Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 97, Issue 6, 2000, Pages 2668-2673

  Gu, Yansong ^a   Sekiguchi, JoAnn ^a   Gao, Yijie ^a   Dikkes, Pieter ^b   Frank, Karen ^a   Ferguson, David ^a   Hasty, Paul ^c   Chun, Jerold ^d   Alt, Frederick W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c LEXICON PHARMACEUTICALS INC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; EMBRYO; ENZYME DEFICIENCY; ENZYME SUBUNIT; GENETIC CONSERVATION; GENETIC RECOMBINATION; MOUSE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, NUCLEAR; APOPTOSIS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CEREBRAL CORTEX; DIENCEPHALON; DNA HELICASES; DNA LIGASES; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FIBROBLASTS; IN SITU NICK-END LABELING; MICE; MICE, MUTANT STRAINS; NEURONS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN-SERINE-THREONINE KINASES; RECOMBINATION, GENETIC; SPINAL CORD; TIME FACTORS;

ANIMALIA; MAMMALIA;

EID: 0034646304     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.97.6.2668     Document Type: Article

References (36)

1. Jeggo, P. A. (1998) Radiat. Res. 150, S80-S91.
2. Lieber, M. R. (1999) Genes Cells 4, 77-85.
3. Nussenzweig, A., Chen, G., da Costa Soares, M., Sanchez, M., Sokol, K., Nussenzweig, M. D. & Li, G. C. (1996) Nature (London) 382, 551-555.
4. Zhu, C., Bogue, M. A., Lim, D.-S., Hasty, P. & Roth, D. B. (1996) Cell 86, 379-389.
5. Gu, Y., Jin, S., Gao, Y., Weaver, D. T. & Alt, F. W. (1997) Proc. Natl. Acad. Sci. USA 94, 8076-8081.
6. Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J., Frank, K., et al. (1997) Immunity 7, 653-665.
7. Ouyang, H., Nussenzweig, A., Kurimasa, A., Soares, V. C., Li, X., Cordon-Cardo, C., Li, W., Cheong, N., Nussenzweig, M., Illakis, G., et al. (1997) J. Exp. Med. 186, 921-929.
8. Barnes, D. E., Stamp, G., Rosewell, I., Denzel, A. & Lindahl, T. (1998) Curr. Biol. 8, 1395-1398.
9. Frank, K. M., Sekiguchi, J. M., Seidl, K. J., Swat, W., Rathbun, G. A., Cheng, H.-L., Davidson, L., Kangaloo, L. & Alt, F. W. (1998) Nature (London) 396, 173-177.
10. Grawunder, U., Zimmer, D., Fugmann, S., Schwarz, K. & Lieber, M. R. (1998) Mol. Cell 2, 477-484.
11. Gao, Y., Chaudhuri, J., Zhu, C., Davidson, L., Weaver, D. T. & Alt, F. W. (1998) Immunity 9, 367-376.
12. Gao, Y., Sun, Y., Frank, K. M., Dikkes, P., Fujiwara, Y., Seidl, K. J., Sekiguchi, J. M., Rathbun, G. A., Swat, W., Wang, J., et al. (1998) Cell 95, 891-902.
13. Taccioli, G., Amatucci, A., Beamish, H., Gell, D., Xiang, X., Arzayus, M., Priestley, A., Jackson, S., Rothstein, A., Jeggo, P., et al. (1998) Immunity 9, 355-366.
14. Kurimasa, A., Ouyang, H., Dong, L. J., Wang, S., Li, X., Cordon-Cardo, C., Chen, D. J. & Li, G. C. (1999) Proc. Natl. Acad. Sci. USA 96, 1403-1408.
15. Chun, J. & Schatz, D. G. (1999) Neuron 22, 7-10.
16. Willerford, D. M., Swat, W. & Alt, F. W. (1996) Curr. Opin. Genet. Dev. 6, 603-609.
17. Gellert, M. (1997) Adv. Immunol. 64, 39-64.
18. Angevine, J. B., Jr. (1970) J. Comp. Neurol. 139, 129-187.
19. Blaschke, A. J., Weiner, J. A. & Chun, J. (1998) J. Comp. Neurol. 396, 39-50.
20. Hatten, M. E. & Heintz, N. (1995) Annu. Rev. Neurosci. 18, 385-408.
21. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E. M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M., et al. (1992) Cell 68, 855-867.
22. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. & Papaioannou, V. E. (1992) Cell 68, 869-877.
23. Bosma, G. C., Fried, M., Custer, R. P., Carroll, A., Gibson, D. M. & Bosma, M. J. (1988) J. Exp. Med. 167, 1016-1033.
24. Nussenzweig, A., Sokol, K., Burgman, P., Li, L. & Li, G. C. (1997) Prof. Natl. Acad. Sci. USA 94, 13588-13593.
25. Thacker, J. (1999) C. R. Acad. Sci. Ser. III 322, 103-108.
26. Sekiguchi, J. M., Gao, Y., Gu, Y., Frank, K., Chaudhuri, J., Zhu, C., Cheng, H.-L., Manis, J., Ferguson, D., Davidson, L., et al. (2000) Cold Spring Harbor Symp. Quant. Biol. 64, in press.
27. Bayer, S. A. & Altman, J. (1991) Neocortical Development (Raven, New York), pp. 128-149.
28. Edgar, B. (1995) Curr. Opin. Cell Biol. 7, 815-824.
29. Paulovich, A. G., Toczyski, D. P. & Hartwell, L. H. (1997) Cell 88, 315-321.
30. Michel, B., Ehrlich, S. D. & Uzest, M. (1997) EMBO J. 16, 430-438.
31. Krasilnikova, M. M., Samadashwily, G. M., Krasilnikov, A. S. & Mirkin, S. M. (1998) EMBO J. 17, 5095-5102.
32. Dulac, C. & Axel, R. (1995) Cell 83, 195-206.
33. Mombaerts, P. (1999) Annu. Rev. Neurosci. 22, 487-509.
34. Kohmura, N., Senzaki, K., Hamada, S., Kai, N., Yasuda, R., Watanabe, M., Ishii, H., Yasuda, M., Mishina, M. & Yagi, T. (1998) Neuron 10, 1137-1151.
35. Obata, S., Sago, H., Mori, N., Davidson, M., St. John, T. & Suzuki, S. T. (1998) Cell Adhes. Commun. 6, 323-333.
36. Wu, Q. & Maniatis, T. (1999) Cell 97, 779-790.