메뉴 건너뛰기




Volumn 18, Issue 3, 1997, Pages 221-235

Expression and function of recombination activating genes in mature b cells

Author keywords

Germinal center; Mature B cell; Receptor editing; Recombination activating gene; V(D)J rearrangement

Indexed keywords

B LYMPHOCYTE; CELL MATURATION; GENE ACTIVATION; GENE EXPRESSION; GENE REARRANGEMENT; GENETIC RECOMBINATION; GERMINAL CENTER; HUMAN; IMMUNOGLOBULIN GENE; LYMPHOID TISSUE; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE RECEPTOR GENE;

EID: 0031391172     PISSN: 10408401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (21)

References (103)
  • 1
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa, S., Somatic generation of antibody diversity, Nature, 302, 575-581, 1983.
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 2
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., Schatz, D. G., Gorka, C., and Baltimore, D., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination, Science, 248, 1517-1523, 1990.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 3
    • 0026708716 scopus 로고
    • V(D)J recombination: Molecular biology and regulation
    • Schatz, D. G., Oettinger, M. A., and Schlissel, M. S., V(D)J recombination: molecular biology and regulation, Ann. Rev. Immunol., 10, 359-383, 1992.
    • (1992) Ann. Rev. Immunol. , vol.10 , pp. 359-383
    • Schatz, D.G.1    Oettinger, M.A.2    Schlissel, M.S.3
  • 4
    • 0028267348 scopus 로고
    • The B cell antigen receptor in B-cell development
    • Desiderio, S., The B cell antigen receptor in B-cell development, Curr. Opin. Immunol., 6, 248-256, 1994.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 248-256
    • Desiderio, S.1
  • 5
    • 0028198052 scopus 로고
    • Regulation of gene expression at early stages of B-cell differentiation
    • Hagman, J. and Grosschedl, R., Regulation of gene expression at early stages of B-cell differentiation, Curr. Opin. Immunol., 6, 222-230, 1994.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 222-230
    • Hagman, J.1    Grosschedl, R.2
  • 8
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG-1 and RAG-2 proteins and occurs in two steps
    • McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M., and Oettinger, M. A., Cleavage at a V(D)J recombination signal requires only RAG-1 and RAG-2 proteins and occurs in two steps., Cell, 83, 387-395, 1995.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Van Gent, D.C.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 9
    • 0030009253 scopus 로고    scopus 로고
    • The RAG-1 and RAG-2 proteins establish the 12/23 rule in V(D)J recombination
    • van Gent, D. C., Ramsden, D. A., and Gellert, M., The RAG-1 and RAG-2 proteins establish the 12/23 rule in V(D)J recombination, Cell, 85, 107-113, 1996.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 10
    • 0030980386 scopus 로고    scopus 로고
    • V(D)J recombination: Modulation of RAG-1 and RAG-2 cleavage activity on 12/23 substrate by whole cell extract and DNA-bending proteins
    • Sawchuk, D. J., Weis-Garcia, F., Malik, S., Besmer, E., Bustin, M., Nussenzweig, M. C., and Cortes, P., V(D)J recombination: modulation of RAG-1 and RAG-2 cleavage activity on 12/23 substrate by whole cell extract and DNA-bending proteins, J. Exp. Med., 185, 2025-2032, 1997.
    • (1997) J. Exp. Med. , vol.185 , pp. 2025-2032
    • Sawchuk, D.J.1    Weis-Garcia, F.2    Malik, S.3    Besmer, E.4    Bustin, M.5    Nussenzweig, M.C.6    Cortes, P.7
  • 11
    • 0030837472 scopus 로고    scopus 로고
    • V(D)J recombination in Ku86-deficient mice: Distinct effects on coding, signal, and hybrid joint formations
    • Bogue, M. A., Wang, C., Zhu, C., and Roth, D. B., V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formations, Immunity, 7, 37-47, 1997.
    • (1997) Immunity , vol.7 , pp. 37-47
    • Bogue, M.A.1    Wang, C.2    Zhu, C.3    Roth, D.B.4
  • 12
    • 0001265782 scopus 로고    scopus 로고
    • RAG-1 mediates signal sequence recognition and recruitment of RAG-2 in V(D)J recombination
    • Difilippantonio, M. J., McMahan, C. J., Eastman, Q. M., Spanopoulou, E., and Schatz, D. G., RAG-1 mediates signal sequence recognition and recruitment of RAG-2 in V(D)J recombination, Cell, 87, 253-262, 1996.
    • (1996) Cell , vol.87 , pp. 253-262
    • Difilippantonio, M.J.1    McMahan, C.J.2    Eastman, Q.M.3    Spanopoulou, E.4    Schatz, D.G.5
  • 13
    • 0030964130 scopus 로고    scopus 로고
    • A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage
    • Hiom, K. and Gellert, M., A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage, Cell, 88, 65-72, 1997.
    • (1997) Cell , vol.88 , pp. 65-72
    • Hiom, K.1    Gellert, M.2
  • 14
    • 0030753633 scopus 로고    scopus 로고
    • Cell-free V(D)J recombination
    • Ramsden, D. A., Paull, T. T., and Gellert, M., Cell-free V(D)J recombination, Nature, 388, 488-491, 1997.
    • (1997) Nature , vol.388 , pp. 488-491
    • Ramsden, D.A.1    Paull, T.T.2    Gellert, M.3
  • 16
    • 0028828269 scopus 로고
    • Downregulation of RAG-1 RAG-2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement
    • Grawunder, U., Leu, T. M. J., Shatz, D. G., Werner, A., Rolink, A. G., Melchers, F., and Winkler, T. H., Downregulation of RAG-1 RAG-2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement, Immunity, 3, 601-608, 1995.
    • (1995) Immunity , vol.3 , pp. 601-608
    • Grawunder, U.1    Leu, T.M.J.2    Shatz, D.G.3    Werner, A.4    Rolink, A.G.5    Melchers, F.6    Winkler, T.H.7
  • 18
    • 0028856335 scopus 로고
    • Immature B cells from human and mouse bone marrow can change their surface light chain expression
    • Ghia, P., Gratwohl, A., Singer, E., Winkler, T. H., Melchers, F., and Rolink, A. G., Immature B cells from human and mouse bone marrow can change their surface light chain expression, Eur. J. Immunol., 25, 3108-3114, 1995.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 3108-3114
    • Ghia, P.1    Gratwohl, A.2    Singer, E.3    Winkler, T.H.4    Melchers, F.5    Rolink, A.G.6
  • 19
    • 0026753294 scopus 로고
    • Crosslinking of the cell surface immunoglobulin-surrogate light chain complex on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus
    • Tsubata, T., Tsubata, R., and Reth, M., Crosslinking of the cell surface immunoglobulin-surrogate light chain complex on pre-B cells induces activation of V gene rearrangements at the immunoglobulin κ locus, Int. lmmunol., 4, 637-641, 1992.
    • (1992) Int. Lmmunol. , vol.4 , pp. 637-641
    • Tsubata, T.1    Tsubata, R.2    Reth, M.3
  • 22
    • 0028256203 scopus 로고
    • Two waves of recombination activating gene expression in developing thymocytes
    • Wilson, A., Held, W., and MacDonald, H. R., Two waves of recombination activating gene expression in developing thymocytes, J. Exp. Med., 179, 1355-1360, 1994.
    • (1994) J. Exp. Med. , vol.179 , pp. 1355-1360
    • Wilson, A.1    Held, W.2    MacDonald, H.R.3
  • 23
    • 0027406812 scopus 로고
    • Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes
    • Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K. M., Loh, D. Y., Reinherz, E. L., and Alt, F. W., Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes, Science, 259, 822-825, 1993.
    • (1993) Science , vol.259 , pp. 822-825
    • Shinkai, Y.1    Koyasu, S.2    Nakayama, K.3    Murphy, K.M.4    Loh, D.Y.5    Reinherz, E.L.6    Alt, F.W.7
  • 25
    • 0026446547 scopus 로고
    • Emergence of committed B lymphoid progenitors in the developing chicken embryo
    • Reynaud, C. A., Imhof, B. A., Anquez, V., and Weill, J. C., Emergence of committed B lymphoid progenitors in the developing chicken embryo, EMBO J., 11, 4349-4358, 1992.
    • (1992) EMBO J. , vol.11 , pp. 4349-4358
    • Reynaud, C.A.1    Imhof, B.A.2    Anquez, V.3    Weill, J.C.4
  • 27
    • 0026571273 scopus 로고
    • Differed expression of the recombination activating gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement
    • Guy-Grand, D., Vanden Broecke, C., Briottet, C., Malassis-Seris, M., Selz, F., and Vassalli, P., Differed expression of the recombination activating gene RAG-1 in various populations of thymocytes, peripheral T cells and gut thymus-independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement, Eur. J. Immunol., 22, 505-510, 1992.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 505-510
    • Guy-Grand, D.1    Vanden Broecke, C.2    Briottet, C.3    Malassis-Seris, M.4    Selz, F.5    Vassalli, P.6
  • 28
    • 0029000949 scopus 로고
    • Intra- And extra-thymic expression of the pre-T cell receptor α gene
    • Bruno, L., Rocha, B., Rolink, A., von Boehmer, H., and Rodewald, H.-R., Intra- and extra-thymic expression of the pre-T cell receptor α gene, Eur. J. Immunol., 25, 1877-1882, 1995.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1877-1882
    • Bruno, L.1    Rocha, B.2    Rolink, A.3    Von Boehmer, H.4    Rodewald, H.-R.5
  • 29
    • 0029847625 scopus 로고    scopus 로고
    • RAG-, RAG-2, and pre-T cell receptor α chain expression by adult human hepatic T cells: Evidence for extrathymic T cell maturation
    • Collins, C., Norris, S., McEntee, G., Traynor, O., Buruno, L., von Boehmer, H., Hegarty, J., and O'Farrelly, C., RAG-, RAG-2, and pre-T cell receptor α chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation, Eur. J. Immunol., 26, 3114-3118, 1996.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 3114-3118
    • Collins, C.1    Norris, S.2    McEntee, G.3    Traynor, O.4    Buruno, L.5    Von Boehmer, H.6    Hegarty, J.7    O'Farrelly, C.8
  • 30
    • 0026029613 scopus 로고
    • The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system
    • Chun, J. J., Schatz, D. G., Oettinger, M. A., Jaenisch, R., and Baltimore, D., The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system, Cell, 64, 189-200, 1991.
    • (1991) Cell , vol.64 , pp. 189-200
    • Chun, J.J.1    Schatz, D.G.2    Oettinger, M.A.3    Jaenisch, R.4    Baltimore, D.5
  • 31
    • 0025642435 scopus 로고
    • V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP
    • Menetski, J. P. and Gellert, M., V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMP, Proc. Natl. Acad. Sci. U.S.A., 87, 9324-9328, 1990.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 9324-9328
    • Menetski, J.P.1    Gellert, M.2
  • 32
    • 0026489124 scopus 로고
    • Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional control
    • Neale, G. A. M., Fitzgerald, T. J., and Goorha, R. M., Expression of the V(D)J recombinase gene RAG-1 is tightly regulated and involves both transcriptional and post-transcriptional control, Mol. Immunol., 29, 1457-1466, 1992.
    • (1992) Mol. Immunol. , vol.29 , pp. 1457-1466
    • Neale, G.A.M.1    Fitzgerald, T.J.2    Goorha, R.M.3
  • 33
    • 0028941675 scopus 로고
    • RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines
    • Casillas, A. M., Thompson, A.D., Cheshier, S., Hernandez, S., and Aguilera, R. J., RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines, Mol. Immunol., 32, 167-175, 1995.
    • (1995) Mol. Immunol. , vol.32 , pp. 167-175
    • Casillas, A.M.1    Thompson, A.D.2    Cheshier, S.3    Hernandez, S.4    Aguilera, R.J.5
  • 34
    • 0023925585 scopus 로고
    • B cell precursor growth-promoting activity: Purification and characterization of a growth factor active on lymphocyte precursors
    • Namen, A. E., Schmierer, A. E., March, C. J., Overell, R. W., Park, L. S., Urdal, D. L., and Mochizuki, D. Y., B cell precursor growth-promoting activity: purification and characterization of a growth factor active on lymphocyte precursors, J. Exp. Med., 167, 988-1002, 1988.
    • (1988) J. Exp. Med. , vol.167 , pp. 988-1002
    • Namen, A.E.1    Schmierer, A.E.2    March, C.J.3    Overell, R.W.4    Park, L.S.5    Urdal, D.L.6    Mochizuki, D.Y.7
  • 35
    • 0024307414 scopus 로고
    • Normal B cell precursors responsive to recombinant IL-7 and inhibition of IL-7 activity by transforming growth factor-β
    • Lee, G., Namen, A. E., Gillis, S., Ellingsworth, L. R., and Kincade, P. W., Normal B cell precursors responsive to recombinant IL-7 and inhibition of IL-7 activity by transforming growth factor-β, J. Immunol., 142, 3875-3883, 1989.
    • (1989) J. Immunol. , vol.142 , pp. 3875-3883
    • Lee, G.1    Namen, A.E.2    Gillis, S.3    Ellingsworth, L.R.4    Kincade, P.W.5
  • 36
    • 0025243360 scopus 로고
    • Regulation of human B cell ontogeny
    • Uckun, F. M., Regulation of human B cell ontogeny, Blood, 76, 1908-1923, 1990.
    • (1990) Blood , vol.76 , pp. 1908-1923
    • Uckun, F.M.1
  • 39
    • 0027450829 scopus 로고
    • Distinctive growth requirements and gene expression pattern distinguish progenitor B cells from pre-B cells
    • Faust, E. A., Saffran, D. C., Toksoz, D., Williams, D. A., and Witte, O. N., Distinctive growth requirements and gene expression pattern distinguish progenitor B cells from pre-B cells, J. Exp. Med., 177, 915-923, 1993.
    • (1993) J. Exp. Med. , vol.177 , pp. 915-923
    • Faust, E.A.1    Saffran, D.C.2    Toksoz, D.3    Williams, D.A.4    Witte, O.N.5
  • 40
    • 0029151210 scopus 로고
    • Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors
    • Billips, L. G., Nunez, C., Bertran III, F. E., Stankovic, A. K., Gartland, G. L., Burrows, P. D., and Cooper, M. D., Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors, J. Exp. Med., 182, 973-982, 1995.
    • (1995) J. Exp. Med. , vol.182 , pp. 973-982
    • Billips, L.G.1    Nunez, C.2    Bertran III, F.E.3    Stankovic, A.K.4    Gartland, G.L.5    Burrows, P.D.6    Cooper, M.D.7
  • 41
    • 0343812092 scopus 로고    scopus 로고
    • IL-7 receptor and VDJ recombination: Trophic versus mechanistic actions
    • Candéias, S., Muegge, K., and Durum, S. K., IL-7 receptor and VDJ recombination: trophic versus mechanistic actions, Immunity, 6, 501-508, 1997.
    • (1997) Immunity , vol.6 , pp. 501-508
    • Candéias, S.1    Muegge, K.2    Durum, S.K.3
  • 43
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis
    • Corcoran, A. E., Smart, F. M., Cowling, R. J., Crompton, T., Owen, M. J., and Venkitaraman, A. R., The interleukin-7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis, EMBO J., 15, 1924-1932, 1996.
    • (1996) EMBO J. , vol.15 , pp. 1924-1932
    • Corcoran, A.E.1    Smart, F.M.2    Cowling, R.J.3    Crompton, T.4    Owen, M.J.5    Venkitaraman, A.R.6
  • 44
    • 0027199434 scopus 로고
    • Interleukin-7: A cofactor for V(D)J rearrangement of the T cell receptor β gene
    • Muege, K., Vila, M. P., and Durum, S. K., Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor β gene, Science, 261, 93-95, 1993.
    • (1993) Science , vol.261 , pp. 93-95
    • Muege, K.1    Vila, M.P.2    Durum, S.K.3
  • 45
    • 0030964406 scopus 로고    scopus 로고
    • Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class II-expressing thymic stromal cells
    • Oosterwegel, M. A., Haka, M. G., Jeffry, Y., Murray, R., and Kruisbeek, M., Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class II-expressing thymic stromal cells, Immunity, 6, 351-360, 1997.
    • (1997) Immunity , vol.6 , pp. 351-360
    • Oosterwegel, M.A.1    Haka, M.G.2    Jeffry, Y.3    Murray, R.4    Kruisbeek, M.5
  • 46
    • 0027296517 scopus 로고
    • Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation
    • Lin, W.-C. and Desiderio, S., Regulation of V(D)J recombination activator protein RAG-2 by phosphorylation, Science, 260, 953-959, 1993.
    • (1993) Science , vol.260 , pp. 953-959
    • Lin, W.-C.1    Desiderio, S.2
  • 47
    • 0029014910 scopus 로고
    • V(D)J recombination and the cell cycle
    • Lin, W.-C. and Desiderio, S., V(D)J recombination and the cell cycle, Immunol. Today, 16, 279-289, 1995.
    • (1995) Immunol. Today , vol.16 , pp. 279-289
    • Lin, W.-C.1    Desiderio, S.2
  • 48
    • 0028223271 scopus 로고
    • Cell cycle regulation of V(D)J recombination activating protein RAG-2
    • Lin, W.-C. and Disiderio, S., Cell cycle regulation of V(D)J recombination activating protein RAG-2, Proc. Natl. Acad. Sci. U.S.A., 91, 2733-2737, 1994.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 2733-2737
    • Lin, W.-C.1    Disiderio, S.2
  • 49
    • 0029553231 scopus 로고
    • Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG-1 and RAG-2
    • Spanopoulou, E., Cortes, P., Shin, C., Huang, C.M., Silver, D. P., and Baltimore, D., Localization, interaction, and RNA binding properties of the V(D)J recombination-activating proteins RAG-1 and RAG-2, Immunity, 3, 715-726, 1995.
    • (1995) Immunity , vol.3 , pp. 715-726
    • Spanopoulou, E.1    Cortes, P.2    Shin, C.3    Huang, C.M.4    Silver, D.P.5    Baltimore, D.6
  • 50
    • 0027994484 scopus 로고
    • RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP-1
    • Cortes, P., Ye, Z.-S., and Baltimore, D., RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP-1, Proc. Natl. Acad. Sci. U.S.A., 91, 6156-6160, 1994.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6156-6160
    • Cortes, P.1    Ye, Z.-S.2    Baltimore, D.3
  • 51
    • 0028307661 scopus 로고
    • Analysis of regions of RAG-2 important for V(D)J recombination
    • Cuomo, C. A. and Oettinger, M. A., Analysis of regions of RAG-2 important for V(D)J recombination, Nucl. Acids Res., 10, 1810-1814, 1994.
    • (1994) Nucl. Acids Res. , vol.10 , pp. 1810-1814
    • Cuomo, C.A.1    Oettinger, M.A.2
  • 52
    • 0025939766 scopus 로고
    • V(D)J recombinase activity in primary and secondary murine lymphoid organs: Assessment by a PCR assay with extrachromosomal plasmid
    • Abe, M., Hayashida, K., Takayama, K., and Shiku, H., V(D)J recombinase activity in primary and secondary murine lymphoid organs: assessment by a PCR assay with extrachromosomal plasmid, Int. Immunol., 3, 1025-1033, 1991.
    • (1991) Int. Immunol. , vol.3 , pp. 1025-1033
    • Abe, M.1    Hayashida, K.2    Takayama, K.3    Shiku, H.4
  • 53
    • 0026638927 scopus 로고
    • Restricted expression of recombination activating gene (RAG-1) in mouse lymphoid tissues
    • Yamamoto, A., Atsuta, M., and Hamatani, K., Restricted expression of recombination activating gene (RAG-1) in mouse lymphoid tissues. Cell Biol. Func., 10, 71-77, 1992.
    • (1992) Cell Biol. Func. , vol.10 , pp. 71-77
    • Yamamoto, A.1    Atsuta, M.2    Hamatani, K.3
  • 54
    • 0029044460 scopus 로고
    • Upregulation of recombination activating gene expression by signal transduction through the surface Ig receptor
    • Verkoczy, L. K., Stiernhdm, B. J. N., and Berinstein, N. L., Upregulation of recombination activating gene expression by signal transduction through the surface Ig receptor, J. Immunol., 154, 5136-5143, 1995.
    • (1995) J. Immunol. , vol.154 , pp. 5136-5143
    • Verkoczy, L.K.1    Stiernhdm, B.J.N.2    Berinstein, N.L.3
  • 55
    • 0030475466 scopus 로고    scopus 로고
    • Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
    • Hikida, M., Mori, M., Takai, T., Tomochika, K., Hamatani, K., and Ohmori, H., Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells, Science, 274, 2092-2094, 1996.
    • (1996) Science , vol.274 , pp. 2092-2094
    • Hikida, M.1    Mori, M.2    Takai, T.3    Tomochika, K.4    Hamatani, K.5    Ohmori, H.6
  • 56
    • 0030460833 scopus 로고    scopus 로고
    • Neoteny in lymphocytes: RAG-1 and RAG-2 expression in germinal center B cells
    • Han, S., Zheng, B., Schatz, D. G., Spanopolou, E., and Kelsoe, G., Neoteny in lymphocytes: RAG-1 and RAG-2 expression in germinal center B cells, Science, 274, 2094-2097, 1996.
    • (1996) Science , vol.274 , pp. 2094-2097
    • Han, S.1    Zheng, B.2    Schatz, D.G.3    Spanopolou, E.4    Kelsoe, G.5
  • 57
    • 0030584698 scopus 로고    scopus 로고
    • Requirements of a costimulus for IL-4-induced IgE class switching in murine B cells activated via antigen receptors. Effectiveness of 8-mercaptoguanosine
    • Hikida, M., Takai, T., and Ohmori, H., Requirements of a costimulus for IL-4-induced IgE class switching in murine B cells activated via antigen receptors. Effectiveness of 8-mercaptoguanosine, J. Immunol., 156, 2730-2736, 1996.
    • (1996) J. Immunol. , vol.156 , pp. 2730-2736
    • Hikida, M.1    Takai, T.2    Ohmori, H.3
  • 58
    • 0027305024 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. Kinetics of V region mutation and selection in germinal center B cells
    • Jacob, J., Przylepa, J., Miller, C., and Kelsoe, G., In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. Kinetics of V region mutation and selection in germinal center B cells, J. Exp. Med., 178, 1293-1307, 1993.
    • (1993) J. Exp. Med. , vol.178 , pp. 1293-1307
    • Jacob, J.1    Przylepa, J.2    Miller, C.3    Kelsoe, G.4
  • 59
    • 0030273141 scopus 로고    scopus 로고
    • The SCID but not the RAG-2 gene product is required for Sμ-Sε heavy chain class switching
    • Rolink, A., Melchers, F., and Andersson, J., The SCID but not the RAG-2 gene product is required for Sμ-Sε heavy chain class switching, Immunity, 5, 319-330, 1996.
    • (1996) Immunity , vol.5 , pp. 319-330
    • Rolink, A.1    Melchers, F.2    Andersson, J.3
  • 60
    • 0028670390 scopus 로고
    • Apoptosis and macrophage-mediated cell deletion in the regulation of B lymphopoiesis in mouse bone marrow
    • Osmond, D. G., Rico-Vargas, S., Valenzona, H., Fauteux, L., Liu, L., Janani, R., Lu, L., and Jacobsen, K., Apoptosis and macrophage-mediated cell deletion in the regulation of B lymphopoiesis in mouse bone marrow, Immunol Rev., 142, 209-230, 1994.
    • (1994) Immunol Rev. , vol.142 , pp. 209-230
    • Osmond, D.G.1    Rico-Vargas, S.2    Valenzona, H.3    Fauteux, L.4    Liu, L.5    Janani, R.6    Lu, L.7    Jacobsen, K.8
  • 61
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K., Clonal selection and learning in the antibody system, Nature, 381, 751-758, 1996.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 62
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
    • Nemazee, D. and Bürki, K., Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes, Nature, 337, 562-566, 1989.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.1    Bürki, K.2
  • 63
    • 0009927162 scopus 로고
    • Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras
    • Nemazee, D. and Bürki, K., Clonal deletion of autoreactive B lymphocytes in bone marrow chimeras, Proc. Natl. Acad. Sci. U.S.A., 86, 8039-8043, 1989.
    • (1989) Proc. Natl. Acad. Sci. U.S.A. , vol.86 , pp. 8039-8043
    • Nemazee, D.1    Bürki, K.2
  • 64
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B-lymphocytes recognizing membrane-bound antigen
    • Hartley, S. B., Crosbie, J., Brink, R., Kantor, A. B., Basten, A., and Goodnow, C. C., Elimination from peripheral lymphoid tissues of self-reactive B-lymphocytes recognizing membrane-bound antigen, Nature, 353, 765-769, 1991.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 66
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S. L., Russell, D. M., and Nemazee, D., Receptor editing in self-reactive bone marrow B cells, J. Exp. Med., 177, 1009-1020, 1993.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 67
    • 0029807629 scopus 로고    scopus 로고
    • B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen
    • Lang, J., Jackson, M., Teyton, L., Brunmark, A., Kane, K., and Nemazee, D., B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen, J. Exp. Med., 184, 1685-1697, 1996.
    • (1996) J. Exp. Med. , vol.184 , pp. 1685-1697
    • Lang, J.1    Jackson, M.2    Teyton, L.3    Brunmark, A.4    Kane, K.5    Nemazee, D.6
  • 68
    • 0023462643 scopus 로고
    • Structure and function of anti-DNA antibodies derived from a Single autoimmune mouse
    • Schlomchik, M. J., Aucoin, A. H., Pisetsky, D. S., and Weigert, M. G., Structure and function of anti-DNA antibodies derived from a Single autoimmune mouse, Proc. Natl. Acad. Sci. U.S.A., 84, 9150-9154, 1987.
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 9150-9154
    • Schlomchik, M.J.1    Aucoin, A.H.2    Pisetsky, D.S.3    Weigert, M.G.4
  • 69
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., Saunders, T., Camper, S., and Weigert, M., Receptor editing: an approach by autoreactive B cells to escape tolerance, J. Exp. Med., 1993; 177, 999-1008.
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 70
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M. Z., Erickson, J., Litwin, S., and Weigert, M., B lymphocytes may escape tolerance by revising their antigen receptors, J. Exp. Med., 177, 1165-1173, 1993.
    • (1993) J. Exp. Med. , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erickson, J.2    Litwin, S.3    Weigert, M.4
  • 71
    • 0025980973 scopus 로고
    • Expression of anti-DNA immunoglobulin transgenes in nonautoimmune mice
    • Erikson, J., Radic, M. Z., Camper, S., Hardy, R. R., and Weigert, M., Expression of anti-DNA immunoglobulin transgenes in nonautoimmune mice, Nature, 349, 331-334, 1991.
    • (1991) Nature , vol.349 , pp. 331-334
    • Erikson, J.1    Radic, M.Z.2    Camper, S.3    Hardy, R.R.4    Weigert, M.5
  • 72
    • 0030997499 scopus 로고    scopus 로고
    • Editing disease-associated autoantibodies
    • Chen, C., Luning Prak, E., and Weigert, M., Editing disease-associated autoantibodies, Immunity, 6, 97-105, 1997.
    • (1997) Immunity , vol.6 , pp. 97-105
    • Chen, C.1    Luning Prak, E.2    Weigert, M.3
  • 75
    • 0029164869 scopus 로고
    • Light chain replace-ment: A new model for antibody gene rearrangement
    • Prak, E. L. and Weigert, M., Light chain replace-ment: a new model for antibody gene rearrangement, J. Exp. Med., 182, 541-548, 1995.
    • (1995) J. Exp. Med. , vol.182 , pp. 541-548
    • Prak, E.L.1    Weigert, M.2
  • 76
    • 0029553058 scopus 로고
    • Immunoglobulin heavy chain gene replacement: A mechanism of receptor editing
    • Chen, C., Nagy, Z., Prak, E. L., and Weigert, M., Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing, Immunity, 3, 747-755, 1995.
    • (1995) Immunity , vol.3 , pp. 747-755
    • Chen, C.1    Nagy, Z.2    Prak, E.L.3    Weigert, M.4
  • 77
    • 0026612593 scopus 로고
    • Ongoing Vκ-Jκ recombination after formation of a productive VκJκ coding point
    • Huber, C., Klobeck, H. G., and Zachau, H. G., Ongoing Vκ-Jκ recombination after formation of a productive VκJκ coding point, Eur. J. Immunol., 22, 1561-1565, 1992.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 1561-1565
    • Huber, C.1    Klobeck, H.G.2    Zachau, H.G.3
  • 78
    • 0025730554 scopus 로고
    • Vλ and Jλ-Cλ gene segments of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism
    • Combriato, G., Klobeck, H. G., and Zachau, H. G., Vλ and Jλ-Cλ gene segments of the human immunoglobulin λ light chain locus are separated by 14 kb and rearrange by a deletion mechanism, Eur. J. Immunol., 21, 1513-1522, 1991.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1513-1522
    • Combriato, G.1    Klobeck, H.G.2    Zachau, H.G.3
  • 79
    • 0030981639 scopus 로고    scopus 로고
    • - bone marrow B cells in vitro
    • - bone marrow B cells in vitro, Immunity, 6, 429-436, 1997.
    • (1997) Immunity , vol.6 , pp. 429-436
    • Hertz, M.1    Nemazee, D.2
  • 80
    • 0030483540 scopus 로고    scopus 로고
    • Receptor editing, immune diversification, and self-tolerance
    • Radic, M. Z. and Zouali, M., Receptor editing, immune diversification, and self-tolerance, Immunity, 5, 505-511, 1996.
    • (1996) Immunity , vol.5 , pp. 505-511
    • Radic, M.Z.1    Zouali, M.2
  • 81
    • 0029928877 scopus 로고    scopus 로고
    • Life and death in germinal centers (redux)
    • Kelsoe, G., Life and death in germinal centers (redux), Immunity, 4, 107-111, 1996.
    • (1996) Immunity , vol.4 , pp. 107-111
    • Kelsoe, G.1
  • 83
    • 0018836189 scopus 로고
    • Peanut lectin binding properties of germinal centers of mouse lymphoid tissue
    • Rose, M. L., Birbeck, M. S. C., Wallis, V. J., Forrester, J. A., and Davies, A. J. S., Peanut lectin binding properties of germinal centers of mouse lymphoid tissue, Nature, 284, 364-366, 1980.
    • (1980) Nature , vol.284 , pp. 364-366
    • Rose, M.L.1    Birbeck, M.S.C.2    Wallis, V.J.3    Forrester, J.A.4    Davies, A.J.S.5
  • 84
    • 0028447437 scopus 로고
    • The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
    • Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H., The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation, Immunity, 1, 167-178, 1994.
    • (1994) Immunity , vol.1 , pp. 167-178
    • Kawabe, T.1    Naka, T.2    Yoshida, K.3    Tanaka, T.4    Fujiwara, H.5    Suematsu, S.6    Yoshida, N.7    Kishimoto, T.8    Kikutani, H.9
  • 88
    • 0028785538 scopus 로고
    • In situ studies or the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance
    • Han, S., Zheng, B., Porto, J. D., and Kelsoe, G., In situ studies or the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance, J. Exp. Med., 182, 1635-1644, 1995.
    • (1995) J. Exp. Med. , vol.182 , pp. 1635-1644
    • Han, S.1    Zheng, B.2    Porto, J.D.3    Kelsoe, G.4
  • 89
    • 0030209983 scopus 로고    scopus 로고
    • Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig downregulates Fas expression on CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis
    • Choe, J., Kim, H.-S., Zhang, X., Armitage, R. J., and Choi, Y. S., Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells. Anti-Ig downregulates Fas expression on CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis, J. Immunol., 157, 1006-1016, 1996.
    • (1996) J. Immunol. , vol.157 , pp. 1006-1016
    • Choe, J.1    Kim, H.-S.2    Zhang, X.3    Armitage, R.J.4    Choi, Y.S.5
  • 90
    • 0030587821 scopus 로고    scopus 로고
    • Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro
    • Wu, J., Qin, D., Burton, G. F., and Szakal, A. K., and Tew, J. G., Follicular dendritic cell-derived antigen and accessory activity in initiation of memory IgG responses in vitro, J. Immunol., 157, 3404-3411, 1996.
    • (1996) J. Immunol. , vol.157 , pp. 3404-3411
    • Wu, J.1    Qin, D.2    Burton, G.F.3    Szakal, A.K.4    Tew, J.G.5
  • 92
    • 0023273826 scopus 로고
    • Murine lupus anti-DNA antibodies cross-react with the hapten (4-hydroxy-5-iodo-3-nitrophenyl) acetyl, but immunization-induced anti-DNA antibodies do not
    • Zouali, M., Migliorini, P., and Stoller, D. B., Murine lupus anti-DNA antibodies cross-react with the hapten (4-hydroxy-5-iodo-3-nitrophenyl) acetyl, but immunization-induced anti-DNA antibodies do not, Eur. J. Immunol., 17, 509-513, 1987.
    • (1987) Eur. J. Immunol. , vol.17 , pp. 509-513
    • Zouali, M.1    Migliorini, P.2    Stoller, D.B.3
  • 93
    • 0029920268 scopus 로고    scopus 로고
    • The double edged sword of the immune response: Mutational analysis of a murine anti-pneumococcal, anti-DNA antibody
    • Putterman, C., Limpanasithikul, W., Edelman, M., and Diamond, B., The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody, J. Clin. Invest., 97, 2215-2259, 1996.
    • (1996) J. Clin. Invest. , vol.97 , pp. 2215-2259
    • Putterman, C.1    Limpanasithikul, W.2    Edelman, M.3    Diamond, B.4
  • 94
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal center B cells
    • Pulendran, B., Kannourakis, G., Nouri, S., Smith, K. G. C., and Nossal, G. J. V., Soluble antigen can cause enhanced apoptosis of germinal center B cells, Nature, 375, 331-334, 1995.
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3    Smith, K.G.C.4    Nossal, G.J.V.5
  • 95
    • 0029014435 scopus 로고
    • Antigen-induced B cell death and elimination during germinal center immune responses
    • Shokat, K. M. and Goodnow, C. C., Antigen-induced B cell death and elimination during germinal center immune responses, Nature, 375, 334-338, 1995.
    • (1995) Nature , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 96
    • 0029826033 scopus 로고    scopus 로고
    • Human follicular dendritic cells and vascular cells produce interleukin-7: A potential role for interleukin-7 in the germinal center reaction
    • Kronke, R., Loppnow, H. Flad, H. D., and Gerdes, J., Human follicular dendritic cells and vascular cells produce interleukin-7: a potential role for interleukin-7 in the germinal center reaction, Eur. J. Immunol., 26, 2541-2544, 1996.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2541-2544
    • Kronke, R.1    Loppnow, H.2    Flad, H.D.3    Gerdes, J.4
  • 97
    • 0029989925 scopus 로고    scopus 로고
    • Alternative pathways for the selection of antigen specific peripheral T cells
    • Zheng, B., Han, S., Xhu, Q., Goldsby, R., and Kelsoe, G., Alternative pathways for the selection of antigen specific peripheral T cells, Nature, 384, 263-266, 1996.
    • (1996) Nature , vol.384 , pp. 263-266
    • Zheng, B.1    Han, S.2    Xhu, Q.3    Goldsby, R.4    Kelsoe, G.5
  • 98
    • 0031569216 scopus 로고    scopus 로고
    • Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes
    • Hikida, M., Mori, M., Kawabata, T., Takai, T., and Ohmori, H., Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes, J. Immunol., 158, 2509-2512, 1997.
    • (1997) J. Immunol. , vol.158 , pp. 2509-2512
    • Hikida, M.1    Mori, M.2    Kawabata, T.3    Takai, T.4    Ohmori, H.5
  • 100
    • 0027691148 scopus 로고
    • Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus
    • Taki, S., Meiering, M., and Rajewsky, K., Targeted insertion of a variable region gene into the immunoglobulin heavy chain locus, Science, 262, 1268-1271, 1993.
    • (1993) Science , vol.262 , pp. 1268-1271
    • Taki, S.1    Meiering, M.2    Rajewsky, K.3
  • 101
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombinase activity in a subset of germinal center B lymphocytes
    • Han, S., Dillon, S. R., Zheng, B., Shimoda, M., Schlissel, M. S., and Kelsoe, G., V(D)J recombinase activity in a subset of germinal center B lymphocytes, Science, 278, 301-305, 1997.
    • (1997) Science , vol.278 , pp. 301-305
    • Han, S.1    Dillon, S.R.2    Zheng, B.3    Shimoda, M.4    Schlissel, M.S.5    Kelsoe, G.6
  • 103
    • 0032473559 scopus 로고    scopus 로고
    • Rearrangement of K light chain genes in mature B cells in vitro and in vivo. Function of reexpressed recombination-activating gene (RAG) products
    • Hikida, M. and Ohmori, H., Rearrangement of K light chain genes in mature B cells in vitro and in vivo. Function of reexpressed recombination-activating gene (RAG) products, J. Exp. Med., 187, 795-799, 1998.
    • (1998) J. Exp. Med. , vol.187 , pp. 795-799
    • Hikida, M.1    Ohmori, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.