Synthesis, crystal structure determination, and biological properties of the DNA-dependent protein kinase (DNA-PK) inhibitor 3-cyano-6-hydrazonomethyl-5-(4-pyridyl)pyrid-[1H]-2-one (OK-1035)

Bioorganic & medicinal chemistry letters

Volumn 11, Issue 21, 2001, Pages 2837-2841

  Stockley, Martin ^a   Clegg, William ^a   Fontana, Gabriele ^a   Golding, Bernard T ^a   Martin, Niall ^b   Rigoreau, Laurent J M ^a   Smith, Graeme C M ^b   Griffin, Roger J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b KuDOS Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 3 CYANO 5 (4 PYRIDYL) 6 HYDRAZONOMETHYL 2 PYRIDONE; 3-CYANO-5-(4-PYRIDYL)-6-HYDRAZONOMETHYL-2-PYRIDONE; CHROMONE DERIVATIVE; DNA BINDING PROTEIN; DNA DEPENDENT PROTEIN KINASE; ENZYME INHIBITOR; HYDRAZONE DERIVATIVE; MORPHOLINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PYRIDONE DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; X RAY CRYSTALLOGRAPHY;

CHROMONES; CRYSTALLOGRAPHY, X-RAY; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; ENZYME INHIBITORS; HYDRAZONES; MODELS, MOLECULAR; MORPHOLINES; PROTEIN-SERINE-THREONINE KINASES; PYRIDONES;

EID: 0035814020     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00537-6     Document Type: Article

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