The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia

Seminars in Hematology

Volumn 37, Issue 4, 2000, Pages 368-380

  Hayashi, Yasuhide ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ACUTE GRANULOCYTIC LEUKEMIA; CANCER DIAGNOSIS; CHROMOSOMAL LOCALIZATION; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION; CONFERENCE PAPER; CYTOGENETICS; FOLLOW UP; GENE LOCATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HUMAN; LEUKEMOGENESIS; MOLECULAR CLONING; PRIORITY JOURNAL;

EID: 0033785391     PISSN: 00371963     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0037-1963(00)90017-9     Document Type: Conference Paper

References (81)

1. The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion
2. The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10
3. The CBP coactivator is a histone acetyltransferase
4. Breakpoint heterogeneity in t(10;11) translocation in AML-M4/M5 resulting in fusion of AF10 and MLL is resolved by fluorescent in situ hybridization analysis
5. The t(7;11) (p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
6. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
7. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites
8. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia
9. Infant acute leukemias show the same biased distribution of ALL1 gene breaks as topoisomerase II related secondary acute leukemias
10. Detection of fusion transcripts generated by the inversion 16 chromosome in acute myelogenous leukemia
11. An MLL-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
12. Association of SET domain and myotubularin-related proteins modulates growth control
13. Abi-2, a novel SH3-containing protein interacts with the c-Abl tyrosine kinase and modulates c-Abl transforming activity
14. The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus
15. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukemias
16. The AML1-ETO chimaeric transcription feature in acute myeloid leukemia: Biology and clinical significance
17. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family
18. Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt
19. Eps 8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals
20. Characterization of acute promyelocytic leukemia cases with PML-RARa break/fusion sites in PML exon 6: Identification of a subgroup with decreased in vitro responsiveness to all-trans retinoic acid
21. The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family
22. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
23. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
24. SN-1, a novel leukemic cell line with t(11;16)(q23;p13): Myeloid characteristics and resistance to retinoids and vitamin D3
25. Immunoglobulin heavy chain gene rearrangements and mixed lineage characteristics in acute leukemias with the 11;19 translocation
26. Defects in yolk sac hematopoiesis in MLL-null embryos
27. HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities
28. The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia
29. An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
30. Adenoviral EIA-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
31. Clinical and hematologic characteristics in acute leukemia with 11q23 translocations
32. The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/COR) family; MTGR 1
33. Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
34. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcript
35. Immortalization and leukemic transformation of a myelomonocytic precursor by retroviral transduced HRX-ENL
36. Fusion between transcription factor CBF β/PEBP2p and a myosin heavy chain in acute myeloid leukemia
37. Oncogenic transcription factors in the human acute leukemias
38. t(8;21) Breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1
39. The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript
40. Genes on chromosomes 4, 9 and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
41. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia
42. NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)
43. Consistent detection of CALM-AF10 chimaeric transcripts in haematological malignancies with t(10;11)(p13;q14) and identification of novel transcripts
44. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias
45. 11p15 translocations involving the NUP98 gene in childhood therapy-related acute myeloid leukemia/myelodysplastic syndrome
46. Persistence of the 8;21 translocation in patients with acute myeloid leukemia type M2 in long term remission
47. Correlation between cell morphology and expression of the AML1/ETO chimeric transcript in patients with acute myeloid leukemia without the t(8;21)
48. The transcriptional coactivators p300 and CBP are histone acetyltransferases
49. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
50. Anatomy of the 5q- deletion: Different sex ratios and deleted 5q bands in MDS and AML
51. Secondary acute myeloid leukemia in children treated for acute lymphoid leukemia
52. Chromosomal translocations in human cancer
53. NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia
54. A new consistent chromosomal abnormality in chronic myelogenous leukemia
55. The critical role of chromosome translocations in human leukemias
56. Mapping chromosome band 11q23 in human acute leukemia with biotinylated probes: Identification of 11q23 translocation breakpoints with a yeast artificial chromosome
57. All patients with the t(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders
58. The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INll and SNR1 proteins, components of the SWI/SNF complex
59. 11q23 rearrangements in acute leukemia
60. Disappearance of AML1-MTG8(ETO) fusion transcript in acute myeloid leukaemia patients with t(8;21) in long-term remission
61. Self fusion of the ALL-1 gene: A new genetic mechanism for acute leukemia
62. An ets-related gene, ERG, is rearranged in human myeloid leukemia with t(16;21) chromosomal translocation
63. Abl-interactor-1, a novel SH3 protein binding to the carboxy-terminal portion of the Abl protein, suppress v-abl transforming activity
64. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
65. EEN encode for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
66. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
67. An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region
68. Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia
69. The t(11;16)(q23;p13) translocation in myelodysplastic syndrome fuses the MLL gene to the CBP gene
70. ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)
71. AF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)
72. AF17q25, a putative seprin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)
73. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
74. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
75. Monitoring of minimal residual discase by quantitative reverse transcriptase-polymerase chain reaction for AML1-MTG8 transcripts in AML-M2 with t(8;21)
76. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDACI complex
77. Role of PML in cell growth and the retinoic acid pathway
78. Embryonic lethality and improvement of hematopoiesis in mice heterozygous for an AML1-ETO fusion gene
79. Altered Hox expression and segmental identity in Mll-mutant mice
80. Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map
81. Identification of a gene (MLL) which spans the breakpoint in 11q23 translocations associated with human leukemias