMB, BealsJM, BriggsSL, ChurgayLM, ClawsonDK, DiMarchiRD, FurmanTC, HaleJE, HsiungHM, SchonerBE, SmithDP, ZhangXY, WeryJ-P, SchevitzRYV1997Crystal structure of the obese protein leptin-E100. Nature387:206-209
5. HamiltonBS, PagliaD, KwanAY, DeitelM1995Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med1:953-956
6. HarrisRB, RamsayTG, SmithSR, BruchRC1996Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. J Clin Invest97:2020-2026
7. CampfieldLA, SmithFJ, GuisezY, DevosR, Burn P1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science269:546-549
8. HalaasJL, GajiwalaKS, MaffeiM, CohenSL, ChaitBT, RabinowitzD, LalloneRL, BurleySK, FriedmanJM1995Weight-reducing effects of the plasma protein encoded by the obese gene. Science269:543-546
9. PelleymounterMA, CullenMJ, BakerMB, HechtR, WintersD, BooneT, Collins F1995 Effects of the obese gene product on body weight regulation in ob/ob mice.Science269:540-543
10. WeigleDS, BukowskiTR, FosterDC, HoldermanS, KramerJM, LasserG, Lofton-DayCE, PrunkardDE, RaymondC, KuijperJL1995Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest96:2065-2070
11. ChenH, CharlatO, TartagliaLA, WoolfEA, WengX, EllisSJ, LakeyND, CulpepperJ, MooreKJ, BreitbartRE, DuykGM, TepperRI, MorgensternJP1996Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell84:491-495
12. LeeGH, ProencaR, MontezJM, CarrollKM, DarvishzadehJG, LeeJI, FriedmanJM1996Abnormal splicing of the leptin receptor in diabetic mice. Nature379:632-635
13. CaroJF, SinhaMK, KolaczynskiJW, ZhangPL, ConsidineRV1996Leptin: the tale of an obesity gene. Diabetes45:1455-1462
14. SchwartzMW, PeskindE, RaskindM, BoykoEJ, PorteJrD1996Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat Med2:589-593
15. CaroJF, KolaczynskiJW, NyceMR, OhannesianJP, OpentanovaI, GoldmanWH, LynnRB, ZhangPL, SinhaMK, ConsidineRV1996Decreased cere-brospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet348:159-161
16. HouseknechtKL, MantzorosCS, KuliawatR, HadroE, FlierJS, KahnBB1996Evidence for leptin binding to proteins in serum of rodents and humans with obesity. Diabetes45:1638-1643
17. BanksWA, KastinAJ, HuangW, JaspanJB, ManessLM1996Leptin enters the brain by a saturable system independent of insulin. Peptides17:305-311
18. BarashIA, CheungCC, WeigleDS, RenH, KabigtingEB, KuijperJL, CliftonDK, SteinerRA1996Leptin is a metabolic signal to the reproductive system. Endocrinology137:3144-3147
19. LevinN, NelsonC, GurneyA, Vandlen R, de Sauvage F 1996 Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA93:1726-1730
20. CollinsS, KuhnCM, PetroAE, SwickAG, ChrunykBA, Surwit RS1996 Role of leptin in fat regulation. Nature380:677
21. LicinioJ, MantzorosC, NegraoAB, CizzaG, WongM-L, BongiornoPB, ChrousosGP, KarpB, AllenC, FlierJS, GoldPW1997Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med3:575-579
22. HarrisRBS, ZhouJ, WeigleDS, KuijperJL1997Recombinant leptin exchanges between parabiosed mice but does not reach equilibrium. Am J Physiol272:R1800-R1808
23. RybkinII, ZhouY, VoulaufovaJ, SmaginGN, RyanDH, HarrisRBS1997The effect of restraint stress on food intake and bodv weight is determined by time of day. Am J Physiol273:R1612-R1622
24. YoungbloodBD, ZhouJ, SmaginGN, RyanDH, HarrisRBS1997Sleep deprivation bv the flower pot technique and spatial reference memory. Physiol Behav61:249-256
25. LoS, RusselJC, TaylorAW1970Determination of glycogen in small tissue samples. J Appl Physiol128:234-236
26. SrerePA1969Citrate synthase.Methods Enzymol13:3-5
27. AskewEW, DohmGL, HustonRL1975Fatty acid and ketone body metabolism in the rat: response to diet and exercise. J Nutr105:1422-1432
28. UyedaF, Racker E1965 Regulatory mechanisms in carbohydrate metabolism. VII. Hexokinse and phosphofructokinase. J Biol Chem240:4682-4688
29. LittellRC, MillikenGA, Stroup WW, Wolfinger RD 1996 SAS System for Mixed Models. SAS Institute, Car)
30. MaffeiM, HalaasJ, RavussinE, PratleyRE, LeeGH, ZhangY, FeiH, KimS, LalloneR, RanganathanS1995Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med1:1155-1161
31. ConsidineRV, SinhaMK, HeimanML, KriauciunasA, StephensTW, NyceMR, OhannesianJP, MarcoCC, McKeeLJ, BauerTL1996Serum immuno-reactive-leptin concentrations in normal-weight and obese humans. N Engl J Med334:292-295
32. HeekMV, ComptonDS, FranceCF, TedescoRP, FawziAB, GrazianoMP, SybertzEJ, StraderDC, DavisJrHR1997Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest99:385-390
33. MurakamiT, YamashitaT, IidaM, KuwajimaM1997A short form of leptin receptor performs signal transduction. Biochem Biophys Res Commun231:26-29
34. WhiteDW, KuropatwinskiKK, DevosR, BaumannH, TartagliaLA1997Leptin receptor (OB-R) signaling.Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization.J Biol Chem272:4065-4071
35. WangMY, ZhouYT, NewgardCB, UngerRH1996A novel leptin receptor isoform in rat. FEBS Lett392:87-90
36. EmilssonV, LiuY-L, CawthomeMA, MortonNM, DavenportM1997Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes46:313-316
37. CohenB, NovickD, RubinsteinM1996Modulation of insulin activities by leptin. Science272:1185-1188
38. MullerG, ErtlJ, GerlM, PreibischG1997Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem272:10585-10593
39. CusinI, Rohner-JeanrenaudF, Stricker-KrongradA, JeanrenaudB1996The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes45:1446-1450
40. SinhaMK, OhannesianJP, HeimanML, KriauciunasA, StephensTW, MagosinS, MarcoC, CaroJF1996Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest97:1344-1347
41. HottaK, GustafsonTA, OrtmeyerHK, BodkinNL, NicolsonMA, HansenBC1996Regulation of obese (ob) mRNA and plasma leptin levels in rhesus monkeys.Effects of insulin, body weight, and non-insulin-dependent diabetes mellitus.J Biol Chem271:25327-25331
42. PaquotN, SchneiterP, JequierE, Tappy L 1995 Effects of glucocorticoids and sympathomimetic agents on basal and insulin-stimulated glucose metabolism. Clin Physiol15:231-240
43. FosterDO, FrydmanML1978Nonshivering thermogenesis in the rat. II. Measurements of blood flow with microspheres point to brown adipose tissue as the dominant site of the calorigenesis induced by noradrenaline. Can J Physiol Pharmacol56:110-122
44. MackowiakPA, BoulantJA1996Fever's glass ceiling.Clin Infect Dis22:525-536
45. LennieTA, McCarthyDO, KeeseyRE1995Body energy status and the metabolic response to acute inflammation. Am J Physiol269:R1024-R1031
46. GainsfordT, WilsonTA, MetcalfD, HandmanE, MacFarlaneC, NgA, NicolaNA, AlexanderWA, HiltonDJ1996Leptin can induce proliferation, differentiation and functional activation of hemopoietic cells. Proc Natl Acad Sd USA93:14564-14568
47. JohnstonJL, RomsosDR, BergenWG1986Reduced brain norepinephrine metabolism in obese (ob/ob) mice is not normalized by tyrosine supplementation. J Nutr116:435-445
48. GillK, Amit ZA 1987 Effects of serotonin uptake blockade on food, water and ethanol consumption in rats.Alcohol Clin Exp Res11:444-449
49. DumontC, LaurentJ, GrandamA, BossierJR1981Anorectic properties of a new long acting serotonin uptake inhibitor. Life Sci28:1939-1945
50. SchwartzMW, BaskinDG, BukowskiTR, KuijperJL, FosterD, LasserG, PrunkardDE, PorteJrD, WoodsSC, SeeleyRJ, WeigleDS1996Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice.Diabetes45:531-535
51. EricksonJC, CleggKE, PalmiterRD1996Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature381:415-421