Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate

BioFactors

Volumn 17, Issue 1-4, 2003, Pages 103-114

  Homolya, László ^a   Váradi, András ^b   Sarkadi, Balázs ^a,c  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b INSTITUTE OF ENZYMOLOGY   (Hungary)

^c NATIONAL MEDICAL CENTER   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; CYCLIC NUCLEOTIDE; GLUCURONIC ACID; GLUCURONIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE DISULFIDE REDUCTASE; HEAVY METAL; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; MULTIDRUG RESISTANCE PROTEIN 6; MULTIDRUG RESISTANCE PROTEIN 7; MULTIDRUG RESISTANCE PROTEIN 8; NUCLEOSIDE DERIVATIVE; OXIDOREDUCTASE; SULFATE; SULFONYLUREA RECEPTOR; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

CELL MEMBRANE; CELLULAR DISTRIBUTION; CONFERENCE PAPER; CONJUGATION; CYTOPLASM; DETOXIFICATION; ENZYME SPECIFICITY; EXTRACELLULAR SPACE; HUMAN; LIPOPHILICITY; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; TISSUE DISTRIBUTION; TRANSPORT KINETICS;

EID: 0142107445     PISSN: 09516433     EISSN: None     Source Type: Journal    
DOI: 10.1002/biof.5520170111     Document Type: Conference Paper

References (50)

1. I. Klein, B. Sarkadi and A. Varadi, An inventory of the human ABC proteins, Biochim. Biophys. Acta 1461 (1999), 237-262.
2. M. Dean, Y. Hamon and G. Chimini, The human ATP-binding cassette (ABC) transporter superfamily, J Lipid Res. 42 (2001), 1007-1017.
3. M.F. Rosenberg, R. Callaghan, R.C. Ford and C.F. Higgins, Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis, J. Biol. Chem. 272 (1997), 10685-10694.
4. G. Chang and C.B. Roth, Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters, Science 293 (2001), 1793-1800.
5. K. Kunzelmann and R. Schreiber, CFTR, a regulator of channels, J. Membr. Biol. 168 (1999), 1-8.
6. C.F. Higgins, ABC transporters: from microorganisms to man, Ann. Rev. Cell Biol. 8 (1992), 67-113.
7. M.M. Gottesman and I. Pastan, Biochemistry of multidrug resistance mediated by the multidrug transporter, Annu. Rev. Biochem. 62 (1993), 385-427.
8. M.M. Gottesman, T. Fojo and S.E. Bates, Multidrug resistance in cancer: role of ATP-dependent transporters, Nat. Rev. Cancer 2 (2002), 48-58.
9. S.E. Bates, R. Robey, K. Miyake, K. Rao, D.D. Ross and T. Litman, The role of half-transporters in multidrug resistance, J. Bioenerg. Biomembr. 33 (2001), 503-511.
10. T. Litman, T.E. Druley, W.D. Stein, S.E. Bates, From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance, Cell. Mol. Life. Sci. 58 (2001), 931-959.
11. P. Borst, R. Evers, M. Kool and J. Wijnholds, A family of drug transporters: the multidrug resistance-associated proteins, J. Natl. Cancer Inst. 92(16) (2000), 1295-1302.
12. E. Bakos, R. Evers, G. Calenda, G.E. Tusnady, G. Szakacs, A. Varadi and B. Sarkadi, Characterization of the amino-terminal regions in the human multidrug resistance protein (MRP1), J. Cell Sci. 113 (2000), 4451-4461.
13. E. Bakos, T. Hegedus, Zs. Hollo, E. Welker, G.E. Tusnady, G.J. Zaman, M.J. Flens, A. Varadi and B. Sarkadi, Membrane topology and glycosylation of the human multidrug resistance-associated protein, J. Biol. Chem. 271(21) (1996), 12322-12326.
14. M. Müller, C. Meijer, G.J. Zaman, P. Borst, R.J. Scheper, N.H. Mulder, E.G. de Vries and P.L. Jansen, Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport, Proc. Natl. Acad. Sci. USA, 91(26) (1994), 13033-13037.
15. G. Jedlitschky, I. Leier, U. Buchholz, K. Barnouin, G. Kurz and D. Keppler, Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump, Cancer Res. 56(5) (1996), 988-994.
16. D. Keppler, Export pumps for glutathione S-conjugates, Free Radic. Biol. Med. 27 (9-10) (1999), 985-991.
17. J. Wijnholds, C.A. Mol, L. van Deemter, M. de Haas, G.L. Scheffer, F. Baas, J.H. Beijnen, R.J. Scheper, S. Hatse, E. De Clercq, J. Balzarini and P. Borst, Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs, Proc. Natl. Acad. Sci. USA, 97(13) (2000), 7476-7481.
18. A. Ilias, Z. Urban, T.L. Seidl, O. Le Saux, E. Sinko, C.D. Boyd, B. Sarkadi and A. Varadi, Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6(MRP6), J. Biol. Chem. 277 (2002), 16860-16867.
19. M.G. Belinsky, Z-S. Chen, I. Shchaveleva, H. Zeng and G.D. Kruh, Characterization of the drug resistance and transport properties of multidrug resistance protein 6 (MRP6, ABCC6), Cancer Research 62 (2002), 6172-6177.
20. P.A. Rea, Z.-S. Li, Y.-P. Lu, Y.M. Drozdowicz and E. Martinoia, From vaculoar GS-X pumps to multispecific ABC-transporters, Annu. Rev. Plant Physiol. Plant Mol. Biol. 49 (1998), 727-760.
21. A. Broeks, B. Gerrard, R. Allikmets, M. Dean and R.H. Plasterk, Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans, EMBO J. 15(22) (1996), 6132-6143.
22. J. König, A.T. Nies, Y. Cui, I. Leier and D. Keppler, Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance, Biochim. Biophys. Acta. 1461(2) (1999), 377-394.
23. T. Hirohashi, H. Suzuki and Y. Sugiyama, Characterization of the transport properties of cloned rat multidrug resistance-associated protein 3 (MRP3), J. Biol. Chem. 274(21) (1999), 15181-15185.
24. J.D. Schuetz, M.C. Connelly, D. Sun, S.G. Paibir, P.M. Flynn, R.V. Srinivas, A. Kumar and A. Fridland, MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs, Nat. Med. 5(9) (1999), 1048-1051.
25. R.A. van Aubel, P.H. Smeets, J.G. Peters, R.J. Bindels and F.G. Russel, The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP, J. Am. Soc. Nephrol. 13(3) (2002), 595-603.
26. T. Ishikawa, The ATP-dependent glutathione S-conjugate export pump, Trends. Biochem. Sci. 17(11) (1992), 463-468.
27. C.C. Paulusma, M. Kool, P.J. Bosma, G.L. Scheffer, F. ter Borg, R.J. Scheper, G.N. Tytgat, P. Borst, F. Baas and R.P. Oude Elferink, A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome, Hepatology 25(6) (1997), 1539-1542.
28. C.C. Paulusma, P.J. Bosma, G.J. Zaman, C.T. Bakker, M. Otter, G.L. Scheffer, R.J. Scheper, P. Borst and R.P. Oude Elferink, Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene, Science 271(5252) (1996), 1126-1128.
29. M. Büchler, J. König, M. Brom, J. Kartenbeck, H. Spring, T. Horie and D. Keppler, cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats, J. Biol. Chem. 271(25) (1996), 15091-15098.
30. K. Ito, H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu and Y. Sugiyama, Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR, Am. J. Physiol. 272 (1997), G16-22.
31. J. König, D. Rost, Y. Cui and D. Keppler, Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane, Hepatology 29(4) (1999), 1156-1163.
32. M. Salerno, M. Petroutsa and A. Garnier-Suillerot, The MRP1 -mediated effluxes of arsenic and antimony do not require arsenic-glutathione and antimony-glutathione complex formation, J. Bioenerg. Biomembr. 34(2) (2002), 135-145.
33. G.J. Zaman, J. Lankelma, O. van Tellingen, J. Beijnen, H. Dekker, C. Paulusma, R.P. Oude Elferink, F. Baas and P. Borst, Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein, Proc. Natl. Acad. Sci. USA, 92(17) (1995), 7690-7694.
34. M.A. McAleer, M.A. Breen, N.L. White and N. Matthews, pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells, J. Biol. Chem. 274(33) (1999), 23541-23548.
35. Z.S. Li, M. Szczypka, Y.P. Lu, D.J. Thiele and P.A. Rea, The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump, J. Biol. Chem. 271(11) (1996), 6509-6517.
36. M.T. Kuo, S. Sen, W.N. Hittelman and T.C. Hsu, Chromosomal fragile sites and DNA amplification in drug-resistant cells, Biochem. Pharmacol. 56(1) (1998), 7-13.
37. D.W. Loe, R.K. Stewart, T.E. Massey, R.G. Deeley and S.P. Cole, ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the multidrug resistance protein (MRP) gene, Mol. Pharmacol. 51(6) (1997), 1034-1041.
38. J.F. Rebbeor, G.C. Connolly, M.E. Dumont and N. Ballatori, ATP-dependent transport of reduced glutathione on YCF1, the yeast orthologue of mammalian multidrug resistance associated proteins, J. Biol. Chem. 273(50) (1998), 33449-33454.
39. C.C. Paulusma, M.A. van Geer, R. Evers, M. Heijn, R. Ottenhoff, P. Borst and R.P. Oude Elferink, Canalicular multi-specific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione, Biochem. J. 338(Pt 2) (1999), 393-401.
40. M. Kool, M. van der Linden, M. de Haas, G.L. Scheffer, J.M. de Vree, A.J. Smith, G. Jansen, G.J. Peters, N. Ponne, R.J. Scheper, R.P. Elferink, F. Baas and P. Borst, MRP3, an organic anion transporter able to transport anti-cancer drugs, Proc. Natl. Acad. Sci. USA, 96(12) (1999), 6914-6919.
41. L. Li, T.K. Lee, P.J. Meier and N. Ballatori, Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter, J. Biol. Chem. 273(26) (1998), 16184-16191.
42. H. Sies, Intracellular effect of glutathione conjugates and their transport from cells, in: Glutathione conjugation: mechanisms and biological significance, H. Sies and B. Ketterer eds, Academic Press, London, 1988, pp. 175-192.
43. T.P. Akerboom, M. Bilzer and H. Sies, The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver, J. Biol. Chem. 257(8) (1982), 4248-4252.
44. Y. Yamane, M. Furuichi, R. Song, N.T. Van, R.T. Mulcahy, T. Ishikawa and M.T. Kuo, Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress, J. Biol. Chem. 273(47) (1998), 31075-31085.
45. T. Ishikawa, C.D. Wright and H. Ishizuka, GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation, J. Biol. Chem. 269(46) (1994), 29085-29093.
46. Q. Wang and W.T. Beck, Transcriptional suppression of multidrug resistance-associated protein (MRP) gene expression by wild-type p53, Cancer Res. 58(24) (1998), 5762-5769.
47. T. Hirohashi, H. Suzuki, K. Ito, K. Ogawa, K. Kume, T. Shimizu and Y. Sugiyama, Hepatic expression of multidrug resistance-associated protein-like proteins maintained in eisai hyperbilirubinemic rats, Mol. Pharmacol. 53(6) (1998), 1068-1075.
48. M. Trauner, M. Arrese, C.J. Soroka, M. Ananthanarayanan, T.A. Koeppel, S.F. Schlosser, F.J. Suchy, D. Keppler and J.L. Boyer, The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis, Gastroenterology 113(1) (1997), 255-264.
49. R. Schreiber, A. Hopf, M. Mall, R. Greger and K. Kunzelmann, The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel. Proc. Natl. Acad. Sci. USA. 96(9) (1999), 5310-5315.
50. D.B. Short, K.W. Trotter, D. Reczek, S.M. Kreda, A. Bretscher, R.C. Boucher, M.J. Stutts and S.L. Milgram, An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton, J. Biol. Chem. 273(31) (1998), 19797-19801.