-
1
-
-
0029981430
-
Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
-
C.C. Paulusma, P.J. Bosma, and G.J. Zaman Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene Science 271 1996 1126 1128
-
(1996)
Science
, vol.271
, pp. 1126-1128
-
-
Paulusma, C.C.1
Bosma, P.J.2
Zaman, G.J.3
-
2
-
-
0040761368
-
CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
-
M. Buchler, J. Konig, and M. Brom cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats J. Biol. Chem. 271 1996 15091 15098
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 15091-15098
-
-
Buchler, M.1
Konig, J.2
Brom, M.3
-
3
-
-
0031031247
-
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR
-
K. Ito, H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR Am. J. Physiol. 272 1997 G16 G22
-
(1997)
Am. J. Physiol.
, vol.272
-
-
Ito, K.1
Suzuki, H.2
Hirohashi, T.3
Kume, K.4
Shimizu, T.5
Sugiyama, Y.6
-
4
-
-
0345724724
-
The MRP family of drug efflux pumps
-
G.D. Kruh, and M.G. Belinsky The MRP family of drug efflux pumps Oncogene 22 2003 7537 7552
-
(2003)
Oncogene
, vol.22
, pp. 7537-7552
-
-
Kruh, G.D.1
Belinsky, M.G.2
-
5
-
-
0031026369
-
Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters
-
G.E. Tusnady, E. Bakos, A. Varadi, and B. Sarkadi Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters FEBS Lett. 402 1997 1 3
-
(1997)
FEBS Lett.
, vol.402
, pp. 1-3
-
-
Tusnady, G.E.1
Bakos, E.2
Varadi, A.3
Sarkadi, B.4
-
6
-
-
0142107445
-
Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate
-
L. Homolya, A. Varadi, and B. Sarkadi Multidrug resistance-associated proteins: export pumps for conjugates with glutathione, glucuronate or sulfate Biofactors 17 2003 103 114
-
(2003)
Biofactors
, vol.17
, pp. 103-114
-
-
Homolya, L.1
Varadi, A.2
Sarkadi, B.3
-
7
-
-
0037122743
-
Role of transporters in the tissue-selective distribution and elimination of drugs: Transporters in the liver, small intestine, brain and kidney
-
H. Kusuhara, and Y. Sugiyama Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney J. Control. Release 78 2002 43 54
-
(2002)
J. Control. Release
, vol.78
, pp. 43-54
-
-
Kusuhara, H.1
Sugiyama, Y.2
-
8
-
-
0346728729
-
The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
-
L.M. Chan, S. Lowes, and B.H. Hirst The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability Eur. J. Pharm. Sci. 21 2004 25 51
-
(2004)
Eur. J. Pharm. Sci.
, vol.21
, pp. 25-51
-
-
Chan, L.M.1
Lowes, S.2
Hirst, B.H.3
-
9
-
-
3542995726
-
The complexities of hepatic drug transport: Current knowledge and emerging concepts
-
P. Chandra, and K.L. Brouwer The complexities of hepatic drug transport: current knowledge and emerging concepts Pharm. Res. 21 2004 719 735
-
(2004)
Pharm. Res.
, vol.21
, pp. 719-735
-
-
Chandra, P.1
Brouwer, K.L.2
-
10
-
-
0031158790
-
Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR?
-
P. Borst, M. Kool, and R. Evers Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR? Semin. Cancer Biol. 8 1997 205 213
-
(1997)
Semin. Cancer Biol.
, vol.8
, pp. 205-213
-
-
Borst, P.1
Kool, M.2
Evers, R.3
-
11
-
-
0032413678
-
Biochemical and molecular aspects of genetic disorders of bilirubin metabolism
-
T. Iyanagi, Y. Emi, and S. Ikushiro Biochemical and molecular aspects of genetic disorders of bilirubin metabolism Biochim. Biophys. Acta 1407 1998 173 184
-
(1998)
Biochim. Biophys. Acta
, vol.1407
, pp. 173-184
-
-
Iyanagi, T.1
Emi, Y.2
Ikushiro, S.3
-
12
-
-
0033361943
-
Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome
-
S. Toh, M. Wada, and T. Uchiumi Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome Am. J. Hum. Genet. 64 1999 739 746
-
(1999)
Am. J. Hum. Genet.
, vol.64
, pp. 739-746
-
-
Toh, S.1
Wada, M.2
Uchiumi, T.3
-
13
-
-
0034674901
-
A family of drug transporters: The multidrug resistance-associated proteins
-
P. Borst, R. Evers, M. Kool, and J. Wijnholds A family of drug transporters: the multidrug resistance-associated proteins J. Natl. Cancer Inst. 92 2000 1295 1302
-
(2000)
J. Natl. Cancer Inst.
, vol.92
, pp. 1295-1302
-
-
Borst, P.1
Evers, R.2
Kool, M.3
Wijnholds, J.4
-
14
-
-
0035813012
-
Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters
-
E.M. Leslie, R.G. Deeley, and S.P. Cole Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters Toxicology 167 2001 3 23
-
(2001)
Toxicology
, vol.167
, pp. 3-23
-
-
Leslie, E.M.1
Deeley, R.G.2
Cole, S.P.3
-
15
-
-
0034671544
-
Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2
-
S. Ryu, T. Kawabe, S. Nada, and A. Yamaguchi Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2 J. Biol. Chem. 275 2000 39617 39624
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39617-39624
-
-
Ryu, S.1
Kawabe, T.2
Nada, S.3
Yamaguchi, A.4
-
16
-
-
0035028211
-
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2
-
K. Ito, H. Suzuki, and Y. Sugiyama Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2 Mol. Pharmacol. 59 2001 1077 1085
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 1077-1085
-
-
Ito, K.1
Suzuki, H.2
Sugiyama, Y.3
-
17
-
-
0035851106
-
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity
-
K. Ito, C.J. Oleschuk, C. Westlake, M.Z. Vasa, R.G. Deeley, and S.P. Cole Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity J. Biol. Chem. 276 2001 38108 38114
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38108-38114
-
-
Ito, K.1
Oleschuk, C.J.2
Westlake, C.3
Vasa, M.Z.4
Deeley, R.G.5
Cole, S.P.6
-
18
-
-
0037666795
-
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
-
N. Zelcer, M.T. Huisman, and G. Reid Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2) J. Biol. Chem. 278 2003 23538 23544
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 23538-23544
-
-
Zelcer, N.1
Huisman, M.T.2
Reid, G.3
-
19
-
-
0037163124
-
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells
-
S.B. Fernandez, Z. Hollo, and A. Kern Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells J. Biol. Chem. 277 2002 31048 31055
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31048-31055
-
-
Fernandez, S.B.1
Hollo, Z.2
Kern, A.3
-
20
-
-
0032884024
-
PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein
-
O. Kocher, N. Comella, and A. Gilchrist PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein Lab. Invest. 79 1999 1161 1170
-
(1999)
Lab. Invest.
, vol.79
, pp. 1161-1170
-
-
Kocher, O.1
Comella, N.2
Gilchrist, A.3
-
21
-
-
0037436789
-
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins
-
T. Hegedus, T. Sessler, and R. Scott C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins Biochem. Biophys. Res. Commun. 302 2003 454 461
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.302
, pp. 454-461
-
-
Hegedus, T.1
Sessler, T.2
Scott, R.3
-
22
-
-
85047697477
-
Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)
-
A.T. Nies, J. Konig, Y. Cui, M. Brom, H. Spring, and D. Keppler Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2) Eur. J. Biochem. 269 2002 1866 1876
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 1866-1876
-
-
Nies, A.T.1
Konig, J.2
Cui, Y.3
Brom, M.4
Spring, H.5
Keppler, D.6
-
23
-
-
0030768373
-
The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes
-
D. Keppler, J. Konig, and M. Buchler The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes Adv. Enzyme Regul. 37 1997 321 333
-
(1997)
Adv. Enzyme Regul.
, vol.37
, pp. 321-333
-
-
Keppler, D.1
Konig, J.2
Buchler, M.3
-
24
-
-
0034978930
-
Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats
-
A.D. Mottino, T. Hoffman, L. Jennes, J. Cao, and M. Vore Expression of multidrug resistance-associated protein 2 in small intestine from pregnant and postpartum rats Am. J. Physiol. Gastrointest. Liver Physiol. 280 2001 G1261 G1273
-
(2001)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.280
-
-
Mottino, A.D.1
Hoffman, T.2
Jennes, L.3
Cao, J.4
Vore, M.5
-
25
-
-
0034760443
-
Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia
-
D. Rost, J. Konig, G. Weiss, E. Klar, W. Stremmel, and D. Keppler Expression and localization of the multidrug resistance proteins MRP2 and MRP3 in human gallbladder epithelia Gastroenterology 121 2001 1203 1208
-
(2001)
Gastroenterology
, vol.121
, pp. 1203-1208
-
-
Rost, D.1
Konig, J.2
Weiss, G.3
Klar, E.4
Stremmel, W.5
Keppler, D.6
-
26
-
-
0036137072
-
Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats
-
N.J. Cherrington, D.P. Hartley, N. Li, D.R. Johnson, and C.D. Klaassen Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats J. Pharmacol. Exp. Ther. 300 2002 97 104
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 97-104
-
-
Cherrington, N.J.1
Hartley, D.P.2
Li, N.3
Johnson, D.R.4
Klaassen, C.D.5
-
27
-
-
0043130332
-
Quantitative determination of the human MRP1 and MRP2 mRNA expression in FACS-sorted peripheral blood CD4+, CD8+, CD19+, and CD56+ cells
-
K. Oselin, P.M. Mrozikiewicz, R. Pahkla, and I. Roots Quantitative determination of the human MRP1 and MRP2 mRNA expression in FACS-sorted peripheral blood CD4+, CD8+, CD19+, and CD56+ cells Eur. J. Haematol. 71 2003 119 123
-
(2003)
Eur. J. Haematol.
, vol.71
, pp. 119-123
-
-
Oselin, K.1
Mrozikiewicz, P.M.2
Pahkla, R.3
Roots, I.4
-
28
-
-
0037119866
-
Expression of rat multidrug resistance protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny
-
D.R. Johnson, G.L. Guo, and C.D. Klaassen Expression of rat multidrug resistance protein 2 (Mrp2) in male and female rats during normal and pregnenolone-16alpha-carbonitrile (PCN)-induced postnatal ontogeny Toxicology 178 2002 209 219
-
(2002)
Toxicology
, vol.178
, pp. 209-219
-
-
Johnson, D.R.1
Guo, G.L.2
Klaassen, C.D.3
-
29
-
-
0034623293
-
Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
-
Y. Zhang, H. Han, W.F. Elmquist, and D.W. Miller Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells Brain Res. 876 2000 148 153
-
(2000)
Brain Res.
, vol.876
, pp. 148-153
-
-
Zhang, Y.1
Han, H.2
Elmquist, W.F.3
Miller, D.W.4
-
30
-
-
6344265573
-
Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
-
A.T. Nies, G. Jedlitschky, and J. Konig Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain Neuroscience 129 2004 349 360
-
(2004)
Neuroscience
, vol.129
, pp. 349-360
-
-
Nies, A.T.1
Jedlitschky, G.2
Konig, J.3
-
31
-
-
0033664346
-
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
-
D.S. Miller, S.N. Nobmann, H. Gutmann, M. Toeroek, J. Drewe, and G. Fricker Xenobiotic transport across isolated brain microvessels studied by confocal microscopy Mol. Pharmacol. 58 2000 1357 1367
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1357-1367
-
-
Miller, D.S.1
Nobmann, S.N.2
Gutmann, H.3
Toeroek, M.4
Drewe, J.5
Fricker, G.6
-
32
-
-
0037665280
-
Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity
-
H. Potschka, M. Fedrowitz, and W. Loscher Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity J. Pharmacol. Exp. Ther. 306 2003 124 131
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.306
, pp. 124-131
-
-
Potschka, H.1
Fedrowitz, M.2
Loscher, W.3
-
33
-
-
4444310389
-
The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours
-
J. Bart, H. Hollema, and H.J. Groen The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular tumours Eur. J. Cancer 40 2004 2064 2070
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 2064-2070
-
-
Bart, J.1
Hollema, H.2
Groen, H.J.3
-
34
-
-
0142212154
-
Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats
-
S. Choudhuri, N.J. Cherrington, N. Li, and C.D. Klaassen Constitutive expression of various xenobiotic and endobiotic transporter mRNAs in the choroid plexus of rats Drug Metab. Dispos. 31 2003 1337 1345
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1337-1345
-
-
Choudhuri, S.1
Cherrington, N.J.2
Li, N.3
Klaassen, C.D.4
-
35
-
-
0037313267
-
Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2
-
G. Tomer, M. Ananthanarayanan, A. Weymann, N. Balasubramanian, and F.J. Suchy Differential developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2 Pediatr. Res. 53 2003 288 294
-
(2003)
Pediatr. Res.
, vol.53
, pp. 288-294
-
-
Tomer, G.1
Ananthanarayanan, M.2
Weymann, A.3
Balasubramanian, N.4
Suchy, F.J.5
-
36
-
-
0038121803
-
ATP binding cassette transporter gene expression in rat liver progenitor cells
-
J.E. Ros, T.A. Roskams, and M. Geuken ATP binding cassette transporter gene expression in rat liver progenitor cells Gut 52 2003 1060 1067
-
(2003)
Gut
, vol.52
, pp. 1060-1067
-
-
Ros, J.E.1
Roskams, T.A.2
Geuken, M.3
-
38
-
-
0036721559
-
Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy
-
J. Cao, B. Stieger, P.J. Meier, and M. Vore Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy Am. J. Physiol. Gastrointest. Liver Physiol. 283 2002 G757 G766
-
(2002)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.283
-
-
Cao, J.1
Stieger, B.2
Meier, P.J.3
Vore, M.4
-
39
-
-
0344927562
-
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
-
J. Konig, A.T. Nies, Y. Cui, I. Leier, and D. Keppler Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance Biochim. Biophys. Acta 1461 1999 377 394
-
(1999)
Biochim. Biophys. Acta
, vol.1461
, pp. 377-394
-
-
Konig, J.1
Nies, A.T.2
Cui, Y.3
Leier, I.4
Keppler, D.5
-
40
-
-
0033745088
-
Hepatic secretion of conjugated drugs and endogenous substances
-
D. Keppler, and J. Konig Hepatic secretion of conjugated drugs and endogenous substances Semin. Liver Dis. 20 2000 265 272
-
(2000)
Semin. Liver Dis.
, vol.20
, pp. 265-272
-
-
Keppler, D.1
Konig, J.2
-
41
-
-
0036365007
-
Transport of leukotriene C4 and structurally related conjugates
-
G. Jedlitschky, and D. Keppler Transport of leukotriene C4 and structurally related conjugates Vitam. Horm. 64 2002 153 184
-
(2002)
Vitam. Horm.
, vol.64
, pp. 153-184
-
-
Jedlitschky, G.1
Keppler, D.2
-
42
-
-
0032434272
-
Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
-
H. Suzuki, and Y. Sugiyama Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2 Semin. Liver Dis. 18 1998 359 376
-
(1998)
Semin. Liver Dis.
, vol.18
, pp. 359-376
-
-
Suzuki, H.1
Sugiyama, Y.2
-
43
-
-
0032407040
-
Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione
-
N. Ballatori, and J.F. Rebbeor Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione Semin. Liver Dis. 18 1998 377 387
-
(1998)
Semin. Liver Dis.
, vol.18
, pp. 377-387
-
-
Ballatori, N.1
Rebbeor, J.F.2
-
44
-
-
0034721764
-
The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
-
S.V. Kala, M.W. Neely, and G. Kala The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic J. Biol. Chem. 275 2000 33404 33408
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33404-33408
-
-
Kala, S.V.1
Neely, M.W.2
Kala, G.3
-
45
-
-
0032769284
-
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2
-
T. Kamisako, I. Leier, and Y. Cui Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2 Hepatology 30 1999 485 490
-
(1999)
Hepatology
, vol.30
, pp. 485-490
-
-
Kamisako, T.1
Leier, I.2
Cui, Y.3
-
46
-
-
0030668526
-
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
-
G. Jedlitschky, I. Leier, U. Buchholz, J. Hummel-Eisenbeiss, B. Burchell, and D. Keppler ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2 Biochem. J. 327 Pt 1 1997 305 310
-
(1997)
Biochem. J.
, vol.327
, Issue.1 PART
, pp. 305-310
-
-
Jedlitschky, G.1
Leier, I.2
Buchholz, U.3
Hummel-Eisenbeiss, J.4
Burchell, B.5
Keppler, D.6
-
47
-
-
1642330416
-
Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3
-
X.Y. Chu, S.E. Huskey, M.P. Braun, B. Sarkadi, D.C. Evans, and R. Evers Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3 J. Pharmacol. Exp. Ther. 309 2004 156 164
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.309
, pp. 156-164
-
-
Chu, X.Y.1
Huskey, S.E.2
Braun, M.P.3
Sarkadi, B.4
Evans, D.C.5
Evers, R.6
-
48
-
-
0033776410
-
Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats
-
H. Xiong, K.C. Turner, E.S. Ward, P.L. Jansen, and K.L. Brouwer Altered hepatobiliary disposition of acetaminophen glucuronide in isolated perfused livers from multidrug resistance-associated protein 2-deficient TR(-) rats J. Pharmacol. Exp. Ther. 295 2000 512 518
-
(2000)
J. Pharmacol. Exp. Ther.
, vol.295
, pp. 512-518
-
-
Xiong, H.1
Turner, K.C.2
Ward, E.S.3
Jansen, P.L.4
Brouwer, K.L.5
-
49
-
-
0035831094
-
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
-
H. Akita, H. Suzuki, and K. Ito Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump Biochim. Biophys. Acta 1511 2001 7 16
-
(2001)
Biochim. Biophys. Acta
, vol.1511
, pp. 7-16
-
-
Akita, H.1
Suzuki, H.2
Ito, K.3
-
50
-
-
0037379362
-
Bile salt transporters: Molecular characterization, function, and regulation
-
M. Trauner, and J.L. Boyer Bile salt transporters: molecular characterization, function, and regulation Physiol. Rev. 83 2003 633 671
-
(2003)
Physiol. Rev.
, vol.83
, pp. 633-671
-
-
Trauner, M.1
Boyer, J.L.2
-
51
-
-
0037626452
-
Biliary excretion of phenolphthalein sulfate in rats
-
H. Tanaka, N. Sano, and H. Takikawa Biliary excretion of phenolphthalein sulfate in rats Pharmacology 68 2003 177 182
-
(2003)
Pharmacology
, vol.68
, pp. 177-182
-
-
Tanaka, H.1
Sano, N.2
Takikawa, H.3
-
52
-
-
0033152212
-
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
-
J.H. Hooijberg, H.J. Broxterman, and M. Kool Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2 Cancer Res. 59 1999 2532 2535
-
(1999)
Cancer Res.
, vol.59
, pp. 2532-2535
-
-
Hooijberg, J.H.1
Broxterman, H.J.2
Kool, M.3
-
54
-
-
0242456093
-
Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat
-
L. Accatino, M. Pizarro, N. Solis, M. Arrese, and C.S. Koenig Bile secretory function after warm hepatic ischemia-reperfusion injury in the rat Liver Transpl. 9 2003 1199 1210
-
(2003)
Liver Transpl.
, vol.9
, pp. 1199-1210
-
-
Accatino, L.1
Pizarro, M.2
Solis, N.3
Arrese, M.4
Koenig, C.S.5
-
55
-
-
0037155204
-
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
-
M. Sasaki, H. Suzuki, K. Ito, T. Abe, and Y. Sugiyama Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2) J. Biol. Chem. 277 2002 6497 6503
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 6497-6503
-
-
Sasaki, M.1
Suzuki, H.2
Ito, K.3
Abe, T.4
Sugiyama, Y.5
-
56
-
-
4944225107
-
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2
-
M. Sasaki, H. Suzuki, J. Aoki, K. Ito, P.J. Meier, and Y. Sugiyama Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2 Mol. Pharmacol. 66 2004 450 459
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 450-459
-
-
Sasaki, M.1
Suzuki, H.2
Aoki, J.3
Ito, K.4
Meier, P.J.5
Sugiyama, Y.6
-
57
-
-
0034083906
-
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
-
I. Leier, J. Hummel-Eisenbeiss, Y. Cui, and D. Keppler ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2 Kidney Int. 57 2000 1636 1642
-
(2000)
Kidney Int.
, vol.57
, pp. 1636-1642
-
-
Leier, I.1
Hummel-Eisenbeiss, J.2
Cui, Y.3
Keppler, D.4
-
58
-
-
0033998261
-
MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells
-
T. Cantz, A.T. Nies, M. Brom, A.F. Hofmann, and D. Keppler MRP2, a human conjugate export pump, is present and transports fluo 3 into apical vacuoles of Hep G2 cells Am. J. Physiol. Gastrointest. Liver Physiol. 278 2000 G522 G531
-
(2000)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.278
-
-
Cantz, T.1
Nies, A.T.2
Brom, M.3
Hofmann, A.F.4
Keppler, D.5
-
59
-
-
0037310954
-
Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver
-
M.J. Zamek-Gliszczynski, H. Xiong, N.J. Patel, R.Z. Turncliff, G.M. Pollack, and K.L. Brouwer Pharmacokinetics of 5 (and 6)-carboxy-2',7'- dichlorofluorescein and its diacetate promoiety in the liver J. Pharmacol. Exp. Ther. 304 2003 801 809
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 801-809
-
-
Zamek-Gliszczynski, M.J.1
Xiong, H.2
Patel, N.J.3
Turncliff, R.Z.4
Pollack, G.M.5
Brouwer, K.L.6
-
60
-
-
0036830243
-
Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome
-
K. Hashimoto, T. Uchiumi, and T. Konno Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome Hepatology 36 2002 1236 1245
-
(2002)
Hepatology
, vol.36
, pp. 1236-1245
-
-
Hashimoto, K.1
Uchiumi, T.2
Konno, T.3
-
61
-
-
0034672539
-
Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes
-
L. Payen, A. Courtois, J.P. Campion, A. Guillouzo, and O. Fardel Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes Biochem. Pharmacol. 60 2000 1967 1975
-
(2000)
Biochem. Pharmacol.
, vol.60
, pp. 1967-1975
-
-
Payen, L.1
Courtois, A.2
Campion, J.P.3
Guillouzo, A.4
Fardel, O.5
-
62
-
-
17544372167
-
Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
-
C.C. Paulusma, M.J. Kothe, and C.T. Bakker Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver Hepatology 31 2000 684 693
-
(2000)
Hepatology
, vol.31
, pp. 684-693
-
-
Paulusma, C.C.1
Kothe, M.J.2
Bakker, C.T.3
-
63
-
-
0037260573
-
Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats
-
C. Chen, D. Scott, and E. Hanson Impact of Mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats Pharm. Res. 20 2003 31 37
-
(2003)
Pharm. Res.
, vol.20
, pp. 31-37
-
-
Chen, C.1
Scott, D.2
Hanson, E.3
-
64
-
-
0033936291
-
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
-
R. Evers, M. de Haas, and R. Sparidans Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export Br. J. Cancer 83 2000 375 383
-
(2000)
Br. J. Cancer
, vol.83
, pp. 375-383
-
-
Evers, R.1
De Haas, M.2
Sparidans, R.3
-
65
-
-
10044241598
-
Hepatobiliary disposition of the metabolically stable opioid peptide [d-penicillamine2,5]enkephalin (DPDPE): Pharmacokinetic consequences of the interplay between multiple transport systems
-
K.A. Hoffmaster, M.J. Zamek-Gliszczynski, G.M. Pollack, and K.L. Brouwer Hepatobiliary disposition of the metabolically stable opioid peptide [d-penicillamine2,5]enkephalin (DPDPE): pharmacokinetic consequences of the interplay between multiple transport systems J. Pharmacol. Exp. Ther. 311 2004 1203 1210
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.311
, pp. 1203-1210
-
-
Hoffmaster, K.A.1
Zamek-Gliszczynski, M.J.2
Pollack, G.M.3
Brouwer, K.L.4
-
66
-
-
0141849078
-
Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites
-
J. Hong, J.D. Lambert, S.H. Lee, P.J. Sinko, and C.S. Yang Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites Biochem. Biophys. Res. Commun. 310 2003 222 227
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, pp. 222-227
-
-
Hong, J.1
Lambert, J.D.2
Lee, S.H.3
Sinko, P.J.4
Yang, C.S.5
-
67
-
-
0037159933
-
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs
-
M.T. Huisman, J.W. Smit, and K.M. Crommentuyn Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs AIDS 16 2002 2295 2301
-
(2002)
AIDS
, vol.16
, pp. 2295-2301
-
-
Huisman, M.T.1
Smit, J.W.2
Crommentuyn, K.M.3
-
68
-
-
10744233896
-
Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin
-
M. Sugie, E. Asakura, and Y.L. Zhao Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin Antimicrob. Agents Chemother. 48 2004 809 814
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 809-814
-
-
Sugie, M.1
Asakura, E.2
Zhao, Y.L.3
-
69
-
-
6944243989
-
Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154
-
T. Takada, H.M. Weiss, O. Kretz, G. Gross, and Y. Sugiyama Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154 Drug Metab. Dispos. 32 2004 1272 1278
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 1272-1278
-
-
Takada, T.1
Weiss, H.M.2
Kretz, O.3
Gross, G.4
Sugiyama, Y.5
-
70
-
-
0037561534
-
Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions
-
N.J. Patel, M.J. Zamek-Gliszczynski, and P. Zhang Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions Mol. Pharmacol. 64 2003 154 159
-
(2003)
Mol. Pharmacol.
, vol.64
, pp. 154-159
-
-
Patel, N.J.1
Zamek-Gliszczynski, M.J.2
Zhang, P.3
-
71
-
-
0141456201
-
Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: Role of multidrug resistance protein 2 (Mrp2)
-
W. Jager, E. Gehring, B. Hagenauer, S. Aust, A. Senderowicz, and T. Thalhammer Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2) Life Sci. 73 2003 2841 2854
-
(2003)
Life Sci.
, vol.73
, pp. 2841-2854
-
-
Jager, W.1
Gehring, E.2
Hagenauer, B.3
Aust, S.4
Senderowicz, A.5
Thalhammer, T.6
-
72
-
-
0035034532
-
Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats
-
C.G. Dietrich, D.R. de Waart, R. Ottenhoff, I.G. Schoots, and R.P. Elferink Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-deficient rats Mol. Pharmacol. 59 2001 974 980
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 974-980
-
-
Dietrich, C.G.1
De Waart, D.R.2
Ottenhoff, R.3
Schoots, I.G.4
Elferink, R.P.5
-
73
-
-
0037432669
-
Interaction of ochratoxin a with human intestinal Caco-2 cells: Possible implication of a multidrug resistance-associated protein (MRP2)
-
V. Berger, A.F. Gabriel, T. Sergent, A. Trouet, Y. Larondelle, and Y.J. Schneider Interaction of ochratoxin A with human intestinal Caco-2 cells: possible implication of a multidrug resistance-associated protein (MRP2) Toxicol. Lett. 140 2003 465 476 -141
-
(2003)
Toxicol. Lett.
, vol.140
, pp. 465-476
-
-
Berger, V.1
Gabriel, A.F.2
Sergent, T.3
Trouet, A.4
Larondelle, Y.5
Schneider, Y.J.6
-
74
-
-
0034072174
-
Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
-
E. Bakos, R. Evers, E. Sinko, A. Varadi, P. Borst, and B. Sarkadi Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions Mol. Pharmacol. 57 2000 760 768
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 760-768
-
-
Bakos, E.1
Evers, R.2
Sinko, E.3
Varadi, A.4
Borst, P.5
Sarkadi, B.6
-
75
-
-
0032836646
-
Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells
-
R.A. Van Aubel, J.B. Koenderink, J.G. Peters, C.H. Van Os, and F.G. Russel Mechanisms and interaction of vinblastine and reduced glutathione transport in membrane vesicles by the rabbit multidrug resistance protein Mrp2 expressed in insect cells Mol. Pharmacol. 56 1999 714 719
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 714-719
-
-
Van Aubel, R.A.1
Koenderink, J.B.2
Peters, J.G.3
Van Os, C.H.4
Russel, F.G.5
-
77
-
-
0036298163
-
Mrp2 modulates the activity of chloride channels in isolated hepatocytes
-
X. Li, and S.A. Weinman Mrp2 modulates the activity of chloride channels in isolated hepatocytes Hepatology 36 2002 65 71
-
(2002)
Hepatology
, vol.36
, pp. 65-71
-
-
Li, X.1
Weinman, S.A.2
-
78
-
-
9144259998
-
Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats
-
E. Asakura, H. Nakayama, and M. Sugie Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats Eur. J. Pharmacol. 484 2004 333 339
-
(2004)
Eur. J. Pharmacol.
, vol.484
, pp. 333-339
-
-
Asakura, E.1
Nakayama, H.2
Sugie, M.3
-
79
-
-
0037084149
-
Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: Evidence for GSH transport on rat Mrp2
-
J.F. Rebbeor, G.C. Connolly, and N. Ballatori Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2 Biochim. Biophys. Acta 1559 2002 171 178
-
(2002)
Biochim. Biophys. Acta
, vol.1559
, pp. 171-178
-
-
Rebbeor, J.F.1
Connolly, G.C.2
Ballatori, N.3
-
80
-
-
0345735895
-
The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2
-
E.J. Wang, and W.W. Johnson The farnesyl protein transferase inhibitor lonafarnib (SCH66336) is an inhibitor of multidrug resistance proteins 1 and 2 Chemotherapy 49 2003 303 308
-
(2003)
Chemotherapy
, vol.49
, pp. 303-308
-
-
Wang, E.J.1
Johnson, W.W.2
-
81
-
-
10744221722
-
Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats
-
K. Arimori, N. Kuroki, and M. Hidaka Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in rats Pharm. Res. 20 2003 910 917
-
(2003)
Pharm. Res.
, vol.20
, pp. 910-917
-
-
Arimori, K.1
Kuroki, N.2
Hidaka, M.3
-
82
-
-
0036293982
-
Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver
-
S.R. Vavricka, J. Van Montfoort, H.R. Ha, P.J. Meier, and K. Fattinger Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver Hepatology 36 2002 164 172
-
(2002)
Hepatology
, vol.36
, pp. 164-172
-
-
Vavricka, S.R.1
Van Montfoort, J.2
Ha, H.R.3
Meier, P.J.4
Fattinger, K.5
-
83
-
-
0033984873
-
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
-
B. Stieger, K. Fattinger, J. Madon, G.A. Kullak-Ublick, and P.J. Meier Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver Gastroenterology 118 2000 422 430
-
(2000)
Gastroenterology
, vol.118
, pp. 422-430
-
-
Stieger, B.1
Fattinger, K.2
Madon, J.3
Kullak-Ublick, G.A.4
Meier, P.J.5
-
84
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
H.R. Kast, B. Goodwin, and P.T. Tarr Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor J. Biol. Chem. 277 2002 2908 2915
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
-
85
-
-
0034949811
-
Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver
-
P. Fickert, G. Zollner, and A. Fuchsbichler Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver Gastroenterology 121 2001 170 183
-
(2001)
Gastroenterology
, vol.121
, pp. 170-183
-
-
Fickert, P.1
Zollner, G.2
Fuchsbichler, A.3
-
86
-
-
12444301770
-
Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine
-
G. Zollner, P. Fickert, and A. Fuchsbichler Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine J. Hepatol. 39 2003 480 488
-
(2003)
J. Hepatol.
, vol.39
, pp. 480-488
-
-
Zollner, G.1
Fickert, P.2
Fuchsbichler, A.3
-
87
-
-
0036725044
-
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
-
G. Paumgartner, and U. Beuers Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and therapeutic use revisited Hepatology 36 2002 525 531
-
(2002)
Hepatology
, vol.36
, pp. 525-531
-
-
Paumgartner, G.1
Beuers, U.2
-
88
-
-
0035038177
-
Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
-
U. Beuers, M. Bilzer, and A. Chittattu Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver Hepatology 33 2001 1206 1216
-
(2001)
Hepatology
, vol.33
, pp. 1206-1216
-
-
Beuers, U.1
Bilzer, M.2
Chittattu, A.3
-
89
-
-
0037422578
-
Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor
-
B. Goodwin, K.C. Gauthier, and M. Umetani Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor Proc. Natl. Acad. Sci. USA 100 2003 223 228
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 223-228
-
-
Goodwin, B.1
Gauthier, K.C.2
Umetani, M.3
-
90
-
-
0032933142
-
Dexamethasone modulation of multidrug transporters in normal tissues
-
M. Demeule, J. Jodoin, E. Beaulieu, M. Brossard, and R. Beliveau Dexamethasone modulation of multidrug transporters in normal tissues FEBS Lett. 442 1999 208 214
-
(1999)
FEBS Lett.
, vol.442
, pp. 208-214
-
-
Demeule, M.1
Jodoin, J.2
Beaulieu, E.3
Brossard, M.4
Beliveau, R.5
-
91
-
-
0036303955
-
Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways
-
D.R. Johnson, and C.D. Klaassen Regulation of rat multidrug resistance protein 2 by classes of prototypical microsomal enzyme inducers that activate distinct transcription pathways Toxicol. Sci. 67 2002 182 189
-
(2002)
Toxicol. Sci.
, vol.67
, pp. 182-189
-
-
Johnson, D.R.1
Klaassen, C.D.2
-
92
-
-
0033564937
-
Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes
-
R. Kubitz, U. Warskulat, M. Schmitt, and D. Haussinger Dexamethasone- and osmolarity-dependent expression of the multidrug-resistance protein 2 in cultured rat hepatocytes Biochem. J. 340 Pt 3 1999 585 591
-
(1999)
Biochem. J.
, vol.340
, Issue.3 PART
, pp. 585-591
-
-
Kubitz, R.1
Warskulat, U.2
Schmitt, M.3
Haussinger, D.4
-
93
-
-
3242740859
-
Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes
-
R.Z. Turncliff, P.J. Meier, and K.L. Brouwer Effect of dexamethasone treatment on the expression and function of transport proteins in sandwich-cultured rat hepatocytes Drug Metab. Dispos. 32 2004 834 839
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 834-839
-
-
Turncliff, R.Z.1
Meier, P.J.2
Brouwer, K.L.3
-
94
-
-
0032835453
-
Up-regulation of multidrug resistance-associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone
-
A. Courtois, L. Payen, A. Guillouzo, and O. Fardel Up-regulation of multidrug resistance-associated protein 2 (MRP2) expression in rat hepatocytes by dexamethasone FEBS Lett. 459 1999 381 385
-
(1999)
FEBS Lett.
, vol.459
, pp. 381-385
-
-
Courtois, A.1
Payen, L.2
Guillouzo, A.3
Fardel, O.4
-
95
-
-
13244258414
-
The involvement of Pxr in hepatic gene regulation during inflammation in mice
-
S. Teng, and M. Piquette-Miller The involvement of Pxr in hepatic gene regulation during inflammation in mice J. Pharmacol. Exp. Ther. 312 2005 841 848
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.312
, pp. 841-848
-
-
Teng, S.1
Piquette-Miller, M.2
-
96
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
S.A. Kliewer, J.T. Moore, and L. Wade An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 92 1998 73 82
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
-
97
-
-
0033988860
-
Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule
-
R. Masereeuw, S.A. Terlouw, R.A. Van Aubel, F.G. Russel, and D.S. Miller Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule Mol. Pharmacol. 57 2000 59 67
-
(2000)
Mol. Pharmacol.
, vol.57
, pp. 59-67
-
-
Masereeuw, R.1
Terlouw, S.A.2
Van Aubel, R.A.3
Russel, F.G.4
Miller, D.S.5
-
98
-
-
0036083728
-
Role of NO in endothelin-regulated drug transport in the renal proximal tubule
-
S. Notenboom, D.S. Miller, P. Smits, F.G. Russel, and R. Masereeuw Role of NO in endothelin-regulated drug transport in the renal proximal tubule Am. J. Physiol. Renal Physiol. 282 2002 F458 F464
-
(2002)
Am. J. Physiol. Renal Physiol.
, vol.282
-
-
Notenboom, S.1
Miller, D.S.2
Smits, P.3
Russel, F.G.4
Masereeuw, R.5
-
99
-
-
2942690045
-
Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule
-
S. Notenboom, D.S. Miller, P. Smits, F.G. Russel, and R. Masereeuw Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule Am. J. Physiol. Renal Physiol. 287 2004 F33 F38
-
(2004)
Am. J. Physiol. Renal Physiol.
, vol.287
-
-
Notenboom, S.1
Miller, D.S.2
Smits, P.3
Russel, F.G.4
Masereeuw, R.5
-
100
-
-
0034990906
-
Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: Effect on drug efflux
-
S.A. Terlouw, R. Masereeuw, F.G. Russel, and D.S. Miller Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux Mol. Pharmacol. 59 2001 1433 1440
-
(2001)
Mol. Pharmacol.
, vol.59
, pp. 1433-1440
-
-
Terlouw, S.A.1
Masereeuw, R.2
Russel, F.G.3
Miller, D.S.4
-
101
-
-
0036329226
-
Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis
-
L.A. Denson, A. Bohan, M.A. Held, and J.L. Boyer Organ-specific alterations in RAR alpha:RXR alpha abundance regulate rat Mrp2 (Abcc2) expression in obstructive cholestasis Gastroenterology 123 2002 599 607
-
(2002)
Gastroenterology
, vol.123
, pp. 599-607
-
-
Denson, L.A.1
Bohan, A.2
Held, M.A.3
Boyer, J.L.4
-
102
-
-
2542642411
-
Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells
-
K. Hisaeda, A. Inokuchi, and T. Nakamura Interleukin-1beta represses MRP2 gene expression through inactivation of interferon regulatory factor 3 in HepG2 cells Hepatology 39 2004 1574 1582
-
(2004)
Hepatology
, vol.39
, pp. 1574-1582
-
-
Hisaeda, K.1
Inokuchi, A.2
Nakamura, T.3
-
103
-
-
0034708264
-
Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation
-
L.A. Denson, K.L. Auld, D.S. Schiek, M.H. McClure, D.J. Mangelsdorf, and S.J. Karpen Interleukin-1beta suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation J. Biol. Chem. 275 2000 8835 8843
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8835-8843
-
-
Denson, L.A.1
Auld, K.L.2
Schiek, D.S.3
McClure, M.H.4
Mangelsdorf, D.J.5
Karpen, S.J.6
-
104
-
-
1842479142
-
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2
-
C.G. Dietrich, A. Geier, and N. Salein Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2 Gastroenterology 126 2004 1044 1053
-
(2004)
Gastroenterology
, vol.126
, pp. 1044-1053
-
-
Dietrich, C.G.1
Geier, A.2
Salein, N.3
-
105
-
-
0033525020
-
Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression
-
J. Nakamura, T. Nishida, and K. Hayashi Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression Biochem. Biophys. Res. Commun. 255 1999 143 149
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.255
, pp. 143-149
-
-
Nakamura, J.1
Nishida, T.2
Hayashi, K.3
-
106
-
-
0042766885
-
Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis
-
A. Geier, C.G. Dietrich, and S. Voigt Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis Hepatology 38 2003 345 354
-
(2003)
Hepatology
, vol.38
, pp. 345-354
-
-
Geier, A.1
Dietrich, C.G.2
Voigt, S.3
-
107
-
-
0141814990
-
Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis
-
A. Bohan, W.S. Chen, L.A. Denson, M.A. Held, and J.L. Boyer Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis J. Biol. Chem. 278 2003 36688 36698
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36688-36698
-
-
Bohan, A.1
Chen, W.S.2
Denson, L.A.3
Held, M.A.4
Boyer, J.L.5
-
108
-
-
0036786429
-
Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia
-
G. Hartmann, A.K. Cheung, and M. Piquette-Miller Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia J. Pharmacol. Exp. Ther. 303 2002 273 281
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.303
, pp. 273-281
-
-
Hartmann, G.1
Cheung, A.K.2
Piquette-Miller, M.3
-
109
-
-
0039849217
-
Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats
-
P.K. Kim, J. Chen, K.M. Andrejko, and C.S. Deutschman Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats Shock 14 2000 176 181
-
(2000)
Shock
, vol.14
, pp. 176-181
-
-
Kim, P.K.1
Chen, J.2
Andrejko, K.M.3
Deutschman, C.S.4
-
110
-
-
4143070233
-
Interleukin-6 regulates hepatic transporters during acute-phase response
-
E. Siewert, C.G. Dietrich, and F. Lammert Interleukin-6 regulates hepatic transporters during acute-phase response Biochem. Biophys. Res. Commun. 322 2004 232 238
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.322
, pp. 232-238
-
-
Siewert, E.1
Dietrich, C.G.2
Lammert, F.3
-
111
-
-
0034976757
-
Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes
-
L. Vernhet, M.P. Seite, N. Allain, A. Guillouzo, and O. Fardel Arsenic induces expression of the multidrug resistance-associated protein 2 (MRP2) gene in primary rat and human hepatocytes J. Pharmacol. Exp. Ther. 298 2001 234 239
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.298
, pp. 234-239
-
-
Vernhet, L.1
Seite, M.P.2
Allain, N.3
Guillouzo, A.4
Fardel, O.5
-
112
-
-
0037186331
-
Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression
-
H.M. Kauffmann, S. Pfannschmidt, and H. Zoller Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression Toxicology 171 2002 137 146
-
(2002)
Toxicology
, vol.171
, pp. 137-146
-
-
Kauffmann, H.M.1
Pfannschmidt, S.2
Zoller, H.3
-
113
-
-
0034925678
-
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic
-
J. Liu, H. Chen, and D.S. Miller Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic Mol. Pharmacol. 60 2001 302 309
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 302-309
-
-
Liu, J.1
Chen, H.2
Miller, D.S.3
-
114
-
-
0030817669
-
Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes
-
H.M. Kauffmann, D. Keppler, J. Kartenbeck, and D. Schrenk Induction of cMrp/cMoat gene expression by cisplatin, 2-acetylaminofluorene, or cycloheximide in rat hepatocytes Hepatology 26 1997 980 985
-
(1997)
Hepatology
, vol.26
, pp. 980-985
-
-
Kauffmann, H.M.1
Keppler, D.2
Kartenbeck, J.3
Schrenk, D.4
-
115
-
-
0035977844
-
Up-regulation of transporters of the MRP family by drugs and toxins
-
D. Schrenk, P.R. Baus, N. Ermel, C. Klein, B. Vorderstemann, and H.M. Kauffmann Up-regulation of transporters of the MRP family by drugs and toxins Toxicol. Lett. 120 2001 51 57
-
(2001)
Toxicol. Lett.
, vol.120
, pp. 51-57
-
-
Schrenk, D.1
Baus, P.R.2
Ermel, N.3
Klein, C.4
Vorderstemann, B.5
Kauffmann, H.M.6
-
116
-
-
0033373863
-
Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter
-
M. Demeule, M. Brossard, and R. Beliveau Cisplatin induces renal expression of P-glycoprotein and canalicular multispecific organic anion transporter Am. J. Physiol. 277 1999 F832 F840
-
(1999)
Am. J. Physiol.
, vol.277
-
-
Demeule, M.1
Brossard, M.2
Beliveau, R.3
-
117
-
-
0035020088
-
Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure
-
D. Laouari, R. Yang, C. Veau, I. Blanke, and G. Friedlander Two apical multidrug transporters, P-gp and MRP2, are differently altered in chronic renal failure Am. J. Physiol. Renal Physiol. 280 2001 F636 F645
-
(2001)
Am. J. Physiol. Renal Physiol.
, vol.280
-
-
Laouari, D.1
Yang, R.2
Veau, C.3
Blanke, I.4
Friedlander, G.5
-
118
-
-
0032540101
-
Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene
-
H.M. Kauffmann, and D. Schrenk Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (mrp2) gene Biochem. Biophys. Res. Commun. 245 1998 325 331
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.245
, pp. 325-331
-
-
Kauffmann, H.M.1
Schrenk, D.2
-
119
-
-
0034105939
-
Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3) gene
-
B. Stockel, J. Konig, A.T. Nies, Y. Cui, M. Brom, and D. Keppler Characterization of the 5'-flanking region of the human multidrug resistance protein 2 (MRP2) gene and its regulation in comparison with the multidrug resistance protein 3 (MRP3) gene Eur. J. Biochem. 267 2000 1347 1358
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 1347-1358
-
-
Stockel, B.1
Konig, J.2
Nies, A.T.3
Cui, Y.4
Brom, M.5
Keppler, D.6
-
120
-
-
0033954736
-
Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells
-
K.W. Bock, T. Eckle, M. Ouzzine, and S. Fournel-Gigleux Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells Biochem. Pharmacol. 59 2000 467 470
-
(2000)
Biochem. Pharmacol.
, vol.59
, pp. 467-470
-
-
Bock, K.W.1
Eckle, T.2
Ouzzine, M.3
Fournel-Gigleux, S.4
-
121
-
-
0033724658
-
The effect of rifampin treatment on intestinal expression of human MRP transporters
-
M.F. Fromm, H.M. Kauffmann, and P. Fritz The effect of rifampin treatment on intestinal expression of human MRP transporters Am. J. Pathol. 157 2000 1575 1580
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 1575-1580
-
-
Fromm, M.F.1
Kauffmann, H.M.2
Fritz, P.3
-
122
-
-
0036021113
-
The drug efflux pump MRP2: Regulation of expression in physiopathological situations and by endogenous and exogenous compounds
-
L. Payen, L. Sparfel, A. Courtois, L. Vernhet, A. Guillouzo, and O. Fardel The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds Cell Biol. Toxicol. 18 2002 221 233
-
(2002)
Cell Biol. Toxicol.
, vol.18
, pp. 221-233
-
-
Payen, L.1
Sparfel, L.2
Courtois, A.3
Vernhet, L.4
Guillouzo, A.5
Fardel, O.6
-
123
-
-
11244283586
-
Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor
-
R. Ruhl, R. Sczech, N. Landes, P. Pfluger, D. Kluth, and F.J. Schweigert Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor Eur. J. Nutr. 43 2004 1 8
-
(2004)
Eur. J. Nutr.
, vol.43
, pp. 1-8
-
-
Ruhl, R.1
Sczech, R.2
Landes, N.3
Pfluger, P.4
Kluth, D.5
Schweigert, F.J.6
-
124
-
-
1942425487
-
St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: A 30-day ingestion study
-
Y. Shibayama, R. Ikeda, T. Motoya, and K. Yamada St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: a 30-day ingestion study Food Chem. Toxicol. 42 2004 995 1002
-
(2004)
Food Chem. Toxicol.
, vol.42
, pp. 995-1002
-
-
Shibayama, Y.1
Ikeda, R.2
Motoya, T.3
Yamada, K.4
-
125
-
-
0035038919
-
The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux
-
T.W. Synold, I. Dussault, and B.M. Forman The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux Nat. Med. 7 2001 584 590
-
(2001)
Nat. Med.
, vol.7
, pp. 584-590
-
-
Synold, T.W.1
Dussault, I.2
Forman, B.M.3
-
126
-
-
6944241732
-
Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2
-
V.A. Catania, E.J. Sanchez Pozzi, and M.G. Luquita Co-regulation of expression of phase II metabolizing enzymes and multidrug resistance-associated protein 2 Ann Hepatol 3 2004 11 17
-
(2004)
Ann Hepatol
, vol.3
, pp. 11-17
-
-
Catania, V.A.1
Sanchez Pozzi, E.J.2
Luquita, M.G.3
-
127
-
-
0346727220
-
Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC-PK1 cells
-
M. Magnarin, M. Morelli, and A. Rosati Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC-PK1 cells Eur. J. Pharmacol. 483 2004 19 28
-
(2004)
Eur. J. Pharmacol.
, vol.483
, pp. 19-28
-
-
Magnarin, M.1
Morelli, M.2
Rosati, A.3
-
128
-
-
0033386105
-
Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver
-
A. Courtois, L. Payen, L. Vernhet, F. Morel, A. Guillouzo, and O. Fardel Differential regulation of canalicular multispecific organic anion transporter (cMOAT) expression by the chemopreventive agent oltipraz in primary rat hepatocytes and in rat liver Carcinogenesis 20 1999 2327 2330
-
(1999)
Carcinogenesis
, vol.20
, pp. 2327-2330
-
-
Courtois, A.1
Payen, L.2
Vernhet, L.3
Morel, F.4
Guillouzo, A.5
Fardel, O.6
-
129
-
-
0034815141
-
Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane
-
L. Payen, A. Courtois, M. Loewert, A. Guillouzo, and O. Fardel Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane Biochem. Biophys. Res. Commun. 282 2001 257 263
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.282
, pp. 257-263
-
-
Payen, L.1
Courtois, A.2
Loewert, M.3
Guillouzo, A.4
Fardel, O.5
-
130
-
-
0035282671
-
Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status
-
Y.C. Lin-Lee, S. Tatebe, N. Savaraj, T. Ishikawa, and M. Tien Kuo Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status Biochem. Pharmacol. 61 2001 555 563
-
(2001)
Biochem. Pharmacol.
, vol.61
, pp. 555-563
-
-
Lin-Lee, Y.C.1
Tatebe, S.2
Savaraj, N.3
Ishikawa, T.4
Tien Kuo, M.5
-
131
-
-
5144232445
-
Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression
-
M. Demeule, M. Brossard, S. Turcotte, A. Regina, J. Jodoin, and R. Beliveau Diallyl disulfide, a chemopreventive agent in garlic, induces multidrug resistance-associated protein 2 expression Biochem. Biophys. Res. Commun. 324 2004 937 945
-
(2004)
Biochem. Biophys. Res. Commun.
, vol.324
, pp. 937-945
-
-
Demeule, M.1
Brossard, M.2
Turcotte, S.3
Regina, A.4
Jodoin, J.5
Beliveau, R.6
-
132
-
-
0037081839
-
Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes
-
A. Courtois, L. Payen, and E. Le Ferrec Differential regulation of multidrug resistance-associated protein 2 (MRP2) and cytochromes P450 2B1/2 and 3A1/2 in phenobarbital-treated hepatocytes Biochem. Pharmacol. 63 2002 333 341
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 333-341
-
-
Courtois, A.1
Payen, L.2
Le Ferrec, E.3
-
133
-
-
4644240254
-
Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance
-
E. Assenat, S. Gerbal-Chaloin, and D. Larrey Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance Hepatology 40 2004 951 960
-
(2004)
Hepatology
, vol.40
, pp. 951-960
-
-
Assenat, E.1
Gerbal-Chaloin, S.2
Larrey, D.3
-
134
-
-
3242723125
-
Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein
-
C.I. Ghanem, P.C. Gomez, and M.C. Arana Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein Biochem. Pharmacol. 68 2004 791 798
-
(2004)
Biochem. Pharmacol.
, vol.68
, pp. 791-798
-
-
Ghanem, C.I.1
Gomez, P.C.2
Arana, M.C.3
-
135
-
-
0033166685
-
Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5- trichlorophenoxyacetic acid in the mouse liver
-
A.M. Wielandt, V. Vollrath, M. Manzano, S. Miranda, L. Accatino, and J. Chianale Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5- trichlorophenoxyacetic acid in the mouse liver Biochem. J. 341 Pt 1 1999 105 111
-
(1999)
Biochem. J.
, vol.341
, Issue.1 PART
, pp. 105-111
-
-
Wielandt, A.M.1
Vollrath, V.2
Manzano, M.3
Miranda, S.4
Accatino, L.5
Chianale, J.6
-
136
-
-
0032432662
-
Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen
-
H.M. Kauffmann, D. Keppler, T.W. Gant, and D. Schrenk Induction of hepatic mrp2 (cmrp/cmoat) gene expression in nonhuman primates treated with rifampicin or tamoxifen Arch. Toxicol. 72 1998 763 768
-
(1998)
Arch. Toxicol.
, vol.72
, pp. 763-768
-
-
Kauffmann, H.M.1
Keppler, D.2
Gant, T.W.3
Schrenk, D.4
-
137
-
-
11144358423
-
Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver
-
J. Shoda, T. Miura, and H. Utsunomiya Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver Hepatology 39 2004 167 178
-
(2004)
Hepatology
, vol.39
, pp. 167-178
-
-
Shoda, J.1
Miura, T.2
Utsunomiya, H.3
-
138
-
-
0030994468
-
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
-
C.C. Paulusma, M. Kool, and P.J. Bosma A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology 25 1997 1539 1542
-
(1997)
Hepatology
, vol.25
, pp. 1539-1542
-
-
Paulusma, C.C.1
Kool, M.2
Bosma, P.J.3
-
139
-
-
0033652766
-
Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
-
V. Keitel, J. Kartenbeck, A.T. Nies, H. Spring, M. Brom, and D. Keppler Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome Hepatology 32 2000 1317 1328
-
(2000)
Hepatology
, vol.32
, pp. 1317-1328
-
-
Keitel, V.1
Kartenbeck, J.2
Nies, A.T.3
Spring, H.4
Brom, M.5
Keppler, D.6
-
140
-
-
0037229540
-
A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
-
V. Keitel, A.T. Nies, M. Brom, J. Hummel-Eisenbeiss, H. Spring, and D. Keppler A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2) Am. J. Physiol. Gastrointest. Liver Physiol. 284 2003 G165 G174
-
(2003)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.284
-
-
Keitel, V.1
Nies, A.T.2
Brom, M.3
Hummel-Eisenbeiss, J.4
Spring, H.5
Keppler, D.6
-
141
-
-
0035813178
-
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
-
R. Mor-Cohen, A. Zivelin, N. Rosenberg, M. Shani, S. Muallem, and U. Seligsohn Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome J. Biol. Chem. 276 2001 36923 36930
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 36923-36930
-
-
Mor-Cohen, R.1
Zivelin, A.2
Rosenberg, N.3
Shani, M.4
Muallem, S.5
Seligsohn, U.6
-
142
-
-
0037225729
-
Mechanism of hepatobiliary transport of a novel thromboxane A2 receptor antagonist, [2-(4-chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335), and its xenobiotic taurine conjugate (Z-335-Tau) in rats
-
Y. Kawabata, H. Nakamura, and E. Kamada Mechanism of hepatobiliary transport of a novel thromboxane A2 receptor antagonist, [2-(4- chlorophenylsulfonylaminomethyl)indan-5-yl]acetate (Z-335), and its xenobiotic taurine conjugate (Z-335-Tau) in rats J. Pharm. Sci. 92 2003 67 76
-
(2003)
J. Pharm. Sci.
, vol.92
, pp. 67-76
-
-
Kawabata, Y.1
Nakamura, H.2
Kamada, E.3
-
143
-
-
0037261286
-
Hepatobiliary transport of a nonpeptidic endothelin antagonist, (+)-(5S,6R,7R)-2-butyl-7-[2((2S)-2-carboxypropyl)-4-methoxyphenyl]-5-(3, 4-methylenedioxyphenyl) cyclopentenol[1,2-b]pyridine-6-carboxylic acid: Uptake by isolated rat hepatocytes and canalicular membrane vesicles
-
N. Kobayashi, T. Tani, A. Hisaka, K. Hara, and T. Yasumori Hepatobiliary transport of a nonpeptidic endothelin antagonist, (+)-(5S,6R,7R)-2-butyl-7- [2((2S)-2-carboxypropyl)-4-methoxyphenyl]-5-(3,4-methylenedioxyphenyl) cyclopentenol[1,2-b]pyridine-6-carboxylic acid: uptake by isolated rat hepatocytes and canalicular membrane vesicles Pharm. Res. 20 2003 89 95
-
(2003)
Pharm. Res.
, vol.20
, pp. 89-95
-
-
Kobayashi, N.1
Tani, T.2
Hisaka, A.3
Hara, K.4
Yasumori, T.5
-
144
-
-
0036288748
-
Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE
-
F. Tang, and R.T. Borchardt Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE Pharm. Res. 19 2002 787 793
-
(2002)
Pharm. Res.
, vol.19
, pp. 787-793
-
-
Tang, F.1
Borchardt, R.T.2
-
145
-
-
9444282080
-
Analysis of ABC transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
-
J.P. Annereau, G. Szakacs, and C.J. Tucker Analysis of ABC transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance Mol. Pharmacol. 66 2004 1397 1405
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1397-1405
-
-
Annereau, J.P.1
Szakacs, G.2
Tucker, C.J.3
-
146
-
-
0036326852
-
Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells
-
Y. Itoh, M. Tamai, and K. Yokogawa Involvement of multidrug resistance-associated protein 2 in in vivo cisplatin resistance of rat hepatoma AH66 cells Anticancer Res. 22 2002 1649 1653
-
(2002)
Anticancer Res.
, vol.22
, pp. 1649-1653
-
-
Itoh, Y.1
Tamai, M.2
Yokogawa, K.3
-
147
-
-
0345299165
-
Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
-
Y. Cui, J. Konig, J.K. Buchholz, H. Spring, I. Leier, and D. Keppler Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells Mol. Pharmacol. 55 1999 929 937
-
(1999)
Mol. Pharmacol.
, vol.55
, pp. 929-937
-
-
Cui, Y.1
Konig, J.2
Buchholz, J.K.3
Spring, H.4
Leier, I.5
Keppler, D.6
-
148
-
-
0346497684
-
Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity
-
P.K. Smitherman, A.J. Townsend, T.E. Kute, and C.S. Morrow Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity J. Pharmacol. Exp. Ther. 308 2004 260 267
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 260-267
-
-
Smitherman, P.K.1
Townsend, A.J.2
Kute, T.E.3
Morrow, C.S.4
-
149
-
-
9544233652
-
A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
-
K. Taniguchi, M. Wada, and K. Kohno A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation Cancer Res. 56 1996 4124 4129
-
(1996)
Cancer Res.
, vol.56
, pp. 4124-4129
-
-
Taniguchi, K.1
Wada, M.2
Kohno, K.3
-
150
-
-
0031468814
-
A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells
-
K. Koike, T. Kawabe, and T. Tanaka A canalicular multispecific organic anion transporter (cMOAT) antisense cDNA enhances drug sensitivity in human hepatic cancer cells Cancer Res. 57 1997 5475 5479
-
(1997)
Cancer Res.
, vol.57
, pp. 5475-5479
-
-
Koike, K.1
Kawabe, T.2
Tanaka, T.3
-
151
-
-
0041342087
-
Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin
-
B. Liedert, V. Materna, D. Schadendorf, J. Thomale, and H. Lage Overexpression of cMOAT (MRP2/ABCC2) is associated with decreased formation of platinum-DNA adducts and decreased G2-arrest in melanoma cells resistant to cisplatin J. Invest. Dermatol. 121 2003 172 176
-
(2003)
J. Invest. Dermatol.
, vol.121
, pp. 172-176
-
-
Liedert, B.1
Materna, V.2
Schadendorf, D.3
Thomale, J.4
Lage, H.5
-
152
-
-
0034046035
-
Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas
-
E. Hinoshita, T. Uchiumi, and K. Taguchi Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas Clin. Cancer Res. 6 2000 2401 2407
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2401-2407
-
-
Hinoshita, E.1
Uchiumi, T.2
Taguchi, K.3
-
153
-
-
0035889601
-
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
-
A.T. Nies, J. Konig, M. Pfannschmidt, E. Klar, W.J. Hofmann, and D. Keppler Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma Int. J. Cancer 94 2001 492 499
-
(2001)
Int. J. Cancer
, vol.94
, pp. 492-499
-
-
Nies, A.T.1
Konig, J.2
Pfannschmidt, M.3
Klar, E.4
Hofmann, W.J.5
Keppler, D.6
-
154
-
-
0031744484
-
Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myeloid leukemia cells, tumor cell lines, and normal hematopoietic CD34+ peripheral blood cells
-
D.M. van der Kolk, E.G. de Vries, J.A. Koning, E. van den Berg, M. Muller, and E. Vellenga Activity and expression of the multidrug resistance proteins MRP1 and MRP2 in acute myeloid leukemia cells, tumor cell lines, and
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 1727-1736
-
-
Van Der Kolk, D.M.1
De Vries, E.G.2
Koning, J.A.3
Van Den Berg, E.4
Muller, M.5
Vellenga, E.6
-
155
-
-
0037342747
-
Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia
-
D. Steinbach, J. Lengemann, A. Voigt, J. Hermann, F. Zintl, and A. Sauerbrey Response to chemotherapy and expression of the genes encoding the multidrug resistance-associated proteins MRP2, MRP3, MRP4, MRP5, and SMRP in childhood acute myeloid leukemia Clin. Cancer Res. 9 2003 1083 1086
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1083-1086
-
-
Steinbach, D.1
Lengemann, J.2
Voigt, A.3
Hermann, J.4
Zintl, F.5
Sauerbrey, A.6
-
156
-
-
0036118852
-
High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival
-
B. Laupeze, L. Amiot, and B. Drenou High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival Br. J. Haematol. 116 2002 834 838
-
(2002)
Br. J. Haematol.
, vol.116
, pp. 834-838
-
-
Laupeze, B.1
Amiot, L.2
Drenou, B.3
-
157
-
-
0033038623
-
Expression of multidrug resistance protein-related genes in lung cancer: Correlation with drug response
-
L.C. Young, B.G. Campling, T. Voskoglou-Nomikos, S.P. Cole, R.G. Deeley, and J.H. Gerlach Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response Clin. Cancer Res. 5 1999 673 680
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 673-680
-
-
Young, L.C.1
Campling, B.G.2
Voskoglou-Nomikos, T.3
Cole, S.P.4
Deeley, R.G.5
Gerlach, J.H.6
-
158
-
-
0034895918
-
Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: Correlation of protein levels with drug response and messenger RNA levels
-
L.C. Young, B.G. Campling, S.P. Cole, R.G. Deeley, and J.H. Gerlach Multidrug resistance proteins MRP3, MRP1, and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels Clin. Cancer Res. 7 2001 1798 1804
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 1798-1804
-
-
Young, L.C.1
Campling, B.G.2
Cole, S.P.3
Deeley, R.G.4
Gerlach, J.H.5
-
159
-
-
0034778022
-
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma
-
Y. Soini, K. Jarvinen, R. Kaarteenaho-Wiik, and V. Kinnula The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma Ann. Oncol. 12 2001 1239 1245
-
(2001)
Ann. Oncol.
, vol.12
, pp. 1239-1245
-
-
Soini, Y.1
Jarvinen, K.2
Kaarteenaho-Wiik, R.3
Kinnula, V.4
-
160
-
-
6444228081
-
Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer
-
I.F. Faneyte, P.M. Kristel, and M.J. van de Vijver Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer Anticancer Res. 24 2004 2931 2939
-
(2004)
Anticancer Res.
, vol.24
, pp. 2931-2939
-
-
Faneyte, I.F.1
Kristel, P.M.2
Van De Vijver, M.J.3
-
161
-
-
0033032730
-
Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma
-
T.P. Schaub, J. Kartenbeck, and J. Konig Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma J. Am. Soc. Nephrol. 10 1999 1159 1169
-
(1999)
J. Am. Soc. Nephrol.
, vol.10
, pp. 1159-1169
-
-
Schaub, T.P.1
Kartenbeck, J.2
Konig, J.3
-
162
-
-
0036533566
-
Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin
-
Y. Tada, M. Wada, and T. Migita Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin Int. J. Cancer 98 2002 630 635
-
(2002)
Int. J. Cancer
, vol.98
, pp. 630-635
-
-
Tada, Y.1
Wada, M.2
Migita, T.3
-
163
-
-
0032740801
-
Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma
-
H.J. Arts, D. Katsaros, and E.G. de Vries Drug resistance-associated markers P-glycoprotein, multidrug resistance-associated protein 1, multidrug resistance-associated protein 2, and lung resistance protein as prognostic factors in ovarian carcinoma Clin. Cancer Res. 5 1999 2798 2805
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2798-2805
-
-
Arts, H.J.1
Katsaros, D.2
De Vries, E.G.3
-
164
-
-
3242663647
-
RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: Correlation with chemotherapeutic response
-
V. Materna, J. Pleger, U. Hoffmann, and H. Lage RNA expression of MDR1/P-glycoprotein, DNA-topoisomerase I, and MRP2 in ovarian carcinoma patients: correlation with chemotherapeutic response Gynecol. Oncol. 94 2004 152 160
-
(2004)
Gynecol. Oncol.
, vol.94
, pp. 152-160
-
-
Materna, V.1
Pleger, J.2
Hoffmann, U.3
Lage, H.4
-
165
-
-
3543004158
-
Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2
-
M. Hirouchi, H. Suzuki, M. Itoda, S. Ozawa, J. Sawada, and I. Ieiri Characterization of the cellular localization, expression level, and function of SNP variants of MRP2/ABCC2 Pharm. Res. 21 2004 742 748
-
(2004)
Pharm. Res.
, vol.21
, pp. 742-748
-
-
Hirouchi, M.1
Suzuki, H.2
Itoda, M.3
Ozawa, S.4
Sawada, J.5
Ieiri, I.6
|