메뉴 건너뛰기




Volumn 55, Issue 5, 2002, Pages 273-283

Molecular aspects of multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN HEAVY CHAIN;

EID: 0036796603     PISSN: 13668714     EISSN: None     Source Type: Journal    
DOI: 10.1136/mp.55.5.273     Document Type: Review
Times cited : (72)

References (121)
  • 1
    • 0030211192 scopus 로고    scopus 로고
    • Multiple myeloma: Almost all patients are cytogenetically abnormal
    • Zandecki M, Lai JL, Facon T. Multiple myeloma: almost all patients are cytogenetically abnormal. Br J Haematol 1996;94:217-27.
    • (1996) Br J Haematol , vol.94 , pp. 217-227
    • Zandecki, M.1    Lai, J.L.2    Facon, T.3
  • 2
    • 0028884252 scopus 로고
    • Interphase fluorescence in situ hybridisation identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance
    • Drach J, Angerler J, Schuster J, et al. Interphase fluorescence in situ hybridisation identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance. Blood 1995;86:3915-21.
    • (1995) Blood , vol.86 , pp. 3915-3921
    • Drach, J.1    Angerler, J.2    Schuster, J.3
  • 3
    • 0029063966 scopus 로고
    • Monoclonal gammopathy of undetermined significance: Chromosome changes are a common finding within plasma cells
    • Zandecki M, Obein V, Bernardi F, et al. Monoclonal gammopathy of undetermined significance: chromosome changes are a common finding within plasma cells. Br J Haematol 1995;90:693-6.
    • (1995) Br J Haematol , vol.90 , pp. 693-696
    • Zandecki, M.1    Obein, V.2    Bernardi, F.3
  • 4
    • 0011005937 scopus 로고    scopus 로고
    • Translocations at 14q32 are common in patients with the monoclonal gammopathy of undetermined significance (MGUS) and involve serial partner chromosomes
    • Fonseca R, Aguayo P, Ahmann GJ, et al. Translocations at 14q32 are common in patients with the monoclonal gammopathy of undetermined significance (MGUS) and involve serial partner chromosomes [abstract]. Blood 1999;10(suppl 1):2943.
    • (1999) Blood , vol.10 , Issue.SUPPL. 1 , pp. 2943
    • Fonseca, R.1    Aguayo, P.2    Ahmann, G.J.3
  • 5
    • 0031985198 scopus 로고    scopus 로고
    • Multiple myeloma: Increasing evidence for a multistep transformation process
    • Hallek M, Bersagel PL, Anderson K. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 1998;91:3-21.
    • (1998) Blood , vol.91 , pp. 3-21
    • Hallek, M.1    Bersagel, P.L.2    Anderson, K.3
  • 6
    • 0021792205 scopus 로고
    • The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukaemia or amyloidosis
    • DeWald G, Kyle R, Hicks G, et al. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukaemia or amyloidosis. Blood 1985;66:380-90.
    • (1985) Blood , vol.66 , pp. 380-390
    • DeWald, G.1    Kyle, R.2    Hicks, G.3
  • 7
    • 0023853845 scopus 로고
    • Plasma cell karyotype in multiple myeloma
    • Gould J, Alexanian R, Goodacre A, et al. Plasma cell karyotype in multiple myeloma. Blood 1988;7:453-6.
    • (1988) Blood , vol.7 , pp. 453-456
    • Gould, J.1    Alexanian, R.2    Goodacre, A.3
  • 8
    • 0027195801 scopus 로고
    • Karyotype in multiple myeloma and plasma cell leukaemia
    • Weh H, Gutensohn K, Selbach J, et al. Karyotype in multiple myeloma and plasma cell leukaemia. Eur J Cancer 1993;29:1269-73.
    • (1993) Eur J Cancer , vol.29 , pp. 1269-1273
    • Weh, H.1    Gutensohn, K.2    Selbach, J.3
  • 10
    • 0028880424 scopus 로고
    • Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities
    • Tricot G, Barlogie B, Jagannath S, et al. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities. Blood 1995;86:4250-6.
    • (1995) Blood , vol.86 , pp. 4250-4256
    • Tricot, G.1    Barlogie, B.2    Jagannath, S.3
  • 11
    • 0028947460 scopus 로고
    • Improved cytogenetics in multiple myeloma: A study of 151 patients including 117 patients at diagnosis
    • Lai JL, Zandecki M, Mary JY, et al. Improved cytogenetics in multiple myeloma: a study of 151 patients including 117 patients at diagnosis. Blood 1995;85:2490-7.
    • (1995) Blood , vol.85 , pp. 2490-2497
    • Lai, J.L.1    Zandecki, M.2    Mary, J.Y.3
  • 12
    • 0031035918 scopus 로고    scopus 로고
    • Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: Primary breakpoints and clinical correlations
    • Calasanz MJ, Cigudosa JC, Odero MD, et al. Cytogenetic analysis of 280 patients with multiple myeloma and related disorders: primary breakpoints and clinical correlations. Genes Chromosomes Cancer 1997;18:84-93.
    • (1997) Genes Chromosomes Cancer , vol.18 , pp. 84-93
    • Calasanz, M.J.1    Cigudosa, J.C.2    Odero, M.D.3
  • 13
    • 7144255524 scopus 로고    scopus 로고
    • Prognostic value of cytogenetics in multiple myeloma
    • Seong C, Delasalle K, Hayes K, et al. Prognostic value of cytogenetics in multiple myeloma. Br J Haematol 1998;101:189-94.
    • (1998) Br J Haematol , vol.101 , pp. 189-194
    • Seong, C.1    Delasalle, K.2    Hayes, K.3
  • 14
    • 0027165569 scopus 로고
    • Improved cytogenetic analysis of bone marrow plasma cells after cytokine stimulation in multiple myeloma: A report on 46 patients
    • Facon T, Lai JL, Preudhomme C, et al. Improved cytogenetic analysis of bone marrow plasma cells after cytokine stimulation in multiple myeloma: a report on 46 patients. Br J Haematol 1993;84:743-5.
    • (1993) Br J Haematol , vol.84 , pp. 743-745
    • Facon, T.1    Lai, J.L.2    Preudhomme, C.3
  • 15
    • 0029072506 scopus 로고
    • Cytogenetic study in multiple myeloma at diagnosis: Comparison of two techniques
    • Smadja NV, Louvet C, Isnard F, et al. Cytogenetic study in multiple myeloma at diagnosis: comparison of two techniques. Br J Haematol 1995;90:619-24.
    • (1995) Br J Haematol , vol.90 , pp. 619-624
    • Smadja, N.V.1    Louvet, C.2    Isnard, F.3
  • 16
    • 0031861960 scopus 로고    scopus 로고
    • Chromosomal analysis in multiple myeloma: Cytogenetic evidence of two different diseases
    • Smadja NV, Fruchart C, Isnard F, et al. Chromosomal analysis in multiple myeloma: cytogenetic evidence of two different diseases. Leukemia 1998;12:960-9.
    • (1998) Leukemia , vol.12 , pp. 960-969
    • Smadja, N.V.1    Fruchart, C.2    Isnard, F.3
  • 17
    • 0018899398 scopus 로고
    • Cellular DNA content as a marker of human multiple myeloma
    • Latreille J, Barlogie B, Gohde W, et al. Cellular DNA content as a marker of human multiple myeloma. Blood 1980;55:403-8.
    • (1980) Blood , vol.55 , pp. 403-408
    • Latreille, J.1    Barlogie, B.2    Gohde, W.3
  • 18
    • 0021879375 scopus 로고
    • Prognostic implications of tumor cell DNA and RNA content in multiple myeloma
    • Barlogie B, Alexanian R, Dixon D, et al. Prognostic implications of tumor cell DNA and RNA content in multiple myeloma. Blood 1985;66:338-41.
    • (1985) Blood , vol.66 , pp. 338-341
    • Barlogie, B.1    Alexanian, R.2    Dixon, D.3
  • 19
    • 0027211943 scopus 로고
    • Use of fluorescence in situ hybridisation for retrospective detection of aneuploidy in multiple myeloma
    • Lee W, Han K, Drut RM, et al. Use of fluorescence in situ hybridisation for retrospective detection of aneuploidy in multiple myeloma. Genes Chromosomes Cancer 1993;7:137-43.
    • (1993) Genes Chromosomes Cancer , vol.7 , pp. 137-143
    • Lee, W.1    Han, K.2    Drut, R.M.3
  • 20
    • 0029124130 scopus 로고
    • Multiple myeloma: High incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridisation
    • Drach J, Schuster J, Nowotny H, et al. Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridisation. Cancer Res 1995;55:3854-9.
    • (1995) Cancer Res , vol.55 , pp. 3854-3859
    • Drach, J.1    Schuster, J.2    Nowotny, H.3
  • 21
    • 0029417027 scopus 로고
    • Interphase fluorescence in situ hybridisation as a powerful tool for the detection of aneuploidy in multiple myeloma
    • Flactif M, Zandecki M, Lai JL, et al. Interphase fluorescence in situ hybridisation as a powerful tool for the detection of aneuploidy in multiple myeloma. Leukemia 1995;9:2109-14.
    • (1995) Leukemia , vol.9 , pp. 2109-2114
    • Flactif, M.1    Zandecki, M.2    Lai, J.L.3
  • 22
    • 17144433568 scopus 로고    scopus 로고
    • Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants
    • Tricot G, Sawyer JR, Jagannath S, et al. Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants. J Clin Oncol 1997;15:2659-66.
    • (1997) J Clin Oncol , vol.15 , pp. 2659-2666
    • Tricot, G.1    Sawyer, J.R.2    Jagannath, S.3
  • 23
    • 0030957791 scopus 로고    scopus 로고
    • Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukaemia measured using comparative genomic hybridisation
    • Avet-Loiseau H, Andree-Ashley LE, Moore D, et al. Molecular cytogenetic abnormalities in multiple myeloma and plasma cell leukaemia measured using comparative genomic hybridisation. Genes Chromosomes Cancer 1997;19:124-33.
    • (1997) Genes Chromosomes Cancer , vol.19 , pp. 124-133
    • Avet-Loiseau, H.1    Andree-Ashley, L.E.2    Moore, D.3
  • 24
    • 0032522947 scopus 로고    scopus 로고
    • Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridisation
    • Cigudosa JC, Rao PH, Calasanz MJ, et al. Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridisation. Blood 1998;91:3007-10.
    • (1998) Blood , vol.91 , pp. 3007-3010
    • Cigudosa, J.C.1    Rao, P.H.2    Calasanz, M.J.3
  • 25
    • 0032170964 scopus 로고    scopus 로고
    • Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma
    • Rao PH, Cigudosa JC, Ning Y, et al. Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood 1998;92:1743-8.
    • (1998) Blood , vol.92 , pp. 1743-1748
    • Rao, P.H.1    Cigudosa, J.C.2    Ning, Y.3
  • 26
    • 0032402134 scopus 로고    scopus 로고
    • Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping
    • Sawyer JR, Lukacs JL, Munshi N, et al. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping. Blood 1998;92:4269-78.
    • (1998) Blood , vol.92 , pp. 4269-4278
    • Sawyer, J.R.1    Lukacs, J.L.2    Munshi, N.3
  • 27
    • 0035839841 scopus 로고    scopus 로고
    • Chromosome translocations in multiple myeloma
    • Bergsagel PL, Kuehl WM. Chromosome translocations in multiple myeloma. Oncogene 2001;20:5611-22.
    • (2001) Oncogene , vol.20 , pp. 5611-5622
    • Bergsagel, P.L.1    Kuehl, W.M.2
  • 28
    • 0026721505 scopus 로고
    • Chromosomal translocations in lymphoid malignancies reveal novel protooncogenes
    • Korsmeyer SJ. Chromosomal translocations in lymphoid malignancies reveal novel protooncogenes. Annu Rev Immunol 1992;10:785-807.
    • (1992) Annu Rev Immunol , vol.10 , pp. 785-807
    • Korsmeyer, S.J.1
  • 29
    • 0035839959 scopus 로고    scopus 로고
    • Mechanisms of chromosomal translocations in B cell lymphomas
    • Kuppers R, Dalla-Favera R. Mechanisms of chromosomal translocations in B cell lymphomas. Oncogene 2001;20:5580-94.
    • (2001) Oncogene , vol.20 , pp. 5580-5594
    • Kuppers, R.1    Dalla-Favera, R.2
  • 30
    • 0030464093 scopus 로고    scopus 로고
    • Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
    • Bersagel PL, Chesi M, Nardini E, et al. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma. Proc Natl Acad Sci U S A 1996;93:13931-6.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13931-13936
    • Bersagel, P.L.1    Chesi, M.2    Nardini, E.3
  • 31
    • 0030792866 scopus 로고    scopus 로고
    • The IgG heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukaemia as detected by in situ hybridisation
    • Nishida K, Tamura A, Nakazawa N, et al. The IgG heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukaemia as detected by in situ hybridisation. Blood 1997;90:526-34.
    • (1997) Blood , vol.90 , pp. 526-534
    • Nishida, K.1    Tamura, A.2    Nakazawa, N.3
  • 32
    • 0343355828 scopus 로고    scopus 로고
    • High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies
    • Avet-Loiseau H, Li JY, Facon T, et al. High incidence of translocations t(11;14)(q13;q32) and t(4;14)(p16;q32) in patients with plasma cell malignancies. Cancer Res 1998;58:5640-5.
    • (1998) Cancer Res , vol.58 , pp. 5640-5645
    • Avet-Loiseau, H.1    Li, J.Y.2    Facon, T.3
  • 33
    • 0032889633 scopus 로고    scopus 로고
    • High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridisation
    • Avet-Loiseau H, Brigaudeau C, Morineau N, et al. High incidence of cryptic translocations involving the Ig heavy chain gene in multiple myeloma, as shown by fluorescence in situ hybridisation. Genes Chromosomes Cancer 1999;24:9-15.
    • (1999) Genes Chromosomes Cancer , vol.24 , pp. 9-15
    • Avet-Loiseau, H.1    Brigaudeau, C.2    Morineau, N.3
  • 34
    • 0011012035 scopus 로고    scopus 로고
    • Immunoglobulin translocations in multiple myeloma: Present in all cell lines but not all primary tumours
    • Martelli ML, Gabrea A, Qi Y, et al. Immunoglobulin translocations in multiple myeloma: present in all cell lines but not all primary tumours. Blood 1999;10(suppl 1):2431.
    • (1999) Blood , vol.10 , Issue.SUPPL. 1 , pp. 2431
    • Martelli, M.L.1    Gabrea, A.2    Qi, Y.3
  • 35
    • 0035863790 scopus 로고    scopus 로고
    • Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival
    • Ho PJ, Brown RD, Pelka GJ, et al. Illegitimate switch recombinations are present in approximately half of primary myeloma tumors, but do not relate to known prognostic indicators or survival. Blood 2001;97:490-5.
    • (2001) Blood , vol.97 , pp. 490-495
    • Ho, P.J.1    Brown, R.D.2    Pelka, G.J.3
  • 36
    • 0011055302 scopus 로고    scopus 로고
    • Withdrawn
    • Withdrawn.
  • 37
    • 0032971585 scopus 로고    scopus 로고
    • Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumour cell
    • Gabrea A, Bergsagel PL, Chesi M, et al. Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumour cell. Molecular Cell 1999;3:119-23.
    • (1999) Molecular Cell , vol.3 , pp. 119-123
    • Gabrea, A.1    Bergsagel, P.L.2    Chesi, M.3
  • 38
    • 0035123860 scopus 로고    scopus 로고
    • Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma
    • Pratt G, Fenton JAL, Davies FE, et al. Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma. Br J Haematol 2001;112:388-91.
    • (2001) Br J Haematol , vol.112 , pp. 388-391
    • Pratt, G.1    Fenton, J.A.L.2    Davies, F.E.3
  • 39
    • 0037085787 scopus 로고    scopus 로고
    • Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed but correlate with natural history, immunological features and clinical presentation
    • Avet-Loiseau H, Facon T, Grosbois B, et al. Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed but correlate with natural history, immunological features and clinical presentation. Blood 2002;99:2185-91.
    • (2002) Blood , vol.99 , pp. 2185-2191
    • Avet-Loiseau, H.1    Facon, T.2    Grosbois, B.3
  • 40
    • 0037092981 scopus 로고    scopus 로고
    • Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients
    • Fonseca R, Blood EA, Oken MM, et al. Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood 2002;99:3735-41.
    • (2002) Blood , vol.99 , pp. 3735-3741
    • Fonseca, R.1    Blood, E.A.2    Oken, M.M.3
  • 41
    • 0035496937 scopus 로고    scopus 로고
    • Translocations involving the immunoglobulin heavy-chain locus are possibly early events in patients with primary systemic amyloidosis
    • Hayman SR, Bailey RJ, Jalal SM, et al. Translocations involving the immunoglobulin heavy-chain locus are possibly early events in patients with primary systemic amyloidosis. Blood 2001;98:2266-8.
    • (2001) Blood , vol.98 , pp. 2266-2268
    • Hayman, S.R.1    Bailey, R.J.2    Jalal, S.M.3
  • 42
    • 0031838436 scopus 로고    scopus 로고
    • Multiple myeloma and the translocation t(11;14)(q13;q32): A report on 13 cases
    • Fonseca R, Witzig TE, Gertz MA, et al. Multiple myeloma and the translocation t(11;14)(q13;q32): a report on 13 cases. Br J Haematol 1998;101:296-301.
    • (1998) Br J Haematol , vol.101 , pp. 296-301
    • Fonseca, R.1    Witzig, T.E.2    Gertz, M.A.3
  • 43
    • 0027499436 scopus 로고
    • Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma
    • Williams ME, Swerdlow SH, Rosenberg CL, et al. Chromosome 11 translocation breakpoints at the PRAD1/cyclin D1 gene locus in centrocytic lymphoma. Leukemia 1993;7:241-5.
    • (1993) Leukemia , vol.7 , pp. 241-245
    • Williams, M.E.1    Swerdlow, S.H.2    Rosenberg, C.L.3
  • 44
    • 0034656068 scopus 로고    scopus 로고
    • Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with a t(11;14)(q13;q32)
    • Janssen JWG, Vaandrager JW, Heuser T, et al. Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with a t(11;14)(q13;q32). Blood 2000;95:2691-8.
    • (2000) Blood , vol.95 , pp. 2691-2698
    • Janssen, J.W.G.1    Vaandrager, J.W.2    Heuser, T.3
  • 45
    • 0033557950 scopus 로고    scopus 로고
    • Molecular analysis of 11q13 breakpoints in multiple myeloma
    • Ronchetti D, Finelli P, Richelda R, et al. Molecular analysis of 11q13 breakpoints in multiple myeloma. Blood 1999;93:1330-7.
    • (1999) Blood , vol.93 , pp. 1330-1337
    • Ronchetti, D.1    Finelli, P.2    Richelda, R.3
  • 46
    • 0026693984 scopus 로고
    • Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation
    • Seto M, Yamamoto K, Iida S, et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene 1992;7:1401-6.
    • (1992) Oncogene , vol.7 , pp. 1401-1406
    • Seto, M.1    Yamamoto, K.2    Iida, S.3
  • 47
    • 0027434804 scopus 로고
    • Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies
    • Raynaud SD, Bekri S, Leroux D, et al. Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies. Genes Chromosomes Cancer 1993;8:80-7.
    • (1993) Genes Chromosomes Cancer , vol.8 , pp. 80-87
    • Raynaud, S.D.1    Bekri, S.2    Leroux, D.3
  • 48
    • 0029099733 scopus 로고
    • Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma
    • Meeus P, Stul MS, Mecucci C, et al. Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma. Cancer Genet Cytogenet 1995;83:25-7.
    • (1995) Cancer Genet Cytogenet , vol.83 , pp. 25-27
    • Meeus, P.1    Stul, M.S.2    Mecucci, C.3
  • 49
    • 0029978550 scopus 로고    scopus 로고
    • Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines
    • Chesi M, Bergsagel PL, Brents LA, et al. Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines. Blood 1996;88:674-81.
    • (1996) Blood , vol.88 , pp. 674-681
    • Chesi, M.1    Bergsagel, P.L.2    Brents, L.A.3
  • 50
    • 0028065439 scopus 로고
    • A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene
    • Komatsu H, Iida S, Yamamoto K, et al. A variant chromosome translocation at 11q13 identifying PRAD1/cyclin D1 as the BCL-1 gene. Blood 1994;84:1226-31.
    • (1994) Blood , vol.84 , pp. 1226-1231
    • Komatsu, H.1    Iida, S.2    Yamamoto, K.3
  • 51
    • 0032528143 scopus 로고    scopus 로고
    • Cytogenetics in multiple myeloma: A multicenter study of 24 patients with t(11;14)(q13;q32) or its variant
    • Lai JL, Michaux L, Dastugue N, et al. Cytogenetics in multiple myeloma: a multicenter study of 24 patients with t(11;14)(q13;q32) or its variant. Cancer Genet Cytogenet 1998;104:133-8.
    • (1998) Cancer Genet Cytogenet , vol.104 , pp. 133-138
    • Lai, J.L.1    Michaux, L.2    Dastugue, N.3
  • 52
    • 0033566346 scopus 로고    scopus 로고
    • Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in-situ hybridisation
    • Finelli P, Fabris S, Zagano S, et al. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by double-color fluorescent in-situ hybridisation. Blood 1999;94:724-32.
    • (1999) Blood , vol.94 , pp. 724-732
    • Finelli, P.1    Fabris, S.2    Zagano, S.3
  • 53
    • 0033887241 scopus 로고    scopus 로고
    • Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts
    • Malgeri U, Baldini L, Perfetti V, et al. Detection of t(4;14)(p16.3;q32) chromosomal translocation in multiple myeloma by reverse transcription-polymerase chain reaction analysis of IGH-MMSET fusion transcripts. Cancer Res 2000;60:4058-61.
    • (2000) Cancer Res , vol.60 , pp. 4058-4061
    • Malgeri, U.1    Baldini, L.2    Perfetti, V.3
  • 54
    • 0032212243 scopus 로고    scopus 로고
    • The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts
    • Chesi M, Nardini E, Lim RSC, et al. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood 1998;92:3025-34.
    • (1998) Blood , vol.92 , pp. 3025-3034
    • Chesi, M.1    Nardini, E.2    Lim, R.S.C.3
  • 55
    • 0030922231 scopus 로고    scopus 로고
    • Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
    • Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet 1997;16:260-4.
    • (1997) Nat Genet , vol.16 , pp. 260-264
    • Chesi, M.1    Nardini, E.2    Brents, L.A.3
  • 56
    • 0031779421 scopus 로고    scopus 로고
    • WHSC-1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
    • Stec I, Wright TJ, van Ommen GJB, et al. WHSC-1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma. Hum Mol Genet 1998;7:1071-82.
    • (1998) Hum Mol Genet , vol.7 , pp. 1071-1082
    • Stec, I.1    Wright, T.J.2    Van Ommen, G.J.B.3
  • 57
    • 0034142212 scopus 로고    scopus 로고
    • Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis
    • Plowright EE, Li Z, Bergsagel PL, et al. Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis. Blood 2000;95:992-8.
    • (2000) Blood , vol.95 , pp. 992-998
    • Plowright, E.E.1    Li, Z.2    Bergsagel, P.L.3
  • 58
    • 0035254612 scopus 로고    scopus 로고
    • Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma
    • Chesi M, Brents LA, Ely SA, et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood 2001;97:729-36.
    • (2001) Blood , vol.97 , pp. 729-736
    • Chesi, M.1    Brents, L.A.2    Ely, S.A.3
  • 59
    • 0035871687 scopus 로고    scopus 로고
    • The myeloma associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells
    • Li Z, Zhu YX, Plowright EE, et al. The myeloma associated oncogene fibroblast growth factor receptor 3 is transforming in hematopoietic cells. Blood 2001;97:2413-19.
    • (2001) Blood , vol.97 , pp. 2413-2419
    • Li, Z.1    Zhu, Y.X.2    Plowright, E.E.3
  • 60
    • 0034888840 scopus 로고    scopus 로고
    • Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14)
    • Intini D, Baldini L, Fabris S, et al. Analysis of FGFR3 gene mutations in multiple myeloma patients with t(4;14). Br J Haematol 2001;114:362-4.
    • (2001) Br J Haematol , vol.114 , pp. 362-364
    • Intini, D.1    Baldini, L.2    Fabris, S.3
  • 61
    • 0035858985 scopus 로고    scopus 로고
    • Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): Comparative analysis of Y373C, K650E and the novel G384D mutations
    • Ronchetti D, Greco A, Compasso S, et al. Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene 2001;20:3553-62.
    • (2001) Oncogene , vol.20 , pp. 3553-3562
    • Ronchetti, D.1    Greco, A.2    Compasso, S.3
  • 62
    • 0033152107 scopus 로고    scopus 로고
    • The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to the translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines
    • Still IH, Vince P, Cowell JK. The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to the translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics 1999;58:165-70.
    • (1999) Genomics , vol.58 , pp. 165-170
    • Still, I.H.1    Vince, P.2    Cowell, J.K.3
  • 63
    • 0035883062 scopus 로고    scopus 로고
    • The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of uncertain significance
    • Fonseca R, Oken MM, Greipp PR. The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of uncertain significance. Blood 2001;98:1271-2.
    • (2001) Blood , vol.98 , pp. 1271-1272
    • Fonseca, R.1    Oken, M.M.2    Greipp, P.R.3
  • 64
    • 0344142025 scopus 로고
    • V-maf, a viral oncogene that encodes a "leucine zipper" motif
    • Nishizawa M, Kataoka K, Goto N, et al. V-maf, a viral oncogene that encodes a "leucine zipper" motif. Proc Natl Acad Sci U S A 1989;86:7711-15.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7711-7715
    • Nishizawa, M.1    Kataoka, K.2    Goto, N.3
  • 65
    • 0027532371 scopus 로고
    • Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family
    • Kataoka K, Nishizawa M, Kawai S. Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family. J Virol 1993;67:2133-41.
    • (1993) J Virol , vol.67 , pp. 2133-2141
    • Kataoka, K.1    Nishizawa, M.2    Kawai, S.3
  • 66
    • 0035890419 scopus 로고    scopus 로고
    • WWOX, the FRA16D gene, behaves as a suppressor of tumor growth
    • Bednarek AK, Keck-Waggoner CL, Daniel RL, et al. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res 2001;61:8068-73.
    • (2001) Cancer Res , vol.61 , pp. 8068-8073
    • Bednarek, A.K.1    Keck-Waggoner, C.L.2    Daniel, R.L.3
  • 67
    • 0035412392 scopus 로고    scopus 로고
    • Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma
    • Shaughnessy J, Gabrea A, Ying Q, et al. Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma. Blood 2001;98:217-23.
    • (2001) Blood , vol.98 , pp. 217-223
    • Shaughnessy, J.1    Gabrea, A.2    Ying, Q.3
  • 68
    • 84984756503 scopus 로고    scopus 로고
    • Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
    • Iida S, Rao PH, Butler M, et al. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma. Nat Genet 1997;17:226-30.
    • (1997) Nat Genet , vol.17 , pp. 226-230
    • Iida, S.1    Rao, P.H.2    Butler, M.3
  • 69
    • 17744386928 scopus 로고    scopus 로고
    • IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy
    • Hatzivassiliou G, Miller I, Takizawa J, et al. IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy. Immunity 2001;14:277-89.
    • (2001) Immunity , vol.14 , pp. 277-289
    • Hatzivassiliou, G.1    Miller, I.2    Takizawa, J.3
  • 70
    • 0035133202 scopus 로고    scopus 로고
    • Multicolor spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma
    • Sawyer JR, Lukacs JL, Thomas EL, et al. Multicolor spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma. Br J Haematol 2001;112:167-74.
    • (2001) Br J Haematol , vol.112 , pp. 167-174
    • Sawyer, J.R.1    Lukacs, J.L.2    Thomas, E.L.3
  • 71
    • 0034602691 scopus 로고    scopus 로고
    • Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma
    • Shou Y, Martelli ML, Gabrea A, et al. Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma. Proc Natl Acad Sci U S A 2000;97:228-33.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 228-233
    • Shou, Y.1    Martelli, M.L.2    Gabrea, A.3
  • 72
    • 0035892119 scopus 로고    scopus 로고
    • Rearrangements of the c-myc oncogene are present in 15% of primary human multiple tumors
    • Avet-Loiseau H, Gerson F, Magrangeas F, et al. Rearrangements of the c-myc oncogene are present in 15% of primary human multiple tumors. Blood 2001;98:3082-6.
    • (2001) Blood , vol.98 , pp. 3082-3086
    • Avet-Loiseau, H.1    Gerson, F.2    Magrangeas, F.3
  • 73
    • 10544241195 scopus 로고    scopus 로고
    • The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene
    • Iida S, Rao PH, Nallasivam P, et al. The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene. Blood 1996;88:4110-17.
    • (1996) Blood , vol.88 , pp. 4110-4117
    • Iida, S.1    Rao, P.H.2    Nallasivam, P.3
  • 74
    • 0032857034 scopus 로고    scopus 로고
    • Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma
    • Avet-Loiseau H, Li JY, Morineau N, et al. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma. Blood 1999;94:2583-9.
    • (1999) Blood , vol.94 , pp. 2583-2589
    • Avet-Loiseau, H.1    Li, J.Y.2    Morineau, N.3
  • 75
    • 17344395438 scopus 로고    scopus 로고
    • In multiple myeloma, deletion of 13q14 remains an independent adverse prognostic parameter despite its frequent detection by interphase FISH
    • Zojer N, Konigsberg R, Ackermann J, et al. In multiple myeloma, deletion of 13q14 remains an independent adverse prognostic parameter despite its frequent detection by interphase FISH. Blood 2000;95:1925-30.
    • (2000) Blood , vol.95 , pp. 1925-1930
    • Zojer, N.1    Konigsberg, R.2    Ackermann, J.3
  • 76
    • 0034663292 scopus 로고    scopus 로고
    • High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH
    • Shaughnessy J, Tian E, Sawyer J, et al. High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH. Blood 2000;96:1505-11.
    • (2000) Blood , vol.96 , pp. 1505-1511
    • Shaughnessy, J.1    Tian, E.2    Sawyer, J.3
  • 77
    • 0035869257 scopus 로고    scopus 로고
    • Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy
    • Facon T, Avet-Loiseau H, Guillerm G, et al. Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy. Blood 2001;97:1566-71.
    • (2001) Blood , vol.97 , pp. 1566-1571
    • Facon, T.1    Avet-Loiseau, H.2    Guillerm, G.3
  • 78
    • 0030940091 scopus 로고    scopus 로고
    • Frequent hypermethylation of p16 and p15 genes in multiple myeloma
    • Ng MHL, Chung YF, Lo KW, et al. Frequent hypermethylation of p16 and p15 genes in multiple myeloma. Blood 1997;87:2500-6.
    • (1997) Blood , vol.87 , pp. 2500-2506
    • Ng, M.H.L.1    Chung, Y.F.2    Lo, K.W.3
  • 79
    • 0030613701 scopus 로고    scopus 로고
    • Role of CDK4 and p16INK4A in interleukin-6 mediated growth of multiple myeloma
    • Urashima M, Teoh G, Ogata A, et al. Role of CDK4 and p16INK4A in interleukin-6 mediated growth of multiple myeloma. Leukemia 1997;11:1957-63.
    • (1997) Leukemia , vol.11 , pp. 1957-1963
    • Urashima, M.1    Teoh, G.2    Ogata, A.3
  • 81
    • 0035412365 scopus 로고    scopus 로고
    • INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance
    • INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance. Blood 2001;98:244-6.
    • (2001) Blood , vol.98 , pp. 244-246
    • Guillerm, G.1    Gyan, E.2    Wolowiec, D.3
  • 82
    • 0034746509 scopus 로고    scopus 로고
    • Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia
    • Uchida T, Kinoshita T, Ohno T, et al. Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia. Leukemia 2001;15:157-65.
    • (2001) Leukemia , vol.15 , pp. 157-165
    • Uchida, T.1    Kinoshita, T.2    Ohno, T.3
  • 83
    • 0031010127 scopus 로고    scopus 로고
    • WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-γ in multiple myeloma cells
    • WAF1 upregulation and G1 growth arrest induced by dexamethasone and interferon-γ in multiple myeloma cells. Blood 1997;90:279-89.
    • (1997) Blood , vol.90 , pp. 279-289
    • Urashima, M.1    Teoh, G.2    Chauhan, D.3
  • 84
    • 0026437723 scopus 로고
    • P53 and RAS gene mutations in multiple myeloma
    • Portier M, Moles JP, Mazars GR, et al. P53 and RAS gene mutations in multiple myeloma. Oncogene 1992;7:2539-43.
    • (1992) Oncogene , vol.7 , pp. 2539-2543
    • Portier, M.1    Moles, J.P.2    Mazars, G.R.3
  • 85
    • 0027212420 scopus 로고
    • Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias
    • Corradini P, Ladetto M, Voena C, et al. Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias. Blood 1993;81:2708-13.
    • (1993) Blood , vol.81 , pp. 2708-2713
    • Corradini, P.1    Ladetto, M.2    Voena, C.3
  • 86
    • 0029819604 scopus 로고    scopus 로고
    • Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: Analysis of the eastern cooperative oncology group phase III trial
    • Liu P, Leong T, Quam L, et al. Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the eastern cooperative oncology group phase III trial. Blood 1996;88:2699-706.
    • (1996) Blood , vol.88 , pp. 2699-2706
    • Liu, P.1    Leong, T.2    Quam, L.3
  • 87
    • 0029124138 scopus 로고
    • Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6
    • Billadeau D, Jelinek DF, Shah N, et al. Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6. Cancer Res 1995;55:3640-6.
    • (1995) Cancer Res , vol.55 , pp. 3640-3646
    • Billadeau, D.1    Jelinek, D.F.2    Shah, N.3
  • 88
    • 0035469865 scopus 로고    scopus 로고
    • Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation
    • Kalakonda N, Rothwell DG, Scarffe JH, et al. Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation. Blood 2001;98:1555-60.
    • (2001) Blood , vol.98 , pp. 1555-1560
    • Kalakonda, N.1    Rothwell, D.G.2    Scarffe, J.H.3
  • 89
    • 4243720267 scopus 로고    scopus 로고
    • Wildtype Rb and p53 can suppress autocrine IL-6 production and proliferation of U266 myeloma cells
    • Liu P, Rowley M, Van Ness B. Wildtype Rb and p53 can suppress autocrine IL-6 production and proliferation of U266 myeloma cells [abstract]. Blood 1996;88(suppl 1):100a.
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Liu, P.1    Rowley, M.2    Van Ness, B.3
  • 90
    • 0027499501 scopus 로고
    • Mutations of the p53 gene in human myeloma cell lines
    • Mazars GR, Portier M, Zhang XG, et al. Mutations of the p53 gene in human myeloma cell lines. Oncogene 1993;8:1107.
    • (1993) Oncogene , vol.8 , pp. 1107
    • Mazars, G.R.1    Portier, M.2    Zhang, X.G.3
  • 91
    • 0027505575 scopus 로고
    • P53 gene mutations in multiple myeloma are associated with advanced forms of malignancy
    • Neri A, Baldini L, Trecca D, et al. P53 gene mutations in multiple myeloma are associated with advanced forms of malignancy. Blood 1993;81:128-35.
    • (1993) Blood , vol.81 , pp. 128-135
    • Neri, A.1    Baldini, L.2    Trecca, D.3
  • 92
    • 0032147210 scopus 로고    scopus 로고
    • Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional dose chemotherapy
    • Drach J, Ackermann J, Fritz E, et al. Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional dose chemotherapy. Blood 1998;92:802-7.
    • (1998) Blood , vol.92 , pp. 802-807
    • Drach, J.1    Ackermann, J.2    Fritz, E.3
  • 93
    • 0029837401 scopus 로고    scopus 로고
    • Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein
    • Urashima M, Ogata A, Chauhan D, et al. Interleukin-6 promotes multiple myeloma cell growth via phosphorylation of retinoblastoma protein. Blood 1996;88:2219-27.
    • (1996) Blood , vol.88 , pp. 2219-2227
    • Urashima, M.1    Ogata, A.2    Chauhan, D.3
  • 94
    • 0029144829 scopus 로고
    • The retinoblastoma gene (RB-1) status in multiple myeloma: A report on 35 cases
    • Zandecki M, Facon T, Preudhomme C, et al. The retinoblastoma gene (RB-1) status in multiple myeloma: a report on 35 cases. Leuk Lymphoma 1995;18:497.
    • (1995) Leuk Lymphoma , vol.18 , pp. 497
    • Zandecki, M.1    Facon, T.2    Preudhomme, C.3
  • 95
    • 0028822374 scopus 로고
    • High incidence of deletions but infrequent inactivation of the retinoblastoma gene in human myeloma cells
    • Juge-Morineau N, Mellerin MP, et al. High incidence of deletions but infrequent inactivation of the retinoblastoma gene in human myeloma cells. Br J Haematol 1995;91:664-7.
    • (1995) Br J Haematol , vol.91 , pp. 664-667
    • Juge-Morineau, N.1    Mellerin, M.P.2
  • 96
    • 0035805634 scopus 로고    scopus 로고
    • Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6 mediated pathway involving the phosphorylation of retinoblastoma protein
    • Vincent T, Jourdan M, Sy MS, et al. Hyaluronic acid induces survival and proliferation of human myeloma cells through an interleukin-6 mediated pathway involving the phosphorylation of retinoblastoma protein. J Biol Chem 2001;276:14728-36.
    • (2001) J Biol Chem , vol.276 , pp. 14728-14736
    • Vincent, T.1    Jourdan, M.2    Sy, M.S.3
  • 97
    • 10544232277 scopus 로고    scopus 로고
    • Melanoma cell expression of Fas (Apo-1/CD95) ligand: Implications for tumor immune escape
    • Hahne M, Rimoldi D, Schroter M, et al. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science 1996;274:1302.
    • (1996) Science , vol.274 , pp. 1302
    • Hahne, M.1    Rimoldi, D.2    Schroter, M.3
  • 98
    • 0035283162 scopus 로고    scopus 로고
    • Fas-L upregulation by highly malignant myeloma plasma cells: Role in the pathogenesis of anaemia and disease progression
    • Silvestris F, Tucci M, Cafforio P, et al. Fas-L upregulation by highly malignant myeloma plasma cells: role in the pathogenesis of anaemia and disease progression. Blood 2001;97:1155-64.
    • (2001) Blood , vol.97 , pp. 1155-1164
    • Silvestris, F.1    Tucci, M.2    Cafforio, P.3
  • 99
    • 0026527344 scopus 로고
    • Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells
    • Pettersson M, Jernberg-Wiklund H, Larsson LG, et al. Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells. Blood 1992;79:495-502.
    • (1992) Blood , vol.79 , pp. 495-502
    • Pettersson, M.1    Jernberg-Wiklund, H.2    Larsson, L.G.3
  • 100
    • 0029082477 scopus 로고
    • Bcl-2 protein expression is not related to short survival in multiple myeloma
    • Ong F, Nieuwkoop JA, De Groot-Swings GMJS, et al. Bcl-2 protein expression is not related to short survival in multiple myeloma. Leukemia 1995;9:1282-4.
    • (1995) Leukemia , vol.9 , pp. 1282-1284
    • Ong, F.1    Nieuwkoop, J.A.2    De Groot-Swings, G.M.J.S.3
  • 102
    • 0029987106 scopus 로고    scopus 로고
    • The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines
    • Tian E, Gazitt Y. The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines. Int J Oncol 1996;8:719-26.
    • (1996) Int J Oncol , vol.8 , pp. 719-726
    • Tian, E.1    Gazitt, Y.2
  • 103
    • 0031957034 scopus 로고    scopus 로고
    • Bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: A comparative study
    • Miguel-Garcia A, Orero T, Matutes E, et al. Bcl-2 expression in plasma cells from neoplastic gammopathies and reactive plasmacytosis: a comparative study. Haematologica 1998;83:298-304.
    • (1998) Haematologica , vol.83 , pp. 298-304
    • Miguel-Garcia, A.1    Orero, T.2    Matutes, E.3
  • 104
    • 0034669945 scopus 로고    scopus 로고
    • Loss of PTEN expression leading to high Akt activation in human multiple myelomas
    • Hyun T, Yam A, Pece S, et al. Loss of PTEN expression leading to high Akt activation in human multiple myelomas. Blood 2000;96:3560-8.
    • (2000) Blood , vol.96 , pp. 3560-3568
    • Hyun, T.1    Yam, A.2    Pece, S.3
  • 105
    • 0036493522 scopus 로고    scopus 로고
    • Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance and normal bone marrow plasma cells
    • Zhan F, Hardin J, Kordsmeier B, et al. Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance and normal bone marrow plasma cells. Blood 2002;99:1745-57.
    • (2002) Blood , vol.99 , pp. 1745-1757
    • Zhan, F.1    Hardin, J.2    Kordsmeier, B.3
  • 106
    • 0028921477 scopus 로고
    • Interleukin-6 in human multiple myeloma
    • Klein B, Zhang XG, Lu ZY, et al. Interleukin-6 in human multiple myeloma. Blood 1995;85:863-72.
    • (1995) Blood , vol.85 , pp. 863-872
    • Klein, B.1    Zhang, X.G.2    Lu, Z.Y.3
  • 107
    • 0033937720 scopus 로고    scopus 로고
    • Novel therapeutic targets in multiple myeloma
    • Davies FE, Anderson KC. Novel therapeutic targets in multiple myeloma. Eur J Haematol 2000;64:359-67.
    • (2000) Eur J Haematol , vol.64 , pp. 359-367
    • Davies, F.E.1    Anderson, K.C.2
  • 108
    • 0034353524 scopus 로고    scopus 로고
    • The IL-6 receptor alpha chain (CD126) is expressed by neoplastic but not normal plasma cells
    • Rawstron AC, Fenton JAL, Ashcroft J, et al. The IL-6 receptor alpha chain (CD126) is expressed by neoplastic but not normal plasma cells. Blood 2000;96:3880-6.
    • (2000) Blood , vol.96 , pp. 3880-3886
    • Rawstron, A.C.1    Fenton, J.A.L.2    Ashcroft, J.3
  • 109
    • 0034700846 scopus 로고    scopus 로고
    • New insights into role of microenvironment in multiple myeloma
    • Tricot G. New insights into role of microenvironment in multiple myeloma. Lancet 2000;355:248-9.
    • (2000) Lancet , vol.355 , pp. 248-249
    • Tricot, G.1
  • 110
    • 0033134764 scopus 로고    scopus 로고
    • Bone marrow neovascularization, plasma cell angiogenic potential and matrix metalloproteinase-2 secretion parallel progression of multiple myeloma
    • Vacca A, Ribatti D, Presta M, et al. Bone marrow neovascularization, plasma cell angiogenic potential and matrix metalloproteinase-2 secretion parallel progression of multiple myeloma. Blood 1999;9:3064-73.
    • (1999) Blood , vol.9 , pp. 3064-3073
    • Vacca, A.1    Ribatti, D.2    Presta, M.3
  • 111
    • 0034329194 scopus 로고    scopus 로고
    • High levels of soluble syndecan-1 in myeloma derived bone marrow: Modulation of hepatocyte growth factor activity
    • Seidel C, Borset M, Hjertner O, et al. High levels of soluble syndecan-1 in myeloma derived bone marrow: modulation of hepatocyte growth factor activity. Blood 2000;96:3139-46.
    • (2000) Blood , vol.96 , pp. 3139-3146
    • Seidel, C.1    Borset, M.2    Hjertner, O.3
  • 112
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Yu-Tzu T, Davies FE, et al. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood 2001;98:428-35.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Yu-Tzu, T.2    Davies, F.E.3
  • 113
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001;98:3527-33.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3
  • 114
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J, et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 2001;98:3534-40.
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3
  • 115
    • 0034618384 scopus 로고    scopus 로고
    • kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
    • kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR). Oncogene 2000;19:4319-27.
    • (2000) Oncogene , vol.19 , pp. 4319-4327
    • Hazlehurst, L.A.1    Damiano, J.S.2    Buyuksal, I.3
  • 116
    • 0030816233 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpes virus infection of bone marrow dendritic cells from multiple myeloma patients
    • Rettig MB, Ma HJ, Vescio RA, et al. Kaposi's sarcoma-associated herpes virus infection of bone marrow dendritic cells from multiple myeloma patients. Science 1997;276:1851-4.
    • (1997) Science , vol.276 , pp. 1851-1854
    • Rettig, M.B.1    Ma, H.J.2    Vescio, R.A.3
  • 117
    • 0033562774 scopus 로고    scopus 로고
    • Kaposi's sarcoma-associated herpes virus and multiple myeloma: Lack of criteria for causality
    • Tarte K, Chang Y, Klein B. Kaposi's sarcoma-associated herpes virus and multiple myeloma: lack of criteria for causality. Blood 1999;10:3159-63.
    • (1999) Blood , vol.10 , pp. 3159-3163
    • Tarte, K.1    Chang, Y.2    Klein, B.3
  • 118
    • 0035496928 scopus 로고    scopus 로고
    • Hypodiploidy is a major prognostic factor in multiple myeloma
    • Smadja NV, Bastard C, Brigaudeau C, et al. Hypodiploidy is a major prognostic factor in multiple myeloma. Blood 2001;98:2229-38.
    • (2001) Blood , vol.98 , pp. 2229-2238
    • Smadja, N.V.1    Bastard, C.2    Brigaudeau, C.3
  • 119
    • 79960970975 scopus 로고    scopus 로고
    • Specific action of FGFR inhibitors against t(4;14) positive myeloma cells
    • Pourgourides E, Heath C, Melo JV, et al. Specific action of FGFR inhibitors against t(4;14) positive myeloma cells [abstract]. Blood 2001;98(suppl 1):1560.
    • (2001) Blood , vol.98 , Issue.SUPPL. 1 , pp. 1560
    • Pourgourides, E.1    Heath, C.2    Melo, J.V.3
  • 120
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis and overcomes drug resistance in human myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis and overcomes drug resistance in human myeloma cells. Cancer Res 2001;61:3071-6.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 121
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 2002;99:4079-86.
    • (2002) Blood , vol.99 , pp. 4079-4086
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.