Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells

Biochemical Pharmacology

Volumn 59, Issue 5, 2000, Pages 467-470

  Bock, Karl Walter ^a   Eckle, Tilman ^a   Ouzzine, Mohamed ^b   Fournel Gigleux, Sylvie ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Antioxidants; Caco 2 cells; cMOAT; Human UGT1A6; MRP2

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ANTIOXIDANT; GLUCURONOSYLTRANSFERASE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; PHENOL DERIVATIVE; PROTEIN; QUERCETIN; TERT BUTYLHYDROQUINONE; UNCLASSIFIED DRUG;

ARTICLE; BRUSH BORDER; CELL STRAIN CACO 2; CONJUGATE; CONTROLLED STUDY; ENZYME INDUCTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; MONOLAYER CULTURE; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN INDUCTION;

ANTIOXIDANTS; ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOBLOTTING; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; QUERCETIN; RECEPTORS, ARYL HYDROCARBON; TERATOGENS; TETRACHLORODIBENZODIOXIN;

EID: 0033954736     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00366-4     Document Type: Article

References (25)

1. Mackenzie P.I., Owens I.S., Burchell B., Bock K.W., Bairoch A., Belanger A., Fournel-Gigleux S., Green M., Hum D.W., Iyanagi T., Lancet D., Louisot P., Magdalou J., Roy Chowdhury J., Ritter J.K., Schachter H., Tephly T.R., Tipton K.F., Nebert D.W. The UDP glucuronosyltransferase gene superfamily; Recommended nomenclature based on evolutionary divergence. Pharmacogenetics. 7:1997;255-269.
2. King C.D., Rios G.R., Assouline J.A., Tephly T.R. Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate. Arch Biochem Biophys. 365:1999;156-162.
3. Bock K.W., Forster A., Gschaidmeier H., Brück M., Münzel P., Schareck W., Fournel-Gigleux S., Burchell B. Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochem Pharmacol. 45:1993;1809-1814.
4. Gschaidmeier H., Seidel A., Burchell B., Bock K.W. Formation of mono- and diglucuronides and of other glycosides of benzo(a)pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronosyltransferases of the UGT1 gene complex. Biochem Pharmacol. 49:1995;1601-1606.
5. Jin C.J., Miners J.O., Burchell B., Mackenzie P.I. The glucuronidation of hydroxylated metabolites of benzo[a]pyrene and 2-acetylaminofluorene by cDNA-expressed human UDP-glucuronosyltransferases. Carcinogenesis. 14:1993;2637-2639.
6. Münzel P.A., Bookjans G., Mehner G., Lehmköster T., Bock K.W. Tissue-specific TCDD-inducible expression of human UDP-glucuronosyltransferase UGT1A6. Arch Biochem Biophys. 335:1996;205-210.
7. Strassburg C.P., Nguyen N., Manns M.P., Tukey R.H. UDP-glucuronosyltransferase activity in human liver and colon. Gastroenterology. 116:1999;149-160.
8. Keppler D., König J. Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver. FASEB J. 11:1997;509-516.
9. Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J., Juijn J.A., Baas F., Borst P. Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res. 57:1997;3537-3547.
10. Narasaki F., Oka M., Nakano R., Ikeda K., Fukuda M., Nakamura T., Soda H., Nakagawa M., Kuwano M., Kohno S. Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells. Biochem Biophys Res Commun. 240:1997;606-611.
11. Cui Y., König J., Buchholz U., Spring H., Leier I., Keppler D. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol Pharmacol. 55:1999;929-937.
12. Münzel P.A., Schmohl S., Heel H., Kälberer K., Bock-Hennig B.S., Bock K.W. Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. Drug Metab Dispos. 27:1999;569-573.
13. Talalay P., Fahey J.W., Holtzclaw W.D., Prestera T., Zhang Y. Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett. 82/83:1995;173-179.
14. Venugopal R., Jaiswal A.K. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene. 17:1998;3145-3156.
15. Carrière V., Lesuffleur T., Barbat A., Rousset M., Dussaulx E., Costet P., de Waziers I., Beaune P., Zweibaum A. Expression of cytochrome P-450 3A in HT29-MTX cells and Caco-2 clone TC7. FEBS Lett. 355:1994;247-250.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem. 193:1951;265-275.
17. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1990;680-685.
18. Ouzzine M., Pillot T., Fournel-Gigleux S., Magdalou J., Burchell B., Siest G. Expression and role of the human liver UDP-glucuronosyltransferase UGT1*6 analyzed by specific antibodies raised against a hybrid protein produced in Escherichia coli. Arch Biochem Biophys. 310:1994;196-204.
19. Jedlitschky G., Leier I., Buchholz U., Hummel-Eisenbeiss J., Burchell B., Keppler D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J. 327:1997;305-310.
20. Fournel-Gigleux S., Sutherland L., Sabolovic N., Burchell B., Siest G. Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures. Mol Pharmacol. 39:1991;177-183.
21. Buchmann A., Kuhlmann W., Schwarz M., Kunz W., Wolf C.R., Moll E., Friedberg T., Oesch F. Regulation and expression of four cytochrome P-450 isoenzymes, NADPH-cytochrome P450 reductase, the glutathione transferases B and C and microsomal epoxide hydrolase in preneoplastic and neoplastic lesions in rat liver. Carcinogenesis. 6:1985;513-521.
22. Jedlitschky G., Leier I., Buchholz U., Barnouin K., Kurz G., Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res. 56:1996;988-994.
23. Lown K.S., Kolars J.C., Thummel K.E., Barnett J.L., Kunze K.L., Wrighton S.A., Watkins P.B. Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Drug Metab Dispos. 22:1994;947-955.
24. Walle U.K., Galijatovic A., Walle T. Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2. Biochem Pharmacol. 58:1999;431-438.
25. Sugiyama Y., Kato Y., Chu X. Multiplicity of biliary excretion mechanisms for the camptothecin derivative irinotecan (CPT-11), its metabolite SN-38, and its glucuronide Role of canalicular multispecific organic transporter and P-glycoprotein . Cancer Chemother Pharmacol. 42:(Suppl):1998;S44-S49.