DNA ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2

Current Biology

Volumn 12, Issue 19, 2002, Pages 1635-1644

  Smogorzewska, Agata ^a   Karlseder, Jan ^a   Holtgreve Grez, Heidi ^b   Jauch, Anna ^b   De Lange, Titia ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE (ATP); TELOMERIC REPEAT BINDING FACTOR 2;

ANIMAL; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL DIVISION; CELL LINE; CHROMATID; DRUG ANTAGONISM; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION REGULATION; GENE TRANSLOCATION; GENETIC RECOMBINATION; GENETICS; HUMAN; METABOLISM; TELOMERE;

ANIMALS; CELL DIVISION; CELL LINE; CHROMATIDS; DNA LIGASES; G1 PHASE; G2 PHASE; GENE EXPRESSION REGULATION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; RECOMBINATION, GENETIC; TELOMERE; TELOMERIC REPEAT BINDING PROTEIN 2; TRANSLOCATION, GENETIC;

ANIMALIA; MAMMALIA;

EID: 0036792871     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01179-X     Document Type: Article

References (48)

1. de Lange, T. (1995). Telomere dynamics and genome instability in human cancer. In Telomeres, C.W. Greider and E.H. Blackburn, eds. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), pp. 265-293.
2. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. (1998). Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352.
3. Vaziri, H., and Benchimol, S. (1998). Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282.
4. Mitchell, J.R., Wood, E., and Collins, K. (1999). A telomerase component is defective in the human disease dyskeratosis congenita. Nature 402, 551-555.
5. Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P.J., and Dokal, I. (2001). The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413, 432-435.
6. de Lange, T. (2002). Protection of mammalian telomeres. Oncogene 21, 532-540.
7. van Steensel, B., Smogorzewska, A., and de Lange, T. (1998). TRF2 protects human telomeres from end-to-end fusions. Cell 92, 401-413.
8. Critchlow, S.E., and Jackson, S.P. (1998). DNA end-joining: from yeast to man. Trends Biochem. Sci. 23, 394-398.
9. Espejel, S., Franco, S., Rodriguez-Perales, S., Bouffler, S.D., Cigudosa, J.C., and Blasco, M.A. (2002). Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres. EMBO J. 21, 2207-2219.
10. Bailey, S.M., Cornforth, M.N., Kurimasa, A., Chen, D.J., and Goodwin, E.H. (2001). Strand-specific postreplicative processing of mammalian telomeres. Science 293, 2462-2465.
11. Bailey, S.M., Meyne, J., Chen, D.J., Kurimasa, A., Li, G.C., Lehnerr, B.E., and Goodwin, E.H. (1999). DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc. Natl. Acad. Sci. USA 96, 14899-14904.
12. d'Adda di Fagagna, F., Hande, M.P., Tong, W.M., Roth, D., Lansdorp, P.M., Wang, Z.Q., and Jackson, S.P. (2001). Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells. Curt. Biol. 11, 1192-1196.
13. Hsu, H.L., Gilley, D., Galande, S.A., Hande, M.P., Allen, B., Kim, S.H., Li, G.C., Campisi, J., Kohwi-Shigematsu, T., and Chen, D.J. (2000). Ku acts in a unique way at the mammalian telomere to prevent end joining. Genes Dev. 14, 2807-2812.
14. Goytisolo, F.A., Samper, E., Edmonson, S., Taccioli, G.E., and Blasco, M.A. (2001). The absence of the DNA-dependent protein kinase catalytic subunit in mice results in anaphase bridges and in increased telomeric fusions with normal telomere length and G-strand overhang. Mol. Cell. Biol. 21, 3642-3651.
15. Samper, E., Goytisolo, F.A., Slijepcevic, P., van Buul, P.P., and Blasco, M.A. (2000). Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep. 1, 244-252.
16. Gilley, D., Tanaka, H., Hande, M.P., Kurimasa, A., Li, G.C., Oshimura, M., and Chen, D.J. (2001). DNA-PKcs is critical for telomere capping. Proc. Natl. Acad. Sci. USA 98, 15084-15088.
17. Hsu, H.L., Gilley, D., Blackburn, E.H., and Chen, D.J. (1999). Ku is associated with the telomere in mammals. Proc. Natl. Acad. Sci. USA 96, 12454-12458.
18. Karlseder, J., Broccoli, D., Dai, Y., Hardy, S., and de Lange, T. (1999). p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283, 1321-1325.
19. Smogorzewska, A., and de Lange, T. (2002). Different telomere damage signaling pathways in human and mouse cells. EMBO J. 21, 4338-4348.
20. Speicher, M.R., Gwyn Ballard, S., and Ward, D.C. (1996). Karyo-typing human chromosomes by combinatorial multi-fluor Fish. Nat. Genet. 12, 368-375.
21. Eils, R., Uhrig, S., Saracoglu, K., Satzler, K., Bolzer, A., Petersen, I., Chassery, J., Ganser, M., and Speicher, M.R. (1998). An optimized, fully automated system for fast and accurate identification of chromosomal rearrangements by multiplex-FISH (M-FISH). Cytogenet. Cell Genet. 82, 160-171.
22. Frank, K.M., Sekiguchi, J.M., Seidl, K.J., Swat, W., Rathbun, G.A., Cheng, H.L., Davidson, L., Kangaloo, L., and Alt, F.W. (1998). Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV. Nature 396, 173-177.
23. Frank, K.M., Sharpless, N.E., Gao, Y., Sekiguchi, J.M., Ferguson, D.O., Zhu, C., Manis, J.P., Homer, J., DePinho, R.A., and Alt, F.W. (2000). DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol. Cell 5, 993-1002.
24. Ferguson, D.O., Sekiguchi, J.M., Chang, S., Frank, K.M., Gao, Y., DePinho, R.A., and Alt, F.W. (2000). The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc. Natl. Acad. Sci. USA 97, 6630-6633.
25. Wright, W.E., Tesmer, V.M., Huffman, K.E., Levene, S.D., and Shay, J.W. (1997). Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11, 2801-2809.
26. Makarov, V.L., Hirose, Y., and Langmore, J.P. (1997). Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666.
27. McElligott, R., and Wellinger, R.J. (1997). The terminal DNA structure of mammalian chromosomes. EMBO J. 16, 3705-3714.
28. Lingner, J., Cooper, J.P., and Cech, T.R. (1995). Telomerase and DNA end replication: no longer a lagging strand problem? Science 269, 1533-1534.
29. Lee, S.E., Moore, J.K., Holmes, A., Umezu, K., Kolodner, R.D., and Haber, J.E. (1998). Saccharomyces Ku70, Mre11/Rad50, and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94, 399-409.
30. Gravel, S., Larrivee, M., Labrecque, P., and Wellinger, R.J. (1998). Yeast Ku as a regulator of chromosomal DNA end structure. Science 280, 741-744.
31. Garvik, B., Carson, M., and Hartwell, L. (1995). Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol. 15, 6128-6138.
32. Lydall, D., and Weinert, T. (1995). Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Science 270, 1488-1491.
33. Baumann, P., and Cech, T.R. (2001). Pot1, the putative telomere end-binding protein in fission yeast and humans. Science 292, 1171-1175.
34. Grandin, N., Reed, S.I., and Charbonneau, M. (1997). Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. Genes Dev. 11, 512-527.
35. Grandin, N., Damon, C., and Charbonneau, M. (2001). Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13. EMBO J. 20, 1173-1183.
36. Lin, J.J., and Zakian, V.A. (1996). The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo. Proc. Natl. Acad. Sci. USA 93, 13760-13765.
37. Nugent, C.I., Hughes, T.R., Lue, N.F., and Lundblad, V. (1996). Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science 274, 249-252.
38. Mitton-Fry, R.M., Anderson, E.M., Hughes, T.R., Lundblad, V., and Wuttke, D.S. (2002). Conserved structure for single-stranded telomeric DNA recognition. Science 296, 145-147.
39. Pennock, E., Buckley, K., and Lundblad, V. (2001). Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell 104, 387-396.
40. Baumann, P., and Cech, T.R. (2000). Protection of telomeres by the Ku protein in fission yeast. Mol. Biol. Cell 11, 3265-3275.
41. Godhino Ferreira, M., and Promisel Cooper, J. (2001). The fission yeast Taz1 protein protects chromosomes from Ku-dependent end-to-end fusions. Mol. Cell 7, 55-63.
42. Pierce, A.J., Hu, P., Han, M., Ellis, N., and Jasin, M. (2001). Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15, 3237-3242.
43. Hastie, N.D., and Allshire, R.C. (1989). Human telomeres: fusion and interstitial sites. Trends Genet. 5, 326-331.
44. de Lange, T., Shiue, L., Myers, R.M., Cox, D.R., Naylor, S.L., Killery, A.M., and Varmus, H.E. (1990). Structure and variability of human chromosome ends. Mol. Cell. Biol. 10, 518-527.
45. Harley, C.B. (1991). Telomere loss: mitotic clock or genetic time bomb? Mutat. Res. 256, 271-282.
46. Karlseder, J., Smogorzewska, A., and de Lange, T. (2002). Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449.
47. Lansdorp, P.M., Verwoerd, N.P., van de Rijke, F.M., Dragowska, V., Little, M.T., Dirks, R.W., Raap, A.K., and Tanke, H.J. (1996). Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5, 685-691.
48. de Lange, T. (1992). Human telomeres are attached to the nuclear matrix. EMBO J. 11, 717-724.