Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats

Shock

Volumn 14, Issue 2, 2000, Pages 176-181

  Kim Patrick K , K ^a   Chen, Jodi ^a   Andrejko, Kenneth M ^a   Deutschman, Clifford S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Dulles 773/HUP ^*  (United States)

Author keywords

Bilirubin; Cecal ligation and puncture; Cholestasis; Interleukin 6; Systemic inflammatory response syndrome

Indexed keywords

CARRIER PROTEIN; COTRANSPORTER; GLYCOPROTEIN P; INTERLEUKIN 6; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2; ORGANIC ANION TRANSPORTER; SODIUM; SODIUM BILE ACID COTRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TAUROCHOLIC ACID;

ANIMAL; ARTICLE; BIOSYNTHESIS; CECUM; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HYPERBILIRUBINEMIA; INTESTINE PERFORATION; INTRAHEPATIC CHOLESTASIS; ION TRANSPORT; LIGATION; LIVER; MALE; METABOLISM; MOUSE; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; CARRIER PROTEINS; CECUM; CHOLESTASIS, INTRAHEPATIC; GENE EXPRESSION REGULATION; HYPERBILIRUBINEMIA; INTERLEUKIN-6; INTESTINAL PERFORATION; ION TRANSPORT; LIGATION; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; P-GLYCOPROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SODIUM; SYMPORTERS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TAUROCHOLIC ACID; TRANSCRIPTION, GENETIC;

EID: 0039849217     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200014020-00017     Document Type: Article

References (49)

1. Deitch EA: Multiple organ failure: pathophysiology and potential future therapy. Ann Surg 216:117-134, 1992.
2. Beal AL, Cerra FB: Multiple organ failure syndrome in the 1990s: systemic inflammatory response and organ dysfunction. JAMA 271:226-233, 1994.
3. Baue AE, Durham R, Faist E: Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 10:79-89, 1998.
4. Regel G, Grotz M, Weltner T, Strum JA, Tscherne H: Pattern of organ failure following severe trauma. World J Surg 20:422-429, 1996.
5. Zimmerman H, Fang M, Utili R, Seeff L, Hoofnagle J: Jaundice due to bacterial infections. Gastroenterology 77:362-374, 1979.
6. Miller D, Keeton G, Webber B, Saunders S: Jaundice in severe bacterial infections. Gastroenterology 71:1799-1805, 1976.
7. Quale JM, Mandel LJ, Bergasa NV, Straus EW: Clinical significance and pathogenesis of hyperbilirubinemia associated with Staphylococcus aureus septicemia. Am J Med 85:615-618, 1988.
8. Andrejko KM, Deutschman CS: Altered hepatic gene expression in fecal peritonitis: Changes in transcription of gluconeogenic, β-oxidative and ureagenic genes. Shock 7:164-167, 1997.
9. Deutschman CS, DeMaio A, Buchman TG, Clemens MG: Sepsis-induced alterations in phosphoenolpyruvate carboxykinase expression: the role of insulin and glucagon. Circ Shock 40:295-302, 1993.
10. Deutschman CS, Andrejko KM, Haber BA, Elenko E, Harrison R, Taub R: Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity. Am J Physiol 273:R1709-R1718, 1997.
11. Andrejko KM, Chen J, Deutschman CS: Intrahepatic STAT-3 activation and acute phase gene expression predict outcome following cecal ligation and puncture sepsis in the rat. Am J Physiol 275:G1423-G1429, 1998.
12. Utili R, Abernathy C, Zimmerman H: Cholestatic effects of Echerichia coli endotoxin on the isolated perfused rat liver. Gastroenterology 70:248-253, 1976.
13. Green RM, Crawford JM: Hepatocellular cholestasis: pathobiology and histologic outcomes. Semin Liv Dis 15:372-389, 1995.
14. Muller M, Jansen PLM: Molecular aspects of hepatobiliary transport. Am J Physiol 272:G1285-G1303, 1997.
15. Suchy FJ, Sippel CJ, Ananthanarayanan M: Bile acid transport across the hepatocyte canalicular membrane. FASEB J 11:199-205, 1997.
16. Green RM, Beier D, Gollan JL: Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology 111:193-198, 1996.
17. Trauner M, Arrese M, Soroka CJ, Ananthanarayanan M, Koeppel TA, Schlosser SF, Suchy FJ, Keppler D, Boyer JL: The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113:255-264, 1997.
18. Green RM, Whiting JF, Rosenbluth AB, Beier D, Gollan JL: Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity. Am J Physiol 267:1094-1100, 1994.
19. Weiss YG, Bouwman AR, Gehan B, Raj N, Deutschman CS: Cecal ligation and double puncture impairs heat shock protein 70 (HSP-70) expression in the lungs of rats. Shock 13:19-23, 2000.
20. Deutschman CS, Haber BA, Andrejko K, Cressman DE, Harrison R, Elenko E, Taub R: Increased expression of cytokine induced neutrophil chemoattractant (CINC) in septic rat liver. Am J Physiol 271:R593-R600, 1996.
21. Andrejko KM, Deutschman CS: Acute phase gene expression correlates with intrahepatic tumor necrosis factor-α abundance but not plasma TNF levels during sepsis/SIRS in the rat. Crit Care Med 24:1947-1952, 1996.
22. Cressman DE, Greenbaum LE, DeAngelis RA, Ciliberto G, Furth EE, Taub R: Liver failure and defective hepatocyte regeneration in interleukin-6 deficient mice. Science 274:1379-1383, 1996.
23. Deutschman CS, De Maio A, Clemens MG: Sepsis-induced attenuation of glucagon and 8-BrcAMP modulation of the phosphoenolpyruvate carboxykinase gene. Am J Physiol 38:R584-R591, 1995.
24. Chomczynski P, Sacchi N: A single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987.
25. Bazel S, Andrejko KM, Chen J, Deutschman CS: Failure of sterile inflammation to alter expression of gluconeogenic, ketogenic and ureagenic hepatic genes in rats. Shock 11:347-355, 1999.
26. Billiar TR, Curran RD, Williams DL, Kispem PH: Liver nonparenchymal cells are stimulated to provide interleukin-6 for induction of hepatic acute phase response in endotoxemia but not in remote localized inflammation. Arch Surg 127:31-43, 1992.
27. 1-adrenoreceptor gene in the rat liver during different phases of sepsis. Biochim Biophys Acta 1453:207-215, 1999.
28. 2-adrenergic receptor gene in rat liver during sepsis. Am J Physiol 277:R132-R139, 1999.
29. Wang P, Chaudry IH: Mechanism of hepatocellular dysfunction during hyperdynamic sepsis. Am J Physiol 270:R927-R938, 1996.
30. Wichterman KA, Baue AE, Chaudry IH: Sepsis and septic shock-A review of laboratory models and a proposal. J Surg Res 29:189-210, 1980.
31. Baker CC, Chaudry IH, Gaines HO, Baue AE: Evaluation of factors effecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 94:331-335, 1983.
32. Trauner M, Meier PJ, Boyer JL: Molecular pathogenesis of cholestasis. N Engl J Med 339:1217-1227, 1998.
33. Sazuki H, Sugiyama Y: Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin Liv Dis 18:359-376, 1998.
34. Gerloff T, Steiger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ: The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273:10046-10050, 1998.
35. Wang K, Deutschman CS, Clemens MG, De Maio A: Reciprocal expression of phosphoenolpyruvate carboxykinase and acute phase genes during acute inflammation. Shock 3:204-209, 1995.
36. Whiting JF, Green RM, Rosenbluth AB, Gollan JL: Tumor necrosis factor-α decreases hepatocyte bile salt uptake and mediates endotoxin induced cholestasis. Hepatology 22:1273-1278, 1995.
37. Moseley RH, Wang W, Takeda H, Lown K, Shick L, Ananthanarayanan M, Suchy FJ: Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am J Physiol 271:G137-G146, 1996.
38. Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ: Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 101:2092-2100, 1998.
39. Ayala A, Deol ZK, Lehman DL, Herdon CD, Chaudry IH: Does endotoxin play a major role in inducing the depression of macrophage function during polymicrobial sepsis? Arch Surg 1178:1185, 1995.
40. Gearing AJH, Beckett P, Christodoulou M, Churchill M, Clements JM, Crimmin M, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, Leber TM, Mangan M, Miller K, Nayee P, Owen K, Patel S, Thomas W, Wells G, Wood LM, Woolley K: Matrix metallopreoteinases and processing of pro-TNF-α. J Leukoc Biol 57:774-777, 1995.
41. Biffl WL, Moore EE, Moore FA, Paterson VM: Interleukin-6 in the injured patient: marker of injury or mediator of inflammation? Ann Surg 271:647-664, 1996.
42. Partrick DA, Moore FA, Moore EE, Biffl WL, Sauaia A, Barnett CCJ: The inflammatory profile of interleukin-6, interleukin-8 and soluble cell adhesion molecule-1 in post-injury multiple organ failure. Am J Surg 172:425-431, 1997.
43. Christ B, Nath A, Heinrich PC, Jungermann K: Inhibition by recombinant interleukin-6 of the glucagon-dependent induction of phosphoenolpyruvate carboxykinase and the insulin-dependent induction of glucokinase gene expression in cultured rat hepatocytes: Regulation of gene transcription and messenger RNA degradation. Hepatology 20:1577-1583, 1994.
44. Metzger S, Goldschmidt N, Barash V, Peretz T, Drize O, Shilyansky J, Shiloni E, Chejek-Shaul T: Interleukin-6 secretion in mice is associated with reduced glucose-6-phosphatase and liver glycogen levels. Am J Physiol 273:E262-E267, 1997.
45. Karpen SJ, Sun AQ, Kudish B, Hagenbuch B, Meier PJ, Ananthanarayanan M, Suchy FJ: Multiple factors regulate the rat basolateral sodium-dependent bile acid cotransporter gene promoter. J Biol Chem 271: 152111-152121, 1996.
46. Hasselgren PO, Jagenburg R, Karlstrom L, Pedersen P, Seeman T: Changes of protein metabolism in liver and skeletal muscle following trauma complicated by sepsis. J Trauma 24:224-228, 1984.
47. Meakins JL: Etiology of multiple organ failure. J Trauma 30:S165-S168, 1990.
48. Barie PS, Hydro LJ, Fischer E: A prospective comparison of two multiple organ dysfunction/failure scoring systems for prediction of mortality on critical surgical illness. J Trauma 37:660-666, 1994.
49. Guillem JG, Clemens MG, Chaudry IH, McDermott PH, Baue AE: Hepatic gluconeogenic capability in sepsis is depressed before changes in oxidative capability. J Trauma 22:723-729, 1982.