Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6400-6404

  Peng, Yuanlin ^a   Zhang, Qinming ^a   Nagasawa, Hatsumi ^a   Okayasu, Ryuichi ^a   Liber, Howard L ^a   Bedford, Joel S ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL KILLING; CELL STRAIN; CHROMOSOME BREAKAGE; CHROMOSOME CONDENSATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MUTATION; GENE SILENCING; GENETIC CODE; HUMAN; HUMAN CELL; INTERPHASE; MAMMAL CELL; METHODOLOGY; MUTAGENESIS; PRIORITY JOURNAL; RADIATION INJURY; RADIOSENSITIZATION; RNA SEQUENCE; STRAIN DIFFERENCE;

NASA DISCIPLINE RADIATION HEALTH; NON-NASA CENTER;

CATALYSIS; CELL DEATH; CELLS, CULTURED; CHROMOSOME ABERRATIONS; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FIBROBLASTS; GENE SILENCING; HUMANS; LYMPHOCYTES; MUTAGENESIS; NUCLEAR PROTEINS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 0037112508     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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