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Volumn 46, Issue 7, 1997, Pages 812-817

Serum leptin is increased in growth hormone-deficient adults: Relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; LEPTIN;

EID: 0030745227     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90128-1     Document Type: Article
Times cited : (75)

References (44)
  • 1
    • 0027942465 scopus 로고
    • Genetics. in search of a satiety factor
    • Rink TJ: Genetics. In search of a satiety factor. Nature 372:406-407, 1994
    • (1994) Nature , vol.372 , pp. 406-407
    • Rink, T.J.1
  • 2
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • Pelleymonter MA, Cullen MJ, Baker MB, et al: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymonter, M.A.1    Cullen, M.J.2    Baker, M.B.3
  • 3
    • 0028825577 scopus 로고    scopus 로고
    • Recombinant ob protein reduces feeding and body weight in the ob/ob mouse
    • Weigle DS, Bukowski TR, Foster DC, et al: Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96:2065-2070, 1996
    • (1996) J Clin Invest , vol.96 , pp. 2065-2070
    • Weigle, D.S.1    Bukowski, T.R.2    Foster, D.C.3
  • 4
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • Zhang Y, Proenca R, Maffei M, et al: Positional cloning of the mouse obese gene and its human homologue. Nature 472:425-432, 1994
    • (1994) Nature , vol.472 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3
  • 5
    • 2442654859 scopus 로고
    • Identification and expression cloning of a leptin receptor, OB-R
    • Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
    • (1995) Cell , vol.83 , pp. 1263-1271
    • Tartaglia, L.A.1    Dembski, M.2    Weng, X.3
  • 6
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • Maffei M, Halaas J, Ravussin E, et al: Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161, 1995
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3
  • 7
    • 0029941697 scopus 로고    scopus 로고
    • Radioimmunoassay of leptin in human plasma
    • Ma Z, Gingerich RL, Santiago JV, et al: Radioimmunoassay of leptin in human plasma. Clin Chem 42:942-946, 1996
    • (1996) Clin Chem , vol.42 , pp. 942-946
    • Ma, Z.1    Gingerich, R.L.2    Santiago, J.V.3
  • 8
    • 0029893211 scopus 로고    scopus 로고
    • Leptin concentrations in diabetic and nondiabetic Mexican-Americans
    • Haffner SM, Stern MP, Miettinen H, et al: Leptin concentrations in diabetic and nondiabetic Mexican-Americans. Diabetes 45:822-824, 1996
    • (1996) Diabetes , vol.45 , pp. 822-824
    • Haffner, S.M.1    Stern, M.P.2    Miettinen, H.3
  • 9
    • 0029974877 scopus 로고    scopus 로고
    • Adipose tissue leptin production and plasma leptin kinetics in humans
    • Klein S, Coppack SW, Mohamed Ali V, et al: Adipose tissue leptin production and plasma leptin kinetics in humans. Diabetes 45:984-987, 1996
    • (1996) Diabetes , vol.45 , pp. 984-987
    • Klein, S.1    Coppack, S.W.2    Mohamed Ali, V.3
  • 10
    • 13344295079 scopus 로고    scopus 로고
    • Serum immunoreactive-leptin concentrations in normal-weight and obese humans
    • Considine RV, Sinha MK, Heiman ML, et al: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
    • (1996) N Engl J Med , vol.334 , pp. 292-295
    • Considine, R.V.1    Sinha, M.K.2    Heiman, M.L.3
  • 11
    • 0029859209 scopus 로고    scopus 로고
    • Leptin: A significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women
    • Dua A, Hennes MI, Hoffmann RG, et al: Leptin: A significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women. Diabetes 45:1635-1637, 1996
    • (1996) Diabetes , vol.45 , pp. 1635-1637
    • Dua, A.1    Hennes, M.I.2    Hoffmann, R.G.3
  • 12
    • 0024854194 scopus 로고
    • The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency
    • Salomon F, Cuneo RC, Hesp R, et al: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-1803, 1989
    • (1989) N Engl J Med , vol.321 , pp. 1797-1803
    • Salomon, F.1    Cuneo, R.C.2    Hesp, R.3
  • 13
    • 0024390712 scopus 로고
    • Beneficial effects of growth hormone treatment in GH-deficient adults
    • Jørgensen JO, Pedersen SA, Thuesen L, et al: Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1:1221-1225, 1989
    • (1989) Lancet , vol.1 , pp. 1221-1225
    • Jørgensen, J.O.1    Pedersen, S.A.2    Thuesen, L.3
  • 14
    • 0027398458 scopus 로고
    • Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency
    • Oxf
    • Rosen T, Bosaeus I, Tolli J, et al: Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol (Oxf) 38:63-71, 1993
    • (1993) Clin Endocrinol , vol.38 , pp. 63-71
    • Rosen, T.1    Bosaeus, I.2    Tolli, J.3
  • 15
    • 0027140982 scopus 로고
    • Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses
    • Amato G, Carella C, Fazio S, et al: Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab 77:1671-1676, 1993
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1671-1676
    • Amato, G.1    Carella, C.2    Fazio, S.3
  • 16
    • 0026724687 scopus 로고
    • Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism
    • Copenh
    • Degerblad M, Elgindy N, Hall K, et al: Potent effect of recombinant growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinol (Copenh) 126:387-393, 1992
    • (1992) Acta Endocrinol , vol.126 , pp. 387-393
    • Degerblad, M.1    Elgindy, N.2    Hall, K.3
  • 17
    • 0026719076 scopus 로고
    • Body composition in growth hormone-deficient adults
    • Binnerts A, Deurenberg P, Swart GR, et al: Body composition in growth hormone-deficient adults. Am J Clin Nutr 55:918-923, 1992
    • (1992) Am J Clin Nutr , vol.55 , pp. 918-923
    • Binnerts, A.1    Deurenberg, P.2    Swart, G.R.3
  • 18
    • 0028278741 scopus 로고
    • Three years of growth hormone treatment in growth hormone-deficient adults: Near normalization of body composition and physical performance
    • Jørgensen JO, Thuesen L, Muller J, et al: Three years of growth hormone treatment in growth hormone-deficient adults: Near normalization of body composition and physical performance. Eur J Endocrinol 130:224-228, 1994
    • (1994) Eur J Endocrinol , vol.130 , pp. 224-228
    • Jørgensen, J.O.1    Thuesen, L.2    Muller, J.3
  • 19
    • 0028895104 scopus 로고
    • Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy
    • Snel YE, Doerga ME, Brummer RJ, et al: Resting metabolic rate, body composition and related hormonal parameters in growth hormone-deficient adults before and after growth hormone replacement therapy. Eur J Endocrinol 133:445-450, 1995
    • (1995) Eur J Endocrinol , vol.133 , pp. 445-450
    • Snel, Y.E.1    Doerga, M.E.2    Brummer, R.J.3
  • 20
    • 0028836575 scopus 로고
    • Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism
    • Hoffman DM, O'Sullivan AJ, Freund J, et al: Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. J Clin Endocrinol Metab 80:72-77, 1995
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 72-77
    • Hoffman, D.M.1    O'Sullivan, A.J.2    Freund, J.3
  • 21
    • 0027267653 scopus 로고
    • Growth hormone receptor and growth hormone-binding protein messages in mouse placenta contain the exon analogous to human exon 3
    • Barnard R, Southard JN, Edens A, et al: Growth hormone receptor and growth hormone-binding protein messages in mouse placenta contain the exon analogous to human exon 3. Endocrinology 133:1474-1477, 1993
    • (1993) Endocrinology , vol.133 , pp. 1474-1477
    • Barnard, R.1    Southard, J.N.2    Edens, A.3
  • 22
    • 0028318660 scopus 로고
    • Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone
    • Oxf
    • Chong PK, Jung RT, Scrimgeour CM, et al: Energy expenditure and body composition in growth hormone deficient adults on exogenous growth hormone. Clin Endocrinol (Oxf) 40:103-110, 1994
    • (1994) Clin Endocrinol , vol.40 , pp. 103-110
    • Chong, P.K.1    Jung, R.T.2    Scrimgeour, C.M.3
  • 23
    • 0027143634 scopus 로고
    • Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: Studies in GH-deficient patients and healthy untreated subjects
    • Jørgensen JO, Møller J, Alberti KG, et al: Marked effects of sustained low growth hormone (GH) levels on day-to-day fuel metabolism: Studies in GH-deficient patients and healthy untreated subjects. J Clin Endocrinol Metab 77:1589-1596, 1993
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1589-1596
    • Jørgensen, J.O.1    Møller, J.2    Alberti, K.G.3
  • 24
    • 0028090633 scopus 로고
    • Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: Studies in GH-deficient adults
    • Oxf
    • Jørgensen JO, Møller J, Laursen T, et al: Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: Studies in GH-deficient adults. Clin Endocrinol (Oxf) 41:609-614, 1994
    • (1994) Clin Endocrinol , vol.41 , pp. 609-614
    • Jørgensen, J.O.1    Møller, J.2    Laursen, T.3
  • 25
    • 0028233730 scopus 로고
    • Fuel metabolism, energy expenditure, and thyroid function in growth hormone-treated obese women: A double-blind placebo-controlled study
    • Jørgensen JO, Pedersen SB, Børglum J, et al: Fuel metabolism, energy expenditure, and thyroid function in growth hormone-treated obese women: A double-blind placebo-controlled study. Metabolism 43:872-877, 1994
    • (1994) Metabolism , vol.43 , pp. 872-877
    • Jørgensen, J.O.1    Pedersen, S.B.2    Børglum, J.3
  • 26
    • 0023448602 scopus 로고
    • The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations
    • Veldhuis JD, Carlson ML, Johnson ML: The pituitary gland secretes in bursts: Appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations. Proc Natl Acad Sci USA 84:7686-7690, 1987
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7686-7690
    • Veldhuis, J.D.1    Carlson, M.L.2    Johnson, M.L.3
  • 27
    • 0014412936 scopus 로고
    • Wick chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone
    • Ørskov H, Thomsen HG, Yde H: Wick chromatography for rapid and reliable immunoassay of insulin, glucagon and growth hormone. Nature 219:193-195, 1968
    • (1968) Nature , vol.219 , pp. 193-195
    • Ørskov, H.1    Thomsen, H.G.2    Yde, H.3
  • 28
    • 0029615371 scopus 로고
    • Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II
    • Frystyk J, Dinesen B, Ørskov H: Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II. Growth Regul 5:169-176, 1995
    • (1995) Growth Regul , vol.5 , pp. 169-176
    • Frystyk, J.1    Dinesen, B.2    Ørskov, H.3
  • 29
    • 0029797622 scopus 로고    scopus 로고
    • A simple, rapid immunometric assay for determination of functional and growth hormone (GH)-occupied GH-binding protein in human serum
    • Fisker S, Frystyk J, Skriver L, et al: A simple, rapid immunometric assay for determination of functional and growth hormone (GH)-occupied GH-binding protein in human serum. Eur J Clin Invest 26:779-785, 1996
    • (1996) Eur J Clin Invest , vol.26 , pp. 779-785
    • Fisker, S.1    Frystyk, J.2    Skriver, L.3
  • 30
    • 0029886765 scopus 로고    scopus 로고
    • Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults
    • Vahl N, Jørgensen JOL, Jurik AG, et al: Abdominal adiposity and physical fitness are major determinants of the age associated decline in stimulated GH secretion in healthy adults. J Clin Endocrinol Metab 81:2209-2215, 1996
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2209-2215
    • Vahl, N.1    Jørgensen, J.O.L.2    Jurik, A.G.3
  • 31
    • 0029558748 scopus 로고
    • Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: A double-blind, randomized, placebo-controlled study
    • Oxf
    • Hansen TB, Vahl N, Jørgensen JOL, et al: Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: A double-blind, randomized, placebo-controlled study. Clin Endocrinol (Oxf) 43:689-696, 1995
    • (1995) Clin Endocrinol , vol.43 , pp. 689-696
    • Hansen, T.B.1    Vahl, N.2    Jørgensen, J.O.L.3
  • 32
    • 0029090011 scopus 로고
    • Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue
    • Masuzaki H, Ogawa Y, Isse N, et al: Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44:855-858, 1995
    • (1995) Diabetes , vol.44 , pp. 855-858
    • Masuzaki, H.1    Ogawa, Y.2    Isse, N.3
  • 33
    • 0029816596 scopus 로고    scopus 로고
    • Effects of gender, body composition, and menopause on plasma concentrations of leptin
    • Rosenbaum M, Nicolson M, Hirsch J, et al: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424-3427, 1996
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3424-3427
    • Rosenbaum, M.1    Nicolson, M.2    Hirsch, J.3
  • 34
    • 0029964173 scopus 로고    scopus 로고
    • Serum growth hormone-binding protein in obesity: Effect of a short-term, very low calorie diet and diet-induced weight loss
    • Rasmussen MH, Ho KKY, Kjems L, et al: Serum growth hormone-binding protein in obesity: Effect of a short-term, very low calorie diet and diet-induced weight loss. J Clin Endocrinol Metab 81:1519-1524, 1996
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1519-1524
    • Rasmussen, M.H.1    Ho, K.K.Y.2    Kjems, L.3
  • 35
    • 0026570421 scopus 로고
    • The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-I (IGF-I), and IGF-I receptors in obesity and anorexia nervosa
    • Hochberg Z, Hertz P, Colin V, et al: The distal axis of growth hormone (GH) in nutritional disorders: GH-binding protein, insulin-like growth factor-I (IGF-I), and IGF-I receptors in obesity and anorexia nervosa. Metabolism 41:106-112, 1992
    • (1992) Metabolism , vol.41 , pp. 106-112
    • Hochberg, Z.1    Hertz, P.2    Colin, V.3
  • 36
    • 0028219566 scopus 로고
    • Direct quantitation of growth hormone binding protein in human serum by a ligand immunofunctional assay: Comparison with immunoprecipitation and Chromatographie methods
    • Rajkovic IA, Valiontis E, Ho KK: Direct quantitation of growth hormone binding protein in human serum by a ligand immunofunctional assay: Comparison with immunoprecipitation and Chromatographie methods. J Clin Endocrinol Metab 78:772-777, 1994
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 772-777
    • Rajkovic, I.A.1    Valiontis, E.2    Ho, K.K.3
  • 37
    • 0029909389 scopus 로고    scopus 로고
    • Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women
    • Larsson H, Elmståhl S, Ahrén B: Plasma leptin levels correlate to islet function independently of body fat in postmenopausal women. Diabetes 45:1580-1584, 1996
    • (1996) Diabetes , vol.45 , pp. 1580-1584
    • Larsson, H.1    Elmståhl, S.2    Ahrén, B.3
  • 38
    • 0029665017 scopus 로고    scopus 로고
    • Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro
    • Kolaczynski JW, Nyce MR, Considine RV, et al: Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45:699-701, 1996
    • (1996) Diabetes , vol.45 , pp. 699-701
    • Kolaczynski, J.W.1    Nyce, M.R.2    Considine, R.V.3
  • 39
    • 0029784397 scopus 로고    scopus 로고
    • Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects
    • Utriainen T, Malmström R, Mäkimattila S, et al: Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45:1364-1366, 1996
    • (1996) Diabetes , vol.45 , pp. 1364-1366
    • Utriainen, T.1    Malmström, R.2    Mäkimattila, S.3
  • 40
    • 0029924714 scopus 로고    scopus 로고
    • Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM
    • Malmström R, Taskinen MR, Karonen SL, et al: Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993-996, 1996
    • (1996) Diabetologia , vol.39 , pp. 993-996
    • Malmström, R.1    Taskinen, M.R.2    Karonen, S.L.3
  • 41
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
    • Frederich RC, Hamann A, Anderson S, et al: Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nat Med 1:1311-1314, 1995
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3
  • 42
    • 0039228752 scopus 로고
    • Studies in the distribution of body fat: I. Effects of age, sex, and obesity
    • Shimokata H, Tobin JD, Muller DC, et al: Studies in the distribution of body fat: I. Effects of age, sex, and obesity. J Gerontol 44:M66-M73, 1989
    • (1989) J Gerontol , vol.44
    • Shimokata, H.1    Tobin, J.D.2    Muller, D.C.3
  • 43
    • 0026374634 scopus 로고
    • Body fat in the adult Danish population aged 35-65 years: An epidemiological study
    • Heitmann BL: Body fat in the adult Danish population aged 35-65 years: An epidemiological study. Int J Obes 15:535-545, 1991
    • (1991) Int J Obes , vol.15 , pp. 535-545
    • Heitmann, B.L.1
  • 44
    • 0028124254 scopus 로고
    • Are gender differences in cardiovascular disease risk factors explained by the level of visceral adipose tissue?
    • Lemieux S, Despres JP, Moorjani S, et al: Are gender differences in cardiovascular disease risk factors explained by the level of visceral adipose tissue? Diabetologia 37:757-764, 1994
    • (1994) Diabetologia , vol.37 , pp. 757-764
    • Lemieux, S.1    Despres, J.P.2    Moorjani, S.3


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