Biliary excretion of phenolphthalein sulfate in rats

Pharmacology

Volumn 68, Issue 4, 2003, Pages 177-182

  Tanaka, Hiroyuki ^a   Sano, Naoyo ^a   Takikawa, Hajime ^a  

^a TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bile acids; Multidrug resistance protein 2 (Mrp2); Organic anions; Phenolphthalein sulfate

Indexed keywords

BILE ACID; LEUKOTRIENE C4; MULTIDRUG RESISTANCE PROTEIN 2; PHENOLPHTHALEIN; SULFATE; TAUROLITHOCHOLIC ACID;

ANIMAL EXPERIMENT; ARTICLE; BILE SECRETION; ENZYME SPECIFICITY; HYPERBILIRUBINEMIA; INHIBITION KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS;

ANIMALS; ANIONS; ATP-BINDING CASSETTE TRANSPORTERS; BILE; CARRIER PROTEINS; LEUKOTRIENE C4; MALE; PHENOLPHTHALEIN; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; SULFOBROMOPHTHALEIN; TAUROLITHOCHOLIC ACID; TIME FACTORS;

EID: 0037626452     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070456     Document Type: Article

References (37)

1. Paulusma CC, Bosma PJ, Zaman GJ, Bakker CT, Otter M, Scheffer GL, Scheper RJ, Borst P, Oude Elferink RP: Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 1996;271:1126-1128.
2. Büchler M, König J, Brom M, Kartenbeck J, Apring H, Horie T, Keppler D: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996;271:15091-15098.
3. Ito K, Suzuki H, Hirahashi T, Kume K, Shimizu T, Sugiyama Y: Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 1997;272:G16-G22.
4. Kartenbeck J, Leuschner U, Mayer R, Keppler D: Absence of the canalicular isoform of the MRP gene-encoded export pump from the hepatocytes in Dubin-Johnson syndrome. Gastroenterology 1996;23:1061-1066.
5. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, ter Borg F, Scheper RJ, Tytgat S, Borst P, Baas F, Oude Elferink RP: A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology 1997;25:1539-1542.
6. Wada M, Toh S, Taniguchi K, Nakamura T, Uchiumi T, Kohno K, Yoshida I, Kimura A, Sakisaka S, Adachi Y, Kuwano M: Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. Hum Mol Genet 1998;7:203-207.
7. Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O: Biliary excretion of bile acid conjugates in hyperbilirubinemic mutant Sprague-Dawley rats. Hepatology 1991;14:352-360.
8. Takikawa H, Sano N, Ogasawara T, Yamanaka M: Enhanced biliary excretion of lithocholate-3-sulfate by ursodeoxycholate-3,7-disulfate infusion in Eisai hyperbilirubinemic rat (EHBR). Dig Dis Sci 1998;43:188-192.
9. Hasegawa Y, Takikawa H: Effect of ursodeoxycholate-3,7-disulfate on biliary excretion of lithocholate-3-O-glucuronide in Eisai hyperbilirubinemic rat (EHBR). Hepatol Res 2002;23:296.
10. Shimamura H, Suzuki H, Hanano M, Suzuki A, Tagaya O, Horie T, Sugiyama Y: Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 1994;271:370-378.
11. Takenaka O, Horie T, Suzuki H, Sugiyama Y: Different biliary excretion systems for glucuronide and sulfate of a model compound: Study using Eisai hyperbilirubinemic rats. J Pharmacol Exp Ther 1995;274:1362-1369.
12. Shimamura H, Suzuki H, Tagaya O, Horie T, Sugiyama Y: Biliary excretion of glycyrrhizin in rats: Kinetic basis for multiplicity in bile canalicular transport of organic anions. Pharm Res 1996;13:1833-1837.
13. Niinuma K, Takenaka O, Horie T, Kobayashi K, Kato Y, Suzuki H, Sugiyama Y: Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: Comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole glucuronide. J Pharmacol Exp Ther 1997;282:866-872.
14. Chu XY, Kato Y, Sugiyama Y: Multiplicity of biliary excretion mechanisms for irinotecan, CPT-11, and its metabolites in rats. Cancer Res 1997;57:1934-1938.
15. Sasabe H, Tsuji A, Sugiyama Y: Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats. J Pharmacol Exp Ther 1998;284:1033-1039.
16. Takikawa H, Yamazaki R, Sano N, Yamanaka M: Biliary excretion of estradiol-17β-glucuronide in the rat. Hepatology 1996;23:607-613.
17. Takikawa H, Sano N, Tadokoro K, Yamanaka M: Biliary excretion of estrone metabolites in the rat. Int Hepatol Commun 1996;5:251-258.
18. Takikawa H, Sano N, Akimoto K, Yamanaka M: Biliary excretion of estrone sulfate in the rat. Hepatol Res 1998;11:201-207.
19. Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y: Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 2001;1511:7-16.
20. Takikawa H, Sano N, Wako Y, Yamanaka M: Effects of organic anions and bile acids on biliary lipid excretion in hyperbilirubinemic mutant Sprague-Dawley rats. J Hepatol 1993;17:247-252.
21. Takikawa H, Sano N, Minagawa K, Yamanaka M: Effects of ursodeoxycholate, its glucuronide and disulfate and β-muricholate on biliary bicarbonate concentration and biliary lipid excretion. J Hepatol 1992;15:77-84.
22. Huber M, Guhlmann A, Jansen PL, Keppler D: Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion. Hepatology 1987;7:224-228.
23. Kitamura T, Jansen P, Hardenbrook C, Kamimoto Y, Gatmaitan Z, Arias IM: Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia. Proc Natl Acad Sci USA 1990;87:3557-3561.
24. Uegaki S, Takikawa H, Yamanaka M: Effect of organic anions and bile acid conjugates on biliary excretion of taurine-conjugated bile acid sulfates in the rat. Steroids 1999;64:790-795.
25. Gustafson JH, Benet LZ: Biliary excretion kinetics of phenolphthalein glucuronide after intravenous and retrograde biliary administration. J Pharm Pharmacol 1974;26:937-944.
26. Tietze F: Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal Biochem 1969;27:502-522.
27. Suzuki C, Sano N, Takikawa H: Effect of dexamethasone on biliary excretion of bile acids and organic anions in rats. Hepatol Res 2003;25:48-54.
28. 4 in the rat. Prostaglandins 1997;54:745-755.
29. Takikawa H, Sano N, Uegaki S, Yamanaka M: Effects of bile acid conjugates on biliary excretion of estradiol-17β-glucuronide in the rat. Hepatol Res 1997;7:28-34.
30. Fukumura S, Takikawa H, Yamanaka M: Effects of organic anions and bile acid conjugates on biliary excretion of pravastatin in the rat. Pharm Res 1998;15:72-76.
31. Ogasawara T, Takikawa H: Biliary excretion of phenolphthalein glucuronide in the rat. Hepatol Res 2001;20:221-231.
32. Takikawa H, Sano N, Sato A, Yamanaka M: Effect of taurolithocholate-3-sulphate on biliary excretion of sulphobromophthalein and di-bromosulphophthalein in the Eisai hyperbilirubinemic rat. J Gastroenterol Hepatol 1997;12:528-531.
33. Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, Borst P, Oude Elferink RP: Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 1999;338:393-401.
34. Wielandt AM, Vollrath V, Manzano M, Miranda S, Accatino L, Chainale J: Induction of the multispecific organic anion transporter (cMoat/mrp2) gene and biliary glutathione secretion by the herbicide 2,4,5-trichlorophenoxyacetic acid in the mouse liver. Biochem J 1999;341:105-111.
35. Takikawa H, Sano N, Kitaura K, Fukumura S, Aiso M, Yamanaka M: Effect of lithocholate-3-sulfate and its amides on biliary excretion of glutathione and phospholipid. Int Hepatol Commun 1996;4:255-262.
36. Takikawa H, Fujiyoshi M, Sano N, Yamanaka M: Effects of organic anions on biliary glutathione excretion in rats. Pharmacology 1996;53:114-122.
37. Takikawa H, Sano N, Yamanaka M: Effect of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats. Dig Dis Sci 1996;41:1953-1958.