Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)

European Journal of Biochemistry

Volumn 269, Issue 7, 2002, Pages 1866-1876

  Nies, Anne T ^a   König, Jörg ^a   Cui, Yunhai ^a   Brom, Manuela ^a   Spring, Herbert ^a   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Epithelial polarity; Green fluorescent protein; Multidrug resistance protein 2; Protein trafficking

Indexed keywords

AMINO ACID; GREEN FLUORESCENT PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL POLARITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA TRANSFECTION; DOG; GENE CONSTRUCT; GENE MUTATION; HEPATOMA CELL; HUMAN; HUMAN CELL; KIDNEY CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; DNA PRIMERS; DNA, COMPLEMENTARY; DOGS; DRUG RESISTANCE, MULTIPLE; ENDOCYTOSIS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICROSCOPY, FLUORESCENCE; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA; CANIS FAMILIARIS;

EID: 85047697477     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.02832.x     Document Type: Article

References (59)

1. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
2. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
3. r 190,000 multidrug protein, MRP, with monoclonal antibodies
4. Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies
5. Tissue distribution of the multidrug resistance protein
6. Basolateral localization and export activity of the human multidrug resistance-associated protein in polarized pig kidney cells
7. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
8. MRP3, an organic anion transporter able to transport anti-cancer drugs
9. Transport function and hepatocellular localization of mrp6 in rat liver
10. Conjugate export pumps of the multidrug resistance protein (MRP) family in liver
11. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyper-bilirubinemic mutant rats
12. Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal-cell carcinoma
13. Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene
14. Molecular cloning of canalicular multi-specific organic anion transporter defective in EHBR
15. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
16. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells
17. A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
18. ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane: Role of the ATP-dependent transport system for glutathione S-conjugates
19. Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B
20. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
21. Functional analysis of a canalicular multi-specific organic anion transporter cloned from rat liver
22. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
23. The canalicular conjugate export pump encoded by the cmrp/cmoat gene
24. Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome
25. Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells
26. Basolateral sorting of LDL receptor in MDCK cells: The cytoplasmic domain contains two tyrosine-dependent targeting determinants
27. The neural cell adhesion molecule expresses a tyrosine-independent basolateral sorting signal
28. Basolateral sorting of the cation-dependent mannose 6-phosphate receptor in Madin-Darby canine kidney cells. Identification of a basolateral determinant unrelated to clathrin-coated pit localization signals
29. Ion pumps in polarized cells: Sorting and regulation of the Na, K-and H, K-ATPases
30. Functional rafts in cell membranes
31. Epithelial polarity: Sorting out the sorters
32. Recognition of unique carboxyl-terminal motifs by distinct PDZ domains
33. PDZ domains: Fundamental building blocks in the organization of protein complexes at the plasma membrane
34. Impaired protein maturation of the conjugate export pump MRP2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
35. PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein
36. Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/MOAT)
37. Identification of EPI64, a TBC/ rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
38. Identification of sorting determinants in the C-terminal cytoplasmic tails of the gamma-aminobutyric acid transporters GAT-2 and GAT-3
39. FACS-optimized mutants of the green fluorescent protein (GFP)
40. Optimized codon usage and chromophore mutations provide enhanced sensitivity with the green fluorescent protein
41. Syntaxin 1A is delivered to the apical and basolateral domains of epithelial cells: The role of munc-18 proteins
42. MRP2, a human conjugate export pump, is present and transports Fluo-3 into apical vacuoles of HepG2 cells
43. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver
44. Membrane topology and glycosylation of the human multidrug resistance-associated protein
45. A hidden Markov model for predicting transmembrane helices in protein sequences
46. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
47. Novel vectors for the expression of antibody molecules using variable regions generated by polymerase chain reaction
48. Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: Evidence for more than one receptor class
49. Bile canaliculus formation in cultured HepG2 cells
50. Sphingolipid transport to the apical plasma membrane domain in human hepatoma cells is controlled by PKC and PKA activity: A correlation with cell polarity in HepG2 cells
51. A PDZ-interacting domain in CFTR is an apical membrane polarization signal
52. Tyrosine-based membrane protein sorting signals are differentially interpreted by polarized Madin-Darby canine kidney and LLC-PK1 epithelial cells
53. i cotransporters
54. Lumenal targeted GFP, used as a marker of soluble cargo, visualises rapid ERGIC to Golgi traffic by a tubulo-vesicular network
55. The C-terminal tail of the metabotropic glutamate receptor subtype 7 is necessary but not sufficient for cell surface delivery and polarized targeting in neurons and epithelia
56. PDZ-mediated interactions retain the epithelial GABA transporter on the basolateral surface of polarized epithelial cells
57. PDZ domains: More than just a glue
58. PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL
59. Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex