Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)lesioned rats: Evidence for loss of its satiety effect in VMH-lesioned rats

Endocrinology

Volumn 138, Issue 3, 1997, Pages 947-954

  Satoh, Noriko ^a   Ogawa, Yoshihiro ^a   Katsuura, Goro ^b   Tsuji, Tetsuo ^b   Masuzaki, Hiroaki ^a   Hiraoka, Junko ^a   Okazaki, Taku ^a   Tamaki, Mikio ^b   Hayase, Minoru ^b   Yoshimasa, Yasunao ^a   Nishi, Shigeo ^a   Hosoda, Kiminori ^a   Nakao, Kazuwa ^a  

^a KYOTO UNIVERSITY   (Japan)

^b SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; FOOD INTAKE; HORMONE DETERMINATION; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SATIETY; WEIGHT GAIN;

EID: 8044227781     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.3.4989     Document Type: Article

References (45)

1. Coleman DL 1978 Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-148
2. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
3. Ogawa Y, Masuzaki H, Isse N, Okazaki T, Mori K, Shigemoto M, Satoh N, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K 1995 Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 96:1547-1652
4. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K 1995 Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855-858
5. Considine RV, Considine EL, Williams CJ, Nyce MR, Magosin SA, Bauer TL, Rosato EL, Colberg J, Caro JF 1995 Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 95:2986-2988
6. Funahashi T, Shimomura I, Hiraoka H, Arai T, Takahashi M, Nakamura T, Nozaki S, Yamashita S, Takemura K, Tokunaga K, Matsuzawa Y 1995 Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 211:469-475
7. Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Freidman JM 1995 Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 92:6957-6960
8. Frederich RC, Lollmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS 1995 Expression of ob mRNA and its encoded protein in rodents: impact of nutrition and obesity. J Clin Invest 96:1658-1663
9. y mice. Am J Physiol 271:E333-E339
10. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, Kern PA, Friedman JM 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
11. Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS 1995 Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314
12. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, Mckee LJ, Bauer TL, Caro JF 1996 Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295
13. Hosoda K, Masuzaki H, Ogawa Y, Miyawaki T, Hiraoka J, Hanaoka I, Yasuno A, Nomura T, Fujisawa Y, Yoshimasa Y, Nishi S, Yamori Y, Nakao K 1996 Development of radioimmunoassny for human leptin. Biochem Biophys Res Commun 221:234-239
14. Peileymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
15. Halaas JL, Gajiwata KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
16. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549
17. Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L, Hale J, Huffman J, Hsiung HM, Kriauciunas A, MacKellar W, Rosteck PR Jr, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Heiman M 1995 The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-532
18. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070
19. Bray GA, Inoue S, Nishizawa Y 1981 Hypothalamic obesity: the autonomic hypothesis and the lateral hypothalamus. Diabetologia 20:366-377
20. Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte Jr D, Woods SC, Seeley RJ, Weigle DS 1996 Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531-535
21. Woods AJ, Stock MJ 1996 Leptin activation in hypothalamus. Nature 381:745
22. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays CG, Woolf EA, Monroe CA, Tepper RI 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
23. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P 1996 Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 387:113-116
24. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey MD, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP 1996 Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495
25. Lee G-H, Proenca R, Montez JM, Carroll KM, Darvishzaeh JG, Lee JI, Freidman JM 1996 Abnormal splicing of the leptin receptor in diabetes mice. Nature 379:632-635
26. Hervey GR 1959 The effects of lesions in the hypothalamus in parabiotic rats. J Physiol 145:336-352
27. Nishizawa Y, Bray GA 1980 Evidence for a circulating ergostatic factor: studies on parabiotic rats. Am J Physiol 239:R344-R351
28. Paxinos G, Watson C 1986 The Rat Brain in Stereotaxic Coordinates, ed 2. Academic Press, Sydney
29. Studier FW, Rosenberg AH, Dunn JJ, Dubendorff JW 1990 Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol 185:60-89
30. Yasueda H, Nagase K, Hosoda A, Akiyama Y, Yamada K 1990 High-level direct expression of semi-synthetic human interleukin-6 in Escherichia coli and production of N-terminus Met-free product. BioTechnology 8:1036-1040
31. Bradford MM 1976 A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
32. Katsuura G, Itoh S 1986 Preventive effect of cholecystokinin octapeptide on experimental amnesia in rats. Peptides 7:105-110
33. Coleman DL, Hummel KP 1969 Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 217:1298-1304
34. Harris RBS, Hervey E, Hervey GR, Tobin G 1987 Body composition of lean and obese Zucker rats in parabiosis. Int J Obes 11:275-283
35. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF 1996 Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13:18-19
36. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K 1996 Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 222:19-26
37. Takaya K, Ogawa Y, Isse N, Okazaki T, Satoh N, Masuzaki H, Mon K, Tamura N, Hosoda K, Nakao K 1996 Molecular cloning of rat leptin receptor isoform complementary DNAs: identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem Biophys Res Commun 225:75-83
38. Berthoud HR, Jeanrenaud B 1979 Acute hyperinsulinemia and its reversal by vagotomy after lesions of the ventromedial hypothalamus in anesthetized rats. Endocrinology 105:146-151
39. Saladin R, Vos PD, Guerre-Millo M, Leturque A, Girad J, Staels B, Auwerx J 1995 Transient increase in obese gene expression after food intake or insulin administration. Nature 377:527-529
40. Trayhurn P, Duncan JS, Rayner V 1995 Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 311:729-733
41. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS 1996 Role of leptin in fat regulation. Nature 380:677
42. Trayhurn P, Thomas MEA, Duncan JS, Rayner DV 1995 Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (ob/ob) mice. FEBS Lett 368:488-490
43. Cusin I, Sainsbury A, Doyle P, Rohner-Jeanrenaud F, Jeanrenaud B 1995 The ob gene and insulin: a relationship leading to clues to the understanding of obesity. Diabetes 44:1467-1470
44. Slicker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW 1996 Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271:5301-5304
45. Enser M, Roberts J, Whittington F 1985 Effect of gold thioglucose-induced obesity on adipose tissue weight and cellularity in male and female mice suckled in large and small litters: investigations into sex differences and site differences. Br J Nutr 54:645-654