DNA ligase IV suppresses medulloblastoma formation

Cancer Research

Volumn 62, Issue 22, 2002, Pages 6395-6399

  Lee, Youngsoo ^a   McKinnon, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE 4; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; CARCINOGENESIS; CELL DEATH; CEREBELLUM; CONTROLLED STUDY; DNA REPAIR; GENE FUNCTION; GENOTOXICITY; IMMUNOREACTIVITY; MEDULLOBLASTOMA; MOUSE; NONHUMAN; ONSET AGE; PRIORITY JOURNAL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CEREBELLAR NEOPLASMS; DNA LIGASES; MEDULLOBLASTOMA; MICE; MICE, MUTANT STRAINS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037112505     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. van Gent, D. C., Hoeijmakers, J. H., and Kanaar, R. Chromosomal stability and the DNA double-stranded break-connection. Nat. Rev. Genet., 2: 196-206, 2001.
2. Friedberg, E. C., and Meira, L. B. Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4. Mutat. Res., 459: 243-274, 2000.
3. Robins, P., and Lindahl, T. DNA ligase IV from HeLa cell nuclei. J. Biol. Chem., 271: 24257-24261, 1996.
4. Lee, Y., Barnes, D. E., Lindahl, T., and McKinnon, P. I. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev., 14: 2576-2580, 2000.
5. Gao, Y., Ferguson, D. O., Xie, W., Manis, J. P., Sekiguchi, J., Frank, K. M., Chaudhuri, J., Homer, J., DePinho, R. A., and Alt, F. W. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature (Lond.), 404: 897-900, 2000.
6. Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K., Ferguson, D., Hasty, P., Chun, J., and Alt, F. W. Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice. Proc. Natl. Acad. Sci. USA, 97: 2668-2673, 2000.
7. Gao, Y., Chaudhuri, J., Zhu, C., Davidson, L., Weaver, D. T., and Alt, F. W. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity, 9: 367-376, 1998.
8. Barnes, D. E., Stamp, G., Rosewell, I., Denzel, A., and Lindahl, T. Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice. Curr. Biol., 8: 1395-1398, 1998.
9. Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., Bronson, R. T., Malynn, B. A., Bryans, M., Zhu, C., Chaudhuri, J., Davidson, L., Ferrini, R., Stamato, T., Orkin, S. H., Greenberg, M. E., and Alt, F. W. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 95: 891-902, 1998.
10. Ferguson, D. O., and Alt, F. W. DNA double strand break repair and chromosomal translocation: Lessons from animal models. Oncogene, 20: 5572-5579, 2001.
11. Frank, K. M., Sharpless, N. E., Gao, Y., Sekiguchi, J. M., Ferguson, D. O., Zhu, C., Manis, J. P., Homer, J., DePinho, R. A., and Alt, F. W. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell, 5: 993-1002, 2000.
12. Guidos, C. J., Williams, C. J., Grandal, I., Knowles, G., Huang, M. T., and Danska, J. S. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev., 10: 2038-2054, 1996.
13. Nacht, M., Strasser, A., Chan, Y. R., Harris, A. W., Schlissel, M., Bronson, R. T., and Jacks, T. Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev., 10: 2055-2066, 1996.
14. Difilippantonio, M. J., Zhu, J., Chen, H. T., Meffre, E., Nussenzweig, M. C., Max, E. E., Ried, T., and Nussenzweig, A. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature (Lond.), 404: 510-514, 2000.
15. Lim, D. S., Vogel, H., Willerford, D. M., Sands, A. T., Platt, K. A., and Hasty, P. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol. Cell. Biol., 20: 3772-3780, 2000.
16. Sharpless, N. E., Ferguson, D. O., O'Hagan, R. C., Castrillon, D. H., Lee, C., Farazi, P. A., Alson, S., Fleming, J., Morton, C. C., Frank, K., Chin, L., Alt, F. W., and DePinho, R. A. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol. Cell, 8: 1187-1196, 2001.
17. Giangaspero, F., Bigner, S. H., Kleihues, P., Pietsch, T., and Trojanowski, J. Q. Medulloblastoma. In: P. Kleihues and W. K. Cavenee (eds.), Pathology and Genetics of Tumours of the Nervous System, pp. 129-137. Lyon, France: IARC Press, 2000.
18. Frank, K. M., Sekiguchi, J. M., Seidl, K. J., Swat, W., Rathbun, G. A., Cheng, H. L., Davidson, L., Kangaloo, L., and Alt, F. W. Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature (Lond.), 396: 173-177, 1998.
19. Wechsler-Reya, R., and Scott, M. P. The developmental biology of brain tumors. Annu. Rev. Neurosci., 24: 385-428, 2001.
20. Giordana, M. T., Duo, D., Gasverde, S., Trevisan, E., Boghi, A., Morra, I., Pradotto, L., Mauro, A., and Chio, A. MDM2 overexpression is associated with short survival in adults with medulloblastoma. Neuro-oncology, 4: 115-122, 2002.
21. Woodbura, R. T., Azzarelli, B., Montebello, J. F., and Goss, I. E. Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. J. Neurooncol., 52: 57-62, 2001.
22. O'Driscoll, M., Cerosaletti, K. M., Girard, P. M., Dai, Y., Stumm, M., Kysela, B., Hirsch, B., Gennery, A., Palmer, S. E., Seidel J., Gatti, R. A., Varon, R., Oettinger, M. A., Neitzel, H., Jeggo, P. A., and Concannon, P. DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency. Mol. Cell, 8: 1175-1185, 2001.
23. Riballo, E., Critchlow, S. E., Teo, S. H., Doherty, A. J., Priestley, A., Broughton, B., Kysela, B., Beamish, H., Plowman N., Ariett, C. F., Lehmann, A. R., Jackson, S. P., and Jeggo, P. A. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient. Curr. Biol., 9: 699-702, 1999.
24. Ben-Arie, N., Bellen, H. J., Armstrong, D. L., McCall, A. E., Gordadze, P. R., Guo, Q., Matzuk, M. M., and Zoghbi, H. Y. Math 1 is essential for genesis of cerebellar granule neurons. Nature (Lond.), 390: 169-172, 1997.
25. Goldowitz, D., and Hamre, K. The cells and molecules that make a cerebellum. Trends Neurosci., 21: 375-382, 1998.
26. Deans, B., Griffin, C. S., Maconochie, M., and Thacker, J. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J., 19: 6675-6685, 2000.
27. Hahn, H., Wojnowski, L., Zimmer, A. M., Hall, J., Miller, G., and Zimmer, A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat. Med., 4: 619-622, 1998.
28. Aszterbaum, M., Epstein, J., Oro, A., Douglas, V., LeBoit, P. E., Scott, M. P., and Epstein, E. H., Jr. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat. Med., 5: 1285-1291, 1999.
29. Barnes, E. A., Kong, M., Ollendorff, V., and Donoghue, D. J. Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J., 20: 2214-2223, 2001.