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Volumn 274, Issue 4 43-4, 1998, Pages

Heterozygosity for Lep(ob) or Lepr(db) affects body composition and leptin homeostasis in adult mice

Author keywords

Diabetes; Fat mass; Leptin receptor; Obesity

Indexed keywords

LEPTIN;

EID: 0031980203     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.4.r985     Document Type: Article
Times cited : (104)

References (48)
  • 1
    • 70449232246 scopus 로고
    • Retinal degeneration combined with obesity, diabetes mellitus and neurogenous deafness: A specific syndrome (not hitherto described) distinct from the Laurence-Moon-Biedl syndrome. A clinical endocrinological and genetic examination based on a large pedigree
    • Alstrom, C., B. Hallgren, L. Nilsson, and H. Asander. Retinal degeneration combined with obesity, diabetes mellitus and neurogenous deafness: a specific syndrome (not hitherto described) distinct from the Laurence-Moon-Biedl syndrome. A clinical endocrinological and genetic examination based on a large pedigree. Acta Psychiatr. Scand. 34: 1-35, 1959.
    • (1959) Acta Psychiatr. Scand. , vol.34 , pp. 1-35
    • Alstrom, C.1    Hallgren, B.2    Nilsson, L.3    Asander, H.4
  • 2
    • 0022435134 scopus 로고
    • Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross
    • Amar, L. C., D. Arnaud, J. Cambrou, J. L. Guenet, and P. R. Avner. Mapping of the mouse X chromosome using random genomic probes and an interspecific mouse cross. EMBO J. 4: 3695-3700, 1985.
    • (1985) EMBO J. , vol.4 , pp. 3695-3700
    • Amar, L.C.1    Arnaud, D.2    Cambrou, J.3    Guenet, J.L.4    Avner, P.R.5
  • 4
    • 0001539825 scopus 로고
    • Ein Geschwisterpaar mit adiposo-genitaler Dystrophie
    • Biedl, A. Ein Geschwisterpaar mit adiposo-genitaler Dystrophie. Dtsch. Med. Wochenschr. 48: 1630, 1922.
    • (1922) Dtsch. Med. Wochenschr. , vol.48 , pp. 1630
    • Biedl, A.1
  • 7
    • 0030028959 scopus 로고    scopus 로고
    • Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor
    • Chua, S. C., W. K. Chung, X. S. Wu-Peng, Y. Zhang, S.-M. Liu, L. Tartaglia, and R. L. Leibel. Phenotypes of mouse diabetes and rat fatty due to mutations in the ob (leptin) receptor. Science 27: 994-996, 1996.
    • (1996) Science , vol.27 , pp. 994-996
    • Chua, S.C.1    Chung, W.K.2    Wu-Peng, X.S.3    Zhang, Y.4    Liu, S.-M.5    Tartaglia, L.6    Leibel, R.L.7
  • 12
    • 0015831045 scopus 로고
    • A new syndrome with hypotonia, obesity, mental deficiency, and facial, oral, ocular and limb abnormalities
    • Cohen, M., B. Hall, D. Smith, C. Graham, and K. Lampert. A new syndrome with hypotonia, obesity, mental deficiency, and facial, oral, ocular and limb abnormalities. J. Pediatr. 83: 280-284, 1973.
    • (1973) J. Pediatr. , vol.83 , pp. 280-284
    • Cohen, M.1    Hall, B.2    Smith, D.3    Graham, C.4    Lampert, K.5
  • 13
    • 0026507488 scopus 로고
    • Economic costs of obesity
    • Colditz, G. A. Economic costs of obesity. Am. J. Clin. Nutr. 55: 503S-507S, 1992.
    • (1992) Am. J. Clin. Nutr. , vol.55
    • Colditz, G.A.1
  • 14
    • 0018355535 scopus 로고
    • Obesity genes: Beneficial effects in heterozygous mice
    • Coleman, D. L. Obesity genes: beneficial effects in heterozygous mice. Science 203: 663-665, 1979.
    • (1979) Science , vol.203 , pp. 663-665
    • Coleman, D.L.1
  • 15
    • 0018905370 scopus 로고
    • Acetone metabolism in mice: Increased activity in mice heterozygous for obesity genes
    • Coleman, D. L. Acetone metabolism in mice: increased activity in mice heterozygous for obesity genes. Proc. Natl. Acad. Sci. USA 77: 290-293, 1980.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 290-293
    • Coleman, D.L.1
  • 16
    • 0029885220 scopus 로고    scopus 로고
    • The hypothalamic leptin receptor in humans: Identification of incidential sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations
    • Considine, R. V., E. L. Considine, C. J. Williams, T. M. Hyde, and J. F. Caro. The hypothalamic leptin receptor in humans: identification of incidential sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45: 992-994, 1996.
    • (1996) Diabetes , vol.45 , pp. 992-994
    • Considine, R.V.1    Considine, E.L.2    Williams, C.J.3    Hyde, T.M.4    Caro, J.F.5
  • 17
    • 0000896471 scopus 로고
    • Nitrogen determination by a continuous digestion and analysis system
    • Ferrari, A. Nitrogen determination by a continuous digestion and analysis system. Ann. NY Acad. Sci. 87: 792-800, 1960.
    • (1960) Ann. NY Acad. Sci. , vol.87 , pp. 792-800
    • Ferrari, A.1
  • 18
    • 0019471997 scopus 로고
    • Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice
    • Flatt, P., and C. Bailey. Abnormal plasma glucose and insulin responses in heterozygous lean (ob/+) mice. Diabetologia 20: 573-577, 1981.
    • (1981) Diabetologia , vol.20 , pp. 573-577
    • Flatt, P.1    Bailey, C.2
  • 19
    • 70449158340 scopus 로고
    • A simple method for isolation and purification of total lipids from animal tissue
    • Folch, J., M. Lees, and G. Sloane-Stanley. A simple method for isolation and purification of total lipids from animal tissue. J. Biol. Chem. 226: 496-503, 1957.
    • (1957) J. Biol. Chem. , vol.226 , pp. 496-503
    • Folch, J.1    Lees, M.2    Sloane-Stanley, G.3
  • 20
    • 0021747317 scopus 로고
    • Family resemblances in height and weight in the Framingham Heart Study
    • Heller, R., R. Garrison, R. Havlik, M. Feinleib, and S. Padgett. Family resemblances in height and weight in the Framingham Heart Study. Int. J. Obes. 8: 399-405, 1984.
    • (1984) Int. J. Obes. , vol.8 , pp. 399-405
    • Heller, R.1    Garrison, R.2    Havlik, R.3    Feinleib, M.4    Padgett, S.5
  • 21
    • 0014682035 scopus 로고
    • Regulation of energy balance
    • Hervey, G. R. Regulation of energy balance. Nature 222: 629-631, 1969.
    • (1969) Nature , vol.222 , pp. 629-631
    • Hervey, G.R.1
  • 23
    • 0015947834 scopus 로고
    • Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob)
    • Joosten, H. F. P., and P. H. W. vanderKroon. Enlargement of epididymal adipocytes in relation to hyperinsulinemia in obese hyperglycemic mice (ob/ob). Metabolism 23: 59-66, 1974.
    • (1974) Metabolism , vol.23 , pp. 59-66
    • Joosten, H.F.P.1    VanderKroon, P.H.W.2
  • 27
    • 0031436635 scopus 로고    scopus 로고
    • The molecular genetics of rodent single gene obesities
    • In press
    • Leibel, R. L., W. K. Chung, and S. C. Chua. The molecular genetics of rodent single gene obesities. J. Biol. Chem. In press.
    • J. Biol. Chem.
    • Leibel, R.L.1    Chung, W.K.2    Chua, S.C.3
  • 29
    • 0030980198 scopus 로고    scopus 로고
    • A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty
    • Mantzoros, C., J. Flier, and A. Rogol. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J. Clin. Endocrinol. Metab. 82: 1066-1070, 1997.
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 1066-1070
    • Mantzoros, C.1    Flier, J.2    Rogol, A.3
  • 31
    • 0031054698 scopus 로고    scopus 로고
    • Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution
    • Montague, C., J. Prins, L. Sanders, J. Digby, and S. O'Rahilly. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46: 342-347, 1997.
    • (1997) Diabetes , vol.46 , pp. 342-347
    • Montague, C.1    Prins, J.2    Sanders, L.3    Digby, J.4    O'Rahilly, S.5
  • 33
    • 0000927260 scopus 로고
    • Ein syndrom von adipositas, kleinwuchs, kryptochismus und oligophrenie nach myatonieartigem zustand im neugeborenenalter
    • Prader, A., A. Labhart, and H. Willi. Ein syndrom von adipositas, kleinwuchs, kryptochismus und oligophrenie nach myatonieartigem zustand im neugeborenenalter. Schweiz. Med. Wochenschr. 86: 1260-1261, 1956.
    • (1956) Schweiz. Med. Wochenschr. , vol.86 , pp. 1260-1261
    • Prader, A.1    Labhart, A.2    Willi, H.3
  • 34
    • 0029938057 scopus 로고    scopus 로고
    • Extreme obesity may be linked to markers flanking the human OB gene
    • Reed, D. R., Y. Ding, W. Xu, C. Cather, E. D. Green, and R. A. Price. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45: 691-694, 1996.
    • (1996) Diabetes , vol.45 , pp. 691-694
    • Reed, D.R.1    Ding, Y.2    Xu, W.3    Cather, C.4    Green, E.D.5    Price, R.A.6
  • 37
    • 0020060156 scopus 로고
    • Composition in liver and brain of genetically obese (ob/ob) heterozygote (ob/+) and normal (+/+) mice
    • Sena, A., G. Rebel, R. Beith, P. Hubert, and A. Waksman. Composition in liver and brain of genetically obese (ob/ob) heterozygote (ob/+) and normal (+/+) mice. Biochim. Biophys. Acta 710: 290-296, 1982.
    • (1982) Biochim. Biophys. Acta , vol.710 , pp. 290-296
    • Sena, A.1    Rebel, G.2    Beith, R.3    Hubert, P.4    Waksman, A.5
  • 39
    • 0030297919 scopus 로고    scopus 로고
    • Adipogenesis and obesity: Rounding out the big picture
    • Spiegelman, B. M., and J. S. Flier. Adipogenesis and obesity: rounding out the big picture. Cell 87: 377-389, 1996.
    • (1996) Cell , vol.87 , pp. 377-389
    • Spiegelman, B.M.1    Flier, J.S.2
  • 40
    • 0022589555 scopus 로고
    • A twin study of human obesity
    • Stunkard, A. J., T. T. Foch, and Z. Hrubec. A twin study of human obesity. JAMA 256: 51-54, 1986.
    • (1986) JAMA , vol.256 , pp. 51-54
    • Stunkard, A.J.1    Foch, T.T.2    Hrubec, Z.3
  • 44
    • 0030915473 scopus 로고    scopus 로고
    • Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians
    • Thompson, D., E. Ravussin, P. Bennett, and C. Bogardus. Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians. Hum. Mol. Genet. 6: 675-679, 1997.
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 675-679
    • Thompson, D.1    Ravussin, E.2    Bennett, P.3    Bogardus, C.4
  • 45
    • 0028797999 scopus 로고
    • Codominant effects of the fatty (fa) gene during early development of obesity
    • Endocrinol. Metab. 31
    • Truett, G. E., R. J. Tempelman, and J. A. Walker. Codominant effects of the fatty (fa) gene during early development of obesity. Am. J. Physiol. 268 (Endocrinol. Metab. 31): E15-E20, 1995.
    • (1995) Am. J. Physiol. , vol.268
    • Truett, G.E.1    Tempelman, R.J.2    Walker, J.A.3
  • 48
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432, 1994.
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.