-
3
-
-
0028286463
-
DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps
-
Morozov, V. E., Falzon, M., Anderson, C. W., and Kuff, E. L. DNA-dependent protein kinase is activated by nicks and larger single-stranded gaps. J. Biol. Chem., 269: 16684-16688, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 16684-16688
-
-
Morozov, V.E.1
Falzon, M.2
Anderson, C.W.3
Kuff, E.L.4
-
4
-
-
0027397867
-
The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
-
Gottlieb, T. M., and Jackson, S. P. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell, 72: 131-142, 1993.
-
(1993)
Cell
, vol.72
, pp. 131-142
-
-
Gottlieb, T.M.1
Jackson, S.P.2
-
5
-
-
0027048773
-
Ku autoantigen is the regulatory component of a template associated protein kinase that phosphorylates RNA polyraerase-II
-
Dvir, A., Peterson, S. R., Knuth, M. W., Lu, H., and Dynan, W. S. Ku autoantigen is the regulatory component of a template associated protein kinase that phosphorylates RNA polyraerase-II. Proc. Natl. Acad. Sci. USA, 89: 11920-11924, 1992.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11920-11924
-
-
Dvir, A.1
Peterson, S.R.2
Knuth, M.W.3
Lu, H.4
Dynan, W.S.5
-
6
-
-
0029156599
-
DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
-
Hartley, K. O., Gell, D., Smith, G. C. M., Zhang, H., Divecha, N., Cotinelly, M A., Admon, A., Lees-Miller, S. P., Anderson, C. W., and Jackson, S. P. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell, 82: 849-856, 1995.
-
(1995)
Cell
, vol.82
, pp. 849-856
-
-
Hartley, K.O.1
Gell, D.2
Smith, G.C.M.3
Zhang, H.4
Divecha, N.5
Cotinelly, M.A.6
Admon, A.7
Lees-Miller, S.P.8
Anderson, C.W.9
Jackson, S.P.10
-
7
-
-
0030442683
-
DNA damage detection by DNA dependent protein kinase and related enzymes
-
Jackson, S. P. DNA damage detection by DNA dependent protein kinase and related enzymes. Cancer Surv., 28: 261-279, 1996.
-
(1996)
Cancer Surv.
, vol.28
, pp. 261-279
-
-
Jackson, S.P.1
-
8
-
-
0028791446
-
DNA double-strand break repair and V(D)J recombination: Involvement of DNA-PK
-
Jackson, S. P., and Jeggo, P. A. DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem. Sci., 20: 412-415, 1995.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 412-415
-
-
Jackson, S.P.1
Jeggo, P.A.2
-
9
-
-
0031059531
-
Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double strand breaks
-
Lieber, M. R., Grawunder, U., Wu, X. T., and Yaneva, M. Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double strand breaks. Curr. Opin. Genet. Dev., 7: 99-104, 1997.
-
(1997)
Curr. Opin. Genet. Dev.
, vol.7
, pp. 99-104
-
-
Lieber, M.R.1
Grawunder, U.2
Wu, X.T.3
Yaneva, M.4
-
10
-
-
12644253825
-
Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice
-
Araki, R., Fujimori, A., Hamatani, K., Mita, K., Saito, T., Mori, M., Fukumura, R., Morimyo, M., Muto, M., Itoh, M., Tatsumi, K. and Abe, M. Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice. Proc. Natl. Acad. Sci. USA, 94: 2438-2443, 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2438-2443
-
-
Araki, R.1
Fujimori, A.2
Hamatani, K.3
Mita, K.4
Saito, T.5
Mori, M.6
Fukumura, R.7
Morimyo, M.8
Muto, M.9
Itoh, M.10
Tatsumi, K.11
Abe, M.12
-
11
-
-
0029788520
-
Identification of a nonsense mutation in the carboxyl region of DNA-dependent protein kinase catalytic subunit in the seid mouse
-
Blunt, T., Gell, D., Fox, M., Taccioli, G. E. Lehmann, A. R., Jackson, S. P., and Jeggo, P. A. Identification of a nonsense mutation in the carboxyl region of DNA-dependent protein kinase catalytic subunit in the seid mouse. Proc. Natl. Acad. Sci. USA, 93: 10285-10290, 1996.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 10285-10290
-
-
Blunt, T.1
Gell, D.2
Fox, M.3
Taccioli, G.E.4
Lehmann, A.R.5
Jackson, S.P.6
Jeggo, P.A.7
-
12
-
-
0029791450
-
Biochemical and genetic defects in the DNA-dependent protein kinase in murine seid lymphocytes
-
Danska, J. S., Holland, D. P., Mariathasan, S., Williams, K. M., and Guidos, C. J. Biochemical and genetic defects in the DNA-dependent protein kinase in murine seid lymphocytes. Mol. Cell. Biol., 16: 5507-5517, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5507-5517
-
-
Danska, J.S.1
Holland, D.P.2
Mariathasan, S.3
Williams, K.M.4
Guidos, C.J.5
-
13
-
-
0030746109
-
Interaction of DNA-dependent protein kinase with DNA and with Ku: Biochemical and atomic force microscopy studies
-
Yaneva, M., Kowalewski, T., and Lieber, M. R. Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic force microscopy studies. EMBO J., 16: 5098-5112, 1997.
-
(1997)
EMBO J.
, vol.16
, pp. 5098-5112
-
-
Yaneva, M.1
Kowalewski, T.2
Lieber, M.R.3
-
14
-
-
0031930488
-
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
-
Hammarsten, O., and Chu, G. DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Proc. Natl. Acad. Sci. USA, 95: 525-530, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 525-530
-
-
Hammarsten, O.1
Chu, G.2
-
15
-
-
0032528228
-
DNA end-independent activation of DNA-PK mediated via association with the DNA binding protein CID
-
Yavuzer, U., Smith, G. C. M., Bliss, T., Werner, D., and Jackson, S. P. DNA end-independent activation of DNA-PK mediated via association with the DNA binding protein CID. Genes Dev., 12: 2188-2199, 1998.
-
(1998)
Genes Dev.
, vol.12
, pp. 2188-2199
-
-
Yavuzer, U.1
Smith, G.C.M.2
Bliss, T.3
Werner, D.4
Jackson, S.P.5
-
16
-
-
0030992837
-
Signalling through the lipid products of phosphoinositide-3-OH kinase
-
Toker, A., and Cantley, L. C. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature (Lond.), 387: 673-676, 1997.
-
(1997)
Nature (Lond.)
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
17
-
-
0029127643
-
ATM-related genes: What do they tell us about functions of the human gene?
-
Zakian, V. A. ATM-related genes: what do they tell us about functions of the human gene? Cell. 82: 685-687, 1995.
-
(1995)
Cell.
, vol.82
, pp. 685-687
-
-
Zakian, V.A.1
-
18
-
-
0028856331
-
When is a lipid kinase not a lipid kinase? When it is a protein kinase
-
Hunter, T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell, 83: 1-4, 1995.
-
(1995)
Cell
, vol.83
, pp. 1-4
-
-
Hunter, T.1
-
19
-
-
0029118603
-
Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase
-
Ui, M., Okada, T., Hazeki, K., and Hazeki, O. Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. Trends Biochem. Sci., 20: 303-307, 1995.
-
(1995)
Trends Biochem. Sci.
, vol.20
, pp. 303-307
-
-
Ui, M.1
Okada, T.2
Hazeki, K.3
Hazeki, O.4
-
20
-
-
0028217223
-
Wortmannin, a potent and selective inhibitor of phosphatidylinositol 3-kinase
-
Powis, G., Bonjouklian, R., Berggren, M. M., Gallegos. A., Abraham, R., Ashendal, C., Zalkow, L., Matter, W. F., Dodge, J., Grindley, G., and Vlahos, C. J. Wortmannin, a potent and selective inhibitor of phosphatidylinositol 3-kinase. Cancer Res., 54: 2419-2423, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 2419-2423
-
-
Powis, G.1
Bonjouklian, R.2
Berggren, M.M.3
Gallegos, A.4
Abraham, R.5
Ashendal, C.6
Zalkow, L.7
Matter, W.F.8
Dodge, J.9
Grindley, G.10
Vlahos, C.J.11
-
21
-
-
0030447538
-
Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts
-
Le Romancer, M., Cosulich, S. C., Jackson, S. P., and Clarke, P. R. Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts. J. Cell. Sci., 709: 3121-3127, 1996.
-
(1996)
J. Cell. Sci.
, vol.709
, pp. 3121-3127
-
-
Le Romancer, M.1
Cosulich, S.C.2
Jackson, S.P.3
Clarke, P.R.4
-
22
-
-
0029840338
-
End-joining of free radical-mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceding removal of damaged 3′ termini
-
Gu, X. Y., Bennet, R. A. O., and Povrik, L. F. End-joining of free radical-mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceding removal of damaged 3′ termini. J. Biol. Chem., 271: 19660-19663, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19660-19663
-
-
Gu, X.Y.1
Bennet, R.A.O.2
Povrik, L.F.3
-
23
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria, J. N., Tibbetts, R. S., Busby, E. C., Kennedy, A. P., Hill, D. E., and Abraham, R. T. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res., 58: 4375-4382, 1998.
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
24
-
-
0030066023
-
The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage
-
Price, B. D., and Youmell, M. B. The phosphatidylinositol 3-kinase inhibitor wortmannin sensitizes murine fibroblasts and human tumor cells to radiation and blocks induction of p53 following DNA damage. Cancer Res., 56: 246-250, 1995.
-
(1995)
Cancer Res.
, vol.56
, pp. 246-250
-
-
Price, B.D.1
Youmell, M.B.2
-
25
-
-
0029803485
-
Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells
-
Lond.
-
Boulton, S., Kyle, S., Yalcintepe, L., and Durkacz, B. W. Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells. Carcinogenesis (Lond.), 17: 2285-2290, 1997.
-
(1997)
Carcinogenesis
, vol.17
, pp. 2285-2290
-
-
Boulton, S.1
Kyle, S.2
Yalcintepe, L.3
Durkacz, B.W.4
-
27
-
-
0031765340
-
A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation
-
Hosoi, Y., Miyachi, H., Matsumoto, Y., Ikehata, H., Komura, J., Ishii, K., Zhao, H. J., Yoshida, M., Takai, Y., Yamada, S., Suzuki, N., and Ono, T. A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer, 78: 642-647, 1998.
-
(1998)
Int. J. Cancer
, vol.78
, pp. 642-647
-
-
Hosoi, Y.1
Miyachi, H.2
Matsumoto, Y.3
Ikehata, H.4
Komura, J.5
Ishii, K.6
Zhao, H.J.7
Yoshida, M.8
Takai, Y.9
Yamada, S.10
Suzuki, N.11
Ono, T.12
-
28
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Washington DC
-
Banin, S., Moyal, L., Sheih, S. Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., and Ziv, Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science (Washington DC), 281: 1674-1677, 1998.
-
(1998)
Science
, vol.281
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Sheih, S.Y.3
Taya, Y.4
Anderson, C.W.5
Chessa, L.6
Smorodinsky, N.I.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
Ziv, Y.11
-
29
-
-
0028937877
-
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
-
Washington DC
-
Lees-Miller, S. P., Godbout, R., Chan, D. W., Weinfeld, M., Day, R. S., Barron, G. M., and Allalunis-Turner, J. Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line. Science (Washington DC), 267; 1183-1185, 1995.
-
(1995)
Science
, vol.267
, pp. 1183-1185
-
-
Lees-Miller, S.P.1
Godbout, R.2
Chan, D.W.3
Weinfeld, M.4
Day, R.S.5
Barron, G.M.6
Allalunis-Turner, J.7
-
30
-
-
0026687883
-
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53
-
Lees-Miller, S. P., Sakaguchi, K., Ullrich, S. J., Appella, E., and Anderson, C. W. Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol. Cell. Biol., 12: 5041-5049, 1992.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5041-5049
-
-
Lees-Miller, S.P.1
Sakaguchi, K.2
Ullrich, S.J.3
Appella, E.4
Anderson, C.W.5
-
31
-
-
0028897304
-
DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
-
Finnie, N. J., Gottlieb, T. M., Blunt, T., Jeggo, P. A., and Jackson, S. P. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc. Natl. Acad. Sci. USA, 92: 320-324, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 320-324
-
-
Finnie, N.J.1
Gottlieb, T.M.2
Blunt, T.3
Jeggo, P.A.4
Jackson, S.P.5
-
32
-
-
0027246193
-
Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II
-
Dvir, A., Stein, L. Y., Calore, B. L., and Dynan, W. S. Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J. Biol. Chem., 268: 10440-10447, 1993.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 10440-10447
-
-
Dvir, A.1
Stein, L.Y.2
Calore, B.L.3
Dynan, W.S.4
-
33
-
-
0029965452
-
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
-
Wymann, M. P., Bulgarelli-leva, G., Zvelebil, M. J., Pirola. L., Vanhaesebroeck, B., Waterfield, M. D., and Panayolou, G. Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. Mol. Cell. Biol., 16: 1722-1733, 1996.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 1722-1733
-
-
Wymann, M.P.1
Bulgarelli-Leva, G.2
Zvelebil, M.J.3
Pirola, L.4
Vanhaesebroeck, B.5
Waterfield, M.D.6
Panayolou, G.7
-
34
-
-
0021100690
-
Accurate transcription initiation by RNA polymerase-II in a soluble extract from isolated mammalian nuclei
-
Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. Accurate transcription initiation by RNA polymerase-II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 5: 1475-1489, 1983.
-
(1983)
Nucleic Acids Res.
, vol.5
, pp. 1475-1489
-
-
Dignam, J.D.1
Lebovitz, R.M.2
Roeder, R.G.3
-
35
-
-
8944241298
-
DNA-dependent protein kinase catalytic subunit: A target for the ICE-like protease CPP32 in apoptosis
-
Song, Q., Lees-Miller, S., Kumar, S., Zhang, N., Smith, G. C. M., Jackson, S. P., Alnemri, E. S., Litwack, G., and Lavin, M. F. DNA-dependent protein kinase catalytic subunit: a target for the ICE-like protease CPP32 in apoptosis. EMBO J., 15: 3238-3246, 1996.
-
(1996)
EMBO J.
, vol.15
, pp. 3238-3246
-
-
Song, Q.1
Lees-Miller, S.2
Kumar, S.3
Zhang, N.4
Smith, G.C.M.5
Jackson, S.P.6
Alnemri, E.S.7
Litwack, G.8
Lavin, M.F.9
-
37
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos, C. J., Matter, W. F., Hui, K. Y., and Brown, R. F. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269: 5241-5248, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
38
-
-
0026726483
-
The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs
-
Matter, W. F., Brown, R. F., and Vlahos, C. J. The inhibition of phosphatidylinositol 3-kinase by quercetin and analogs. Biochem. Biophys. Res. Commun., 186: 624-631, 1992.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.186
, pp. 624-631
-
-
Matter, W.F.1
Brown, R.F.2
Vlahos, C.J.3
-
39
-
-
0024413698
-
Screening of phosphatidylinositol kinase inhibitors from streptomyces
-
Tokyo
-
Nishioka, H., Imoto, M., Sawa, T., Hamada, M., Naganawa, H., Takeuchi, T., and Umezawa, K. Screening of phosphatidylinositol kinase inhibitors from streptomyces. J. Antibiol. (Tokyo), 42: 823-825, 1989.
-
(1989)
J. Antibiol.
, vol.42
, pp. 823-825
-
-
Nishioka, H.1
Imoto, M.2
Sawa, T.3
Hamada, M.4
Naganawa, H.5
Takeuchi, T.6
Umezawa, K.7
-
40
-
-
0028881847
-
DNA-dependent protein kinase is one of a subset of autoanligens specifically cleaved early during apoptosis
-
Casciola-Rosen, L. A., Anhalt, G. J., and Rosen, A. DNA-dependent protein kinase is one of a subset of autoanligens specifically cleaved early during apoptosis. J. Exp. Med., 182: 1625-1634, 1995.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1625-1634
-
-
Casciola-Rosen, L.A.1
Anhalt, G.J.2
Rosen, A.3
-
41
-
-
0029763211
-
DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease
-
Han, Z., Malik, N., Carter, W. H., Reeves, J. H., Wyche, J. H., and Hendrickson, E. A. DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease. J. Biol. Chem., 271: 25035-25040, 1996.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 25035-25040
-
-
Han, Z.1
Malik, N.2
Carter, W.H.3
Reeves, J.H.4
Wyche, J.H.5
Hendrickson, E.A.6
|