-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432 (1994).
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
-
2
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
-
3
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter, M.A. et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540-543 (1995).
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
-
4
-
-
0029048408
-
Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks
-
Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546-549 (1995).
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
Devos, R.4
Burn, P.5
-
5
-
-
13344280346
-
Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice
-
Schwartz, M.W. et al. Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45, 531-535 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 531-535
-
-
Schwartz, M.W.1
-
6
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei, M. et al. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med. 1, 1155-1161 (1995).
-
(1995)
Nature Med.
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
-
7
-
-
13344295079
-
Serum immunoreactive-leptin concentrations in normal-weight and obese humans
-
Considine, R.V. et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334, 292-295 (1996).
-
(1996)
N. Engl. J. Med.
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
-
8
-
-
0018139377
-
Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
-
Coleman, D.L. Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-148 (1978).
-
(1978)
Diabetologia
, vol.14
, pp. 141-148
-
-
Coleman, D.L.1
-
9
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OB-R
-
Tartaglia, L.A. et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 85, 1265-1271 (1995).
-
(1995)
Cell
, vol.85
, pp. 1265-1271
-
-
Tartaglia, L.A.1
-
10
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee, G.-H. et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632-635 (1996).
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.-H.1
-
11
-
-
0029071972
-
Reduced insulin secretion: An independent predictor of body weight gain
-
Schwartz, M.W., Boyko, E.J., Kahn, S.E., Ravussin, E. & Bogardus, C. Reduced insulin secretion: An independent predictor of body weight gain. J. Clin. Endocrinol. Metab. 80, 1571-1576 (1995).
-
(1995)
J. Clin. Endocrinol. Metab.
, vol.80
, pp. 1571-1576
-
-
Schwartz, M.W.1
Boyko, E.J.2
Kahn, S.E.3
Ravussin, E.4
Bogardus, C.5
-
12
-
-
0025783337
-
Insulin resistance associated with lower rates of weight gain in Pima Indians
-
Swinburn, B.A. et al. Insulin resistance associated with lower rates of weight gain in Pima Indians. J. Clin. Invest. 88, 168-173 (1991).
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 168-173
-
-
Swinburn, B.A.1
-
13
-
-
0023851885
-
Reduced rate of energy expenditure as a risk factor for bodyweight gain
-
Ravussin, E. et al. Reduced rate of energy expenditure as a risk factor for bodyweight gain. N. Engl. J. Med. 318, 467-472 (1988).
-
(1988)
N. Engl. J. Med.
, vol.318
, pp. 467-472
-
-
Ravussin, E.1
-
14
-
-
15844373886
-
The human obese gene: Isolation, characterization, identification of a DNA polymorphism and mutation screening in obese/diabetic subjects
-
Maffei, M. et al. The human obese gene: Isolation, characterization, identification of a DNA polymorphism and mutation screening in obese/diabetic subjects. Diabetes 45, 679-682 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 679-682
-
-
Maffei, M.1
-
15
-
-
0029020677
-
Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity
-
Considine, R.V. et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J. Clin. Invest. 95, 2986-2988 (1995).
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2986-2988
-
-
Considine, R.V.1
-
16
-
-
0029821904
-
Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians
-
Norman, R.A. et al. Absence of linkage of obesity and energy metabolism to markers flanking homologues of rodent obesity genes in Pima Indians. Diabetes 45, 1229-1232 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 1229-1232
-
-
Norman, R.A.1
-
17
-
-
0029150525
-
Identification of microsatellite markers near the human OB gene and linkage studies in NIDDM-affected sib pairs
-
Stirling, B. et al. Identification of microsatellite markers near the human OB gene and linkage studies in NIDDM-affected sib pairs. Diabetes 44, 999-1001 (1995).
-
(1995)
Diabetes
, vol.44
, pp. 999-1001
-
-
Stirling, B.1
-
18
-
-
0029938057
-
Extreme obesity may be linked to markers flanking the human OB gene
-
Reed, D.R. et al. Extreme obesity may be linked to markers flanking the human OB gene. Diabetes 45, 691-694 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 691-694
-
-
Reed, D.R.1
-
19
-
-
0345335191
-
Indication of linkage of the human OB gene region with extreme obesity
-
Clément, K. et al. Indication of linkage of the human OB gene region with extreme obesity. Diabetes 45, 687-690 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 687-690
-
-
Clément, K.1
-
20
-
-
0029157428
-
Transient increase in obese gene expression after food intake or insulin administration
-
Saladin, R. et al. Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527-529 (1995).
-
(1995)
Nature
, vol.377
, pp. 527-529
-
-
Saladin, R.1
-
21
-
-
0029665017
-
Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro
-
Kolaczynski, J.W. et al. Acute and chronic effect of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45, 699-701 (1996).
-
(1996)
Diabetes
, vol.45
, pp. 699-701
-
-
Kolaczynski, J.W.1
-
22
-
-
0029098589
-
The role of neuropeptide Y in the antiobesity action of the obese gene product
-
Stephens, T.W. et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530-532 (1995).
-
(1995)
Nature
, vol.377
, pp. 530-532
-
-
Stephens, T.W.1
-
23
-
-
0029881125
-
Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans
-
Schwartz, M.W., Peskind, E., Raskind, M., Boyko, E.J. & Porte, D., Jr. Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans. Nature Med. 2, 589-592 (1996).
-
(1996)
Nature Med.
, vol.2
, pp. 589-592
-
-
Schwartz, M.W.1
Peskind, E.2
Raskind, M.3
Boyko, E.J.4
Porte Jr., D.5
-
24
-
-
15844409555
-
Leptin stimulates sympathetic outflow to brown adipose tissue
-
Collins, S. et al. Leptin stimulates sympathetic outflow to brown adipose tissue. Nature 380, 677 (1996).
-
(1996)
Nature
, vol.380
, pp. 677
-
-
Collins, S.1
-
25
-
-
0027360269
-
Reduced sympathetic nervous activity: A potential mechanism predisposing to body weight gain
-
Spraul, M. et al. Reduced sympathetic nervous activity: A potential mechanism predisposing to body weight gain. J. Clin. Invest. 92, 1730-1735 (1993).
-
(1993)
J. Clin. Invest.
, vol.92
, pp. 1730-1735
-
-
Spraul, M.1
-
26
-
-
70349566593
-
Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"
-
Neel, J.V. Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress." Am. J. Hum. Genet. 14, 353-362 (1962).
-
(1962)
Am. J. Hum. Genet.
, vol.14
, pp. 353-362
-
-
Neel, J.V.1
-
27
-
-
0029896530
-
Role of leptin in the neuroendocrine response to fasting
-
Ahima, R.S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252 (1996).
-
(1996)
Nature
, vol.382
, pp. 250-252
-
-
Ahima, R.S.1
-
28
-
-
0027762766
-
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus
-
Lillioja, S. et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. N. Engl. J. Med. 329, 1988-1992 (1993).
-
(1993)
N. Engl. J. Med.
, vol.329
, pp. 1988-1992
-
-
Lillioja, S.1
|