The life and death of DNA-PK

Oncogene

Volumn 24, Issue 6, 2005, Pages 949-961

  Collis, Spencer J ^a,c   DeWeese, Theodore L ^a   Jeggo, Penelope A ^b   Parker, Antony R ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SUSSEX   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

DNA PK; Function; Gene therapy; Molecular targeting; Protein interactions; Radiosensitization; Regulation; Small molecule inhibitors

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ARTEMIS PROTEIN; BINDING PROTEIN; CISPLATIN; COMPLEMENTARY DNA; DNA LIGASE IV; DNA PROTEIN KINASE; DNA PROTEIN KINASE INHIBITOR; DOUBLE STRANDED DNA; EXONUCLEASE; KU ANTIGEN; NU 7026; OK 1035; ONCOLYTIC VIRUS; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN E1B 55K; PROTEIN E4 11K; PROTEIN E4 34K; PROTEIN ICP0; PROTEIN KINASE INHIBITOR; PROTEIN KU80; PROTEIN SERINE THREONINE KINASE; PROTEIN XRCC4; RADIOSENSITIZING AGENT; SMALL INTERFERING RNA; SU 11752; SU 11753; UNCLASSIFIED DRUG; VANILLIN; VIRUS PROTEIN; WORTMANNIN; DNA; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN;

ADENOVIRUS 5; CANCER RADIOTHERAPY; CATALYSIS; CATALYST; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GENOMIC INSTABILITY; GENOTOXICITY; HERPES SIMPLEX VIRUS 1; HUMAN; IMMEDIATE EARLY GENE; IONIZING RADIATION; MAMMAL CELL; NONHOMOLOGOUS END JOINING REPAIR; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN PHOSPHORYLATION; RADIOSENSITIZATION; REVIEW; TUMOR CELL DESTRUCTION; DNA DAMAGE; GENE THERAPY; GENETICS; NEOPLASM; RNA INTERFERENCE;

DNA; DNA DAMAGE; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; GENE THERAPY; HUMANS; NEOPLASMS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE;

EID: 13944277701     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1208332     Document Type: Review

References (200)

1. Anderson CW and Lees-Miller SP. (1992). Crit. Rev. Eukaryot. Gene Expr., 2, 283-314.
2. Arcaro A and Wymann MP. (1993). Biochem. J., 296, 297-301.
3. Ariumi Y, Masutani M, Copeland TD, Mimori T, Sugimura T, Shimotohno K, Ueda K, Hatanaka M and Noda M. (1999). Oncogene, 18, 4616-4625.
4. Bailey SM, Brenneman MA, Halbrook J, Nickoloff JA, Ullrich RL and Goodwin EH. (2004a). DNA Repair (Amst.), 3, 225-233.
5. Bailey SM, Cornforth MN, Ullrich RL and Goodwin EH. (2004b). DNA Repair (Amst.), 3, 349-357.
6. Bannister AJ, Gottlieb TM, Kouzarides T and Jackson SP. (1993). Nucleic Acids Res., 21, 1289-1295.
7. Bassing CH, Swat W and Alt FW. (2002). Cell, 109 (Suppl), S45-S55.
8. Beamish HJ, Jessberger R, Riballo E, Priestley A, Blunt T, Kysela B and Jeggo PA. (2000). Nucleic Acids Res., 28, 1506-1513.
9. Belenkov AI, Paiement JP, Panasci LC, Monia BP and Chow TY. (2002). Cancer Res., 62, 5888-5896.
10. Bharti A, Kraeft SK, Gounder M, Pandey P, Jin S, Yuan ZM, Lees-Miller SP, Weichselbaum R, Weaver D, Chen LB, Kufe D and Kharbanda S. (1998). Mol. Cell. Biol. 18, 6719-6728.
11. Blier PR, Griffith AJ, Craft J and Hardin JA. (1993). J. Biol. Chem., 268, 7594-7601.
12. Block WD, Yu Y and Lees-Miller SP. (2004a). Nucleic Acids Res., 32, 997-1005.
13. Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K and Lees-Miller SP. (2004b). Nucleic Acids Res., 32, 4351-4357.
14. Bogue MA, Jhappan C and Roth DB. (1998). Proc. Natl. Acad. Sci. USA, 95, 15559-15564.
15. Boskovic J, Rivera-Calzada A, Maman JD, Chacon P, Willison KR, Pearl LH and Llorca O. (2003). EMBO J., 22, 5875-5882.
16. Boubnov NV and Weaver DT. (1995). Mol. Cell. Biol., 15, 5700-5706.
17. Boulton S, Kyle S and Durkacz BW. (2000). Eur. J. Cancer, 36, 535-541.
18. Boyer J, Rohleder K and Ketner G. (1999). Virology, 263, 307-312.
19. Brush GS, Anderson CW and Kelly TJ. (1994). Proc. Natl. Acad. Sci. USA, 91, 12520-12524.
20. Burma S and Chen DJ. (2004). DNA Repair (Amst.), 3, 909-918.
21. Calsou P, Frit P, Humbert O, Muller C, Chen DJ and Salles B. (1999). J. Biol. Chem., 274, 7848-7856.
22. Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV and Weitzman MD. (2003). EMBO J., 22, 6610-6620.
23. Carter T, Vancurova I, Sun I, Lou W and DeLeon S. (1990). Mol. Cell. Biol., 10, 6460-6471.
24. Casciola-Rosen LA, Anhalt GJ and Rosen A. (1995). J. Exp. Med., 182, 1625-1634.
25. Cervantes RB and Lundblad V. (2002). Curr. Opin. Cell. Biol., 14, 351-356.
26. Chan DW, Chen BP, Prithivirajsingh S, Kurimasa A, Story MD, Qin J and Chen DJ. (2002). Genes Dev., 16, 2333-2338.
27. Chan DW and Lees-Miller SP. (1996). J. Biol. Chem., 271, 8936-8941.
28. Chan DW, Ye R, Veillette CJ and Lees-Miller SP. (1999). Biochemistry, 38, 1819-1828.
29. Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M and West SC. (2002). EMBO J., 21, 2827-2832.
30. Chen Y, DeWeese T, Dilley J, Zhang Y, Li Y, Ramesh N, Lee J, Pennathur-Das R, Radzyminski J, Wypych J, Brignetti D, Scott S, Stephens J, Karpf DB, Henderson DR and Yu DC. (2001). Cancer Res., 61, 5453-5460.
31. Chen YR, Lees-Miller SP, Tegtmeyer P and Anderson CW. (1991). J. Virol., 65, 5131-5140.
32. Chernikova SB, Wells RL and Elkind MM. (1999). Radiat. Res., 151, 159-166.
33. Chibazakura T, Watanabe F, Kitajima S, Tsukada K, Yasukochi Y and Teraoka H. (1997). Eur. J. Biochem., 247, 1166-1173.
34. Chu G. (1997). J. Biol. Chem., 272, 24097-24100.
35. Collis SJ, Ketner GW, Hicks JL, Nelson WG, Demarzo AM and Deweese TL. (2003a). Int. J. Radiat. Biol., 79, 53-60.
36. Collis SJ, Swartz MJ, Nelson WG and DeWeese TL. (2003b). Cancer Res., 63, 1550-1554.
37. Critchlow SE, Bowater RP and Jackson SP. (1997). Curr. Biol., 7, 588-598.
38. Custer RP, Bosma GC and Bosma MJ. (1985). Am. J. Pathol., 120, 464-477.
39. d'Adda di Fagagna F, Hande MP, Tong WM, Roth D, Lansdorp PM, Wang ZQ and Jackson SP. (2001). Curr. Biol., 11, 1192-1196.
40. de Lange T. (2002). Oncogene, 21, 532-540.
41. DeFazio LG, Stansel RM, Griffith JD and Chu G. (2002). EMBO J., 21, 3192-3200.
42. DiBiase SJ, Zeng ZC, Chen R, Hyslop T, Curran Jr WJ and Iliakis G. (2000). Cancer Res., 60, 1245-1253.
43. Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP and Meek K. (2003). Mol. Cell. Biol., 23, 5836-5848.
44. Douglas P, Moorhead GB, Ye R and Lees-Miller SP. (2001). J. Biol. Chem., 276, 18992-18998.
45. Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR and Lees-Miller SP. (2002). Biochem. J., 368, 243-251.
46. Durant S and Karran P. (2003). Nucleic Acids Res., 31, 5501-5512.
47. Dynan WS and Hoo S. (1998). Nucleic Acids Res., 26, 1551-1559.
48. Edwards E, Geng L, Tan J, Onishko H, Donnelly E and Hallahan DE. (2002). Cancer Res., 62, 4671-4677.
49. Elliott B and Jasin M. (2002). Cell Mol. Life Sci., 59, 373-385.
50. Erdemir T, Bilican B, Oncel D, Goding CR and Yavuzer U. (2002). J. Cell Sci., 115, 207-216.
51. Espejel S, Franco S, Sgura A, Gae D, Bailey SM, Taccioli GE and Blasco MA. (2002). EMBO J., 21, 6275-6287.
52. Espejel S, Martin M, Klatt P, Martin-Caballero J, Flores JM and Blasco MA. (2004). EMBO Rep., 5, 503-509.
53. Falzon M, Fewell JW and Kuff EL. (1993). J. Biol. Chem., 268, 10546-10552.
54. Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT and Alt FW. (1998). Immunity, 9, 367-376.
55. Gauss GH and Lieber MR. (1996). Mol. Cell. Biol., 16, 258-269.
56. Gell D and Jackson SP. (1999). Nucleic Acids Res., 27, 3494-3502.
57. Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M and Chen DJ. (2001). Proc. Natl. Acad. Sci. USA, 98, 15084-15088.
58. Girard PM, Foray N, Stumm M, Waugh A, Riballo E, Maser RS, Phillips WP, Petrini J, Arlett CF and Jeggo PA. (2000). Cancer Res., 60, 4881-4888.
59. Goedecke W, Eijpe M, Offenberg HH, van Aalderen M and Heyting C. (1999). Nat. Genet., 23, 194-198.
60. Gottlieb TM and Jackson SP. (1993). Cell, 72, 131-142.
61. Goudelock DM, Jiang K, Pereira E, Russell B and Sanchez Y. (2003). J. Biol. Chem., 278, 29940-29947.
62. Goytisolo FA, Samper E, Edmonson S, Taccioli GE and Blasco MA. (2001). Mol. Cell Biol., 21, 3642-3651.
63. Gu XY, Bennett RA and Povirk LF. (1996). J. Biol. Chem., 271, 19660-19663.
64. Gupta AK, Bakanauskas VJ, Cerniglia GJ, Cheng Y, Bernhard EJ, Muschel RJ and McKenna WG. (2001). Cancer Res., 61, 4278-4282.
65. Gupta AK, Cerniglia GJ, Mick R, Ahmed MS, Bakanauskas VJ, Muschel RJ and McKenna WG. (2003). Int. J. Radiat Oncol. Biol. Phys., 56, 846-853.
66. Haber JE. (2000). Trends Genet., 16, 259-264.
67. Hammarsten O and Chu G. (1998). Proc. Natl. Acad. Sci. USA, 95, 525-530.
68. Han Z, Johnston C, Reeves WH, Carter T, Wyche JH and Hendrickson EA. (1996a). J. Biol. Chem., 271, 14098-14104.
69. Han Z, Malik N, Carter T, Reeves WH, Wyche JH and Hendrickson EA. (1996b). J. Biol. Chem., 271, 25035-25040.
70. Harris R, Esposito D, Sankar A, Maman JD, Hinks JA, Pearl LH and Driscoll PC. (2004). J. Mol. Biol., 335, 573-582.
71. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW and Jackson SP. (1995). Cell, 82, 849-856.
72. Hashimoto M, Rao S, Tokuno O, Yamamoto K, Takata M, Takeda S and Utsumi H. (2003). J. Radiat. Res. (Tokyo), 44, 151-159.
73. Hickson ID. (2003). Nat. Rev. Cancer, 3, 169-178.
74. Hoeijmakers JH. (2001). Nature, 411, 366-374.
75. Hollick JJ, Golding BT, Hardcastle IR, Martin N, Richardson C, Rigoreau LJ, Smith GC and Griffin RJ. (2003). Bioorg. Med. Chem. Lett., 13, 3083-3086.
76. Hoppe BS, Jensen RB and Kirchgessner CU. (2000). Radiat. Res., 153, 125-130.
77. Horejsi Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J and Bartek J. (2004). Oncogene, 23, 3122-3127.
78. Hsu HL, Yannone SM and Chen DJ. (2002). DNA Repair (Amst.), 1, 225-235.
79. Hu L, Zaloudek C, Mills GB, Gray J and Jaffe RB. (2000). Clin. Cancer Res., 6, 880-886.
80. Huang J and Dynan WS. (2002). Nucleic Acids Res., 30, 667-674.
81. Huang J, Nueda A, Yoo S and Dynan WS. (1997). J. Biol. Chem., 272, 26009-26016.
82. Iijima S, Teraoka H, Date T and Tsukada K. (1992). Eur. J. Biochem., 206, 595-603.
83. Ismail IH, Martensson S, Moshinsky D, Rice A, Tang C, Hewlett A, McMahon G and Hammarsten O. (2003). Oncogene, 8, 8.
84. Izzard RA, Jackson SP and Smith GC. (1999). Cancer Res., 59, 2581-2586.
85. Jackson SP. (2001). Biochem. Soc. Trans., 29, 655-661.
86. Jackson SP, MacDonald JJ, Lees-Miller S and Tjian R. (1990). Cell, 63, 155-165.
87. Jeggo P, Singleton B, Beamish H and Priestley A. (1999). Comptes Rendus L'Achademi Sci., 322, 109-112.
88. Jeggo PA and O'Neill P. (2002). DNA Repair, 67, 1-7.
89. Jeggo PA, Taccioli GE and Jackson SP. (1995). BioEssays, 17, 949-957.
90. Jhappan C, Morse III HC, Fleischmann RD, Gottesman MM and Merlino G. (1997). Nat. Genet., 17, 483-486.
91. Jin S, Kharbanda S, Mayer B, Kufe D and Weaver DT. (1997). Am. Soc. Biochem. Mol. Biol., 272, 24763-24766.
92. Jin S and Weaver DT. (1997). EMBO J., 16, 6874-6885.
93. Karmakar P, Piotrowski J, Brosh Jr RM, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA and Bohr VA. (2002). J. Biol. Chem., 277, 18291-18302.
94. Karran P. (2000). Curr. Opin. Genet. Dev., 10, 144-150.
95. Kharbanda S, Pandey P, Jin S, Inoue S, Bharti A, Yuan ZM, Weichselbaum R, Weaver D and Kufe D. (1997). Nature, 386, 732-735.
96. Kienker LJ, Shin EK and Meek K. (2000). Nucleic Acids Res., 28, 2752-2761.
97. Kim CH, Park SJ and Lee SH. (2002). J. Pharmacol. Exp. Ther., 303, 753-759.
98. Kobayashi J, Antoccia A, Tauchi H, Matsuura S and Komatsu K. (2004). DNA Repair (Amst), 3, 855-861.
99. Kuhn A, Gottlieb TM, Jackson SP and Grummt I. (1995). Genes Dev., 9, 193-203.
100. Kumar S, Pandey P, Bharti A, Jin S, Weichselbaum R, Weaver D, Kufe D and Kharbanda S. (1998). J. Biol. Chem., 273, 25654-25658.
101. Kurimasa A, Kumano S, Boubnov NV, Story MD, Tung CS, Peterson SR and Chen DJ. (1999). Mol. Cell. Biol., 19, 3877-3884.
102. Labhart P. (1995). Proc. Natl. Acad. Sci. USA, 92, 2934-2938.
103. Leber R, Wise TW, Mizuta R and Meek K. (1998). J. Biol. Chem., 273, 1794-1801.
104. Lee JH and Paull TT. (2004). Science, 304, 93-96.
105. Lee SE, Mitchell RA, Cheng A and Hendrickson EA. (1997). Mol. Cell. Biol., 17, 1425-1433.
106. Lees-Miller SP and Anderson CW. (1989). J. Biol Chem., 264, 17275-17280.
107. Lees-Miller SP and Anderson CW. (1991). Cancer Cells, 3, 341-346.
108. Lees-Miller SP, Chen YR and Anderson CW. (1990). Mol. Cell. Biol., 10, 6472-6481.
109. Lees-Miller SP, Godbout R, Chan DW, Weinfeld M, Day III RS, Barron GM and Allalunis-Turner J. (1995). Science, 267, 1183-1185.
110. Lees-Miller SP, Long MC, Kilvert MA, Lam V, Rice SA and Spencer CA. (1996). J. Virol., 70, 7471-7477.
111. Lees-Miller SP and Meek K. (2003). Biochimie, 85, 1161-1173.
112. Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E and Anderson CW. (1992). Mol. Cell. Biol., 12, 5041-5049.
113. Lengauer C, Kinzler KW and Vogelstein B. (1998). Nature, 396, 643-649.
114. Leuther KK, Hammarsten O, Kornberg RD and Chu G. (1999). EMBO J., 18, 1114-1123.
115. Li B and Comai L. (2002). Nucleic Acids Res., 30, 3653-3661.
116. Li GC, He F, Shao X, Urano M, Shen L, Kim D, Borrelli M, Leibel SA, Gutin PH and Ling CC. (2003a). Cancer Res., 63, 3268-3274.
117. Li S, Takeda Y, Wragg S, Barrett J, Phillips A and Dynan WS. (2003b). Nucleic Acids Res., 31, 5848-5857.
118. Lieber MR, Ma Y, Pannicke U and Schwarz K. (2003). Nat. Rev. Mol. Cell. Biol., 4, 712-720.
119. Liu SH, Ma JT, Yueh AY, Lees-Miller SP, Anderson CW and Ng SY. (1993). J. Biol. Chem., 268, 21147-21154.
120. Llorca O and Pearl LH. (2004). Micron, 35, 625-633.
121. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ and Chen J. (2004). J. Biol. Chem., 279, 46359-46362.
122. Ma Y, Pannicke U, Schwarz K and Lieber MR. (2002). Cell, 108, 781-794.
123. Mahajan KN, Gangi-Peterson L, Sorscher DH, Wang J, Gathy KN, Mahajan NP, Reeves WH and Mitchell BS. (1999). Proc. Natl. Acad. Sci. USA, 96, 13926-13931.
124. Mahajan KN, Nick McElhinny SA, Mitchell BS and Ramsden DA. (2002). Mol. Cell. Biol., 22, 5194-5202.
125. Marangoni E, Foray N, O'Driscoll M, Douc-Rasy S, Bernier J, Bourhis J and Jeggo P. (2000a). Nucleic Acids Res., 28, 4778-4782.
126. Marangoni E, Le Romancer M, Foray N, Muller C, Douc-Rasy S, Vaganay S, Abdulkarim B, Barrois M, Calsou P, Bernier J, Salles B and Bourhis J. (2000b). Cancer Gene Ther., 7, 339-346.
127. Marples B, Cann NE, Mitchell CR, Johnston PJ and Joiner MC. (2002). Int. J. Radiat. Biol., 78, 1139-1147.
128. Matsumoto Y, Suzuki N, Namba N, Umeda N, Ma XJ, Morita A, Tomita M, Enomoto A, Serizawa S, Hirano K, Sakaia K, Yasuda H and Hosoi Y. (2000). FEBS Lett., 478, 67-71.
129. Mayo LD, Turchi JJ and Berberich SJ. (1997). Cancer Res., 57, 5013-5016.
130. McKenna WG and Muschel RJ. (2003). Genes Chromosomes Cancer, 38, 330-338.
131. Michaelidis TM and Grummt I. (2002). Biol Chem., 383, 1683-1690.
132. Mickelsen S, Snyder C, Trujillo K, Bogue M, Roth DB and Meek K. (1999). J. Immunol., 163, 834-843.
133. Mimori T, Akizuki M, Yamagata H, Inada S, Yoshida S and Homma M. (1981). J. Clin. Invest., 68, 611-620.
134. Mimori T and Hardin JA. (1986). J. Cell. Biochem., 261, 375-379.
135. Mizuta R, Cheng HL, Gao Y and Alt FW. (1997). Int. Immunol., 9, 1607-1613.
136. Modesti M, Hesse JE and Gellert M. (1999). EMBO J., 18, 2008-2018.
137. Morrison C, Smith CM, Stingl L, Jackson SP, Wagner EF and Wang Z-Q. (1997). Nat. Genet., 17, 479-482.
138. Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, Tezcan I, Sanal O, Bertrand Y, Philippe N, Fischer A and de Villartay JP. (2001). Cell, 105, 177-186.
139. Muller C and Salles B. (1997). Oncogene, 15, 2343-2348.
140. Myung K, He DM, Lee SE and Hendrickson EA. (1997). EMBO J., 16, 3172-3184.
141. Nicolas N, Finnie NJ, Cavazzana-Calvo M, Papadopoulo D, Le Deist F, Fischer A, Jackson SP and de Villartay JP. (1996). Eur. J. Immunol., 26, 1118-1122.
142. Norbury CJ and Hickson ID. (2001). Annu. Rev. Pharmacol. Toxicol., 41, 367-401.
143. Oakley GG, Patrick SM, Yao J, Carty MP, Turchi JJ and Dixon K. (2003). Biochemistry, 42, 3255-3264.
144. Omori S, Takiguchi Y, Suda A, Sugimoto T, Miyazawa H, Tanabe N, Tatsumi K, Kimura H, Pardington PE, Chen F, Chen DJ and Kuriyama T. (2002). DNA Repair (Amst.), 1, 299-310.
145. O'Neill T, Dwyer AJ, Ziv Y, Chan DW, Lees-Miller SP, Abraham RH, Lai JH, Hill D, Shiloh Y, Cantley LC and Rathbun GA. (2000). J. Biol. Chem., 275, 22719-22727.
146. Park EJ, Chan DW, Park JH, Oettinger MA and Kwon J. (2003). Nucleic Acids Res., 31, 6819-6827.
147. Parkinson J, Lees-Miller SP and Everett RD. (1999). J. Virol., 73, 650-657.
148. Peng Y, Zhang Q, Nagasawa H, Okayasu R, Liber HL and Bedford JS. (2002). Cancer Res., 62, 6400-6404.
149. Peterson SR, Jesch SA, Chamberlin TN, Dvir A, Rabindran SK, Wu C and Dynan WS. (1995). J. Biol. Chem., 270, 1449-1454.
150. Price BD and Youmell MB. (1996). Cancer Res., 56, 246-250.
151. Rebuzzini P, Lisa A, Giulotto E and Mondello C. (2004). Cancer Lett., 203, 79-86.
152. Riballo E, Kühne M, Rief N, Doherty A, Smith G, Recio J-M, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson S, Gennery A, Jeggo PA and Löbrich M. (2004). Mol. Cell, in press.
153. Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D and Alt FW. (2002). Mol. Cell, 10, 1379-1390.
154. Rosenzweig KE, Youmell MB, Palayoor ST and Price BD. (1997). Clin. Cancer Res., 3, 1149-1156.
155. Ruscetti T, Lehnert BE, Halbrook J, Le Trong H, Hoekstra MF, Chen DJ and Peterson SR. (1998). J. Biol. Chem., 273, 14461-14467.
156. Sak A, Stuschke M, Wurm R, Schroeder G, Sinn B, Wolf G and Budach V. (2002). Cancer Res., 62, 6621-6624.
157. Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE and Abraham RT. (1998). Cancer Res., 58, 4375-4382.
158. Schild-Poulter C, Shih A, Yarymowich NC and Hache RJ. (2003). Cancer Res., 63, 7197-7205.
159. Semba S, Itoh N, Ito M, Harada M and Yamakawa M. (2002). Clin. Cancer Res., 8, 1957-1963.
160. Shieh SY, Ikeda M, Taya Y and Prives C. (1997). Cell, 91, 325-334.
161. Shiloh Y. (2003). Nat. Rev. Cancer, 3, 155-168.
162. Shintani S, Mihara M, Li C, Nakahara Y, Hino S, Nakashiro K and Hamakawa H. (2003). Cancer Sci., 94, 894-900.
163. Singleton BK, Torres-Arzayus MI, Rottinghaus ST, Taccioli GE and Jeggo PA. (1999). Mol. Cell. Biol., 19, 3267-3277.
164. Sirzen F, Nilsson A, Zhivotovsky B and Lewensohn R. (1999). Eur. J. Cancer. 35, 111-116.
165. Smith GC and Jackson SP. (1999). Genes Dev., 13, 916-934.
166. Song Q, Lees-Miller SP, Kumar S, Zhang Z, Chan DW, Smith GC, Jackson SP, Alnemri ES, Litwack G, Khanna KK and Lavin MF. (1996). EMBO J., 15, 3238-3246.
167. Stein RC. (2001). Endocr. Relat. Cancer, 8, 237-248.
168. Stockley M, Clegg W, Fontana G, Golding BT, Martin N, Rigoreau LJ, Smith GC and Griffin RJ. (2001). Bioorg. Med. Chem. Lett., 11, 2837-2841.
169. Stracker TH, Carson CT and Weitzman MD. (2002). Nature, 418, 348-352.
170. Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA and Herrera VL. (1998). Immunity, 9, 355-366.
171. Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A and Takeda S. (1998). EMBO J., 17, 5497-5508.
172. Take Y, Kumano M, Hamano Y, Fukatsu H, Teraoka H, Nishimura S and Okuyama A. (1995). Biochem. Biophys. Res. Commun., 215, 41-47.
173. Thompson LH and Schild D. (2002). Mutat. Res., 509, 49-78.
174. Ui M, Okada T, Hazeki K and Hazeki O. (1995). Trends Biochem. Sci., 20, 303-307.
175. Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L and Shiloh Y. (2003). EMBO J., 22, 5612-5621.
176. Vaganay-Juery S, Muller C, Marangoni E, Abdulkarim B, Deutsch E, Lambin P, Calsou P, Eschwege F, Salles B, Joiner M and Bourhis J. (2000). Br. J. Cancer, 83, 514-518.
177. Valerie K and Povirk LF. (2003). Oncogene, 22, 5792-5812.
178. van Gent DC, Hoeijmakers JH and Kanaar R. (2001). Nat. Rev. Genet., 2, 196-206.
179. Veuger SJ, Curtin NJ, Richardson CJ, Smith GC and Durkacz BW. (2003). Cancer Res., 63, 6008-6015.
180. Vilenchik MM and Knudson AG. (2003). Proc. Natl. Acad. Sci. USA, 100, 12871-12876 (Epub 2003 October 17).
181. Vlahos CJ, Matter WF, Hui KY and Brown RF. (1994). J. Biol. Chem., 269, 5241-5248.
182. Walker JR, Corpina RA and Goldberg J. (2001). Nature, 412, 607-614.
183. Ward JF. (1988). Prog. Nucleic Acid Res. Mol. Biol., 35, 95-125.
184. Watanabe F, Shirakawa H, Yoshida M, Tsukada K and Teraoka H. (1994). Biochem. Biophys. Res. Commun., 202, 736-742.
185. Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ and Wahl M. (2004). Proc. Natl. Acad Sci. USA, 101, 1247-1252.
186. Wilson CR, Davidson SE, Margison GP, Jackson SP, Hendry JH and West CM. (2000). Br. J. Cancer, 83, 1702-1706.
187. Wu X and Lieber MR. (1996). J. Mol. Cell. Biol., 16, 5186-5193.
188. Wymann MP, Bulgarelli-Leva G, Zvelebil MJ, Pirola L, Vanhaesebroeck B, Waterfield MD and Panayotou G. (1996). Mol. Cell. Biol., 16, 1722-1733.
189. Yaneva M, Kowalewski T and Leiber MR. (1997). EMBO J., 16, 5098-5112.
190. Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, Chen DJ and Boothman DA. (1999). Nucleic Acids Res., 27, 2165-2174.
191. Yang CR, Leskov K, Hosley-Eberlein K, Criswell T, Pink JJ, Kinsella TJ and Boothman DA. (2000). Proc. Natl. Acad .Sci. USA, 97, 5907-5912.
192. Yang J, Yu Y, Hamrick HE and Duerksen-Hughes PJ. (2003). Carcinogenesis, 24, 1571-1580.
193. Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J and Chen DJ. (2001). J. Biol. Chem., 276, 38242-38248.
194. Yavuzer U, Smith GC, Bliss T, Werner D and Jackson SP. (1998). Genes Dev., 12, 2188-2199.
195. Yeo TC, Xia D, Hassouneh S, Yang XO, Sabath DE, Sperling K, Gatti RA, Concannon P and Willerford DM. (2000). Mol. Immunol., 37, 1131-1139.
196. Yoo S and Dynan WS. (1999). Nucleic Acid Res., 27, 4679-4686.
197. Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K and Lees-Miller SP. (2003). DNA Repair (Amst.), 2, 1239-1252.
198. Yumoto Y, Shirakawa H, Yoshida M, Suwa A, Watanabe F and Teraoka H. (1998). J. Biochem. (Tokyo), 124, 519-527.
199. Zhang S, Schlott B, Gorlach M and Grosse F. (2004). Nucleic Acids Res., 32, 1-10.
200. Zhao HJ, Hosoi Y, Miyachi H, Ishii K, Yoshida M, Nemoto K, Takai Y, Yamada S, Suzuki N and Ono T. (2000). Clin. Cancer Res., 6, 1073-1078.