-
2
-
-
0142168803
-
-
Appleton & Lange, Norwalk, CT
-
Smart,R.C. (1994) Carcinogenesis. Appleton & Lange, Norwalk, CT.
-
(1994)
Carcinogenesis
-
-
Smart, R.C.1
-
3
-
-
0037223730
-
Protein kinases and their involvement in the cellular responses to genotoxic stress
-
Yang,J., Yu,Y.N. and Duerksen-Hughes,P.J. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Rev. Mutat. Res., 543, 31-58.
-
(2003)
Rev. Mutat. Res.
, vol.543
, pp. 31-58
-
-
Yang, J.1
Yu, Y.N.2
Duerksen-Hughes, P.J.3
-
4
-
-
0029961252
-
Differential activation of ERK, JNK/SAK and p38/CSBP/PK MAP kinase family members during the cellular response to arsenite
-
Liu,Y., Guyton,K.Z., Gorospe,M., Xu,Q., Lee,J.C. and Holbrook,N.J. (1996) Differential activation of ERK, JNK/SAK and p38/CSBP/PK MAP kinase family members during the cellular response to arsenite. Free Radic. Biol. Med., 21, 771-781.
-
(1996)
Free Radic. Biol. Med.
, vol.21
, pp. 771-781
-
-
Liu, Y.1
Guyton, K.Z.2
Gorospe, M.3
Xu, Q.4
Lee, J.C.5
Holbrook, N.J.6
-
5
-
-
0031926177
-
A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage
-
Yang,J. and Duerksen-Hughes,P.J. (1998) A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis. 19, 1117-1125.
-
(1998)
Carcinogenesis
, vol.19
, pp. 1117-1125
-
-
Yang, J.1
Duerksen-Hughes, P.J.2
-
6
-
-
0031003783
-
Maintaining genetic stability through TP53 mediated checkpoint control
-
Wahl,G.M., Linke,S.P., Paulson,T.G. and Huang,L.C. (1997) Maintaining genetic stability through TP53 mediated checkpoint control. Cancer Surv., 29, 183-219.
-
(1997)
Cancer Surv.
, vol.29
, pp. 183-219
-
-
Wahl, G.M.1
Linke, S.P.2
Paulson, T.G.3
Huang, L.C.4
-
8
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham,R.T. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev., 15, 2177-2196.
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
9
-
-
0037178748
-
Interface between the detection, signaling and repair of DNA damage
-
Rouse,J. and Jackson,S.P. (2002) Interface between the detection, signaling and repair of DNA damage. Science, 297, 547-551.
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
10
-
-
0034237496
-
The G2-phase DNA-damage checkpoint
-
O'Connell,M.J., Walworth,N.C. and Carr,A.M. (2000) The G2-phase DNA-damage checkpoint. Trends Cell Biol., 10, 296-303.
-
(2000)
Trends Cell Biol.
, vol.10
, pp. 296-303
-
-
O'Connell, M.J.1
Walworth, N.C.2
Carr, A.M.3
-
11
-
-
0033965418
-
A novel Rad24 checkpoint protein complex closely related to replication factor C
-
Green,C.M., Erdjument-Bromage,H., Tempst,P. and Lowndes,N.F. (2000) A novel Rad24 checkpoint protein complex closely related to replication factor C. Curr. Biol., 10, 39-42.
-
(2000)
Curr. Biol.
, vol.10
, pp. 39-42
-
-
Green, C.M.1
Erdjument-Bromage, H.2
Tempst, P.3
Lowndes, N.F.4
-
12
-
-
0037113871
-
Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event
-
Roos-Mattjus,P., Vroman,B.T., Burtelow,M.A., Rauen,M., Eapen,A.K. and Karnitz,L.M. (2002) Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. J. Biol. Chem., 277, 43809-43812.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43809-43812
-
-
Roos-Mattjus, P.1
Vroman, B.T.2
Burtelow, M.A.3
Rauen, M.4
Eapen, A.K.5
Karnitz, L.M.6
-
13
-
-
0037365789
-
ATM and related protein kinases: Safeguarding genome integrity
-
Shiloh,Y. (2003) ATM and related protein kinases: safeguarding genome integrity. Nature Rev. Cancer, 3, 155-168.
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 155-168
-
-
Shiloh, Y.1
-
14
-
-
0035313706
-
DNA-PK, ATM and ATR as sensors of DNA damage: Variations on a theme?
-
Durocher,D. and Jackson,S.P.(2001) DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Curr. Opin. Cell. Biol., 13, 225-231.
-
(2001)
Curr. Opin. Cell. Biol.
, vol.13
, pp. 225-231
-
-
Durocher, D.1
Jackson, S.P.2
-
15
-
-
0033229933
-
ATM: A mediator of multiple responses to genotoxic stress
-
Rotman,G. and Shiloh,Y. ( 1999) ATM: a mediator of multiple responses to genotoxic stress. Oncogene, 18, 6135-6144.
-
(1999)
Oncogene
, vol.18
, pp. 6135-6144
-
-
Rotman, G.1
Shiloh, Y.2
-
16
-
-
0035927713
-
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
-
Bao,S., Tibbetts,R.S., Brumbaugh,K.M., Fang,Y., Richardson,D.A., Ali,A., Chen,S.M., Abraham,R.T. and Wang,X.F. (2001) ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature, 411, 969-974.
-
(2001)
Nature
, vol.411
, pp. 969-974
-
-
Bao, S.1
Tibbetts, R.S.2
Brumbaugh, K.M.3
Fang, Y.4
Richardson, D.A.5
Ali, A.6
Chen, S.M.7
Abraham, R.T.8
Wang, X.F.9
-
17
-
-
0032978973
-
DNA-PK activation by ionizing radiation-induced DNA single-strand breaks
-
Plumb,M.A., Smith,G.C., Cunniffe,S.M., Jackson,S.P. and O'Neill,P. (1999) DNA-PK activation by ionizing radiation-induced DNA single-strand breaks. Int. J. Radiat. Biol., 75, 553-561.
-
(1999)
Int. J. Radiat. Biol.
, vol.75
, pp. 553-561
-
-
Plumb, M.A.1
Smith, G.C.2
Cunniffe, S.M.3
Jackson, S.P.4
O'Neill, P.5
-
18
-
-
0034624782
-
Ionizing radiation activates the ATM kinase throughout the cell cycle
-
Pandita,T.K., Lieberman.H.B., Lim,D.S., Dhar,S., Zheng,W., Taya,Y. and Kastan,M.B. (2000) Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene, 19, 1386-1391.
-
(2000)
Oncogene
, vol.19
, pp. 1386-1391
-
-
Pandita, T.K.1
Lieberman, H.B.2
Lim, D.S.3
Dhar, S.4
Zheng, W.5
Taya, Y.6
Kastan, M.B.7
-
19
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko.Y., Moyal,L., Mittelman,L., Tsarfaty,I., Shiloh,Y. and Rotman.G. (2001) Nuclear retention of ATM at sites of DNA double strand breaks. J. Biol. Chem., 276, 38224-38230.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
Mittelman, L.3
Tsarfaty, I.4
Shiloh, Y.5
Rotman, G.6
-
20
-
-
0032560556
-
Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control
-
Wright,J.A., Keegan,K.S., Herendeen,D.R., Bentley.N.J., Carr,A.M., Hoekstra,M.F. and Concannon,P. (1998) Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control. Proc. Natl Acad. Sci. USA, 95, 7445-7450.
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 7445-7450
-
-
Wright, J.A.1
Keegan, K.S.2
Herendeen, D.R.3
Bentley, N.J.4
Carr, A.M.5
Hoekstra, M.F.6
Concannon, P.7
-
21
-
-
0034649590
-
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
-
Hekmat Nejad,M., You,Z., Yee,M.C., Newport,J.W. and Cimprich,K.A. (2000) Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint. Curr. Biol., 10, 1565-1573.
-
(2000)
Curr. Biol.
, vol.10
, pp. 1565-1573
-
-
Hekmat Nejad, M.1
You, Z.2
Yee, M.C.3
Newport, J.W.4
Cimprich, K.A.5
-
22
-
-
0036800479
-
Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene
-
Hannan,M.A., Hellani,A., Al-Khodairy,F.M., Kunhi,M., Siddiqui,Y., Al-Yussef,N., Paugue-Cruz,N., Siewertsen.M., Al-Ahdal,M.N. and Aboussekhra,A. (2002) Deficiency in the repair of UV-induced DNA damage in human skin fibroblasts compromised for the ATM gene. Carcinogenesis, 23, 1617-1624.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1617-1624
-
-
Hannan, M.A.1
Hellani, A.2
Al-Khodairy, F.M.3
Kunhi, M.4
Siddiqui, Y.5
Al-Yussef, N.6
Paugue-Cruz, N.7
Siewertsen, M.8
Al-Ahdal, M.N.9
Aboussekhra, A.10
-
23
-
-
0038305968
-
Ataxia telangiectasia mutated proteins. MAPKs and RSK2 are involved in the phosphorylation of STAT3
-
Zhang,Y., Cho,Y.Y., Petersen,B.L., Bode,A.M., Zhu,F. and Dong,Z. (2003) Ataxia telangiectasia mutated proteins. MAPKs and RSK2 are involved in the phosphorylation of STAT3. J. Biol. Chem., 278, 12650-12659.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12650-12659
-
-
Zhang, Y.1
Cho, Y.Y.2
Petersen, B.L.3
Bode, A.M.4
Zhu, F.5
Dong, Z.6
-
24
-
-
0036479241
-
Requirement of ATM in UVA-induced signaling and apoptosis
-
Zhang,Y., Ma,W.Y., Kaji,A., Bode,A.M. and Dong,Z. (2002) Requirement of ATM in UVA-induced signaling and apoptosis. J. Biol. Chem., 277, 3124-3131.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3124-3131
-
-
Zhang, Y.1
Ma, W.Y.2
Kaji, A.3
Bode, A.M.4
Dong, Z.5
-
25
-
-
0036892831
-
An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage
-
Heffernan.T.P., Simpson,D.A., Frank,A.R., Heinloth,A.N., Paules,R.S., Cordeiro-Stone,M. and Kanfmann,W.K. (2002) An ATR- and Chk1-dependent S checkpoint inhibits replicon initiation following UVC-induced DNA damage. Mol. Cell. Biol., 22, 8552-8561.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 8552-8561
-
-
Heffernan, T.P.1
Simpson, D.A.2
Frank, A.R.3
Heinloth, A.N.4
Paules, R.S.5
Cordeiro-Stone, M.6
Kanfmann, W.K.7
-
26
-
-
0038381451
-
Chromium(VI) activates ATM: Requirement of ATM for both apoptosis and recovery from terminal growth arrest
-
Ha,L., Ceryak,S. and Patierno,S.R. (2003) Chromium(VI) activates ATM: requirement of ATM for both apoptosis and recovery from terminal growth arrest. J. Biol. Chem., 278, 17885-17894.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17885-17894
-
-
Ha, L.1
Ceryak, S.2
Patierno, S.R.3
-
27
-
-
0037273063
-
Oxidative stress in ataxia telangiectasia
-
Watters,D.J. (2003) Oxidative stress in ataxia telangiectasia. Redox Rep., 8, 23-29.
-
(2003)
Redox Rep.
, vol.8
, pp. 23-29
-
-
Watters, D.J.1
-
28
-
-
0036179376
-
Hypoxia links ATR and p53 through replication arrest
-
Hammond,E.M., Denko,N.C., Dorie,M.J., Abraham,R.T. and Giaccia,A.J. (2002) Hypoxia links ATR and p53 through replication arrest. Mol. Cell. Biol., 22, 1834-1843.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 1834-1843
-
-
Hammond, E.M.1
Denko, N.C.2
Dorie, M.J.3
Abraham, R.T.4
Giaccia, A.J.5
-
29
-
-
0038146962
-
ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
-
Hammond,E.M., Dorie,M.J. and Giaccia,A.J. (2003) ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J. Biol. Chem., 278, 12207-12213.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 12207-12213
-
-
Hammond, E.M.1
Dorie, M.J.2
Giaccia, A.J.3
-
30
-
-
0038188668
-
Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation
-
Wang,X., Zalcenstein,A. and Oren,M. (2003) Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation. Cell Death Differ., 10, 468-476.
-
(2003)
Cell Death Differ.
, vol.10
, pp. 468-476
-
-
Wang, X.1
Zalcenstein, A.2
Oren, M.3
-
31
-
-
0037422535
-
Nitric oxide-induced cellular stress and p53 activation in chronic inflammation
-
Hofseth,L.J., Saito,S., Hussain,S.P., Espey,M.G., Miranda,K.M., Araki,Y., Jhappan,C., Higashimoto,Y., He,P., Linke,S.P., Quezado,M.M., Zurer,I., Rotter,V., Wink,D.A., Appella,E. and Harris,C.C. (2003) Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc. Natl Acad. Sci. USA, 100, 143-148.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 143-148
-
-
Hofseth, L.J.1
Saito, S.2
Hussain, S.P.3
Espey, M.G.4
Miranda, K.M.5
Araki, Y.6
Jhappan, C.7
Higashimoto, Y.8
He, P.9
Linke, S.P.10
Quezado, M.M.11
Zurer, I.12
Rotter, V.13
Wink, D.A.14
Appella, E.15
Harris, C.C.16
-
32
-
-
0037449734
-
Phosphorylation and hsp90 binding mediate heat shock stabilization of p53
-
Wang,C. and Chen,J. (2003) Phosphorylation and hsp90 binding mediate heat shock stabilization of p53. J. Biol. Chem., 278, 2066-2071.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2066-2071
-
-
Wang, C.1
Chen, J.2
-
33
-
-
0037414761
-
Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein
-
Suzuki,A., Kusakai,G., Kishimoto,A., Lu,J., Ogura,T., Lavin,M.F. and Esumi,H. (2003) Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein. J. Biol. Chem., 278, 48-53.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48-53
-
-
Suzuki, A.1
Kusakai, G.2
Kishimoto, A.3
Lu, J.4
Ogura, T.5
Lavin, M.F.6
Esumi, H.7
-
34
-
-
0037446871
-
Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response
-
Daniel,R., Kao,G., Taganov,K., Greger,J.G., Favorova,O., Merkel,G., Yen,T.J., Katz,R.A. and Skalka,A.M. (2003) Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response. Proc. Natl Acad. Sci. USA, 100, 4778-4783.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4778-4783
-
-
Daniel, R.1
Kao, G.2
Taganov, K.3
Greger, J.G.4
Favorova, O.5
Merkel, G.6
Yen, T.J.7
Katz, R.A.8
Skalka, A.M.9
-
35
-
-
0037830710
-
Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R
-
Roshal,M., Kim,B., Zhu.Y., Nghiem,P. and Planelles,V. (2003) Activation of the ATR-mediated DNA damage response by the HIV-1 viral protein R. J. Biol. Chem., 278, 25879-25886.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25879-25886
-
-
Roshal, M.1
Kim, B.2
Zhu, Y.3
Nghiem, P.4
Planelles, V.5
-
36
-
-
0035195557
-
The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
-
Wahl,G.M. and Carr,A.M. (2001) The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nature Cell Biol., 3, E227-E286.
-
(2001)
Nature Cell Biol.
, vol.3
-
-
WahlG, M.1
Carr, A.M.2
-
37
-
-
0033520432
-
Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation
-
Suzuki,K., Kodama,S. and Watanabe,M. (1999) Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J. Biol. Chem., 274, 25571-25575.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 25571-25575
-
-
Suzuki, K.1
Kodama, S.2
Watanabe, M.3
-
38
-
-
0033613099
-
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
-
Smith,G.C., Cary,R.B., Lakin,N.D., Hann,B.C., Teo,S.H., Chen,D.J. and Jackson,S.P. (1999) Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. Proc. Natl Acad. Sci. USA, 96, 11134-11139.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 11134-11139
-
-
Smith, G.C.1
Cary, R.B.2
Lakin, N.D.3
Hann, B.C.4
Teo, S.H.5
Chen, D.J.6
Jackson, S.P.7
-
39
-
-
0034312277
-
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extract
-
Guo,Z., Kumagai,A., Wang,S.X. and Dunphy,W.G. (2000) Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extract. Genes Dev., 14, 2745-2756.
-
(2000)
Genes Dev.
, vol.14
, pp. 2745-2756
-
-
Guo, Z.1
Kumagai, A.2
Wang, S.X.3
Dunphy, W.G.4
-
40
-
-
0037076402
-
Preferential binding of ATR protein to UV-damaged DNA
-
Unsal-Kacmaz,K., Makhov,A.M., Griffith,J.D. and Sancar,A. (2002) Preferential binding of ATR protein to UV-damaged DNA. Proc. Natl Acad. Sci. USA, 99, 6673-6678.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 6673-6678
-
-
Unsal-Kacmaz, K.1
Makhov, A.M.2
Griffith, J.D.3
Sancar, A.4
-
41
-
-
0038660596
-
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation
-
Kozlov.S., Gueven,N., Keating,K., Ramsay,J. and Lavin,M.F. (2003) ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation. J. Biol. Chem., 278, 9309-9317.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 9309-9317
-
-
Kozlov, S.1
Gueven, N.2
Keating, K.3
Ramsay, J.4
Lavin, M.F.5
-
42
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist,C.J. and Kastan,M.B. (2003) DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature, 421, 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
43
-
-
0034655991
-
BASC, a super complex of BRCA1-associated proteins: Involved in the recognition and repair of aberrant DNA structures
-
Wang.Y., Cortez,D., Yazdi,P., Neff,N., Elledge,S.J. and Qin,J. (2000) BASC, a super complex of BRCA1-associated proteins: involved in the recognition and repair of aberrant DNA structures. Genes Dev., 14, 927-939.
-
(2000)
Genes Dev.
, vol.14
, pp. 927-939
-
-
Wang, Y.1
Cortez, D.2
Yazdi, P.3
Neff, N.4
Elledge, S.J.5
Qin, J.6
-
44
-
-
0038182453
-
A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein
-
Foray,N., Marot.D., Gabriel,A., Randrianarison,V., Carr,A.M., Perricaudet,M., Ashworth,A. and Jeggo,P. (2003) A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein. EMBO J., 21, 2860-2871.
-
(2003)
EMBO J.
, vol.21
, pp. 2860-2871
-
-
Foray, N.1
Marot, D.2
Gabriel, A.3
Randrianarison, V.4
Carr, A.M.5
Perricaudet, M.6
Ashworth, A.7
Jeggo, P.8
-
45
-
-
0037449747
-
Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization
-
Okada,S. and Ouchi,T. (2003) Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. J. Biol. Chem., 278, 2015-2020.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2015-2020
-
-
Okada, S.1
Ouchi, T.2
-
46
-
-
0037112506
-
Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha
-
Liu,Y., Virshup.D.M., White,R.L. and Hsu,L.C. (2002) Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Res., 62, 6357-6361.
-
(2002)
Cancer Res.
, vol.62
, pp. 6357-6361
-
-
Liu, Y.1
Virshup, D.M.2
White, R.L.3
Hsu, L.C.4
-
47
-
-
0036829505
-
Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation
-
Guo,C.Y., Brautigan,D.L. and Larner,J.M. (2002) Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation. J. Biol. Chem., 277, 41756-41761.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 41756-41761
-
-
Guo, C.Y.1
Brautigan, D.L.2
Larner, J.M.3
-
48
-
-
0030992749
-
Interaction between ATM protein and c-Abl in response to DNA damage
-
Shafman,T., Khanna,K.K., Kedar,P., Spring.K., Kozlov,S., Yen.T., Hobson,K., Gatei,M., Zhang,N., Watters,D., Egerton,M., Shiloh,Y., Kharbanda,S., Kufe,D. and Lavin,M.F. (1997) Interaction between ATM protein and c-Abl in response to DNA damage. Nature, 387, 520-523.
-
(1997)
Nature
, vol.387
, pp. 520-523
-
-
Shafman, T.1
Khanna, K.K.2
Kedar, P.3
Spring, K.4
Kozlov, S.5
Yen, T.6
Hobson, K.7
Gatei, M.8
Zhang, N.9
Watters, D.10
Egerton, M.11
Shiloh, Y.12
Kharbanda, S.13
Kufe, D.14
Lavin, M.F.15
-
49
-
-
0030925565
-
Ataxia telangiectasia mulant protein activates c-Abl tyrosine kinase in response to ionizing radiation
-
Baskaran,R., Wood,L.D., Whitaker,L.L., Xu,Y., Barlow,C., Canman,C.E., Morgan,S.E., Baltimore,D., Wynshan-Boris,A., Kastan,M.B. and Wang,J.Y.J. (1997) Ataxia telangiectasia mulant protein activates c-Abl tyrosine kinase in response to ionizing radiation. Nature, 387, 516-519.
-
(1997)
Nature
, vol.387
, pp. 516-519
-
-
Baskaran, R.1
Wood, L.D.2
Whitaker, L.L.3
Xu, Y.4
Barlow, C.5
Canman, C.E.6
Morgan, S.E.7
Baltimore, D.8
Wynshan-Boris, A.9
Kastan, M.B.10
Wang, J.Y.J.11
-
50
-
-
0034730513
-
Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated Abl kinase is an ATM-dependent process
-
Shangary,S., Brown,K.D., Adamson,A.W., Edmonson,S., Ng,B., Pandita,T.K., Yalowich,J., Taccioli,G.E. and Baskaran,R. (2000) Regulation of DNA-dependent protein kinase activity by ionizing radiation-activated Abl kinase is an ATM-dependent process. J. Biol. Chem., 275, 30163-30168.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 30163-30168
-
-
Shangary, S.1
Brown, K.D.2
Adamson, A.W.3
Edmonson, S.4
Ng, B.5
Pandita, T.K.6
Yalowich, J.7
Taccioli, G.E.8
Baskaran, R.9
-
51
-
-
0033956865
-
c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance
-
Takao,N., Mori,R., Kato,H., Shinohara,A. and Yamamoto,K. (2000) c-Abl tyrosine kinase is not essential for ataxia telangiectasia mutated functions in chromosomal maintenance. J. Biol. Chem., 275, 725-728.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 725-728
-
-
Takao, N.1
Mori, R.2
Kato, H.3
Shinohara, A.4
Yamamoto, K.5
-
52
-
-
0036258350
-
Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation
-
Foray,N., Marot,D., Randrianarison,V., Venezia,N.D., Picard,D., Perricaudet,M., Favaudon,V. and Jeggo,P. (2002) Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation. Mol. Cell. Biol., 22, 4020-4032.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 4020-4032
-
-
Foray, N.1
Marot, D.2
Randrianarison, V.3
Venezia, N.D.4
Picard, D.5
Perricaudet, M.6
Favaudon, V.7
Jeggo, P.8
-
53
-
-
0038820065
-
Phosphorylation of histone H2AX and activation of Mre11. Rad50 and Nbs1 in response to replication-dependent DNA-double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
-
Furuta,T., Takemura,H., Liao,Z.Y., Aune,G.J., Redon.C., Sedelnikova,O.A., Pilch,D.R., Rogakou,E.P., Celeste.A., Chen,H.T., Nussenzaweig,A., Aladjem,M.I., Bonner,W.M. and Pommier,Y. (2003) Phosphorylation of histone H2AX and activation of Mre11. Rad50 and Nbs1 in response to replication-dependent DNA-double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem., 278, 20303-20312.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20303-20312
-
-
Furuta, T.1
Takemura, H.2
Liao, Z.Y.3
Aune, G.J.4
Redon, C.5
Sedelnikova, O.A.6
Pilch, D.R.7
Rogakou, E.P.8
Celeste, A.9
Chen, H.T.10
Nussenzaweig, A.11
Aladjem, M.I.12
Bonner, W.M.13
Pommier, Y.14
-
54
-
-
0037226818
-
DNA replication-dependent nuclear dynamics of the mre11 complex
-
Mirzoeva,O.K. and Petrini,J.H. (2003) DNA replication-dependent nuclear dynamics of the mre11 complex. Mol. Cancer Res., 1, 207-218.
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 207-218
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
55
-
-
0038143321
-
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX
-
Ward,I.M., Minn,K., Jorda,K.G. and Chen,J. (2003) Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J. Biol. Chem., 278, 19579-19582.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 19579-19582
-
-
Ward, I.M.1
Minn, K.2
Jorda, K.G.3
Chen, J.4
-
56
-
-
0037468192
-
MDC1 is a mediator of the mammalian DNA damage checkpoint
-
Stewart,G.S., Wang,B., Bignell,C.R., Taylor,A.M. and Elledge,S.J. (2003) MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature, 421, 961-966.
-
(2003)
Nature
, vol.421
, pp. 961-966
-
-
Stewart, G.S.1
Wang, B.2
Bignell, C.R.3
Taylor, A.M.4
Elledge, S.J.5
-
57
-
-
0037424296
-
NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways
-
Xu,X. and Stern,D.F. (2003) NFBD1/KIAA0170 is a chromatin-associated protein involved in DNA damage signaling pathways. J. Biol. Chem., 278, 8795-8803.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8795-8803
-
-
Xu, X.1
Stern, D.F.2
-
58
-
-
0038496703
-
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control
-
Lou,Z., Chini,C.C., Minter-Dykhouse,K. and Chen,J. (2003) Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J. Biol. Chem., 278, 13599-13602.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13599-13602
-
-
Lou, Z.1
Chini, C.C.2
Minter-Dykhouse, K.3
Chen, J.4
-
59
-
-
0037468232
-
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways
-
Lou,Z., Minter-Dykhouse,K., Wu,X. and Chen,J. (2003) MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature, 421, 957-961.
-
(2003)
Nature
, vol.421
, pp. 957-961
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Wu, X.3
Chen, J.4
-
60
-
-
0037468169
-
MDC1 is required for the intra-S-phase DNA damage checkpoint
-
Goldberg,M., Stucki,M., Falck,J., D'Amours.D., Rahman,D., Pappin,D., Bartek,J. and Jackson,S.P. (2003) MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature, 421, 952-956.
-
(2003)
Nature
, vol.421
, pp. 952-956
-
-
Goldberg, M.1
Stucki, M.2
Falck, J.3
D'Amours, D.4
Rahman, D.5
Pappin, D.6
Bartek, J.7
Jackson, S.P.8
-
61
-
-
0037435026
-
Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle
-
Pichierri,P., Rosselli,F. and Franchitto.A. (2003) Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle. Oncogene, 22, 1491-1500.
-
(2003)
Oncogene
, vol.22
, pp. 1491-1500
-
-
Pichierri, P.1
Rosselli, F.2
Franchitto, A.3
-
62
-
-
0141480945
-
WRN interacts physically and functionally with the recombination mediator protein RAD52
-
E-published ahead of print at
-
Baynton,K., Otterlei,M., Bjoras,M., Von Kobbe,C., Bohr,V.A. and Seeberg,E. (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. J. Biol. Chem., E-published ahead of print at http://www.jbc.org/cgi/reprint/M303885200v1.
-
(2003)
J. Biol. Chem.
-
-
Baynton, K.1
Otterlei, M.2
Bjoras, M.3
Von Kobbe, C.4
Bohr, V.A.5
Seeberg, E.6
-
63
-
-
0037185024
-
DNA damage-induced translocation of the Werner helicase is regulated by acetylation
-
Blander,G., Zallc,N., Daniely,Y., Taplick,J., Gray,M.D. and Oren,M. (2002) DNA damage-induced translocation of the Werner helicase is regulated by acetylation. J. Biol. Chem., 277, 50934-50940.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50934-50940
-
-
Blander, G.1
Zallc, N.2
Daniely, Y.3
Taplick, J.4
Gray, M.D.5
Oren, M.6
-
64
-
-
0037979238
-
PML colocalizes with and stabilizes the DNA damage response protein TopBP1
-
Xu,Z.X., Timanova-Atanasova,A., Zhao,R.X. and Chang,K.S. (2003) PML colocalizes with and stabilizes the DNA damage response protein TopBP1. Mol. Cell. Biol., 23, 4247-4256.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4247-4256
-
-
Xu, Z.X.1
Timanova-Atanasova, A.2
Zhao, R.X.3
Chang, K.S.4
-
65
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1
-
Fernandez-Capetillo,O., Chen,H.T., Celeste,A., Ward,I., Romanienko,P.J., Morales.J.C., Naka,K., Xia,Z., Camerini-Otero,R.D., Motoyama,N., Carpenter,P.B., Bonner,W.M., Chen,J. and Nussenzweig,A. (2002) DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biol., 4, 993-997.
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
Carpenter, P.B.11
Bonner, W.M.12
Chen, J.13
Nussenzweig, A.14
-
66
-
-
0037772381
-
Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability
-
Morales,J.C., Xia,Z., Lu,T., Aldrich,M.B., Wang,B., Rosales,C., Kellems,R.E., Hittelman,W.N., Elledge,S.J. and Carpenter,P.B. (2003) Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J. Biol. Chem., 278, 14971-14977.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14971-14977
-
-
Morales, J.C.1
Xia, Z.2
Lu, T.3
Aldrich, M.B.4
Wang, B.5
Rosales, C.6
Kellems, R.E.7
Hittelman, W.N.8
Elledge, S.J.9
Carpenter, P.B.10
-
67
-
-
0037378527
-
p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
-
Ward,I.M., Minn,K., Van Deursen,J. and Chen,J. (2003) p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol. Cell. Biol., 23, 2556-2563.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2556-2563
-
-
Ward, I.M.1
Minn, K.2
Van Deursen, J.3
Chen, J.4
-
68
-
-
0036902410
-
53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer
-
DiTullio,R.A.,Jr. Mochan,T.A., Venere,M., Bartkova,J., Sehested,M., Bartek,J. and Halazonetis,T.D. (2002) 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nature Cell Biol., 4, 998-1002.
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 998-1002
-
-
DiTullio Jr., R.A.1
Mochan, T.A.2
Venere, M.3
Bartkova, J.4
Sehested, M.5
Bartek, J.6
Halazonetis, T.D.7
-
69
-
-
0345352653
-
Regulation of E2F1 by BRCT domain-containing, protein TopBP1
-
Liu,K., Lin,F.T., Ruppert,J.M. and Lin,W.C. (2003) Regulation of E2F1 by BRCT domain-containing, protein TopBP1. Mol. Cell. Biol., 23, 3287-3304.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 3287-3304
-
-
Liu, K.1
Lin, F.T.2
Ruppert, J.M.3
Lin, W.C.4
-
70
-
-
0037448689
-
ATM is a target for positive regulation by E2F-1
-
Berkovich,E. and Ginsberg,D. (2003) ATM is a target for positive regulation by E2F-1. Oncogene, 22, 161-167.
-
(2003)
Oncogene
, vol.22
, pp. 161-167
-
-
Berkovich, E.1
Ginsberg, D.2
-
71
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou,L. and Elledge,S.J. (2003) Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science, 300, 1542-1548.
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
-
72
-
-
0037245862
-
An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of' DNA replication
-
Costanzo,V., Shechter,D., Lupardus,P.J., Cimprich,K.A., Gottesman,M. and Gautier,J. (2003) An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of' DNA replication. Mol. Cell, 11, 203-213.
-
(2003)
Mol. Cell
, vol.11
, pp. 203-213
-
-
Costanzo, V.1
Shechter, D.2
Lupardus, P.J.3
Cimprich, K.A.4
Gottesman, M.5
Gautier, J.6
-
73
-
-
0033615547
-
Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase
-
Kim,G.D., Choi,Y.H., Dimtchev,A., Jeong,S.J., Dritschilo,A. and Jung,M. (1999) Sensing of ionizing radiation-induced DNA damage by ATM through interaction with histone deacetylase. J. Biol. Chem., 274, 31127-31130.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31127-31130
-
-
Kim, G.D.1
Choi, Y.H.2
Dimtchev, A.3
Jeong, S.J.4
Dritschilo, A.5
Jung, M.6
-
74
-
-
0033517797
-
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4
-
Schmidt,D.R. and Schreiber,S.L. (1999) Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry, 38, 14711-14717.
-
(1999)
Biochemistry
, vol.38
, pp. 14711-14717
-
-
Schmidt, D.R.1
Schreiber, S.L.2
-
75
-
-
0038243113
-
Histone deacetylase inhibitors activate p21 (WAF1) expression via ATM
-
Ju,R. and Muller,M.T. (2003) Histone deacetylase inhibitors activate p21 (WAF1) expression via ATM. Cancer Res., 63, 2891-2897.
-
(2003)
Cancer Res.
, vol.63
, pp. 2891-2897
-
-
Ju, R.1
Muller, M.T.2
-
76
-
-
0037427194
-
Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells
-
Yuan,S.S., Chang,H.L. and Lee,E.Y. (2003) Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM(-/-) and c-Abl(-/-) cells. Mutat. Rev., 525, 85-92.
-
(2003)
Mutat. Rev.
, vol.525
, pp. 85-92
-
-
Yuan, S.S.1
Chang, H.L.2
Lee, E.Y.3
-
77
-
-
0036921395
-
Arg tyrosine kinase is involved in homologous recombinational DNA repair
-
Li,Y., Shimizu,H., Xiang,S.L., Maru,Y., Takao,N. and Yamamoto,K. (2002) Arg tyrosine kinase is involved in homologous recombinational DNA repair. Biochem. Biophys. Res. Commun., 299, 697-702.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.299
, pp. 697-702
-
-
Li, Y.1
Shimizu, H.2
Xiang, S.L.3
Maru, Y.4
Takao, N.5
Yamamoto, K.6
-
78
-
-
0043032435
-
Human Claspin is required for replication checkpoint control
-
E-published ahead of print at
-
Chini,C.C. and Chen,J. (2003) Human Claspin is required for replication checkpoint control. J. Biol. Chem., E-published ahead of print at http://www.jbc.org/cgi/reprint/M301136200v1.
-
(2003)
J. Biol. Chem.
-
-
Chini, C.C.1
Chen, J.2
-
79
-
-
0034142325
-
Chk2/hCds1 functions as a DNA damaging checkpoint in G1 by stabilizing p53
-
Chehab,N.H., Malikzay,A., Appel,M. and Halazonetis,T.D. (2000) Chk2/hCds1 functions as a DNA damaging checkpoint in G1 by stabilizing p53. Genes Dev., 14, 278-288.
-
(2000)
Genes Dev.
, vol.14
, pp. 278-288
-
-
Chehab, N.H.1
Malikzay, A.2
Appel, M.3
Halazonetis, T.D.4
-
80
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao,A., Kong,Y.-Y., Matsuoka,S., Wakeham,A., Ruland,J., Yoshida,H., Liu,D., Elledge,S.J. and Mak,T.W. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science, 287, 1824-1827.
-
(2000)
Science
, vol.287
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.-Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
Yoshida, H.6
Liu, D.7
Elledge, S.J.8
Mak, T.W.9
-
81
-
-
0034326802
-
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
-
Ahn,J.Y., Schwarz,J.K., Piwnica-Worms,H. and Canman,C.E. (2000) Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation. Cancer Res., 60. 5934-5936.
-
(2000)
Cancer Res.
, vol.60
, pp. 5934-5936
-
-
Ahn, J.Y.1
Schwarz, J.K.2
Piwnica-Worms, H.3
Canman, C.E.4
-
82
-
-
0034641724
-
ATM phosphorylates Chk2 in vivo and in vitro
-
Matsuoka,S., Rotman,G., Ogawa,A., Shiloh,Y., Tamai,K. and Elledge,S. (2000) ATM phosphorylates Chk2 in vivo and in vitro. Proc. Natl Acad. Sci. USA, 97, 10389-10394.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 10389-10394
-
-
Matsuoka, S.1
Rotman, G.2
Ogawa, A.3
Shiloh, Y.4
Tamai, K.5
Elledge, S.6
-
83
-
-
0035848819
-
The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis
-
Falck,J., Mailand,N., Syljuasen,R.G., Bartek,J. and Lukas,J. (2001) The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature, 410, 842-847.
-
(2001)
Nature
, vol.410
, pp. 842-847
-
-
Falck, J.1
Mailand, N.2
Syljuasen, R.G.3
Bartek, J.4
Lukas, J.5
-
84
-
-
0037484271
-
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA damaging agents
-
Xiao,Z., Chen,Z., Gunasekera,A.H., Sowin,T.J., Rosenberg,S.H., Fesik,S. and Zhang,H. (2003) Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA damaging agents. J. Biol. Chem., 278, 21767-21773.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21767-21773
-
-
Xiao, Z.1
Chen, Z.2
Gunasekera, A.H.3
Sowin, T.J.4
Rosenberg, S.H.5
Fesik, S.6
Zhang, H.7
-
85
-
-
0034713466
-
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
-
Wu,X., Ranganathan,V., Weisman,D.S., Heine,W.F., Ciccone,D.N., O'Neill,T.B., Crick,K.E., Pierce,K.A., Lane,W.S., Rathbun,G., Livingston,D.M. and Weaver,D.T. (2000) ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature, 405, 477-482.
-
(2000)
Nature
, vol.405
, pp. 477-482
-
-
Wu, X.1
Ranganathan, V.2
Weisman, D.S.3
Heine, W.F.4
Ciccone, D.N.5
O'Neill, T.B.6
Crick, K.E.7
Pierce, K.A.8
Lane, W.S.9
Rathbun, G.10
Livingston, D.M.11
Weaver, D.T.12
-
86
-
-
0033637170
-
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
-
Tibbetts,R.S., Cortez,D., Brumbaugh,K.M., Scully,R., Livingston,D., Elledge,S.J. and Abraham,R.T. (2000) Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev., 14, 2989-3002.
-
(2000)
Genes Dev.
, vol.14
, pp. 2989-3002
-
-
Tibbetts, R.S.1
Cortez, D.2
Brumbaugh, K.M.3
Scully, R.4
Livingston, D.5
Elledge, S.J.6
Abraham, R.T.7
-
87
-
-
0035972194
-
Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage signaling pathways
-
Rappold,I., Iwabuchi,K., Date,T. and Chen,J. (2001) Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage signaling pathways. J. Cell. Biol., 153, 613-620.
-
(2001)
J. Cell. Biol.
, vol.153
, pp. 613-620
-
-
Rappold, I.1
Iwabuchi, K.2
Date, T.3
Chen, J.4
-
88
-
-
0037142619
-
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest
-
Girard,P.M., Riballo,E., Begg,A.C., Waugh,A. and Jeggo,P.A. (2002) Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene, 21, 4191-4199.
-
(2002)
Oncogene
, vol.21
, pp. 4191-4199
-
-
Girard, P.M.1
Riballo, E.2
Begg, A.C.3
Waugh, A.4
Jeggo, P.A.5
-
89
-
-
0037102275
-
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation
-
XU,B., O'Donnell,A.H., Kim,S.T. and Kastan,M.B. (2002) Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res., 62, 4588-4591.
-
(2002)
Cancer Res.
, vol.62
, pp. 4588-4591
-
-
Xu, B.1
O'Donnell, A.H.2
Kim, S.T.3
Kastan, M.B.4
-
90
-
-
4544280871
-
Interaction of FANCD2 and NBS1 in the DNA damage response
-
Nakanishi,K., Taniguchi,T., Ranganathan,V., New,H.V., Moreau,L.A., Stotsky,M., Mathew,C.G., Kastan,M.B., Weaver,D.T. and D'Andrea,A.D. (2002) Interaction of FANCD2 and NBS1 in the DNA damage response. Nature Cell Biol., 4, 913-920.
-
(2002)
Nature Cell Biol.
, vol.4
, pp. 913-920
-
-
Nakanishi, K.1
Taniguchi, T.2
Ranganathan, V.3
New, H.V.4
Moreau, L.A.5
Stotsky, M.6
Mathew, C.G.7
Kastan, M.B.8
Weaver, D.T.9
D'Andrea, A.D.10
-
91
-
-
0037821657
-
Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation
-
Cerosaletti,K.M. and Concannon,P. (2003) Nibrin forkhead-associated domain and breast cancer C-terminal domain are both required for nuclear focus formation and phosphorylation. J. Biol. Chem., 278, 21944-21951.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 21944-21951
-
-
Cerosaletti, K.M.1
Concannon, P.2
-
92
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas,C., Falck,J., Bartkova,J., Bartek,J. and Lukas,J. (2003) Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nature Cell Biol., 5, 255-260.
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
93
-
-
0037068770
-
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation
-
Zhou,X.Y., Wang,X., Wang,H., Chen,D.J., Li,G.C., Iliakis,G. and Wain,Y. (2002) Ku affects the ATM-dependent S phase checkpoint following ionizing radiation. Oncogene, 21, 6377-6381.
-
(2002)
Oncogene
, vol.21
, pp. 6377-6381
-
-
Zhou, X.Y.1
Wang, X.2
Wang, H.3
Chen, D.J.4
Li, G.C.5
Iliakis, G.6
Wain, Y.7
-
94
-
-
0036569855
-
Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment
-
Wang,H., Wang,X., Zhou,X.Y., Chen,D.J., Li,G.C., Iliakis,G. and Wang,Y. (2002) Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. Cancer Res., 62, 2483-2487.
-
(2002)
Cancer Res.
, vol.62
, pp. 2483-2487
-
-
Wang, H.1
Wang, X.2
Zhou, X.Y.3
Chen, D.J.4
Li, G.C.5
Iliakis, G.6
Wang, Y.7
-
95
-
-
0034967556
-
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
-
Zhao,H. and Piwnica-Worms,H. (2001) ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol. Cell. Biol., 21, 4129-4139.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 4129-4139
-
-
Zhao, H.1
Piwnica-Worms, H.2
-
96
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
-
Liu,Q., Guntuku.S., Cui,X.S., Matsuoka,S., Cortez,D., Tamai,K., Luo,G., Carattini-Rivera,S., DeMayo,F., Bradley,A., Donehower,L.A. and Elledge,S.J. (2000) Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint. Genes Dev., 14, 1448-1459.
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
Donehower, L.A.11
Elledge, S.J.12
-
97
-
-
0036510163
-
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
-
Yarden,R.I., Pardo-Reoyo,S., Sgagias,M., Cowan,K.H. and Brody,L.C. (2002) BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nature Genet., 30, 285-289.
-
(2002)
Nature Genet.
, vol.30
, pp. 285-289
-
-
Yarden, R.I.1
Pardo-Reoyo, S.2
Sgagias, M.3
Cowan, K.H.4
Brody, L.C.5
-
98
-
-
0036902096
-
Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest
-
Capasso,H., Palermo,C., Wan,S., Rao,H., John,U.P., O'Connell,M.J. and Walworth,N.C. (2002) Phosphorylation activates Chk1 and is required for checkpoint-mediated cell cycle arrest. J. Cell Sci., 115. 4555-4564.
-
(2002)
J. Cell Sci.
, vol.115
, pp. 4555-4564
-
-
Capasso, H.1
Palermo, C.2
Wan, S.3
Rao, H.4
John, U.P.5
O'Connell, M.J.6
Walworth, N.C.7
-
99
-
-
0042242580
-
Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser345
-
Jiang,K., Pereira,E., Maxfield,M., Russell,B., Goudelock,D.M. and Sanchez,Y. (2003) Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser345J. Biol. Chem., 278, 25207-25217.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 25207-25217
-
-
Jiang, K.1
Pereira, E.2
Maxfield, M.3
Russell, B.4
Goudelock, D.M.5
Sanchez, Y.6
-
100
-
-
0033616828
-
A human Cds1-related kinase that functions down-stream of ATM protein in the cellular response to DNA damage
-
Brown,A.L., Lee,C.H., Schwarz,J.K., Mitiku,N., Piwnica-Worms,H. and Chung,J.H. (1999) A human Cds1-related kinase that functions down-stream of ATM protein in the cellular response to DNA damage. Proc. Natl Acad. Sci. USA, 96, 3745-3750.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 3745-3750
-
-
Brown, A.L.1
Lee, C.H.2
Schwarz, J.K.3
Mitiku, N.4
Piwnica-Worms, H.5
Chung, J.H.6
-
101
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown,E.J. and Baltimore,D. (2003) Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev., 17, 615-628.
-
(2003)
Genes Dev.
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
102
-
-
0043234465
-
An over-activated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells
-
E-published ahead of print at
-
Wang,X., Khadpe,J., Hu,B., Iliakis,G. and Wang,Y. (2003) An over-activated ATR/CHK1 pathway is responsible for the prolonged G2 accumulation in irradiated AT cells. J. Biol. Chem., E-published ahead of print at http://www.jbc.org/cgi/reprint/M301876200v1.
-
(2003)
J. Biol. Chem.
-
-
Wang, X.1
Khadpe, J.2
Hu, B.3
Iliakis, G.4
Wang, Y.5
-
103
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei,M., Sloper,K., Sorensen,C., Syljuasen,R., Falck,J., Hobson,K., Savage,K., Lukas,J., Zhou,B.B., Bartek,J. and Khanna,K.K. (2003) Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem., 278, 14806-14811.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
Sloper, K.2
Sorensen, C.3
Syljuasen, R.4
Falck, J.5
Hobson, K.6
Savage, K.7
Lukas, J.8
Zhou, B.B.9
Bartek, J.10
Khanna, K.K.11
-
104
-
-
0012966157
-
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
-
Sorensen,C.S., Syljuasen,R.G., Falck,J., Schroeder,T., Ronnstrand,L., Khanna,K.K., Zhou,B.B., Bartek,J. and Lukas,J. (2003) Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3, 247-258.
-
(2003)
Cancer Cell
, vol.3
, pp. 247-258
-
-
Sorensen, C.S.1
Syljuasen, R.G.2
Falck, J.3
Schroeder, T.4
Ronnstrand, L.5
Khanna, K.K.6
Zhou, B.B.7
Bartek, J.8
Lukas, J.9
-
105
-
-
0037198145
-
DNA-dependent protein kinase complex: A multifunctional protein in DNA repair and damage checkpoint
-
Lee,S.H. and Kim,C.H. (2002) DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint. Mol. Cell, 13, 159-166.
-
(2002)
Mol. Cell
, vol.13
, pp. 159-166
-
-
Lee, S.H.1
Kim, C.H.2
-
106
-
-
0030783087
-
Double-strand break repair
-
Chu,G. (1997) Double-strand break repair. J. Biol. Chem., 272, 24097-24100.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 24097-24100
-
-
Chu, G.1
-
107
-
-
0000391880
-
Evidence for DNA-PK-dependent and independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle
-
Lee,S.E., Mitchell,R.A., Cheng,A. and Hendrickson,E.A. (1997) Evidence for DNA-PK-dependent and independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle. Mol. Cell. Biol., 17, 1425-1433.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1425-1433
-
-
Lee, S.E.1
Mitchell, R.A.2
Cheng, A.3
Hendrickson, E.A.4
-
108
-
-
0033560796
-
The DNA-dependent protein kinase
-
Smith,G.C.M. and Jackson,S.P. (1999) The DNA-dependent protein kinase. Genes Dev., 13, 916-934.
-
(1999)
Genes Dev.
, vol.13
, pp. 916-934
-
-
Smith, G.C.M.1
Jackson, S.P.2
-
109
-
-
0031930488
-
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
-
Hammersten,O. and Chu,G. (1998) DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl Acad. Sci. USA, 95, 525-530.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 525-530
-
-
Hammersten, O.1
Chu, G.2
-
110
-
-
0035859812
-
Activation and autoregulation of DNA-PK from structural single-stranded DNA and coding end hairpins
-
Soubeyrand,S., Torrance,H., Giffin,W., Gong,W., Schild-Poulter,C. and Hache,R.J.G. (2001) Activation and autoregulation of DNA-PK from structural single-stranded DNA and coding end hairpins. Proc. Natl Acad. Sci. USA, 98, 9605-9610.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9605-9610
-
-
Soubeyrand, S.1
Torrance, H.2
Giffin, W.3
Gong, W.4
Schild-Poulter, C.5
Hache, R.J.G.6
-
111
-
-
0032528228
-
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein CID
-
Yavuzer,U., Smith,G.C., Bliss,T., Werner,D. and Jackson,S.P. (1998) DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein CID. Genes Dev., 12, 2188-2199.
-
(1998)
Genes Dev.
, vol.12
, pp. 2188-2199
-
-
Yavuzer, U.1
Smith, G.C.2
Bliss, T.3
Werner, D.4
Jackson, S.P.5
-
112
-
-
0031696265
-
High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro
-
Yumoto,Y., Shirakawa,H., Yoshida,M., Suwa,A., Watanabe,F. and Teraoka,H. (1998) High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro. J. Biochem. (Tokyo), 124, 519-527.
-
(1998)
J. Biochem. (Tokyo)
, vol.124
, pp. 519-527
-
-
Yumoto, Y.1
Shirakawa, H.2
Yoshida, M.3
Suwa, A.4
Watanabe, F.5
Teraoka, H.6
-
113
-
-
0030771917
-
Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase
-
Huang,J., Nueda,A., Yoo,S. and Dynan,W.S. (1997) Heat shock transcription factor 1 binds selectively in vitro to Ku protein and the catalytic subunit of the DNA-dependent protein kinase. J. Biol. Chem., 272, 26009-26016.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 26009-26016
-
-
Huang, J.1
Nueda, A.2
Yoo, S.3
Dynan, W.S.4
-
114
-
-
0036025187
-
DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells
-
Oliveira,N.G., Castro,M., Rodrigues,A.S., Gil,O.M., Toscano-Rico,J.M. and Rueff,J. (2002) DNA-PK inhibitor wortmannin enhances DNA damage induced by bleomycin in V79 Chinese hamster cells. Teratog. Carcinog. Mutagen., 22, 343-351.
-
(2002)
Teratog. Carcinog. Mutagen.
, vol.22
, pp. 343-351
-
-
Oliveira, N.G.1
Castro, M.2
Rodrigues, A.S.3
Gil, O.M.4
Toscano-Rico, J.M.5
Rueff, J.6
-
115
-
-
0034031137
-
DNA double strand break repair in mammalian cells
-
Karran,P. (2000) DNA double strand break repair in mammalian cells. Curr. Opin. Genet. Dev., 10, 144-150.
-
(2000)
Curr. Opin. Genet. Dev.
, vol.10
, pp. 144-150
-
-
Karran, P.1
-
116
-
-
0037124373
-
Synapsis of DNA ends by DNA-dependent protein kinase
-
DeFazio,L.G., Stansel,R.M., Griffith,J.D. and Chu,G. (2002) Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J., 21, 3192-3200.
-
(2002)
EMBO J.
, vol.21
, pp. 3192-3200
-
-
DeFazio, L.G.1
Stansel, R.M.2
Griffith, J.D.3
Chu, G.4
-
117
-
-
0037106537
-
DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: Evidence for assembly of a repair complex
-
Mauldin,S.K., Getts,R.C., Liu,W. and Stamato,T.D. (2002) DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex. Nucleic Acids Res., 30, 4075-4087.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 4075-4087
-
-
Mauldin, S.K.1
Getts, R.C.2
Liu, W.3
Stamato, T.D.4
-
118
-
-
0031939411
-
The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase
-
Leber,R., Wise,T.W., Mizuta,R. and Meek,K. (1998) The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase. J. Biol. Chem., 273, 1794-1801.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1794-1801
-
-
Leber, R.1
Wise, T.W.2
Mizuta, R.3
Meek, K.4
-
119
-
-
0031214080
-
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
-
Critchlow,S.E., Bowater,R.P. and Jackson,S.P. (1997) Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol., 7, 588-598.
-
(1997)
Curr. Biol.
, vol.7
, pp. 588-598
-
-
Critchlow, S.E.1
Bowater, R.P.2
Jackson, S.P.3
-
120
-
-
0032085295
-
The 3′- to -5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks
-
Paull,T.T. and Gellert,M. (1998) The 3′- to -5′ exonuclease activity of Mre11 facilitates repair of DNA double-strand breaks. Mol. Cell, 1, 969-979.
-
(1998)
Mol. Cell
, vol.1
, pp. 969-979
-
-
Paull, T.T.1
Gellert, M.2
-
121
-
-
2242484657
-
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
-
Douglas,P., Sapkota,G.P., Morrice,N., Yu,Y., Goodarzi,A.A., Merkle,D., Meek,K., Alessi,D.R. and Lees-Miller,S.P. (2002) Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem. J., 368, 243-251.
-
(2002)
Biochem. J.
, vol.368
, pp. 243-251
-
-
Douglas, P.1
Sapkota, G.P.2
Morrice, N.3
Yu, Y.4
Goodarzi, A.A.5
Merkle, D.6
Meek, K.7
Alessi, D.R.8
Lees-Miller, S.P.9
-
122
-
-
0037106180
-
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
-
Chan,D.W., Chen,B.P., Prithivirajsingh,S., Kurimasa,A., Story,M.D., Qin,J. and Chen,D.J. (2002) Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks. Genes Dev., 16, 2333-2338.
-
(2002)
Genes Dev.
, vol.16
, pp. 2333-2338
-
-
Chan, D.W.1
Chen, B.P.2
Prithivirajsingh, S.3
Kurimasa, A.4
Story, M.D.5
Qin, J.6
Chen, D.J.7
-
123
-
-
0037166306
-
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro and its catalytic activities are regulated by phosphorylation
-
Karmakar,P., Piotrowski,J., Brosh,R.M.,Jr, Sommers,J.A., Miller,S.P., Cheng,W.H., Snowden.C.M., Ramsden,D.A. and Bohr,V.A. (2002) Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro and its catalytic activities are regulated by phosphorylation. J. Biol. Chem., 277, 18291-18302.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 18291-18302
-
-
Karmakar, P.1
Piotrowski, J.2
Brosh Jr., R.M.3
Sommers, J.A.4
Miller, S.P.5
Cheng, W.H.6
Snowden, C.M.7
Ramsden, D.A.8
Bohr, V.A.9
-
124
-
-
0036714151
-
Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein
-
Li,B. and Comai,L. (2002) Displacement of DNA-PKcs from DNA ends by the Werner syndrome protein. Nucleic Acids Res., 30, 3653-3661.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3653-3661
-
-
Li, B.1
Comai, L.2
-
125
-
-
0035893389
-
Interaction of p53 and DNA-PK in response to nucleoside analogues: Potential role as a sensor complex for DNA damage
-
Achanta,G., Pelicano,H., Feng,L., Plunkett,W. and Huang,P. (2001) Interaction of p53 and DNA-PK in response to nucleoside analogues: potential role as a sensor complex for DNA damage. Cancer Res., 61, 8723-8729.
-
(2001)
Cancer Res.
, vol.61
, pp. 8723-8729
-
-
Achanta, G.1
Pelicano, H.2
Feng, L.3
Plunkett, W.4
Huang, P.5
-
126
-
-
0030667702
-
DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2
-
Shieh,S.Y., Ikeda,M., Taya,Y. and Prives,C. (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell, 91, 325-334.
-
(1997)
Cell
, vol.91
, pp. 325-334
-
-
Shieh, S.Y.1
Ikeda, M.2
Taya, Y.3
Prives, C.4
-
127
-
-
0032514485
-
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
-
Woo,R.A., McLure,K.G., Lees-Miller,S.P., Rancourt,D.E. and Lee,P.W. (1998) DNA-dependent protein kinase acts upstream of p53 in response to DNA damage. Nature, 394, 700-704.
-
(1998)
Nature
, vol.394
, pp. 700-704
-
-
Woo, R.A.1
McLure, K.G.2
Lees-Miller, S.P.3
Rancourt, D.E.4
Lee, P.W.5
-
128
-
-
0031025079
-
DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage
-
Rathmell,W.K., Kaufmann,W.K., Hurt,J.C., Byrd,L.L. and Chu,G. (1997) DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Cancer Res., 57, 68-74.
-
(1997)
Cancer Res.
, vol.57
, pp. 68-74
-
-
Rathmell, W.K.1
Kaufmann, W.K.2
Hurt, J.C.3
Byrd, L.L.4
Chu, G.5
-
129
-
-
0034025078
-
The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase
-
Jhappan,C., Yusufzai,T.M., Anderson,S., Anver,M.R. and Merlino,G. (2000) The p53 response to DNA damage in vivo is independent of DNA-dependent protein kinase. Mol. Cell. Biol., 20, 4075-4083.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 4075-4083
-
-
Jhappan, C.1
Yusufzai, T.M.2
Anderson, S.3
Anver, M.R.4
Merlino, G.5
-
130
-
-
0033546182
-
DNA-dependent protein kinase-independent activation of p53 in response to DNA damage
-
Burma,S., Kurimasa,A., Xie,G., Taya,Y., Araki,R., Abe,M., Crissman,H.A., Ouyang,H., Li,G.C. and Chen,D.J. (1999) DNA-dependent protein kinase-independent activation of p53 in response to DNA damage. J. Biol. Chem., 274, 17139-17143.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 17139-17143
-
-
Burma, S.1
Kurimasa, A.2
Xie, G.3
Taya, Y.4
Araki, R.5
Abe, M.6
Crissman, H.A.7
Ouyang, H.8
Li, G.C.9
Chen, D.J.10
-
131
-
-
12944316615
-
The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest
-
Wang,S., Guo,M., Ouyang,H., Li,X., Cordon-Cardo,C., Kurimasa,A., Chen,D.J., Fuks,Z., Ling,C.C. and Li,G.C. (2000) The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest. Proc. Natl Acad. Sci. USA, 97, 1584-1588.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 1584-1588
-
-
Wang, S.1
Guo, M.2
Ouyang, H.3
Li, X.4
Cordon-Cardo, C.5
Kurimasa, A.6
Chen, D.J.7
Fuks, Z.8
Ling, C.C.9
Li, G.C.10
-
132
-
-
0037124322
-
DNA damage-induced apoptosis requires the DNA-dependent protein kinase and is mediated by the latent population of p53
-
Woo,R.A., Jack,M.T., Xu,Y., Burma,S., Chen,D.J. and Lee,P.W. (2002) DNA damage-induced apoptosis requires the DNA-dependent protein kinase and is mediated by the latent population of p53. EMBO J., 21, 3000-3008.
-
(2002)
EMBO J.
, vol.21
, pp. 3000-3008
-
-
Woo, R.A.1
Jack, M.T.2
Xu, Y.3
Burma, S.4
Chen, D.J.5
Lee, P.W.6
-
133
-
-
0030945148
-
Functional interaction of DNA-PK and c-Abl in response to DNA damage
-
Kharbanda,S., Pandey,P., Jin,S., Inoue.S., Bharti,A., Yuan,Z.-M., Weichselbaum,R., Weaver,D. and Kufe,D. (1997) Functional interaction of DNA-PK and c-Abl in response to DNA damage. Nature, 386, 732-735.
-
(1997)
Nature
, vol.386
, pp. 732-735
-
-
Kharbanda, S.1
Pandey, P.2
Jin, S.3
Inoue, S.4
Bharti, A.5
Yuan, Z.-M.6
Weichselbaum, R.7
Weaver, D.8
Kufe, D.9
-
134
-
-
0037080675
-
Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin
-
Zou,L., Cortez,D. and Elledge,S.J. (2002) Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev., 16, 198-208.
-
(2002)
Genes Dev.
, vol.16
, pp. 198-208
-
-
Zou, L.1
Cortez, D.2
Elledge, S.J.3
-
135
-
-
0036544565
-
Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest
-
Franchitto,A. and Pichierri,P. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. J. Cell Biol., 157, 19-30.
-
(2002)
J. Cell Biol.
, vol.157
, pp. 19-30
-
-
Franchitto, A.1
Pichierri, P.2
-
136
-
-
0036317093
-
The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA
-
Offer,H., Erez,N., Zurer,I., Tang,X., Milyavsky,M., Goldfinger,N. and Rotter,V. (2002) The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA. Carcinogenesis, 23, 1025-1032.
-
(2002)
Carcinogenesis
, vol.23
, pp. 1025-1032
-
-
Offer, H.1
Erez, N.2
Zurer, I.3
Tang, X.4
Milyavsky, M.5
Goldfinger, N.6
Rotter, V.7
|