Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)

Journal of Biological Chemistry

Volumn 278, Issue 26, 2003, Pages 23538-23544

  Zelcer, Noam ^a   Huisman, Maarten T ^a   Reid, Glen ^a   Wielinga, Peter ^a   Breedveld, Pauline ^a   Kuil, Annemieke ^a   Knipscheer, Puck ^a   Schellens, Jan H M ^a   Schinkel, Alfred H ^a   Borst, Piet ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG PRODUCTS; MONOLAYERS; NEGATIVE IONS; ORGANIC COMPOUNDS; SUBSTRATES; TUMORS;

BILE ACIDS;

PROTEINS;

ABC TRANSPORTER; ATP BINDING CASETTE C2; BILE ACID; ESTRADIOL 17 GLUCURONIDE; FOLIC ACID ANTAGONIST; GLUTATHIONE DERIVATIVE; GLUTATHIONE S DINITROPHENOL; INDOMETACIN; LIGAND; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN 2; ORGANIC ANION TRANSPORTER; PROBENECID; SAQUINAVIR; SULFANITRAN; SULFINPYRAZONE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG TRANSPORT; HORMONE TRANSPORT; INHIBITION KINETICS; INSECT CELL; INTRACELLULAR TRANSPORT; KIDNEY CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CELL LINE; ESTRADIOL; HUMANS; KINETICS; LIGANDS; METHOTREXATE; MITOCHONDRIAL PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RIBOSOMAL PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSDUCTION, GENETIC;

INSECTA;

EID: 0037666795     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M303504200     Document Type: Article

References (57)

1. Higgins, C. F. (1992) Annu. Rev. Cell Biol. 8, 67-113
2. Borst, P., and Oude Elferink, R. (2002) Annu. Rev. Biochem. 71, 537-592
3. Dean, M., Rzhetsky, A., and Allikmets, R. (2001) Genome Res. 11, 1156-1166
4. Borst, P., Evers, R., Kool, M., and Wijnholds, J. (2000) J. Natl. Cancer Inst. 92, 1295-1302
5. Renes, J., de Vries, E. G., Jansen, P. L., and Muller, M. (2000) Drug Resist. Update 3, 289-302
6. Cole, S. P., Bhardwaj, G., Gerlach, J. H., Mackie, J. E., Grant, C. E., Almquist, K. C., Stewart, A. J., Kurz, E. U., Duncan, A. M., and Deeley, R. G. (1992) Science 258, 1650-1654
7. Jedlitschky, G., Leier, I., Buchholz, U., Barnouin, K., Kurz, G., and Keppler, D. (1996) Cancer Res. 56, 988-994
8. Konig, J., Nies, A. T., Cui, Y., Leier, I., and Keppler, D. (1999) Biochim. Biophys. Acta 1461, 377-394
9. Jedlitschky, G., and Keppler, D. (2002) Vitam. Horm. 64, 153-184
10. Leslie, E. M., Deeley, R. G., and Cole, S. P. (2001) Toxicology 167, 3-23
11. Varadi, A., Tusnady, G. E., and Sarkadi, B. (2002) in ABC Proteins from Bacteria to Man (Holland, I. B., Cole, S. P., Kuchler, K., and Higgins, C. F., eds) pp. 37-46, Academic Press, London
12. Hung, L. W., Wang, I. X., Nikaido, K., Liu, P. Q., Ames, G. F., and Kim, S. H. (1998) Nature 396, 703-707
13. Locher, K. P., Lee, A. T., and Rees, D. C. (2002) Science 296, 1091-1098
14. Rosenberg, M. F., Callaghan, R., Ford, R. C., and Higgins, C. F. (1997) J. Biol. Chem. 272, 10685-10694
15. Rosenberg, M. F., Kamis, A. B., Callaghan, R., Higgins, C. F., and Ford, R. C. (2002) J. Biol. Chem. 278, 8294-8299
16. Rosenberg, M. F., Mao, Q., Holzenburg, A., Ford, R. C., Deeley, R. G., and Cole, S. P. (2001) J. Biol. Chem. 276, 16076-16082
17. Martin, C., Berridge, G., Higgins, C. F., Mistry, P., Charlton, P., and Callaghan, R. (2000) Mol. Pharmacol. 58, 624-632
18. Shapiro, A. B., Fox, K., Lam, P., and Ling, V. (1999) Eur. J. Biochem. 259, 841-850
19. Loo, T. W., and Clarke, D. M. (2002) J. Biol. Chem. 277, 44332-44338
20. Kondratov, R. V., Komarov, P. G., Becker, Y., Ewenson, A., and Gudkov, A. V. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 14078-14083
21. Deeley, R. G., and Cole, S. P. (2002) in ABC Proteins from Bacteria to Man (Holland, I. B., Cole, S. P., Kuchler, K., and Higgins, C. F., eds) pp. 393-422, Academic Press, London
22. Chen, Z. S., Kawabe, T., Ono, M., Aoki, S., Sumizawa, T., Furukawa, T., Uchiumi, T., Wada, M., Kuwano, M., and Akiyama, S. I. (1999) Mol. Pharmacol. 56, 1219-1228
23. Cui, Y., Konig, J., Buchholz, J. K., Spring, H., Leier, I., and Keppler, D. (1999) Mol. Pharmacol. 55, 929-937
24. Evers, R., Kool, M., van Deemter, L., Janssen, H., Calafat, J., Oomen, L. C., Paulusma, C. C., Oude Elferink, R. P., Baas, F., Schinkel, A. H., and Borst, P. (1998) J. Clin. Invest. 101, 1310-1319
25. Bakos, E., Evers, R., Sinko, E., Varadi, A., Borst, P., and Sarkadi, B. (2000) Mol. Pharmacol. 57, 760-768
26. Evers, R., de Haas, M., Sparidans, R., Beijnen, J., Wielinga, P. R., Lankelma, J., and Borst, P. (2000) Br. J. Cancer 83, 375-383
27. Leslie, E. M., Ito, K., Upadhyaya, P., Hecht, S. S., Deeley, R. G., and Cole, S. P. (2001) J. Biol. Chem. 276, 27846-27854
28. Huisman, M. T., Smit, J. W., Crommentuyn, K. M., Zelcer, N., Wiltshire, H. R., Beijnen, J. H., and Schinkel, A. H. (2002) Aids 16, 2295-2301
29. Zelcer, N., Saeki, T., Reid, G., Beijnen, J. H., and Borst, P. (2001) J. Biol. Chem. 276, 46400-46407
30. van Aubel, R. A., Smeets, P. H., Peters, J. G., Bindels, R. J., and Russel, F. G. (2002) J. Am. Soc. Nephrol. 13, 595-603
31. Zelcer, N., Reid, G., Wielinga, P., Kuil, A., Van Der Heijden, I., Schuetz, J. D., and Borst, P. (2003) Biochem. J. 371, 361-367
32. Heijn, M., Hooijberg, J. H., Scheffer, G. L., Szabo, G., Westerhoff, H. V., and Lankelma, J. (1997) Biochim. Biophys. Acta 1326, 12-22
33. Chen, Z. S., Lee, K., Walther, S., Raftogianis, R. B., Kuwano, M., Zeng, H., and Kruh, G. D. (2002) Cancer Res. 62, 3144-3150
34. Paulusma, C. C., van Geer, M. A., Evers, R., Heijn, M., Ottenhoff, R., Borst, P., and Oude Elferink, R. P. (1999) Biochem. J. 338, 393-401
35. Akita, H., Suzuki, H., Ito, K., Kinoshita, S., Sato, N., Takikawa, H., and Sugiyama, Y. (2001) Biochim. Biophys. Acta 1511, 7-16
36. Chen, C., Scott, D., Hanson, E., Franco, J., Berryman, E., Volberg, M., and Liu, X. (2003) Pharm. Res. (N. Y.) 20, 31-37
37. Loe, D. W., Almquist, K. C., Cole, S. P., and Deeley, R. G. (1996) J. Biol. Chem. 271, 9683-9689
38. Zelcer, N., Saeki, T., Bot, I., Kuil, A., and Borst, P. (2003) Biochem. J. 369, 23-30
39. Zeng, H., Chen, Z. S., Belinsky, M. G., Rea, P. A., and Kruh, G. D. (2001) Cancer Res. 61, 7225-7232
40. Ito, K., Oleschuk, C. J., Westlake, C., Vasa, M. Z., Deeley, R. G., and Cole, S. P. (2001) J. Biol. Chem. 276, 38108-38114
41. Suzuki, H., and Sugiyama, Y. (1998) Semin. Liver Dis. 18, 359-376
42. Sharom, F. J., Yu, X., DiDiodato, G., and Chu, J. W. (1996) Biochem. J. 320, 421-428
43. Dey, S., Ramachandra, M., Pastan, I., Gottesman, M. M., and Ambudkar, S. V. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 10594-10599
44. Leslie, E. M., Deeley, R. G., and Cole, S. P. (2003) Drug Metab. Dispos. 31, 11-15
45. Loe, D. W., Almquist, K. C., Deeley, R. G., and Cole, S. P. (1996) J. Biol. Chem. 271, 9675-9682
46. Loe, D. W., Deeley, R. G., and Cole, S. P. (1998) Cancer Res. 58, 5130-5136
47. Qian, Y. M., Song, W. C., Cui, H., Cole, S. P., and Deeley, R. G. (2001) J. Biol. Chem. 276, 6404-6411
48. Loe, D. W., Deeley, R. G., and Cole, S. P. (2000) J. Pharmacol. Exp. Ther. 293, 530-538
49. Loe, D. W., Oleschuk, C. J., Deeley, R. G., and Cole, S. P. (2000) Biochem. Biophys. Res. Commun. 275, 795-803
50. Harlow, G. R., and Halpert, J. R. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6636-6641
51. Cupp-Vickery, J., Anderson, R., and Hatziris, Z. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3050-3055
52. Cantor, R. S. (1999) Biophys. J. 77, 2643-2647
53. Ito, K., Suzuki, H., and Sugiyama, Y. (2001) Am. J. Physiol. 281, G1034-G1043
54. Klein, M., Martinoia, E., and Weissenbock, G. (1998) J. Biol. Chem. 273, 262-270
55. Hirohashi, T., Suzuki, H., and Sugiyama, Y. (1999) J. Biol. Chem. 274, 15181-15185
56. Fernandez, S. B., Hollo, Z., Kern, A., Bakos, E., Fischer, P. A., Borst, P., and Evers, R. (2002) J. Biol. Chem. 277, 31048-31055
57. Bodó, A., Bakos, E., Szeri, F., Váradi, A., and Sarkadi, B. (2003) J. Biol. Chem. 278, 23529-23537