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Volumn 18, Issue 5, 1998, Pages 3089-3100

Gene amplification in a p53-deficient cell line requires cell cycle progression under conditions that generate DNA breakage

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMETABOLITE; PROTEIN P53;

EID: 0031893222     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.18.5.3089     Document Type: Article
Times cited : (78)

References (85)
  • 1
    • 0028969514 scopus 로고
    • Genetic instability as a consequence of inappropriate entry into and progression through S-phase
    • Almasan, A., S. P. Linke, T. G. Paulson, L. Huang, and G. M. Wahl. 1995. Genetic instability as a consequence of inappropriate entry into and progression through S-phase. Cancer Metas. Rev. 14:59-73.
    • (1995) Cancer Metas. Rev. , vol.14 , pp. 59-73
    • Almasan, A.1    Linke, S.P.2    Paulson, T.G.3    Huang, L.4    Wahl, G.M.5
  • 2
    • 0029050533 scopus 로고
    • pRb deficiency leads to inappropriate entry into S-phase, activation of E2F responsive genes and apoptosis
    • Almasan, A., Y. Yin, R. Kelly, E. Lee, A. Bradley, W. Li, J. Bertino, and G. Wahl. 1995. pRb deficiency leads to inappropriate entry into S-phase, activation of E2F responsive genes and apoptosis. Proc. Natl. Acad. Sci. USA 92:5436-5440.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.3    Lee, E.4    Bradley, A.5    Li, W.6    Bertino, J.7    Wahl, G.8
  • 4
    • 0025319930 scopus 로고
    • Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin
    • Andrulis, I. L., R. Argonza, and A. E. Cairney. 1990. Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin. Somat. Cell Mol. Genet. 16:59-65.
    • (1990) Somat. Cell Mol. Genet. , vol.16 , pp. 59-65
    • Andrulis, I.L.1    Argonza, R.2    Cairney, A.E.3
  • 6
    • 0021112720 scopus 로고
    • Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells
    • Ayusawa, D., K. Shimizu, H. Koyama, K. Takeishi, and T. Seno. 1983. Accumulation of DNA strand breaks during thymineless death in thymidylate synthase-negative mutants of mouse FM3A cells. J. Biol. Chem. 258: 12448-12454.
    • (1983) J. Biol. Chem. , vol.258 , pp. 12448-12454
    • Ayusawa, D.1    Shimizu, K.2    Koyama, H.3    Takeishi, K.4    Seno, T.5
  • 7
    • 0026102788 scopus 로고
    • Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines
    • Benner, S. E., G. M. Wahl, and H. D. Von. 1991. Double minute chromosomes and homogeneously staining regions in tumors taken directly from patients versus in human tumor cell lines. Anticancer Drugs 2:11-25.
    • (1991) Anticancer Drugs , vol.2 , pp. 11-25
    • Benner, S.E.1    Wahl, G.M.2    Von, H.D.3
  • 9
    • 0020604325 scopus 로고
    • Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea
    • Brown, P. C., T. D. Tlsty, and R. T. Schimke. 1983. Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol. Cell. Biol. 3:1097-1107.
    • (1983) Mol. Cell. Biol. , vol.3 , pp. 1097-1107
    • Brown, P.C.1    Tlsty, T.D.2    Schimke, R.T.3
  • 10
    • 0029741951 scopus 로고    scopus 로고
    • Separate pathways for p53 induction by ionizing radiation and N-(Phosphonoacetyl)-L aspartate
    • Chen, C., I. Hall, T. Lansing, T. Gilmer, and M. Kastan. 1996. Separate pathways for p53 induction by ionizing radiation and N-(Phosphonoacetyl)-L aspartate. Cancer Res. 56:3659-3662.
    • (1996) Cancer Res. , vol.56 , pp. 3659-3662
    • Chen, C.1    Hall, I.2    Lansing, T.3    Gilmer, T.4    Kastan, M.5
  • 11
    • 0017346890 scopus 로고
    • In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain
    • Chen, T. R. 1977. In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechst 33258 stain. Exp. Cell Res. 104:255-262.
    • (1977) Exp. Cell Res. , vol.104 , pp. 255-262
    • Chen, T.R.1
  • 12
    • 0027532443 scopus 로고
    • An analysis of vincristine-resistance in BHK cells pretreated with 1-beta-D-arabinofuranosylcytosine
    • Chen, Y., B. Goz, and L. Kirkman. 1993. An analysis of vincristine-resistance in BHK cells pretreated with 1-beta-D-arabinofuranosylcytosine. Anticancer Res. 13:249-255.
    • (1993) Anticancer Res. , vol.13 , pp. 249-255
    • Chen, Y.1    Goz, B.2    Kirkman, L.3
  • 13
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons
    • Coquelle, A., E. Pipiras, F. Toledo, G. Buttin, and M. Debatisse. 1997. Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons. Cell 89:215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 14
    • 0020965275 scopus 로고
    • Occurrence and evolution of homogeneously staining regions may be due to breakage-fusion-bridge cycles following telomere loss
    • Cowell, J. K., and O. J. Miller. 1983. Occurrence and evolution of homogeneously staining regions may be due to breakage-fusion-bridge cycles following telomere loss. Chromosoma 88:216-221.
    • (1983) Chromosoma , vol.88 , pp. 216-221
    • Cowell, J.K.1    Miller, O.J.2
  • 17
    • 0029616222 scopus 로고
    • Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-ras
    • Denko, N., J. Stringer, M. Wani, and P. Stambrook. 1995. Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-ras. Somat. Cell Mol. Genet. 21:241-253.
    • (1995) Somat. Cell Mol. Genet. , vol.21 , pp. 241-253
    • Denko, N.1    Stringer, J.2    Wani, M.3    Stambrook, P.4
  • 18
    • 0028338927 scopus 로고
    • The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle
    • Denko, N. C., A. J. Giaccia, J. R. Stringer, and P. J. Stambrook. 1994. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proc. Natl. Acad. Sci. USA 91:5124-5128.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5124-5128
    • Denko, N.C.1    Giaccia, A.J.2    Stringer, J.R.3    Stambrook, P.J.4
  • 19
    • 0027155140 scopus 로고
    • Transfected c-Ha-ras oncogene enhances karyotypic instability and integrates predominantly in aberrant chromosomes
    • de Vries, J. E., F. H. Kornips, P. Marx, F. T. Bosman, J. P. Geraedts, and J. ten Kate. 1993. Transfected c-Ha-ras oncogene enhances karyotypic instability and integrates predominantly in aberrant chromosomes. Cancer Genet. Cytogenet. 67:35-43.
    • (1993) Cancer Genet. Cytogenet. , vol.67 , pp. 35-43
    • De Vries, J.E.1    Kornips, F.H.2    Marx, P.3    Bosman, F.T.4    Geraedts, J.P.5    Ten Kate, J.6
  • 20
    • 0027536498 scopus 로고
    • DNA topoisomerase II inhibition and gene amplification in V79/B7 cells
    • Di Leonardo, A., P. Cavolina, and A. Maddalena. 1993. DNA topoisomerase II inhibition and gene amplification in V79/B7 cells. Mutat. Res. 301:177-182.
    • (1993) Mutat. Res. , vol.301 , pp. 177-182
    • Di Leonardo, A.1    Cavolina, P.2    Maddalena, A.3
  • 21
    • 0030929838 scopus 로고    scopus 로고
    • DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function
    • Di Leonardo, A., S. H. Khan, S. P. Linke, V. Greco, G. Seidita, and G. M. Wahl. 1997. DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function. Cancer Res. 57:1013-1019.
    • (1997) Cancer Res. , vol.57 , pp. 1013-1019
    • Di Leonardo, A.1    Khan, S.H.2    Linke, S.P.3    Greco, V.4    Seidita, G.5    Wahl, G.M.6
  • 22
    • 0027970713 scopus 로고
    • DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts
    • Di Leonardo, A., S. P. Linke, K. Clarkin, and G. M. Wahl. 1994. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8:2540-2551.
    • (1994) Genes Dev. , vol.8 , pp. 2540-2551
    • Di Leonardo, A.1    Linke, S.P.2    Clarkin, K.3    Wahl, G.M.4
  • 24
    • 0016958680 scopus 로고
    • Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells
    • Flintoff, W. F., S. V. Davidson, and L. Siminovitch. 1976. Isolation and partial characterization of three methotrexate-resistant phenotypes from Chinese hamster ovary cells. Somat. Cell Genet. 2:245-261.
    • (1976) Somat. Cell Genet. , vol.2 , pp. 245-261
    • Flintoff, W.F.1    Davidson, S.V.2    Siminovitch, L.3
  • 26
    • 0031035639 scopus 로고    scopus 로고
    • Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
    • Fukasawa, K., and G. F. Vande Woude. 1997. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability. Mol. Cell. Biol. 17:506-518.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 506-518
    • Fukasawa, K.1    Vande Woude, G.F.2
  • 27
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt, M. S., W. P. Bennett, M. Hollstein, and C. C. Harris. 1994. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54:4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 28
    • 0027631352 scopus 로고
    • Molecular biology of double-minute chromosomes
    • Hahn, P. J. 1993. Molecular biology of double-minute chromosomes. Bioessays 15:477-484.
    • (1993) Bioessays , vol.15 , pp. 477-484
    • Hahn, P.J.1
  • 29
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell, L. H., and M. B. Kastan. 1994. Cell cycle control and cancer. Science 266:1821-1828.
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 30
    • 0022385486 scopus 로고
    • Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations
    • Hill, A., and R. Schimke. 1985. Increased gene amplification in L5178Y mouse lymphoma cells with hydroxyurea-induced chromosomal aberrations. Cancer Res. 45:5050-5057.
    • (1985) Cancer Res. , vol.45 , pp. 5050-5057
    • Hill, A.1    Schimke, R.2
  • 31
    • 0029897210 scopus 로고    scopus 로고
    • Sensitivity and selectivity of the p53-mediated DNA damage sensor
    • Huang, L.-C., K. C. Clarkin, and G. M. Wahl. 1996. Sensitivity and selectivity of the p53-mediated DNA damage sensor. Proc. Natl. Acad. Sci. USA 93:4827-4832.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 4827-4832
    • Huang, L.-C.1    Clarkin, K.C.2    Wahl, G.M.3
  • 32
    • 0031012977 scopus 로고    scopus 로고
    • Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53
    • Hundley, J. E., S. K. Koester, D. A. Troyer, S. G. Hilsenbeck, M. A. Subler, and J. J. Windle. 1997. Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53. Mol. Cell. Biol. 17:723-731.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 723-731
    • Hundley, J.E.1    Koester, S.K.2    Troyer, D.A.3    Hilsenbeck, S.G.4    Subler, M.A.5    Windle, J.J.6
  • 33
    • 0022445768 scopus 로고
    • Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene
    • Johnson, B. E., J. Battey, I. Linnoila, K. L. Becker, R. W. Makuch, R. H. Snider, D. N. Carney, and J. D. Minna. 1986. Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c-myc proto-oncogene. J. Clin. Invest. 78:525-32.
    • (1986) J. Clin. Invest. , vol.78 , pp. 525-532
    • Johnson, B.E.1    Battey, J.2    Linnoila, I.3    Becker, K.L.4    Makuch, R.W.5    Snider, R.H.6    Carney, D.N.7    Minna, J.D.8
  • 34
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D. G., J. K. Schwarz, W. D. Cress, and J. R. Nevins. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365:349-352.
    • (1993) Nature , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 35
    • 0020530971 scopus 로고
    • Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting
    • Johnston, R., S. Beverley, and R. Schimke. 1983. Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proc. Natl. Acad. Sci. USA 80:3711-3715.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3711-3715
    • Johnston, R.1    Beverley, S.2    Schimke, R.3
  • 37
  • 38
    • 0021814288 scopus 로고
    • Cellular and clinical pharmacology of low-dose ara-C
    • Kufe, D. W., J. D. Griffin, and D. R. Spriggs. 1985. Cellular and clinical pharmacology of low-dose ara-C. Semin. Oncol. 2(Suppl. 3):200-207.
    • (1985) Semin. Oncol. , vol.2 , Issue.3 SUPPL. , pp. 200-207
    • Kufe, D.W.1    Griffin, J.D.2    Spriggs, D.R.3
  • 39
    • 0027982007 scopus 로고
    • Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells
    • Kuo, M. T., R. C. Vyas, L. X. Jiang, and W. N. Hittelman. 1994. Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Mol. Cell. Biol. 14:5202-5211.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 5202-5211
    • Kuo, M.T.1    Vyas, R.C.2    Jiang, L.X.3    Hittelman, W.N.4
  • 40
    • 0029112238 scopus 로고
    • Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: The use of human papillomavirus E6 to target p53
    • Labrecque, S., and G. J. Matlashewski. 1995. Viability of wild type p53-containing and p53-deficient tumor cells following anticancer treatment: the use of human papillomavirus E6 to target p53. Oncogene 11:387-392.
    • (1995) Oncogene , vol.11 , pp. 387-392
    • Labrecque, S.1    Matlashewski, G.J.2
  • 41
    • 0029038135 scopus 로고
    • Apoptosis, cancer and the p53 tumour suppressor gene
    • Lee, J. M., and A. Bernstein. 1995. Apoptosis, cancer and the p53 tumour suppressor gene. Cancer Metastasis Rev. 14:149-161.
    • (1995) Cancer Metastasis Rev. , vol.14 , pp. 149-161
    • Lee, J.M.1    Bernstein, A.2
  • 42
    • 0028827582 scopus 로고
    • Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines
    • Li, C. Y., H. Nagasawa, W. K. Dahlberg, and J. B. Little. 1995. Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines. Oncogene 11:1885-1892.
    • (1995) Oncogene , vol.11 , pp. 1885-1892
    • Li, C.Y.1    Nagasawa, H.2    Dahlberg, W.K.3    Little, J.B.4
  • 43
    • 0006889222 scopus 로고
    • Accumulation of DNA strand breaks and methotrexate cytotoxicity
    • Li, J. C., and E. Kaminskas. 1984. Accumulation of DNA strand breaks and methotrexate cytotoxicity. Proc. Natl. Acad. Sci. USA 81:5694-5698.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 5694-5698
    • Li, J.C.1    Kaminskas, E.2
  • 45
    • 0029964158 scopus 로고    scopus 로고
    • A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
    • Linke, S. P., K. C. Clarkin, L. A. Di, A. Tsou, and G. M. Wahl. 1996. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage. Genes Dev. 10:934-947.
    • (1996) Genes Dev. , vol.10 , pp. 934-947
    • Linke, S.P.1    Clarkin, K.C.2    Di, L.A.3    Tsou, A.4    Wahl, G.M.5
  • 46
    • 0028990145 scopus 로고
    • Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status
    • Little, J. B., H. Nagasawa, P. C. Keng, Y. Yu, and C. Y. Li. 1995. Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. J. Biol. Chem. 270:11033-11036.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11033-11036
    • Little, J.B.1    Nagasawa, H.2    Keng, P.C.3    Yu, Y.4    Li, C.Y.5
  • 47
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone, L. R., A. White, J. Sprouse, E. Livanos, T. Jacks, and T. D. Tisty. 1992. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 70:923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tisty, T.D.6
  • 48
    • 0027152244 scopus 로고
    • Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells
    • Ma, C., S. Martin, B. Trask, and J. L. Hamlin. 1993. Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in Chinese hamster cells. Genes Dev. 7:605-620.
    • (1993) Genes Dev. , vol.7 , pp. 605-620
    • Ma, C.1    Martin, S.2    Trask, B.3    Hamlin, J.L.4
  • 49
    • 0027380346 scopus 로고
    • Delayed chromosomal instability induced by DNA damage
    • Marder, B. A., and W. F. Morgan. 1993. Delayed chromosomal instability induced by DNA damage. Mol. Cell. Biol. 13:6667-6677.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6667-6677
    • Marder, B.A.1    Morgan, W.F.2
  • 50
    • 0021715393 scopus 로고
    • The significance of responses of the genome to challenge
    • McClintock, B. 1984. The significance of responses of the genome to challenge. Science 226:792-801.
    • (1984) Science , vol.226 , pp. 792-801
    • McClintock, B.1
  • 51
    • 0018682878 scopus 로고
    • Role of thymidylate synthetase activity in development of methotrexate cytotoxicity
    • Moran, R. G., M. Mulkins, and C. Heidelberger. 1979. Role of thymidylate synthetase activity in development of methotrexate cytotoxicity. Proc. Natl. Acad. Sci. USA 76:5924-5928.
    • (1979) Proc. Natl. Acad. Sci. USA , vol.76 , pp. 5924-5928
    • Moran, R.G.1    Mulkins, M.2    Heidelberger, C.3
  • 52
    • 0020443654 scopus 로고
    • Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells
    • Moyer, J. D., P. A. Smith, E. J. Levy, and R. E. Handschumacher. 1982. Kinetics of N-(phosphonacetyl)-L-aspartate and pyrazofurin depletion of pyrimidine ribonucleotide and deoxyribonucleotide pools and their relationship to nucleic acid synthesis in intact and permeabilized cells. Cancer Res. 42:4525-4531.
    • (1982) Cancer Res. , vol.42 , pp. 4525-4531
    • Moyer, J.D.1    Smith, P.A.2    Levy, E.J.3    Handschumacher, R.E.4
  • 53
    • 0028986606 scopus 로고
    • Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells
    • Nagasawa, H., C. Y. Li, C. G. Maki, A. C. Imrich, and J. B. Little. 1995. Relationship between radiation-induced G1 phase arrest and p53 function in human tumor cells. Cancer Res. 55:1842-1846.
    • (1995) Cancer Res. , vol.55 , pp. 1842-1846
    • Nagasawa, H.1    Li, C.Y.2    Maki, C.G.3    Imrich, A.C.4    Little, J.B.5
  • 54
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson, W. G., and M. B. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 55
    • 0028204160 scopus 로고
    • DNA strand breaks: The DNA template alterations that trigger p53-dependent DNA damage response pathways
    • Nelson, W. G., and M. B. Kastan. 1994. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1815-1823.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1815-1823
    • Nelson, W.G.1    Kastan, M.B.2
  • 57
    • 0029873705 scopus 로고    scopus 로고
    • Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles
    • Poupon, M. F., K. A. Smith, O. B. Chernova, C. Gilbert, and G. R. Stark. 1996. Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles. Mol. Biol. Cell 7:345-354.
    • (1996) Mol. Biol. Cell , vol.7 , pp. 345-354
    • Poupon, M.F.1    Smith, K.A.2    Chernova, O.B.3    Gilbert, C.4    Stark, G.R.5
  • 58
    • 0016373845 scopus 로고
    • Characterization of a newly derived human sarcoma cell line (HT-1080)
    • Rasheed, S. 1974. Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33:1027-1033.
    • (1974) Cancer , vol.33 , pp. 1027-1033
    • Rasheed, S.1
  • 59
    • 0025330850 scopus 로고
    • Chromosomal destabilization during gene amplification
    • Ruiz, J. C., and G. M. Wahl. 1990. Chromosomal destabilization during gene amplification. Mol. Cell. Biol. 10:3056-3066.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 3056-3066
    • Ruiz, J.C.1    Wahl, G.M.2
  • 60
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 61
    • 0023940788 scopus 로고
    • Gene amplification in cultured cells
    • Schimke, R. T. 1988. Gene amplification in cultured cells. J. Biol. Chem. 263:5989-5992.
    • (1988) J. Biol. Chem. , vol.263 , pp. 5989-5992
    • Schimke, R.T.1
  • 62
    • 13844320300 scopus 로고
    • Gene amplification; what are we learning?
    • Schimke, R. T. 1992. Gene amplification; what are we learning? Mutat. Res. 276:145-149.
    • (1992) Mutat. Res. , vol.276 , pp. 145-149
    • Schimke, R.T.1
  • 64
    • 0024405687 scopus 로고
    • Enhancement of the frequency of methotrexate resistance by G-radiation in Chinese hamster ovary and mouse 3T6 cells
    • Sharma, R. C., and R. T. Schimke. 1989. Enhancement of the frequency of methotrexate resistance by G-radiation in Chinese hamster ovary and mouse 3T6 cells. Cancer Res. 49:3861-3866.
    • (1989) Cancer Res. , vol.49 , pp. 3861-3866
    • Sharma, R.C.1    Schimke, R.T.2
  • 65
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Sherr, C. J. 1996. Cancer cell cycles. Science 274:1672-1677.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 68
    • 0031055329 scopus 로고    scopus 로고
    • Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: Carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged
    • Smith, K. A., O. B. Chernova, R. P. Groves, M. B. Stark, J. L. Martinez, J. N. Davidson, J. M. Trent, T. E. Patterson, A. Agarwal, P. Duncan, M. L. Agarwal, and G. R. Stark. 1997. Multiple mechanisms of N-phosphonacetyl-L-aspartate resistance in human cell lines: carbamyl-P synthetase/aspartate transcarbamylase/dihydro-orotase gene amplification is frequent only when chromosome 2 is rearranged. Proc. Natl. Acad. Sci. USA 94:1816-1821.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1816-1821
    • Smith, K.A.1    Chernova, O.B.2    Groves, R.P.3    Stark, M.B.4    Martinez, J.L.5    Davidson, J.N.6    Trent, J.M.7    Patterson, T.E.8    Agarwal, A.9    Duncan, P.10    Agarwal, M.L.11    Stark, G.R.12
  • 69
    • 0026636626 scopus 로고
    • Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells
    • Smith, K. A., M. B. Stark, P. A. Gorman, and G. R. Stark. 1992. Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells. Proc. Natl. Acad. Sci. USA 89:5427-5431.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5427-5431
    • Smith, K.A.1    Stark, M.B.2    Gorman, P.A.3    Stark, G.R.4
  • 70
    • 0022835788 scopus 로고
    • Microinjection of the ras oncogene protein into nonestablished rat embryo fibroblasts
    • Sullivan, N. F., R. W. Sweet, M. Rosenberg, and J. R. Feramisco. 1986. Microinjection of the ras oncogene protein into nonestablished rat embryo fibroblasts. Cancer Res. 6427-6432
    • (1986) Cancer Res. , vol.6427-6432
    • Sullivan, N.F.1    Sweet, R.W.2    Rosenberg, M.3    Feramisco, J.R.4
  • 71
    • 0016242582 scopus 로고
    • N-(Phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture
    • Swyryd, E. A., S. S. Seaver, and G. R. Stark. 1974. N-(Phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture. J. Biol. Chem. 249:6945-6950.
    • (1974) J. Biol. Chem. , vol.249 , pp. 6945-6950
    • Swyryd, E.A.1    Seaver, S.S.2    Stark, G.R.3
  • 72
    • 0009605722 scopus 로고
    • Enhanced frequency of generation of methotrexate resistance and gene amplification in cultured mouse and hamster cell lines
    • R. T. Schimke (ed.), Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • Tlsty, T., P. C. Brown, R. Johnston, and R. T. Schimke. 1982. Enhanced frequency of generation of methotrexate resistance and gene amplification in cultured mouse and hamster cell lines, p. 231-238. In R. T. Schimke (ed.), Gene amplification. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
    • (1982) Gene Amplification , pp. 231-238
    • Tlsty, T.1    Brown, P.C.2    Johnston, R.3    Schimke, R.T.4
  • 73
    • 0025253116 scopus 로고
    • Normal diploid human and rodent cells lack a detectable 0frequency of gene amplification
    • Tlsty, T. D. 1990. Normal diploid human and rodent cells lack a detectable 0frequency of gene amplification. Proc. Natl. Acad. Sci. USA 87:3132-3136:
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 3132-3136
    • Tlsty, T.D.1
  • 74
    • 0024357990 scopus 로고
    • Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis
    • Tlsty, T. D., B. H. Margolin and K. Lum. 1989. Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc. Natl. Acad. Sci. USA 86:9441-9445.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 9441-9445
    • Tlsty, T.D.1    Margolin, B.H.2    Lum, K.3
  • 75
    • 0019480401 scopus 로고
    • Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion
    • Varshavsky, A. 1981. Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion. Cell 25:561-572.
    • (1981) Cell , vol.25 , pp. 561-572
    • Varshavsky, A.1
  • 77
    • 0025271203 scopus 로고
    • Association of human papillomavirus types 16 and 18 E6 proteins with p53
    • Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
    • (1990) Science , vol.248 , pp. 76-79
    • Werness, B.A.1    Levine, A.J.2    Howley, P.M.3
  • 78
    • 0028034571 scopus 로고
    • Drug-specific rearrangements of chromosome 12 in hydroxyurea-resistant mouse SEWA cells: Support for chromosomal breakage model of gene amplification
    • Wettergren, Y., A. Kullberg, and G. Levan. 1994. Drug-specific rearrangements of chromosome 12 in hydroxyurea-resistant mouse SEWA cells: support for chromosomal breakage model of gene amplification. Somat. Cell Mol. Genet. 20:267-285.
    • (1994) Somat. Cell Mol. Genet. , vol.20 , pp. 267-285
    • Wettergren, Y.1    Kullberg, A.2    Levan, G.3
  • 79
    • 0028331229 scopus 로고
    • Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins
    • White, A. E., E. M. Livanos, and T. D. Tlsty. 1994. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev. 8:666-677.
    • (1994) Genes Dev. , vol.8 , pp. 666-677
    • White, A.E.1    Livanos, E.M.2    Tlsty, T.D.3
  • 80
    • 0026018901 scopus 로고
    • A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration
    • Windle, B., B. W. Draper, Y. X. Yin, S. O'Gorman and G. M. Wahl. 1991. A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. Genes Dev. 5:160-174.
    • (1991) Genes Dev. , vol.5 , pp. 160-174
    • Windle, B.1    Draper, B.W.2    Yin, Y.X.3    O'Gorman, S.4    Wahl, G.M.5
  • 81
    • 0242672936 scopus 로고
    • Molecular dissection of mammalian gene amplification: New mechanistic insights revealed by analyses of very early events
    • Windle, B. E., and G. M. Wahl. 1992. Molecular dissection of mammalian gene amplification: new mechanistic insights revealed by analyses of very early events. Mutat. Res. 276:199-224.
    • (1992) Mutat. Res. , vol.276 , pp. 199-224
    • Windle, B.E.1    Wahl, G.M.2
  • 83
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X., and A. J. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:3602-3606.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 84
    • 0021659679 scopus 로고
    • Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5′ non-coding sequence and strong intron size divergence from homologous mammalian genes
    • Yang, J. K., J. N. Masters, and G. Attardi. 1984. Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5′ non-coding sequence and strong intron size divergence from homologous mammalian genes. J. Mol. Biol. 176:169-187.
    • (1984) J. Mol. Biol. , vol.176 , pp. 169-187
    • Yang, J.K.1    Masters, J.N.2    Attardi, G.3
  • 85
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin, Y., M. A. Tainsky, F. Z. Bischoff, L. C. Strong, and G. M. Wahl. 1992. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5


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