Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo

Cancer Research

Volumn 63, Issue 12, 2003, Pages 3268-3274

  Li, Gloria C ^a   He, Fuqui ^a   Shao, Xiyun ^a   Urano, Muneysau ^a   Shen, Lingbo ^a   Kim, Dooha ^a   Borrelli, Michael ^b   Leibel, Steven A ^a   Gutin, Philip H ^a   Ling, C Clifton ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 70; KU ANTIGEN; RECOMBINANT DNA; RNA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DOWN REGULATION; ENZYME ACTIVATION; FEMALE; FLOW CYTOMETRY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TRANSFER; HEAT TREATMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RADIOSENSITIZATION; RAT; TEMPERATURE DEPENDENCE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS INFECTION;

ADENOCARCINOMA; ANIMALS; ANTIGENS, NUCLEAR; BRAIN NEOPLASMS; CARCINOMA, SQUAMOUS CELL; COMBINED MODALITY THERAPY; DNA HELICASES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEASIBILITY STUDIES; FEMALE; FIBROSARCOMA; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENES, REPORTER; GENETIC VECTORS; GLIOMA; GREEN FLUORESCENT PROTEINS; HEAT; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LUMINESCENT PROTEINS; MALE; MASTADENOVIRUS; MICE; MICE, INBRED C3H; NEOPLASM PROTEINS; NUCLEAR PROTEINS; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROMOTER REGIONS (GENETICS); PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RATS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038407413     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Anderson, C. W. DNA damage and the DNA-activated protein kinase. Trends Biochem. Sci., 18: 433-437, 1993.
2. Featherstone, C., and Jackson, S. P. Ku, a DNA repair protein with multiple cellular functions? Mutat. Res., 434: 3-15, 1999.
3. Tuteja, R., and Tuteja, N. Ku autoantigen: a multifunctional DNA-binding protein. Crit. Rev. Biochem. Mol. Biol., 35: 1-33, 2000.
4. Bannister, A. J., Gottlieb, T. M., Kouzarides, T., and Jackson, S. P. c-Jun is phosphorylated by the DNA-dependent protein kinase in vitro: definition of the minimal kinase recognition motif. Nucleic Acids Res., 21: 1289-1295, 1993.
5. Gottlieb, T. M., and Jackson, S. P. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell, 72: 131-142, 1993.
6. Lees-Miller, S. P., and Anderson, C. W. The DNA-activated protein kinase. DNA-PK: a potential coordinator of nuclear events. Cancer Cells, 3: 341-346, 1991.
7. Lees-Miller, S. P., Chen, Y-R., and Anderson, C. W. Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen. Mol. Cell. Biol., 10: 6472-6481, 1990.
8. 1 extracts is catalyzed by cdk-cyclin A complex and DNA dependent protein kinase. Proc. Natl. Acad. Sci. USA, 91: 8343-8347, 1994.
9. Giffin, W., Torrance, H., Rodda, D. J., Préfontaine, G. G., Pope, L., and Haché, R. J. G. Sequence-specific DNA binding by Ku autoantigen and its effect on transcription. Nature (Lond.), 380: 265-268, 1996.
10. Giffin, W., Gong, W., Schild-Poulter, C., and Haché, R. J. G. Ku antigen-DNA confomatiion determines the activation of DNA dependent protein kinase an DNA sequence-directed repression of mouse mammary tumor virus transcription. Mol. Cell. Biol., 19, 4065-4078, 1999.
11. Torrance, H., Giffin, W., Rodda, D. J., Pope, L., and Haché, R. J. G. Sequence-specific binding of Ku autoantigen to single-stranded DNA. J. Biol. Chem., 273: 20810-20819, 1998.
12. Kurimasa, A., Ouyang, H., Dong, L-J., Wang, S., Li, X., Cordon-Cardo, C., Chen, D. J., and Li, G. C. Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis. Proc. Natl. Acad. Sci. USA, 96: 1403-1408, 1999.
13. Nussenzweig, A., Chen, C., da Costa Soares, V., Sanchez, M., Sokol, K., Nussenzweig, M. C., and Li, G. C. Requirement lot Ku80 in growth and immunoglobulin V(D)J recombination. Nature (Lond.). 382: 551-555, 1996.
14. Ouyang, H., Nussenzweig, A., Kurimasa, A., da Costa Soares, V., Li, X., Cordon-Cardo, C., Li, W., Cheong, N., Nussenzweig, M., Iliakis, G., Chen, D., and Li, G. C. Ku70 is required for DNA repair but not for TCR gene recombination in vivo. J. Exp. Med., 186: 921-929, 1997.
15. Morimoto, R. I., Tissieres, A., and Georgopoulos, C. Stress Proteins in Biology and Medicine, pp. 411-442. Plainview: Cold Spring Harbor Laboratory Press, 1990.
16. Maresca, B., and Lindquist, S. Heat Shock, pp. 17-34. New York: Springer-Verlag, 1991.
17. Wu, C., Zimarino, V., Tsai, C., Walker, B., and Wilson, S. Transcriptional regulation of heat shock genes. In: R. I. Morimoto, A. Tissieres, and C. Georgopoulos (eds.), Stress Proteins in Biology and Medicine, pp. 429-442. Plainview: Cold Spring Harbor Laboratory Press, 1990.
18. Borrelli, M. J., Schoenherr, D. M., Wong, A. Bernock, L. J., and Corry, P. M. Heat-activated transgene expression from adenovirus vectors infected into human prostate cancer cells. Cancer Res., 61: 1113-1121, 2001.
19. Morimoto, R. I., Tissieres, A., and Georgopoulos, C. The Biology of Heat Shock Proteins and Molecular Chaperones, pp. 375-455. Plainview: Cold Spring Harbor Laboratory Press, 1994.
20. Marangoni, E., Le Romancer, M., Foray, N., Muller, C., Doue-Rasy, S., Vaganay, S., Abdulkarim, B., Barrois, M., Calsou, P., Bernier, J., Salles, B., and Bourhis, J. Transfer of Ku86 RNA antisense decreases the radioresistance of human fibroblasts. Cancer Gene Ther., 7: 339-346, 2000.
21. Gupta, N. Current status of viral gene therapy for brain tumors. Exp. Opin. Investig. Drugs, 9: 713-726, 2000.
22. Danthinne, X., and Imperiale, M. J. Production of first generation adenovirus vectors: a review. Gene Ther., 7: 1707-1714, 2000.
23. Blackburn, R. V., Galoforo, S. S., Corry, P. M., and Lee, Y. J. Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells. Cancer Res., 58: 1358-1362, 1998.
24. Fisher, K. J., Choi, H., Burda, J., Chen, S. J., and Wilson, J. M. Recombinant adenovirus deleted of all viral genes for gene therapy of cystic fibrosis. Virology, 217: 11-22, 1996.
25. Huang, Q., Hu, J. K., Lohr, F., Zhang, L., Braun, R., Lanzen, J., Little, J. B., Dewhirst, M. W., and Li, C-Y. Heat induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res., 60: 3435-3439, 2000.
26. Le Gal La Salle, G., Robert, J. J., Berrard, S., Ridoux, V., Stratford-Perricaudet, L. D., Perricaudet, M., and Mallet, J. An adenovirus vector for gene transfer into neurons and glia in the brain. Science (Wash. DC), 259: 988-990, 1993.
27. Wang, Q., and Finer, M. H. Second-generation adenovirus vectors. Nat. Med., 2: 714-716, 1996.
28. Yang, Y., Nunes, F. A., Berencsi, K., Furth, E. E., Gonczol, E., and Wilson, J. M. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA, 91: 4407-4411, 1994.
29. Zhang, Y., and Schneider, R. Adenovirus inhibition of cell translation facilitates release of virus particles and enhances degradation of the cytokeratin network. J. Virol., 68: 2544-2555, 1994.
30. Li, G. C., Li, L., Liu, R. Y., Rehman, M., and Lee, W. M. F. Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. Proc. Natl. Acad. Sci. USA, 89: 2036-2040, 1992.
31. Urano, M., and Kahn, J. The change in hypoxic and chronically hypoxic cell fraction in marine tumors treated with hyperthermia. Radiat. Res., 96: 549-559, 1983.
32. Urano, M., Suit, H. D., Dunn, P., Lansdale, T., and Sedlacek, R. S. Enhancement of the thermal response of animal tumors by Corynebacterium parvum. Cancer Res., 39: 3454-3457, 1979.
33. Li, G. C., Li, L., Liu, Y-K., Mak, J. Y., Chen, L., and Lee, W. M. F. Thermal response of rat fibroblasts stably-transfected with the human 70 kDa heat shock protein-encoding gene. Proc. Natl. Acad. Sci. USA, 88: 1681-1685, 1991.
34. Li, G. C., and Werb, Z. Correlation between synthesis or heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts. Proc. Natl. Acad. Sci. USA, 79: 3218-3222, 1982.
35. Kim, D., Ouyang, H., Yang, S-H., Nussenzweig, A., Burgman, P., and Li, G. C. A constitutive heat shock element-binding factor is immunologically identical to the Ku-autoantigen. J. Biol. Chem., 270: 15277-15284, 1995.
36. Pirity, M., Nguyen, V. T., Dubois, M. F., Bensaude, O., Héver-Szabó, A., and Venetianer, A. Decreased stress inducibility of the HSP68 protein in a rat hepatoma variant clone. Eur. J. Biochem., 210: 793-800, 1992.
37. Graham, F. L., and Prevec, L. Manipulation of andenovirus vectors. In: E. J. Murray (ed.) Methods in Molecular Biology, pp. 109-128. Clifton, NJ: The Human Press, 1991.
38. Gerard, R. D., and Meidell, R. S. Adenoviral vectors. In: B. D. Hames and D. M. Glover (eds.), DNA Cloning: A Practical Approach, pp. 285-306. Oxford: Oxford University Press, 1995.
39. Li, G. C., and Kal, H. B. Effect of hyperthermia on the radiation response of two mammalian cell lines. Eur. J. Cancer, 13: 65-69, 1977.
40. Li, G. C., Ouyang, H., Li, X., Nagasawa, H., Little, J. B., Chen, D. J., Ling, C. C., Fuks, Z., and Cordon-Cardo, C. Ku70: a candidate tumor suppressor gene for routine T cell lymphoma. Mol. Cell, 2: 1-8, 1998.
41. Nussenzweig, A., Sokol, K., Burgman, P., Li, L., and Li, G. C. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development. Proc. Natl. Acad. Sci. USA, 94: 13588-13593, 1997.
42. Leibel, S., and Phillips, T. Textbook of Radiation Oncology, pp. 1241-1262, Philadelphia, PA: W. B. Saunders, 1998.
43. Oleson, J. R., Calderwood, S. K., Coughlin, C. T., Dewhirst, M. W., Gerweck, L. E., Gibbs, F. A., and Kapp, D. S. Biological and clinical aspects of hyperthermia in cancer therapy. Am. J. Clin. Oncol., 11: 368-380, 1988.
44. Kong, G., Anyarambhatla, G., Petros, W. P., Braun, R. D., Colvin, M., Needham, D., and Dewhirst, M. W. Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res., 60: 6950-6957, 2000.
45. Schuster, J., Zalusky, M., Noska, M., Dodge, R., Friedman, H., Bigner, D., and Dewhirst, M. W. Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues. Int. J. Hypertherm., 11: 59-72, 1995.
46. Hauck, M., Coffin, D., Dodge, R., Dewhirst, M. W., Mitchell, M., and Zalusky, M. A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumor interstitial fluid pressure. Int. J. Hypertherm., 13: 307-316, 1997.
47. Fujiwara, K., and Watanabe, T. Effects of hyperthermia, radiotherapy and thermoradiotherapy on tumor microvascular permeability. Acta Pathol. Jpn., 40: 79-84, 1990.
48. Gaber, M. H., Wu, N. Z., Hong, K., Hung, S. K., Dewhirst, M. W., and Papahadjopoulos, D. Tnermosensitive liposomes: extravasation and release of contents of tumor microvascular networks. Int. J. Radiat. Oncol. Biol. Phys., 36: 1177-1187, 1996.
49. Lefor, A., Makohon, S., and Ackerman, N. The effects of hyperthermia on vascular permeability in experimental liver metastasis. J. Surg. Oncol., 28: 297-300, 1985.
50. Magin, R. L., and Niesman, M. R. Temperature-dependent drug release from large unilamellar liposomes. Cancer Drug Delivery, 1: 109-117, 1984.
51. Merlin, J. L. In vitro evaluation of the association of thermosensitive liposome-encapsulated doxorubicin with hyperthermia. Eur. J. Cancer, 27: 1031-1034, 1991.