Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

Genes and Development

Volumn 16, Issue 18, 2002, Pages 2333-2338

  Chan, Doug W ^a,b   Chen, Benjamin Ping Chi ^a   Prithivirajsingh, Sheela ^c   Kurimasa, Akihiro ^a,d   Story, Michael D ^c   Qin, Jun ^b   Chen, David J ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d TOTTORI UNIVERSITY   (Japan)

Author keywords

Autophosphorytation; DNA damage response; DNA PK; DNA PKcs; Ionizing radiation; Ku; Nonhomologous end joining; Radiation sensitivity

Indexed keywords

DEOXYRIBONUCLEOPROTEIN; DNA DEPENDENT PROTEIN KINASE; DOUBLE STRANDED DNA; THREONINE;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CATALYST; CONTROLLED STUDY; DNA REPAIR; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

NON-PROGRAMMATIC;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, NUCLEAR; BASE SEQUENCE; CATALYTIC DOMAIN; CELL LINE; CRICETINAE; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE;

MAMMALIA;

EID: 0037106180     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1015202     Document Type: Article

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