A potential role for the XRCC2 R188H polymorphic site in DNA-damage repair and breast cancer

Human Molecular Genetics

Volumn 11, Issue 12, 2002, Pages

  Chattopadhyay, Subrata ^a   Ito, Masumi ^a   Cooper, Jonathan D ^b   Brooks, Andrew I ^a   Curran, Timothy M ^a   Powers, James M ^a   Pearce, David A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; DOUBLE STRANDED DNA; RAD51 PROTEIN;

ADULT; AGED; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; FAMILY HISTORY; GENE DELETION; GENETIC POLYMORPHISM; GENETIC STABILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; ONSET AGE; PRIORITY JOURNAL; PROTEIN FAMILY; SITE DIRECTED MUTAGENESIS;

AGED; AMINO ACID SUBSTITUTION; BREAST NEOPLASMS; CELL SURVIVAL; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MIDDLE AGED; MITOMYCIN; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; POLYMORPHISM, GENETIC;

EID: 71749087375     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

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16. Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination
17. Xrcc3 is required for assembly of Rad51 complexes in vivo
18. XRCC2 is a nuclear RAD51-like protein, required for damage-dependent RAD51 focus formation without the need for ATP binding
19. XRCC2 is required for genetic stability, embryonic neurogenesis and viability in mice
20. A common variant in BRCA2 is associated with both breast cancer risk and prenatal viability
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27. No association between the XPD (Lys751Gln) polymorphism or the XRCC3 (Thr541 Met) polymorphism and lung cancer risk
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