Molecular genetic characterization of XRCC4 function

International Immunology

Volumn 9, Issue 10, 1997, Pages 1607-1613

  Mizuta, Ryushin ^b   Cheng, Hwei Ling ^b   Gao, Yijie ^b   Alt, Frederick W ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

DNA dependent protein kinase; Double strand break repair; V(D)J recombination; XRCC4

Indexed keywords

DIMER; DNA BINDING PROTEIN; DOUBLE STRANDED DNA;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; DNA REPAIR; DNA STRAND BREAKAGE; GENE MUTATION; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; HYBRID; MOLECULAR GENETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; X RAY;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL NUCLEUS; CHO CELLS; CRICETINAE; DIMERIZATION; DNA REPAIR; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; GENES, IMMUNOGLOBULIN; HUMANS; MICE; MOLECULAR BIOLOGY; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE;

EID: 0030767402     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.10.1607     Document Type: Article

References (20)

1. Alt, F. W., Oltz, E. M., Young, F., Gorman, J., Taccioli, G. and Chen, J. 1992. VDJ recombination. Immunol. Today 13:306.
2. Gellert, M. and McBlane, J. F. 1995. Steps along the pathway of V(D)J recombination. Phil. Trans. Roy. Soc. (Lond.) B 347:43.
3. Lansford, R., Okada, A., Chen, J., Oltz, E. M., Blackwell, T. K., Alt, F. W. and Rathbun, G. 1995. Mechanism and control of immunoglobulin gene rearrangement. In Hames, B. D., ed., Molecular Immunology, 2nd edn. IRL Press, Oxford.
4. McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C. Cuomo, C. A., Gellert, M. and Oettinger, M. A. 1995. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83:387.
5. Eastman, Q, M., Leu, T. M. J. and Schatz, D. G. 1996. Initiation of V(D)J recombination in vitro obeying the 12/23 rule. Nature 380:85.
6. van Gent, D. C., Ramsden, D. A. and Gellert, M. 1996. The RAG1 and RAG2 proteins establish the 12/23 Rule in V(D)J Recombination. Cell 85:107.
7. Taccioli, G. E. and Alt, F. W. 1995. Potential targets for autosomal SCID mutations. Curr. Opin. Immunol. 7:436.
8. Li, Z., Ostevrel, T., Gao, Y., Cheng, H., Seed, B., Stmato, T. D., Taccioli, G. E. and Alt, F. W. 1995. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Cell 83:1079.
9. Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A. R., Alt, F. W., Jackson, S. P. and Jeggo, P. A. 1994. Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265:1442.
10. Smider, V., Rathmell, W. K., Lieber, M. R. and Chu, G. 1994. Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 266:288.
11. Boubnov, N. V., Hall, K. T., Wills, Z., Lee, S. E., He, D. M., Benjamin, D. M., Pulaski, C. R., Band, H., Reeves, W., Hendrickson, E. A. and Weaver, D. T. 1995. Complementation of the ionizing radiation sensitivity, DNA end binding and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen. Proc. Natl Acad. Sci USA 92:890.
12. Blunt, T., Finnie, N. J., Taccioli, G. E., Smith, G. C. M., Demengeot, J., Gottlieb, T. M., Mizuta, R., Varghese, A. J., Alt, F. W., Jeggo, P. A. and Jackson, S. P. 1995. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80:813.
13. Kirchgessner, C. U., Patil, C. K., Evans, J. W., Cuomo, C. A., Fried, L. M., Carter, T., Oettinger, M. A. and Brown, J. M. 1995. DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178.
14. Peterson, S. R., Kurimasa, A., Oshimura, M., Dynan, W. S., Bradbury, E. M. and Chen, D. J. 1995. Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc. Natl Acad. Sci. USA 92:3171.
15. Mizuta, R., Taccioli, G. E. and Alt, F. W. 1996. The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the K80 gene. Int. Immunol. 8:1467.
16. Singleton, B. K., Priestley, A., Steingrimsdottir, H., Gell, D., Blunt, T., Jackson, S. P., Lehmann, A. R. and Jeggo, P.A. 1997. Molecular and biochemical characterization of xrs mutants defective in Ku80. Mol. Cell Biol. 17:1264.
17. Gu, Y., Jin, S., Gao, Y., Weaver, D. and Alt, F. W. 1997. Ku70-deficient ES cells have increased ionizing radiosensitivity, defective DNA end binding activity, and inability to support V(D)J recombination. Proc. Natl Acad. Sci. USA 94:8076.
18. Mizuta, R., LaSalle, J. M., Cheng, H.-L., Shinohara, A., Ogawa, H., Copeland, N., Jenkins, N. A., Lalande, M. and Alt, F. W. 1997. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with RAD51 protein. Proc. Natl Acad. Sci. USA 94:6927.
19. Anderson, C. W. 1993. DNA damage and the DNA-activated protein kinase. Trends Biochem. Sci. 18:433.
20. Zervos, A. S., Gyuris, J. and Brent, R. 1993. Mxi1, a protein that specifically interacts with max to bind myc-max recognition sites. Cell 72:223.