메뉴 건너뛰기




Volumn 31, Issue 19, 2003, Pages 5501-5512

Vanillins - A novel family of DNA-PK inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMUTAGENIC AGENT; ANTINEOPLASTIC AGENT; BENZALDEHYDE DERIVATIVE; CISPLATIN; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; NUCLEAR PROTEIN; PRKDC PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; RAD51 PROTEIN; RAD51 PROTEIN, HUMAN; VANILLIN; CELL EXTRACT; DNA; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; VANILLIN DERIVATIVE;

EID: 0141974936     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg753     Document Type: Article
Times cited : (162)

References (45)
  • 1
    • 0034195218 scopus 로고    scopus 로고
    • Partners and pathways repairing a double-strand break
    • Haber, J.E. (2000) Partners and pathways repairing a double-strand break. Trends Genet., 16, 259-264.
    • (2000) Trends Genet. , vol.16 , pp. 259-264
    • Haber, J.E.1
  • 2
    • 0035093737 scopus 로고    scopus 로고
    • DNA double-strand breaks: Signalling, repair and the cancer connection
    • Khanna, K.K. and Jackson, S.P. (2001) DNA double-strand breaks: signalling, repair and the cancer connection. Nature Genet., 27, 247-254.
    • (2001) Nature Genet. , vol.27 , pp. 247-254
    • Khanna, K.K.1    Jackson, S.P.2
  • 3
    • 0034031137 scopus 로고    scopus 로고
    • DNA double strand break repair in mammalian cells
    • Karran, P. (2000) DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev., 10, 144-150.
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 144-150
    • Karran, P.1
  • 7
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double strand break connection
    • van Gent, D.C., Hoeijmakers, J.H.J. and Kanaar, R. (2001) Chromosomal stability and the DNA double strand break connection. Nature Rev. Genet., 2, 196-206.
    • (2001) Nature Rev. Genet. , vol.2 , pp. 196-206
    • van Gent, D.C.1    Hoeijmakers, J.H.J.2    Kanaar, R.3
  • 8
    • 0036261707 scopus 로고    scopus 로고
    • Sensing and repairing DNA double-strand breaks
    • Jackson, S.P. (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis, 23, 687-696.
    • (2002) Carcinogenesis , vol.23 , pp. 687-696
    • Jackson, S.P.1
  • 9
    • 0034664805 scopus 로고    scopus 로고
    • Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair
    • Hanakahi, L.A., Bartlet-Jones, M., Chappell, C., Pappin, D. and West, S. (2000) Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair. Cell, 102, 721-729.
    • (2000) Cell , vol.102 , pp. 721-729
    • Hanakahi, L.A.1    Bartlet-Jones, M.2    Chappell, C.3    Pappin, D.4    West, S.5
  • 10
  • 12
    • 0030048511 scopus 로고    scopus 로고
    • High frequency and error-prone DNA recombination in Ataxia Telangiecstasia cell lines
    • Luo, C.-M., Tang, W., Mekeel, K.L., DeFrank, J.S., Anne, R. and Powell, S.N. (1996) High frequency and error-prone DNA recombination in Ataxia Telangiecstasia cell lines. J. Biol. Chem., 271, 4497-4503.
    • (1996) J. Biol. Chem. , vol.271 , pp. 4497-4503
    • Luo, C.-M.1    Tang, W.2    Mekeel, K.L.3    DeFrank, J.S.4    Anne, R.5    Powell, S.N.6
  • 14
    • 0029127643 scopus 로고
    • ATM-related genes: What do they tell us about about functions of the human gene?
    • Zakian, V.A. (1995) ATM-related genes: what do they tell us about about functions of the human gene? Cell, 82, 685-687.
    • (1995) Cell , vol.82 , pp. 685-687
    • Zakian, V.A.1
  • 15
    • 0028856331 scopus 로고
    • When is a lipid kinase not a lipid kinase? When it is a protein kinase
    • Hunter, T. (1995) When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell, 83, 1-4.
    • (1995) Cell , vol.83 , pp. 1-4
    • Hunter, T.1
  • 16
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • Sarkaria, J.N., Tibbetts, R.S., Busby, E.C., Kennedy, A.P., Hill, D.E. and Abraham, R.T. (1998) Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58, 4375-4382.
    • (1998) Cancer Res. , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 17
    • 0032564469 scopus 로고    scopus 로고
    • DNA end-joining catalyzed by human cell-free extracts
    • Baumann, P. and West, S.C. (1998) DNA end-joining catalyzed by human cell-free extracts. Proc. Natl Acad. Sci. USA, 95, 14066-14070.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 14066-14070
    • Baumann, P.1    West, S.C.2
  • 18
    • 0034033712 scopus 로고    scopus 로고
    • Sensitisation of HL60 human leukaemia cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals
    • O'Gorman, D.M., McKenna, S.L., McGahon, A.J., Knox, K.A. and Cotter, T.G. (2000) Sensitisation of HL60 human leukaemia cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals. Leukemia, 4, 602-611.
    • (2000) Leukemia , vol.4 , pp. 602-611
    • O'Gorman, D.M.1    McKenna, S.L.2    McGahon, A.J.3    Knox, K.A.4    Cotter, T.G.5
  • 19
    • 0034984092 scopus 로고    scopus 로고
    • Cell cycle-dependent effects of wortmannin on radiation survival and mutation
    • Chernikova, S.B., Lindquist, K.L. and Elkind, M.M. (2001) Cell cycle-dependent effects of wortmannin on radiation survival and mutation. Radiat. Res., 155, 826-831.
    • (2001) Radiat. Res. , vol.155 , pp. 826-831
    • Chernikova, S.B.1    Lindquist, K.L.2    Elkind, M.M.3
  • 20
    • 0027277078 scopus 로고
    • Modification of genotoxicity by naturally occurring flavorings and their derivatives
    • Ohta , T. (1993) Modification of genotoxicity by naturally occurring flavorings and their derivatives. Crit. Rev. Toxicol., 23, 127-146.
    • (1993) Crit. Rev. Toxicol. , vol.23 , pp. 127-146
    • Ohta, T.1
  • 21
    • 0025217222 scopus 로고
    • Inhibition of induction of adaptive response by o-vanillin in Escherichia coli B
    • Watanabe, K., Ohta, T., Watanabe, M., Kato, T. and Shirasu, Y. (1990) Inhibition of induction of adaptive response by o-vanillin in Escherichia coli B. Mutat. Res., 243, 273-280.
    • (1990) Mutat. Res. , vol.243 , pp. 273-280
    • Watanabe, K.1    Ohta, T.2    Watanabe, M.3    Kato, T.4    Shirasu, Y.5
  • 22
    • 0032472890 scopus 로고    scopus 로고
    • Protective effect of vanillin on radiation-induced micronuclei and chromosomal aberrations in V79 cells
    • Keshava, C., Keshava, N., Ong, T. and Nath, J. (1998) Protective effect of vanillin on radiation-induced micronuclei and chromosomal aberrations in V79 cells. Mutat. Res., 397, 149-159.
    • (1998) Mutat. Res. , vol.397 , pp. 149-159
    • Keshava, C.1    Keshava, N.2    Ong, T.3    Nath, J.4
  • 24
    • 0023101259 scopus 로고
    • Effects of vanillin on sister-chromatid exchanges and chromosome aberrations in human lymphocytes
    • Jansson, T. and Zech, L. (1987) Effects of vanillin on sister-chromatid exchanges and chromosome aberrations in human lymphocytes. Mutat. Res., 190, 221-224.
    • (1987) Mutat. Res. , vol.190 , pp. 221-224
    • Jansson, T.1    Zech, L.2
  • 26
    • 0025017468 scopus 로고
    • Suppression of 6-TG-resistant mutations in V79 cells and recessive spot formations in mice by vanillin
    • Imanishi, H., Sasaki, Y.F., Matsumoto, K., Watanabe, M., Ohta , T., Shirasu, Y. and Tutikawa, K. (1990) Suppression of 6-TG-resistant mutations in V79 cells and recessive spot formations in mice by vanillin. Mutat. Res. 243, 151-158.
    • (1990) Mutat. Res. , vol.243 , pp. 151-158
    • Imanishi, H.1    Sasaki, Y.F.2    Matsumoto, K.3    Watanabe, M.4    Ohta, T.5    Shirasu, Y.6    Tutikawa, K.7
  • 27
    • 0025173752 scopus 로고
    • Suppressing effects of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells
    • Sasaki, Y.F., Imanishi, H., Watanabe, M., Ohta, T. and Shirasu, Y. (1990) Suppressing effects of antimutagenic flavorings on chromosome aberrations induced by UV-light or X-rays in cultured Chinese hamster cells. Mutat. Res., 229, 1-10.
    • (1990) Mutat. Res. , vol.229 , pp. 1-10
    • Sasaki, Y.F.1    Imanishi, H.2    Watanabe, M.3    Ohta, T.4    Shirasu, Y.5
  • 28
    • 0029648971 scopus 로고
    • Modulating effects of elagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model
    • Akagi, K., Hirose, M., Hoshiya, T., Mizoguchi, Y., Ito, N. and Shrai, T. (1995) Modulating effects of elagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model, Cancer Lett., 94, 113-121.
    • (1995) Cancer Lett. , vol.94 , pp. 113-121
    • Akagi, K.1    Hirose, M.2    Hoshiya, T.3    Mizoguchi, Y.4    Ito, N.5    Shrai, T.6
  • 29
    • 0028670227 scopus 로고
    • Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4, 5-f]quinoline in the rat
    • Tsuda, H., Uehara, N., Iwahori, Y., Asamoto, M., Iigo, M., Nagao, M., Matsumoto, K., Ito, M. and Hirono, I. (1994) Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4, 5-f]quinoline in the rat. Jpn J. Cancer Res., 85, 1214-1219.
    • (1994) Jpn J. Cancer Res. , vol.85 , pp. 1214-1219
    • Tsuda, H.1    Uehara, N.2    Iwahori, Y.3    Asamoto, M.4    Iigo, M.5    Nagao, M.6    Matsumoto, K.7    Ito, M.8    Hirono, I.9
  • 30
    • 0025358680 scopus 로고
    • Mammalian DNA ligases. Catalytic domain and size of DNA ligase I
    • Tomkinson, A.E., Lasko, D.D., Daly, G. and Lindahl, T. (1990) Mammalian DNA ligases. Catalytic domain and size of DNA ligase I. J. Biol. Chem., 265, 12611-12617.
    • (1990) J. Biol. Chem. , vol.265 , pp. 12611-12617
    • Tomkinson, A.E.1    Lasko, D.D.2    Daly, G.3    Lindahl, T.4
  • 31
    • 0029803485 scopus 로고    scopus 로고
    • Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
    • Boulton, S., Kyle, S., Yalcintepe, L. and Durkacz, B.W. (1996) Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis, 17, 2285-2290.
    • (1996) Carcinogenesis , vol.17 , pp. 2285-2290
    • Boulton, S.1    Kyle, S.2    Yalcintepe, L.3    Durkacz, B.W.4
  • 32
    • 0036682122 scopus 로고    scopus 로고
    • An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells
    • Delacôte, F., Han, M., Stamato, T.D., Jasin, M. and Lopez, B.S. (2002) An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double-strand breaks in mammalian cells. Nucleic Acids Res., 30, 3454-3463.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3454-3463
    • Delacôte, F.1    Han, M.2    Stamato, T.D.3    Jasin, M.4    Lopez, B.S.5
  • 33
    • 0029965452 scopus 로고    scopus 로고
    • Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
    • Wymann, M.P., Bulgarelli-Leva, G., Zvelebil, M.J., Pirola, L., Vanhaesebroeck, B., Waterfield, M.D. and Panayotou, G. (1996) Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol., 16, 1722-1733.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1722-1733
    • Wymann, M.P.1    Bulgarelli-Leva, G.2    Zvelebil, M.J.3    Pirola, L.4    Vanhaesebroeck, B.5    Waterfield, M.D.6    Panayotou, G.7
  • 34
    • 0033152759 scopus 로고    scopus 로고
    • Competitive and noncompetitive inhibition of the DNA-dependent protein kinase
    • Izzard, R.A., Jackson, S.P. and Smith, G.C.M. (1999) Competitive and noncompetitive inhibition of the DNA-dependent protein kinase. Cancer Res., 59, 2581-2586.
    • (1999) Cancer Res. , vol.59 , pp. 2581-2586
    • Izzard, R.A.1    Jackson, S.P.2    Smith, G.C.M.3
  • 35
    • 0033804684 scopus 로고    scopus 로고
    • Kinetics of interaction of vanillin with amino acids and peptides in model systems
    • Chobpattana, W., Jeon, I.J. and Smith, J.S. (2000) Kinetics of interaction of vanillin with amino acids and peptides in model systems. J. Agric. Food Chem., 48, 3885-3889.
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 3885-3889
    • Chobpattana, W.1    Jeon, I.J.2    Smith, J.S.3
  • 36
    • 0030066023 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
    • Price, B.D. and Youmell, M.B. (1996) The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res., 56, 246-250.
    • (1996) Cancer Res. , vol.56 , pp. 246-250
    • Price, B.D.1    Youmell, M.B.2
  • 37
    • 0021894582 scopus 로고
    • Adducts of the anticancer drug cis-diamminedichloroplatinum(II) with DNA: Formation, identification and quantification
    • Fichtinger-Schepman, A.M., van der veer, J.L., den Hartog, J.H., Lohman, P.H. and Reedijk, J. (1985) Adducts of the anticancer drug cis-diamminedichloroplatinum(II) with DNA: formation, identification and quantification. Biochemistry, 24, 707-713.
    • (1985) Biochemistry , vol.24 , pp. 707-713
    • Fichtinger-Schepman, A.M.1    van der veer, J.L.2    den Hartog, J.H.3    Lohman, P.H.4    Reedijk, J.5
  • 38
    • 0026489326 scopus 로고
    • An intrastrand d(GpG) platinum cross-link in duplex M13 DNA is refractory to repair by human cell extracts
    • Szymkowski, D.E., Yarema, K., Essigman, J.M., Lippard, S.J. and Wood, R.D. (1992) An intrastrand d(GpG) platinum cross-link in duplex M13 DNA is refractory to repair by human cell extracts. Proc. Natl Acad. Sci. USA, 89, 10772-10776.
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 10772-10776
    • Szymkowski, D.E.1    Yarema, K.2    Essigman, J.M.3    Lippard, S.J.4    Wood, R.D.5
  • 39
    • 0029911744 scopus 로고    scopus 로고
    • Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1, 3-intrastrand d(GpTpG)-cisplatin adduct
    • Moggs, J.G., Yarema, K.J., Essigmann, J.M. and Wood, R.D. (1996) Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1, 3-intrastrand d(GpTpG)-cisplatin adduct. J. Biol. Chem., 271, 7177-7186.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7177-7186
    • Moggs, J.G.1    Yarema, K.J.2    Essigmann, J.M.3    Wood, R.D.4
  • 40
    • 0036238641 scopus 로고    scopus 로고
    • The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents
    • Morishita, T., Tsutsui, Y., Iwasaki, H. and Shinagawa, H. (2002) The Schizosaccharomyces pombe rad60 gene is essential for repairing double-strand DNA breaks spontaneously occurring during replication and induced by DNA-damaging agents. Mol. Cell. Biol., 22, 3537-3548.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3537-3548
    • Morishita, T.1    Tsutsui, Y.2    Iwasaki, H.3    Shinagawa, H.4
  • 41
    • 0032933747 scopus 로고    scopus 로고
    • Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes
    • Durant, S.T., Morris, M.M., Illand, M., McKay, H.J., McCormick, C., Hirst, G.L., Borts, R.H. and Brown, R. (1999). Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes. Curr. Biol., 9, 51-54.
    • (1999) Curr. Biol. , vol.9 , pp. 51-54
    • Durant, S.T.1    Morris, M.M.2    Illand, M.3    McKay, H.J.4    McCormick, C.5    Hirst, G.L.6    Borts, R.H.7    Brown, R.8
  • 42
    • 0033042494 scopus 로고    scopus 로고
    • Modification of non-conservative double-strand break (DSB) rejoining activity after the induction of cisplatin resistance in human tumour cells
    • Britten, R.A., Kuny, S. and Perdue, S. (1999) Modification of non-conservative double-strand break (DSB) rejoining activity after the induction of cisplatin resistance in human tumour cells. Br. J. Cancer, 79, 843-849.
    • (1999) Br. J. Cancer , vol.79 , pp. 843-849
    • Britten, R.A.1    Kuny, S.2    Perdue, S.3
  • 43
    • 0034753160 scopus 로고    scopus 로고
    • Functions of BRCA1 and BRCA2 in the biological response to DNA damage
    • Venkitaraman, A.R. (2001) Functions of BRCA1 and BRCA2 in the biological response to DNA damage. J. Cell Sci., 114, 3591-3598.
    • (2001) J. Cell Sci. , vol.114 , pp. 3591-3598
    • Venkitaraman, A.R.1
  • 44
    • 0024322141 scopus 로고
    • Modulation of cis-diammineplatinum(II)-induced cytotoxicity by benzaldehyde derivatives
    • Dornish, J.M. and Pettersen, E.O. (1989) Modulation of cis-diammineplatinum(II)-induced cytotoxicity by benzaldehyde derivatives. Cancer Lett., 46, 63-68.
    • (1989) Cancer Lett. , vol.46 , pp. 63-68
    • Dornish, J.M.1    Pettersen, E.O.2
  • 45
    • 0018358427 scopus 로고
    • Selective inhibitory effect of benzaldehyde on the growth of simian virus 40-transformed cells
    • Miyakawa, T., Zundel, J.-L. and Sakaguchi, K. (1979) Selective inhibitory effect of benzaldehyde on the growth of simian virus 40-transformed cells. Biochem. Biophys. Res. Commun., 87, 1024-1030.
    • (1979) Biochem. Biophys. Res. Commun. , vol.87 , pp. 1024-1030
    • Miyakawa, T.1    Zundel, J.-L.2    Sakaguchi, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.