Do cMOAT (MRP2), other MRP homologues, and LRP play a role in MDR?

Seminars in Cancer Biology

Volumn 8, Issue 3, 1997, Pages 205-213

  Borst, P ^a   Kool, M ^a   Evers, R ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Cisplatin; cMOAT; LRP; MDR; MRP2

Indexed keywords

ANION; ANTINEOPLASTIC AGENT; BILIRUBIN GLUCURONIDE; CISPLATIN; DOXORUBICIN; GLUTATHIONE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; VINBLASTINE;

ANIMAL CELL; BILE; CELL LINE; CELL SURVIVAL; COMPLEX FORMATION; CONFERENCE PAPER; DATA BASE; DNA TRANSFECTION; DRUG SENSITIVITY; DRUG TRANSPORT; DUBIN JOHNSON SYNDROME; ENZYME SPECIFICITY; GENE ISOLATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; INBORN ERROR OF METABOLISM; MULTIDRUG RESISTANCE; NONHUMAN; PHYLOGENY; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RAT; SEQUENCE HOMOLOGY;

EID: 0031158790     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1997.0071     Document Type: Conference Paper

References (60)

1. 1. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AMV, Deeley GR (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258:1650-1654
2. 2. Deeley RG, Cole SPC (1997) Function, evolution and structure of Multidrug Resistance Protein (MRP). Sem Cancer Biol 8:193-204
3. 3. Jedlitschky G, Leier I, Bucholz U, Center M, Keppler D (1994) ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein. Cancer Res 54:4833-4836
4. 4 and structurally related conjugates. J Biol Chem 269:27807-27810
5. 5. Müller M, Meijer C, Zaman GJR, Borst P, Scheper RJ, Mulder NH, De Vries EGE, Jansen PLM (1994) Overexpression of the multidrug resistance associated protein (MRP) gene results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci USA 91:13033-13037
6. 6. Cole SPC, Sparks KE, Fraser K, Loe DW, Grant CE, Wilson GM, Deeley RG (1994) Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res 54:5902-5910
7. 7. Zaman GJR, Lankelma J, Van Tellingen O, Beijnen J, Dekker H, Paulusma CC, Oude Elferink RPJ, Baas F, Borst P (1995) Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein. Proc Natl Acad Sci USA 92:7690-7694
8. 8. Gosland M, Lum B, Schimmelpfennig J, Baker J, Doukas M (1996) Insights into mechanisms of cisplatin resistance and potential for its clinical reversal. Pharmacotherapy 16:16-39
9. 9. Naredi P, Heath DD, Enns RE, Howell SB (1995) Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells. J Clin Invest 95:1193-1198
10. 10. Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. TIBS 17:463-468
11. 11. Ishikawa T, Ali-Osman F (1993) Glutathione-associated cis-diamminedichloroplatinum (II) metabolism and ATP-dependent efflux from leukemia cells. J Biol Chem 268:20116-20125
12. 12. Fujii R, Mutoh M, Niwa K, Yamada K, Aikou T, Nakagawa M, Kuwano M, Akiyama S (1994) Active eflux system for cisplatin in cisplatin-resistant human KB cells. Jap J Cancer Res 85:426-433
13. 4 by membrane vesicles prepared from cisplatinum-resistant human epidermoid carcinoma tumor cells. J Natl Cancer Inst 86:1781-1784
14. 14. Goto S, Yoshida K, Morikawa T, Urata Y, Suzuki K, Kondo T (1995) Augmentation of transport for cisplatin-glutathione adduct in cisplatin-resistant cancer cells. Cancer Res 55:4297-4301
15. 15. Ishikawa T, Wright CD, Ishizuka H (1994) GS-X pump is functionally overexpressed in cis-diammine-dichloroplatinum(II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation. J Biol Chem 269:29085-29093
16. 4 transporter in cisplatin-resistant human KB cells. Biochem Biophys Res Commun 226:158-165
17. 17 Ishikawa T, Bao J, Yamane Y, Akimaru K, Frindrich K, Wright CD, Kuo MT (1996) Coordinated induction of MRP/GS-X pump and τ-glutamylcysteine synthetase by heavy metals in human leukemia cells. J Biol Chem 271:14981-14988
18. 18. Godwin AK, Meister A, O'Dwyer PJ, Huang CS, Hamilton TC, Anderson ME (1992) High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci USA 89:3070-3074
19. 19. Hao HY, Bergh J, Brodin O, Hellman U, Mannervik B (1994) Acquired resistance to cisplatin and doxorubicin in a small cell lung cancer cell line is correlated to elevated expression of glutathione-linked detoxification enzymes. Carcinogenesis 15:1167-1173
20. 20. Yao KS, Godwin AK, Johnson SW, Ozols RF, O'Dwyer PJ, Hamilton TC (1995) Evidence for altered regulation of τ-glutamylcysteine synthetase gene expression among cisplatin-sensitive and cisplatin-resistant human ovarian cancer cell lines. Cancer Res 55:4367-4374
21. 21. Kool M, de Haas M, Scheffer GL, Scheper RJ, Van Eijk MJT, Juijn JA, Baas F, Borst P (1997) Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologs of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res 57:3537-3547
22. 22. Grant CE, Valdimarsson G, Hipfner DR, Almquist KC, Cole SP, Deeley RG (1994) Overexpression of multidrug resistance-associated protein (MRP)increases resistance to natural product drugs. Cancer Res 54:357-361
23. 23. Zaman GJR, Borst P (1996) MRP, mode of action and role in MDR, in Multidrug resistance in cancer cells (Gupta S, Tsuruo T, eds) pp 95-107. John Wiley & Sons Ltd. Sussex
24. 24. Wijnholds J, Evers R, van Leusden MR, Mol CAAM, Zaman GJR, Mayer U, Beijnen J, Van der Valk M, Krimpenfort P, Borst P (1997) Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking MRP. Submitted Nature Med., in press
25. 25. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, Okumura K, Akiyama S, Kuwano M (1996) A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 56:4124-4129
26. 26. Müller M, Roelofsen H, Jansen PLM (1996) Secretion of organic anions by hepatocytes: involvement of homologues of the multidrug resistance protein. Semin Liver Dis 16:211-220
27. 27. Jansen PLM, Peters WH, Lamers WH (1985) Hereditary chronic conjugated hyperbilirubinemia in mutant rats caused by defective hepatic anion transport. Hepatology 5:573-579
28. 28. Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, Tagaya O (1991) Biliary excretion of bile acid conjugate in a hyperbilirubinemic mutant Sprague-Dawley rat. Hepatology 14:352-360
29. 29. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK, Groothuis GMM (1995) Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268
30. 30. Mayer R, Kartenbeck J, Büchler M, Jedlitschky G, Leier I, Keppler D (1995) Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. J Cell Biol 131:137-150
31. 31. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, Borst P, Oude Elferink RPJ (1996) Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene. Science 271:1126-1128
32. 32. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Horie T, Keppler D (1996) cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 271:15091-15098
33. 33. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y (1996) Expression of the putative ATP-binding cassette region, homologous to that in multidrug resistance associated protein (MRP), is hereditarily defective in Eisai hyperbilirubinemic rats (EHBR). Int Hepatol Comm 292:292-299
34. 34. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y (1997) Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 272:G16-G22
35. 35. Madon J, Eckhardt U, Gerloff T, Stieger B, Meier PJ (1997) Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein. FEBS Lett 406:75-78
36. 36. Kartenbeck J, Leuschner U, Mayer R, Keppler D (1996) Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology 23:1061-1066
37. 37. Paulusma CC, Kool M, Bosma PJ, Scheffer GL, Ter Borg F, Scheper RJ, Tytgat GNJ, Borst P, Baas F, Oude Elferink RPJ (1997) A mutation in the human cMOAT gene causes the Dubin-Johnson syndrome. Hepatology 25:1539-1542
38. 38. Van Kuijck MA, Van Aubel RAMH, Busch AE, Lang F, Russel FGM, Bindels RJM, Van Os CH, Deen PMT (1996) Molecular cloning and expression of acyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter. Proc Natl Acad Sci USA 93:5401-5406
39. 39. Heijn M, Oude Elferink RPJ, Jansen PLM (1992) ATP-dependent multispecific organic anion tranport system in rat erythrocyte membrane vesicles. Am J Physiol 262:C104-C110
40. 40. Pulaski L, Jedlitschky G, Leier I, Buchholz U, Keppler D (1996) Identification of the multidrug-resistance protein (MRP) as the glutathione-S-conjugate export pump of erythrocytes. Eur J Biochem 241:644-648
41. 41. Evers R, Kool M, Van Deemter L, Jansen H, Calafat J, Oomen LCJM, Paulusma CC, Oude Elferink RPJ, Baas F, Schinkel AH, Borst P (1996) Drug export activity and apical localization of the human canalicular multispecific organic anion transporter (cMOAT) in polarized kidney cells. Submitted
42. 42. Tommasini R, Evers R, Vogt E, Mornet C, Zaman GJR, Schinkel AH, Borst P, Martinoia E (1996) The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1. Proc Natl Acad Sci USA 93:6743-6748
43. 43. Zaman GJR, Cnubben NHP, Van Bladeren PJ, Evers R, Borst P (1996) Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP. FEBS Lett 391:126-130
44. 44. Evers R, Zaman GJR, Van Deemter L, Jansen H, Calafat J, Oomen LCJM, Oude Elferink RPJ, Borst P, Schinkel AH (1996) Basolateral localization and export activity of the human multidrug resistance-associated protein (MRP) in polarized pig kidney cells. J Clin Invest 97:1211-1218
45. 45. van Helvoort A, Smidi AJ, Sprong H, Fritzsche I, Schinkel AH, Borst P, van Meer G (1996) MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell 87:507-517
46. 46. Stride BD, Valdimarsson G, Gerlach JH, Wilson GM, Cole SPC, Deeley RG (1996) Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol 49:962-971
47. 47. Eijdems EWHM, Zaman GJR, De Haas M, Versantvoort CHM, Flens MJ, Scheper RJ, Kamst E, Borst P, Baas F (1995) Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells. Br J Cancer 72:298-306
48. 48. Li Z-S, Szczypka M, Lu Y-P, Thiele DJ, Rea PA (1996) The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J Biol Chem 271:6509-6517
49. 49. Decottignies A, Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15:137-145
50. 50. Broeks A, Gerrard B, Allikmets R, Dean M, Plasterk RHA (1996) Homologs of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J 15:6132-6143
51. 51. Allikmets R, Gerrard B, Hutchinson A, Dean M (1996) Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the Expressed Sequence Tags database. Hum Mol Genet 5:1649-1655
52. 52. Scheffer GL, Wijngaard PLJ, Flens MJ, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJLM, Clevers HC, Scheper RJ (1995) The drug resistance-related protein LRP is the human major vault protein. Nat Med 1:578-582
53. 53. Rome L, Kedersha N, Chugani D (1991) Unlocking vaults: organelles in search of a function. Trends Cell Biol 1:47-50
54. 54. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, Vander Valk P, Scheper RJ (1996) Major vault protein LRP-related multidrug resistance. Eur J Cancer 32A:979-984
55. 55. Izquierdo MA, Van der Zee AGJ, Vermorken JB, Van der Valk P, Beliën JAM, Giaccone G, Scheffer GL, Flens MJ, Pinedo HM, Kenemans P, Meijer CJLM, De Vries EGE, Scheper RJ (1995) Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J Natl Cancer Inst 87:1230-1237
56. 56. List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman HJ, Scheffer GL, Scheper RJ, Dalton WS (1996) Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87:2464-2469
57. 57. Eijdems EWHM, Borst P, Jongsma AP, De Jong S, de Vries EG, van Groenigen M, Versantvoort CH, Nieuwint AW, Baas F (1992) Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype. Proc Natl Acad Sci USA 89:3498-3502
58. 58. Eijdems EWHM, De Haas M, Timmerman AJ, van der Schans GP, Kamst E, de Nooij J, Astaldi Ricotti GCB, Borst P, Baas F (1995) Reduced topoisomerase II activity in multidrug-resistance human non-small cell lung cancer cell lines. Br J Cancer 71:40-47
59. 59. Bakos E, Hegedüs T, Holló Z, Welker E, Tusnády GE, Zaman GJR, Flens MJ, Váradi A, Sarkadi B (1996) Membrane topology and glycosylation of the human multidrug resistance-associated protein. J Biol Chem 271:12322-12326
60. 60. Tusnády GE, Bakos E, Váradi A, Sarkadi B (1997) Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett 402:1-3