Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to early amplicons

Cell

Volumn 89, Issue 2, 1997, Pages 215-225

  Coquelle, Arnaud ^a   Pipiras, Eva ^a   Toledo, Franck ^a   Buttin, Gérard ^a   Debatisse, Michelle ^a  

^a CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN; COFORMYCIN; DACTINOMYCIN; DOXORUBICIN; METHOTREXATE; VINBLASTINE;

ARTICLE; CHROMOSOME BREAKAGE; CHROMOSOME FRAGILE SITE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG RESISTANCE; GENE AMPLIFICATION; ONCOGENE; PRIORITY JOURNAL; TUMOR CELL;

MAMMALIA;

EID: 0030904279     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80201-9     Document Type: Article

References (67)

1. Balaban-Mallenbaum, G., Grove, G., and Gilbert, F.W. (1981). The proposed origin of double minutes from homogeneously staining regions (HSR)-marker chromosomes in human neuroblastoma hybrid cell lines. Cancer Genet. Cytogenet. 2, 339-348.
2. Ban, S., Cologne, J.B., and Neriishi, K. (1995). Effect of radiation and cigarette smoking on expression of FUdR-inducible common fragile sites in human peripheral lymphocytes. Mutat. Res. 334, 197-203.
3. Barrett, M., and Andrulis, I. (1992). Asparagine Synthetase Gene Amplification in Albizziin-Resistant Hamster and Human Cell Lines. In Gene Amplification in Mammalian Cells - A Comprehensive Guide, R.E. Kellems, ed. (New York: Marcel Dekker Inc.), pp. 119-129.
4. Bertoni, L., Attolini, C., Tessera, L., Mucciolo, E., and Giulotto, E. (1994). Telomeric and nontelomeric (TTAGGG)n sequences in gene amplification and chromosome stability. Genomics 24, 53-62.
5. Biedler, J.L., Chang, T.D., Scotto, K.W., Melera, P.W., and Spengler, B.A. (1988). Chromosomal organization of amplified genes in multi-drug-resistant Chinese hamster cells. Cancer Res. 48, 3179-3187.
6. Bishop, J.M. (1991). Molecular themes in oncogenesis. Cell 64, 235-248.
7. Brison, O. (1993). Gene amplification and tumor progression. Biochim. Biophys. Acta 1155, 25-41.
8. Carroll, S.M., Gaudray, P., DeRose, M.L., Emery, J.F., Meinkoth, J.L., Nakkim, E., Subler, M., VonHoff, D.D., and Wahl, G.M. (1987). Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol. Cell. Biol. 7, 1740-1750.
9. Champeme, M.H., Bieche, I., Lizard, S., and Lidereau, R. (1995). 11q13 amplification in local recurrence of human primary breast cancer. Genes Chromosom. Cancer 12, 128-133.
10. Chen, A.T., Reidy, J.A., Annest, J.L., Welty, T.K., and Zhou, H.G. (1989). Increased chromosome fragility as a consequence of blood folate levels, smoking status, and coffee consumption. Environ. Mol. Mutagen 13, 319-324.
11. Collins, V.P. (1995). Gene amplification in human gliomas. Glia 15, 289-296.
12. Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., and Bachetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
13. Cowell, J.K. (1982). Double minutes and homogeneously staining regions: gene amplification in mammalian cells. Annu. Rev. Genet. 16, 21-59.
14. Debatisse, M., Berry, M., and Buttin, G. (1982). Stepwise isolation and properties of unstable Chinese hamster cell variants that over-produce adenylate deaminase. Mol. Cell. Biol. 2, 1346-1353.
15. Debatisse, M., Robert de Saint Vincent, B., and Buttin, G. (1984). Expression of several amplified genes in an adenylate-deaminase overproducing variant of Chinese hamster fibroblasts. EMBO J. 3, 3123-3127.
16. Debatisse, M., Saito, I., Buttin, G., and Stark, G.R. (1988). Preferential amplification of rearranged sequences near amplified adenylate deaminase genes. Mol. Cell. Biol. 8, 17-24.
17. Denissenko, M.F., Pao, A., Tang, M.S., and Pfeifer, G.P. (1996). Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274, 430-432.
18. Evans, H.J. (1974). Effects of ionizing radiation on mammalian chromosomes. In Chromosomes and Cancer, J. German, ed. (New York: John Wiley and Sons), pp. 191-237.
19. Fritsche, M., Haessler, C., and Brandner, G. (1993). Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents [published erratum appears in Oncogene (1993) 8, 2605]. Oncogene 8, 307-318.
20. George, D., and Powers, V. (1982). Amplified DNA sequences in Y1 mouse adrenal tumor cells: association with double minutes and localization to a homogeneously staining chromosomal region. Proc. Natl. Acad. Sci. USA 79, 1597-1601.
21. Glover, T.W., and Stein, C.K. (1988). Chromosome breakage and recombination at fragile sites. Am. J. Hum. Genet. 43, 265-273.
22. Gottesman, M.M., Hrycyna, C.A., Schoenlein, P.V., Germann, U.A., and Pastan, I. (1995). Genetic analysis of the multidrug transporter. Annu. Rev. Genet. 29, 607-649.
23. Gottesman, M.M., Pastan, I., and Ambudkar, S.V. (1996). P-glycoprotein and multidrug resistance. Curr. Opin. Genet. Dev. 6, 610-617.
24. Hastie, N.D., and Allshire, R.C. (1989). Human telomeres: fusion and interstitial sites. Trends Genet. 5, 326-331.
25. Jones, C., Penny, L., Mattina, T., Yu, S., Baker, E., Voullaire, L., Langdon, W.Y., Sutherland, G.R., Richards, R.I., and Tunnacliffe, A. (1995). Association of a chromosome deletion syndrome with a fragile site within the proto-oncogene CBL2. Nature 376, 145-149.
26. Kao-Shan, C.S., Fine, R.L., Whang-Peng, J., Lee, E.C., and Chabner, B.A. (1987). Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers. Cancer Res. 47, 6278-6282.
27. Kuo, M.T., Vyas, R.C., Jiang, L., and Hittelman, W.N. (1994). Chromosome breakage at amajorfragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Mol. Cell. Biol., 14, 5202-5211.
28. Lebeau, M.M., and Rowley, J.D. (1984). Heritables fragile sites in cancer. Nature 308, 607-608.
29. Lese, C.M., Rossie, K.M., Appel, B.N., Reddy, J.K., Johnson, J.T., Myers, E.N., and Gollin, S.M. (1995). Visualization of INT2 and HST1 amplification in oral squamous cell carcinomas. Genes Chromosom. Cancer 12, 288-295.
30. Li, J.C., and Kaminskas, E. (1984). Accumulation of DNA strand breaks and methotrexate cytotoxicity. Proc. Natl. Acad. Sci. USA 81, 5694-5698.
31. Ma, C., Martin, S., Trask, B., and Hamlin, J.L. (1993). Sister chromatid fusion initiates amplification of the dihydrofolate reductase gene in chinese hamster cells. Genes Dev. 7, 605-620.
32. Martins, M.B., Sabatier, L., Ricoul, M., Pinton, A., and Dutrillaux, B. (1993). Specific chromosome instability induced by heavy ions: a step towards transformation of human fibroblasts? Mutat. Res. 285, 229-237.
33. Maurer, B.J., Lai, E., Hamkalo, B.A., Hood, L., and Attardi, G. (1987). Novel submicroscopic extrachromosomic elements containing amplified genes in human cells. Nature 327, 434-437.
34. McClintock, B. (1951). Chromosome organization and genie expression. Cold Spring Harbor Symp. Quant. Biol. 16, 13-47.
35. 2? In Chromosomal Aberrations, Basic and Applied Aspects, G. Obe and A.T. Natarajan, eds. (Berlin: Springer Verlag), pp. 41-49.
36. Nelson, W.G., and Kastan, M.B. (1994). DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14, 1815-1823.
37. Nowell, P.C. (1976). The clonal evolution of tumor cell populations. Science 194, 23-28.
38. Ohta, M., Inoue, H., Cotticelli, M.G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., et al. (1996). The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84, 587-597.
39. Pedeutour, F., Suijkerbuijk, R.F., Forus, A., Van Gaal, J., Van de Klundert, W., Coindre, J.M., Nicolo, G., Collin, F., Van Haelst, U., Huffermann, K., et al. (1994). Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcoma. Genes Chromosom. Cancer 10, 85-94.
40. Pinkel, D., Landegent, J., Collins, C., Fuscoe, J., Segraves, R., Lucas, J., and Gray, J. (1988). Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. Proc. Natl. Acad. Sci. USA 85, 9138-9142.
41. Poupon, M.F., Smith, K.A., Chernova, O.B., Gilbert, C., and Stark, G.R. (1996). Inefficient growth arrest in response to dNTP starvation stimulates gene amplification through bridge-breakage-fusion cycles. Mol. Biol. Cell 7, 345-354.
42. Rassool, F.V., McKeithan, T.W., Neilly, M.E., van Melle, E., Espinosa, R.D., and Le Beau, M.M. (1991). Preferential integration of marker DNA into the chromosomal fragile site at 3p14: an approach to cloning fragile sites. Proc. Natl. Acad. Sci. USA 88, 6657-6661.
43. Rath, H., Tlsty, T., and Schimke, R.T. (1984). Rapid emergence of methotrexate resistance in cultured mouse cells. Cancer Res. 44, 3303-3306.
44. Robinson, T.J., and Elder, F.F. (1987). Multiple common fragile sites are expressed in the genome of the laboratory rat. Chromosoma 96, 45-49.
45. Roelofs, H., Schuuring, E., Wiegant, J., Michalides, R., and Giphart-Gassler, M. (1993). Amplification of the 11q13 region in human carcinoma cell lines: a mechanistic view. Genes Chromosom. Cancer 7, 74-84.
46. Saltman, D., Morgan, R., Cleary, M.L., and Lange, T.D. (1993). Telomeric structure in cells with chromosome end associations. Chromosoma 102, 121-128.
47. Schimke, R.T. (1988). Gene amplification in cultured mammalian cells. J. Biol. Chem. 263, 5989-5992.
48. Schuuring, E. (1995). The involvement of the chromosome 11q13 region in human malignancies: cyclin D1 and EMS1 are two new candidate oncogenes - a review. Gene 159, 83-96.
49. Seabright, M. (1971). A rapid banding technique for human chromosomes. Lancet 2, 971-972.
50. Sen, S., Teeter, L.D., and Kuo, T. (1987). Specific gene amplification associated with consistent chromosomal abnormality in independently established multidrug-resistant Chinese hamster ovary cells. Chromosoma 95, 117-125.
51. Smith, K.A., Gorman, P.A., Stark, M.B., Groves, R.P., and Stark, G.R. (1990). Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Cell 63, 1219-1227.
52. Smith, K.A., Stark, M.B., German, P.A., and Stark, G.R. (1992). Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells. Proc. Natl. Acad. Sci. USA 89, 5427-5431.
53. Sozzi, G., Veronese, M.L., Negrini, M., Baffa, R., Cotticelli, M.G., Inoue, H., Tornielli, S., Pilotti, S., De Gregorio, L., Pastorino, U., et al. (1996). The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell 85, 17-26.
54. Spriggs, A.I., Boddington, M.M., and Clarke, C.M. (1962). Chromosomes of human cancer cells. Brit. Med. J. ii, 1431-1435.
55. Sutherland, G.R. (1979). Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture. Am. J. Hum. Genet. 31, 125-135.
56. Sutherland, G.R., and Richards, R.I. (1995). The molecular basis of fragile sites in human chromosomes. Curr. Opin. Genet. Dev. 5, 323-327.
57. Tkachuk, D.C., Westbrook, C.A., Andreeff, M., Donlon, T.A., Cleary, M.L., Suryanarayan, K., Homge, M., Redner, A., Gray, J., and Pinkel, D. (1990). Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization. Science 250, 559-562.
58. Tlsty, T.D., Brown, P.C., and Schimke, R.T. (1984). UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells. Mol. Cell. Biol. 4, 1050-1056.
59. Toledo, F., Buttin, G., and Debatisse, M. (1993). The origin of chromosome rearrangements at early stages of AMPD2 gene amplification in Chinese hamster cells. Curr. Biol. 3, 255-264.
60. Toledo, F., LeRoscouet, D., Buttin, G., and Debatisse, M. (1992b). Co-amplified markers alternate in megabase long chromosomal inverted repeats and cluster independently in interphase nuclei at early steps of mammalian gene amplification. EMBO J. 11, 2665-2673.
61. Toledo, F., Smith, K.A., Buttin, G., and Debatisse, M. (1992a). The evolution of the amplified adenylate-deaminase-2 domains in Chinese hamster cells suggests the sequential intervention of different mechanisms of DNA amplification. Mutat. Res. 276, 261-273.
62. Veinot, L., and Ling, V. (1992). Amplification of the P-glycoprotein genefamily and multidrug resistance. In Gene Amplification in Mammalian Cells - A Comprehensive Guide, R.E. Kellems, ed. (New York: Marcel Dekker Inc), pp. 287-299.
63. Warren, S.T., Zhang, F., Licameli, G.R., and Peters, J.F. (1987). The fragile X site in somatic cell hybrids: an approach for molecular cloning of fragile sites. Science 237, 420-423.
64. Windle, B., Draper, B.W., Yin, Y., O'Gorman, S., and Wahl, G.M. (1991). A central role for chromosome breakage in gene amplification, deletion formation and amplicon integration. Genes Dev. 5, 160-174.
65. Yunis, J.J. (1983). The chromosomal basis of human neoplasia. Science 221, 227-236.
66. Yunis, J.J., and Soreng, A.L. (1984). Constitutive fragile sites and cancer. Science 226, 1199-1204.
67. Yunis, J.J., Soreng, A.L., and Bowe, A.E. (1987). Fragile sites are targets of diverse mutagens and carcinogens. Oncogene 1, 59-69.