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Volumn 23, Issue 16, 2003, Pages 5836-5848

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; MUTANT PROTEIN;

EID: 0043133778     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.16.5836-5848.2003     Document Type: Article
Times cited : (282)

References (53)
  • 1
    • 0032564469 scopus 로고    scopus 로고
    • DNA end-joining catalyzed by human cell-free extracts
    • Baumann, P., and S. C. West. 1998. DNA end-joining catalyzed by human cell-free extracts. Proc. Natl. Acad. Sci. USA 95:14066-14070.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14066-14070
    • Baumann, P.1    West, S.C.2
  • 2
    • 0032438115 scopus 로고    scopus 로고
    • Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation
    • Bogue, M. A., C. Jhappan, and D. B. Roth. 1998. Analysis of variable (diversity) joining recombination in DNA-dependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation. Proc. Natl. Acad. Sci. USA 95:15559-15564.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15559-15564
    • Bogue, M.A.1    Jhappan, C.2    Roth, D.B.3
  • 3
    • 0037106180 scopus 로고    scopus 로고
    • Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
    • Chan, D. W., B. P. Chen, S. Prithivirajsingh, A. Kurimasa, M. D. Story, J. Qin, and D. J. Chen. 2002. Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev. 16:2333-2338.
    • (2002) Genes Dev. , vol.16 , pp. 2333-2338
    • Chan, D.W.1    Chen, B.P.2    Prithivirajsingh, S.3    Kurimasa, A.4    Story, M.D.5    Qin, J.6    Chen, D.J.7
  • 4
    • 0030009738 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
    • Chan, D. W., and S. P. Lees-Miller. 1996. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. J. Biol. Chem. 271:8936-8941.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8936-8941
    • Chan, D.W.1    Lees-Miller, S.P.2
  • 5
    • 0032972734 scopus 로고    scopus 로고
    • DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer
    • Chan, D. W., R. Ye, C. J. Veillette, and S. P. Lees-Miller. 1999. DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry 38:1819-1828.
    • (1999) Biochemistry , vol.38 , pp. 1819-1828
    • Chan, D.W.1    Ye, R.2    Veillette, C.J.3    Lees-Miller, S.P.4
  • 7
    • 0037124373 scopus 로고    scopus 로고
    • Synapsis of DNA ends by DNA-dependent protein kinase
    • DeFazio, L. G., R. M. Stansel, J. D. Griffith, and G. Chu. 2002. Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J. 21:3192-3200.
    • (2002) EMBO J. , vol.21 , pp. 3192-3200
    • DeFazio, L.G.1    Stansel, R.M.2    Griffith, J.D.3    Chu, G.4
  • 8
    • 0035374588 scopus 로고    scopus 로고
    • Protein phosphatases regulate DNA-dependent protein kinase activity
    • Douglas, P., G. B. Moorhead, R. Ye, and S. P. Lees-Miller. 2001. Protein phosphatases regulate DNA-dependent protein kinase activity. J. Biol. Chem. 276:18992-18998.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18992-18998
    • Douglas, P.1    Moorhead, G.B.2    Ye, R.3    Lees-Miller, S.P.4
  • 11
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie, N. J., T. M. Gottlieb, T. Blunt, P. A. Jeggo, and S. P. Jackson. 1995. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA 92:320-324.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.M.2    Blunt, T.3    Jeggo, P.A.4    Jackson, S.P.5
  • 12
    • 0032167446 scopus 로고    scopus 로고
    • A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
    • Gao, Y., J. Chaudhuri, C. Zhu, L. Davidson, D. T. Weaver, and F. W. Alt. 1998. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity 9:367-376.
    • (1998) Immunity , vol.9 , pp. 367-376
    • Gao, Y.1    Chaudhuri, J.2    Zhu, C.3    Davidson, L.4    Weaver, D.T.5    Alt, F.W.6
  • 13
    • 0033198709 scopus 로고    scopus 로고
    • Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
    • Gell, D., and S. P. Jackson. 1999. Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res. 27:3494-3502.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3494-3502
    • Gell, D.1    Jackson, S.P.2
  • 14
    • 0035997348 scopus 로고    scopus 로고
    • V(D)J recombination: Rag proteins, repair factors, and regulation
    • Gellert, M. 2002. V(D)J recombination: rag proteins, repair factors, and regulation. Annu. Rev. Biochem. 71:101-132.
    • (2002) Annu. Rev. Biochem. , vol.71 , pp. 101-132
    • Gellert, M.1
  • 15
    • 0030743386 scopus 로고    scopus 로고
    • Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
    • Grawunder, U., M. Wilm, X. Wu, P. Kulesza, T. E. Wilson, M. Mann, and M. R. Lieber. 1997. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature 388:492-495.
    • (1997) Nature , vol.388 , pp. 492-495
    • Grawunder, U.1    Wilm, M.2    Wu, X.3    Kulesza, P.4    Wilson, T.E.5    Mann, M.6    Lieber, M.R.7
  • 16
    • 0035125901 scopus 로고    scopus 로고
    • Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis
    • Gurley, K. E., and C. J. Kemp. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr. Biol. 11:191-194.
    • (2001) Curr. Biol. , vol.11 , pp. 191-194
    • Gurley, K.E.1    Kemp, C.J.2
  • 17
    • 0034695658 scopus 로고    scopus 로고
    • Activation of DNA-dependent protein kinase by single-stranded DNA ends
    • Hammarsten, O., L. G. DeFazio, and G. Chu. 2000. Activation of DNA-dependent protein kinase by single-stranded DNA ends. J. Biol. Chem. 275:1541-1550.
    • (2000) J. Biol. Chem. , vol.275 , pp. 1541-1550
    • Hammarsten, O.1    DeFazio, L.G.2    Chu, G.3
  • 20
    • 0031607707 scopus 로고    scopus 로고
    • DNA breakage and repair
    • Jeggo, P. A. 1998. DNA breakage and repair. Adv. Genet. 38:185-218.
    • (1998) Adv. Genet. , vol.38 , pp. 185-218
    • Jeggo, P.A.1
  • 21
    • 0034662228 scopus 로고    scopus 로고
    • Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination
    • Kienker, L. J., E. K. Shin, and K. Meek. 2000. Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Res. 28:2752-2761.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 2752-2761
    • Kienker, L.J.1    Shin, E.K.2    Meek, K.3
  • 22
    • 0032938747 scopus 로고    scopus 로고
    • Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
    • Kurimasa, A., S. Kumano, N. V. Boubnov, M. D. Story, C. S. Tung, S. R. Peterson, and D. J. Chen. 1999. Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining. Mol. Cell. Biol. 19:3877-3884.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 3877-3884
    • Kurimasa, A.1    Kumano, S.2    Boubnov, N.V.3    Story, M.D.4    Tung, C.S.5    Peterson, S.R.6    Chen, D.J.7
  • 24
    • 0031939411 scopus 로고    scopus 로고
    • The XRCC4 gene product is a target for, and interacts with the DNA dependent protein kinase
    • Leber, R., T. W. Wise, R. Mizuta, and K. Meek. 1998. The XRCC4 gene product is a target for, and interacts with the DNA dependent protein kinase. J. Biol. Chem. 273:1794-1801.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1794-1801
    • Leber, R.1    Wise, T.W.2    Mizuta, R.3    Meek, K.4
  • 25
    • 0030339852 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight
    • Lees-Miller, S. P. 1996. The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight. Biochem. Cell. Biol. 74:503-512.
    • (1996) Biochem. Cell. Biol. , vol.74 , pp. 503-512
    • Lees-Miller, S.P.1
  • 27
    • 0033104498 scopus 로고    scopus 로고
    • Structure of DNA-dependent protein kinase: Implications for its regulation by DNA
    • Leuther, K. K., O. Hammarsten, R. D. Kornberg, and G. Chu. 1999. Structure of DNA-dependent protein kinase: implications for its regulation by DNA. EMBO J. 18:1114-1123.
    • (1999) EMBO J. , vol.18 , pp. 1114-1123
    • Leuther, K.K.1    Hammarsten, O.2    Kornberg, R.D.3    Chu, G.4
  • 28
    • 0029585872 scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J. Recombination
    • Li, Z., T. Otevrel, Y. Gao, H. L. Cheng, B. Seed, T. D. Stamato, G. E. Taccioli, and F. W. Alt. 1995. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J. recombination. Cell 83:1079-1089.
    • (1995) Cell , vol.83 , pp. 1079-1089
    • Li, Z.1    Otevrel, T.2    Gao, Y.3    Cheng, H.L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 29
    • 0032904693 scopus 로고    scopus 로고
    • The biochemistry and biological significance of nonhomologous DNA end joining: An essential repair process in multicellular eukaryotes
    • Lieber, M. R. 1999. The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes. Genes Cells 4:77-85.
    • (1999) Genes Cells , vol.4 , pp. 77-85
    • Lieber, M.R.1
  • 30
  • 31
    • 0037155703 scopus 로고    scopus 로고
    • Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination
    • Ma, Y., U. Pannicke, K. Schwarz, and M. R. Lieber. 2002. Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell 108:781-794.
    • (2002) Cell , vol.108 , pp. 781-794
    • Ma, Y.1    Pannicke, U.2    Schwarz, K.3    Lieber, M.R.4
  • 33
    • 0037159220 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
    • Merkle, D., P. Douglas, G. B. Moorhead, Z. Leonenko, Y. Yu, D. Cramb, D. P. Bazett-Jones, and S. P. Lees-Miller. 2002. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 41:12706-12714.
    • (2002) Biochemistry , vol.41 , pp. 12706-12714
    • Merkle, D.1    Douglas, P.2    Moorhead, G.B.3    Leonenko, Z.4    Yu, Y.5    Cramb, D.6    Bazett-Jones, D.P.7    Lees-Miller, S.P.8
  • 34
    • 0033119394 scopus 로고    scopus 로고
    • DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity
    • Modesti, M., J. E. Hesse, and M. Gellert. 1999. DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity. EMBO J. 18:2008-2018.
    • (1999) EMBO J. , vol.18 , pp. 2008-2018
    • Modesti, M.1    Hesse, J.E.2    Gellert, M.3
  • 37
    • 0035451068 scopus 로고    scopus 로고
    • Genomic integrity and the repair of double-strand DNA breaks
    • Pastink, A., J. C. Eeken, and P. H. Lohman. 2001. Genomic integrity and the repair of double-strand DNA breaks. Mutat. Res. 480-481:37-50.
    • (2001) Mutat. Res. , vol.480-481 , pp. 37-50
    • Pastink, A.1    Eeken, J.C.2    Lohman, P.H.3
  • 41
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes
    • Roth, D. B., J. P. Menetski, P. B. Nakajima, M. J. Bosma, and M. Gellert. 1992. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes. Cell 70:983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.B.3    Bosma, M.J.4    Gellert, M.5
  • 43
    • 0034132349 scopus 로고    scopus 로고
    • Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: Implications for the role of DNA-dependent protein kinase in V(D)J recombination
    • Shin, E. K., T. Rijkers, A. Pastink, and K. Meek. 2000. Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombination. J. Immunol. 164:1416-1424.
    • (2000) J. Immunol. , vol.164 , pp. 1416-1424
    • Shin, E.K.1    Rijkers, T.2    Pastink, A.3    Meek, K.4
  • 44
    • 0037444375 scopus 로고    scopus 로고
    • Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation
    • Soubeyrand, S., L. Pope, B. Pakuts, and R. J. Hache. 2003. Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation. Cancer Res. 63:1198-1201.
    • (2003) Cancer Res. , vol.63 , pp. 1198-1201
    • Soubeyrand, S.1    Pope, L.2    Pakuts, B.3    Hache, R.J.4
  • 46
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker, J. R., R. A. Corpina, and J. Goldberg. 2001. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412:607-614.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 47
    • 0024368474 scopus 로고
    • Cell cycle responses of two X-ray sensitive mutants defective in DNA repair
    • Whitmore, G. F., A. J. Varghese, and S. Gulyas. 1989. Cell cycle responses of two X-ray sensitive mutants defective in DNA repair. Int. J. Radiat. Biol. 56:657-665.
    • (1989) Int. J. Radiat. Biol. , vol.56 , pp. 657-665
    • Whitmore, G.F.1    Varghese, A.J.2    Gulyas, S.3
  • 48
    • 0029582791 scopus 로고
    • Equine severe combined immunodeficiency: A defect in V(D)J recombination and DNA-dependent protein kinase activity
    • Wiler, R., R. Leber, B. B. Moore, L. F. VanDyk, L. E. Perryman, and K. Meek. 1995. Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc. Natl. Acad. Sci. USA 92:11485-11489.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 11485-11489
    • Wiler, R.1    Leber, R.2    Moore, B.B.3    VanDyk, L.F.4    Perryman, L.E.5    Meek, K.6
  • 49
    • 0036920441 scopus 로고    scopus 로고
    • A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2
    • Woods, T., W. Wang, E. Convery, A. Errami, M. Z. Zdzienicka, and K. Meek. 2002. A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2. Nucleic Acids Res. 30:5120-5128.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 5120-5128
    • Woods, T.1    Wang, W.2    Convery, E.3    Errami, A.4    Zdzienicka, M.Z.5    Meek, K.6
  • 50
    • 0030746109 scopus 로고    scopus 로고
    • Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic-force microscopy studies
    • Yaneva, M., T. Kowalewski, and M. R. Lieber. 1997. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies. EMBO J. 16:5098-5112.
    • (1997) EMBO J. , vol.16 , pp. 5098-5112
    • Yaneva, M.1    Kowalewski, T.2    Lieber, M.R.3
  • 51
    • 0033572709 scopus 로고    scopus 로고
    • Geometry of a complex formed by double strand break repair proteins at a single DNA end: Recruitment of DNA-PKcs induces inward translocation of Ku protein
    • Yoo, S., and W. S. Dynan. 1999. Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein. Nucleic Acids Res. 27:4679-4686.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4679-4686
    • Yoo, S.1    Dynan, W.S.2
  • 52
    • 0032716120 scopus 로고    scopus 로고
    • Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair
    • Zdzienicka, M. 1999. Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair. Biochimie 81:107-116.
    • (1999) Biochimie , vol.81 , pp. 107-116
    • Zdzienicka, M.1
  • 53
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu, C., and D. B. Roth. 1995. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity 2:101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2


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