Mutation of Trp1254 in the Multispecific Organic Anion Transporter, Multidrug Resistance Protein 2 (MRP2) (ABCC2), Alters Substrate Specificity and Results in Loss of Methotrexate Transport Activity

Journal of Biological Chemistry

Volumn 276, Issue 41, 2001, Pages 38108-38114

  Ito, Ken Ichi ^a,b   Oleschuk, Curtis J ^a   Westlake, Chris ^a   Vasa, Monika Z ^a   Deeley, Roger G ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; BIOLOGICAL MEMBRANES; MUTAGENESIS; NEGATIVE IONS; PROTEINS; SUBSTITUTION REACTIONS; SUBSTRATES;

MULTIDRUG RESISTANCE PROTEINS (MRP); TRANSMEMBRANE TRANSPORTERS;

BIOCHEMISTRY;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ESTRADIOL 17 GLUCURONIDE; LEUKOTRIENE C4; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; SULFINPYRAZONE; TRYPTOPHAN; CARRIER PROTEIN; ESTRADIOL; GLUCURONIDE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; PRIMER DNA;

AMINO ACID SUBSTITUTION; APICAL MEMBRANE; ARTICLE; CELL POLARITY; CONTROLLED STUDY; ENZYME SPECIFICITY; GENE MUTATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; LIVER CELL; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; PROTEIN TRANSPORT; TRANSPORT KINETICS; AMINO ACID SEQUENCE; CELL LINE; CHEMISTRY; DRUG EFFECT; GENETICS; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TRANSPORT AT THE CELLULAR LEVEL;

AMINO ACID SEQUENCE; BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL LINE; DNA PRIMERS; ESTRADIOL; GLUCURONIDES; HUMANS; LEUKOTRIENE C4; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; SULFINPYRAZONE; TRYPTOPHAN;

EID: 0035851106     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105160200     Document Type: Article

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