Characterization of the efflux transporter(s) responsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE

Pharmaceutical Research

Volumn 19, Issue 6, 2002, Pages 787-793

  Tang, Fuxing ^a   Borchardt, Ronald T ^b  

^a UNIVERSITY OF KANSAS   (United States)

^b FOREST RESEARCH INSTITUTE   (United States)

Author keywords

Acid based cyclic prodrug; Caco 2 cell monolayers; DADLE; MDR 1; MRP 1

Indexed keywords

COUMARIN; CYCLOSPORIN A; ELACRIDAR; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; OPIATE PEPTIDE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ACTIVITY; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE MUCOSA; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL;

ACIDS; ANIMALS; CACO-2 CELLS; CELL LINE; COUMARINS; DOGS; ENKEPHALIN, LEUCINE-2-ALANINE; GENES, MDR; HUMANS; INTESTINAL MUCOSA; MITOCHONDRIAL PROTEINS; OPIOID PEPTIDES; P-GLYCOPROTEIN; PERMEABILITY; PRODRUGS; RIBOSOMAL PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 0036288748     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016196514217     Document Type: Article

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