Molecular insights into the immunopathogenesis of follicular lymphoma

Immunology Today

Volumn 21, Issue 6, 2000, Pages 298-305

  Stamatopoulos, Kostas ^a   Kosmas, Christos ^a   Belessi, Chryssoula ^a   Stavroyianni, Niki ^a   Kyriazopoulos, Panayiotis ^a   Papadaki, Theodora ^b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b EVANGELISMOS HOSPITAL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; DNA; IMMUNOGLOBULIN M; PROTEIN BCL 2; PROTEIN BCL 6; PROTEIN P53;

ANTIGEN BINDING; B LYMPHOCYTE; CHROMOSOME 18; CHROMOSOME TRANSLOCATION 14; CONTROLLED STUDY; DNA SEQUENCE; FOLLICULAR LYMPHOMA; GENETIC HETEROGENEITY; GERMINAL CENTER; HODGKIN DISEASE; HUMAN; IMMUNOGLOBULIN GENE; IMMUNOPATHOGENESIS; LYMPHOCYTE TRANSFORMATION; LYMPHOMA CELL; PRIORITY JOURNAL; PROTO ONCOGENE; REED STERNBERG CELL; REVIEW; SOMATIC MUTATION;

B-LYMPHOCYTE SUBSETS; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; CLONAL DELETION; DNA NUCLEOTIDYLTRANSFERASES; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; GERMINAL CENTER; HEMATOPOIESIS; HODGKIN DISEASE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOMA, FOLLICULAR; MODELS, IMMUNOLOGICAL; MUTATION; NEOPLASM PROTEINS; REED-STERNBERG CELLS; TRANSLOCATION, GENETIC; TUMOR STEM CELLS; VDJ RECOMBINASES;

EID: 0034106391     PISSN: 01675699     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-5699(00)01650-9     Document Type: Review

References (46)

1. Schatz D.G.et al. V(D)J recombination. molecular biology and regulation Annu. Rev. Immunol. 10:1992;359-383.
2. MacLennan I.C.M. Germinal centers. Annu. Rev. Immunol. 12:1994;117-139.
3. Berek C., Milstein C. Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 96:1987;23-41.
4. Neuberger M.S.et al. Monitoring and interpreting the intrinsic features of somatic hypermutation. Immunol. Rev. 162:1998;107-116.
5. Storb U.et al. Cis-acting sequences that affect somatic hypermutation of Ig genes. Immunol. Rev. 162:1998;153-160.
6. Betz A.G.et al. Elements regulating somatic hypermutation of an immunoglobulin κ gene. critical role of the intron enhancer/matrix attachment region Cell. 77:1994;239-248.
7. Betz A.G.et al. Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism. clustering, polarity, and specific hot spots Proc. Natl. Acad. Sci. U. S. A. 90:1993;2385-2388.
8. Wagner S.D.et al. Codon bias targets mutation. Nature. 376:1995;732.
9. Milstein C.et al. Both DNA strands of antibody genes are hypermutation targets. Proc. Natl. Acad. Sci. U. S. A. 95:1998;8791-8794.
10. Goossens T.et al. Frequent occurrence of deletions and duplications during somatic hypermutation. implications for oncogene translocations and heavy chain disease Proc. Natl. Acad. Sci. U. S. A. 95:1998;2463-2468.
11. H rearrangements. Immunol. Rev. 162:1998;161-171.
12. Rada C.et al. Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting. Immunity. 9:1998;135-141.
13. Bahler D.W.et al. Antigen selection in human lymphomagenesis. Cancer Res. 52:1992;5547S-5551S.
14. Zhu D.et al. Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes. Br. J. Haematol. 86:1994;505-512.
15. Stamatopoulos K.et al. Follicular lymphoma immunoglobulin κ light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains. Br. J. Haematol. 96:1997;132-146.
16. Kosmas C.et al. Somatic hypermutation of immunoglobulin genes. focus on follicular lymphoma and multiple myeloma Immunol. Rev. 162:1998;281-292.
17. Chang B., Casali P. The CDR1 sequences of a major proportion of human germline IgVH genes are inherently susceptible to amino acid replacement. Immunol. Today. 15:1994;367-373.
18. + B cells. J. Clin. Invest. 99:1997;1614-1627.
19. H sequences reveal a complementary imprint of antigen selection in tumor cells. Blood. 89:1997;219-226.
20. L gene mutations. Blood. 90:1997;1334-1335.
21. Wiens G.D.et al. Harmful somatic mutations. lessons from the dark side Immunol. Rev. 162:1998;197-209.
22. Kanzler H.et al. Hodgkin's and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells. J. Exp. Med. 184:1996;1495-1505.
23. Marafioti T.et al. Origin of nodular lymphocyte predominant Hodgkin's disease fom a clonal expansion of highly mutated germinal-center B cells. New Engl. J. Med. 337:1997;453-458.
24. Küppers R., Rajewsky K. The origin of Hodgkin and Reed-Sternberg cells in Hodgkin's disease. Annu. Rev. Immunol. 16:1998;471-493.
25. Noppe S.M.et al. The genetic variability of the VH genes in follicular lymphoma. the impact of the hypermutation mechanism Br. J. Haematol. 107:1999;625-640.
26. Wilson P.C.et al. Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes. J. Exp. Med. 187:1998;59-70.
27. Klein U.et al. Somatic hypermutation in normal and transformed human B cells. Immunol. Rev. 162:1998;261-280.
28. Kosmas C.et al. Analysis of κ light chain variable region in multiple myeloma. Br. J. Haematol. 94:1996;306-317.
29. Shen H.M.et al. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science. 280:1998;1750-1752.
30. Pasqualucci L.et al. bcl-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc. Natl. Acad. Sci. U. S. A. 95:1998;11816-11821.
31. Lossos I.S., Levy R. Mutational analysis of the 5′ noncoding regulatory region of the BCL-6 gene in non-Hodgkin's lymphoma: evidence for recurrent mutations and intraclonal heterogeneity. Blood. 95:2000;1400-1405.
32. Peng H.-Z.et al. Nonimmunoglobulin gene hypermutation in germinal center B cells. Blood. 93:1999;2167-2172.
33. Vanasse G.J.et al. Regulated genomic instability and neoplasia in the lymphoid lineage. Blood. 94:1999;3997-4010.
34. Matolcsy A.et al. Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated BCL-2 gene. Blood. 88:1996;3937-3944.
35. Ottensmeier C.H.et al. Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early disease with changes during disease progression. Blood. 91:1998;4292-4299.
36. Bräuninger A.et al. Identification of common germinal-center B-cell precursors in two patients with both Hodgkin's disease and non-Hodgkin's lymphoma. New Engl. J. Med. 340:1999;1239-1247.
37. Kanzler H.et al. Hodgkin and Reed-Sternberg-like cells in B-cell chronic lymphocytic leukemia represent the outgrowth of single germinal-center B-cell-derived clones. potential precursors of Hodgkin and Reed-Sternberg cells in Hodgkin's disease Blood. 95:2000;1023-1031.
38. Wyatt R.T.et al. bcl-2 oncogene translocation is mediated by an x-like consensus. J. Exp. Med. 175:1992;1575-1588.
39. H and at later stages in the rearrangement process of the immunoglobulin heavy chain gene locus Br. J. Haematol. 99:1997;866-872.
40. Johnson P.W.M.et al. Detection of cells bearing the t(14;18) translocation following myeloablative treatment and autologous bone marrow transplantation for follicular lymphoma. J. Clin. Oncol. 12:1994;798-805.
41. Stamatopoulos K.et al. Molecular analysis of bcl-1-IgH junctional sequences in mantle cell lymphoma. potential mechanisms of the t(11;14) chromosomal translocation Br. J. Haematol. 105:1999;190-197.
42. Rimokh R.et al. Detection of the chromosomal translocation t(11;14) by polymerase chain reaction in mantle cell lymphomas. Blood. 83:1994;1871-1875.
43. Pott C.et al. Structure of Bcl-1 and IgH-CDR3 rearrangements as clonal markers in mantle cell lymphomas. Leukemia. 12:1998;1630-1637.
44. Stamatopoulos K.et al. Selection of immunoglobulin diversity gene reading frames in B-cell lymphoproliferative disorders. Leukemia. 13:1999;601-604.
45. Ghia P.et al. Unbalanced expression of bcl-2 family proteins in follicular lymphoma. contribution of CD40 signaling in promoting survival Blood. 91:1998;244-251.
46. Sander C.A.et al. p53 mutation is associated with progression in follicular lymphomas. Blood. 82:1993;1994-2004.