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Volumn 7, Issue 1, 1997, Pages 99-104

Tying loose ends: Roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; PROTEIN KINASE;

EID: 0031059531     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(97)80116-5     Document Type: Article
Times cited : (128)

References (68)
  • 1
    • 0004228157 scopus 로고
    • of outstanding interest. ASM Press, Washington, DC, Outstanding standard-setting review for all DNA repair and related aspects of nucleic acid metabolism
    • Friedberg EC, Walker GC, Siede W. . of outstanding interest DNA Repair and Mutagenesis. 1995;ASM Press, Washington, DC, Outstanding standard-setting review for all DNA repair and related aspects of nucleic acid metabolism.
    • (1995) DNA Repair and Mutagenesis
    • Friedberg, E.C.1    Walker, G.C.2    Siede, W.3
  • 2
    • 0002895728 scopus 로고    scopus 로고
    • Illegitimate recombination in mammalian cells
    • R. Kucherlapapti, Smith G.R. Washington, DC: American Society for Microbiology
    • Roth D, Wilson J. Illegitimate recombination in mammalian cells. Kucherlapapti R, Smith GR. In Genetic Recombination. 1998;621-653 American Society for Microbiology, Washington, DC.
    • (1998) In Genetic Recombination , pp. 621-653
    • Roth, D.1    Wilson, J.2
  • 3
  • 4
    • 0028805853 scopus 로고
    • Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps
    • of outstanding interest. The authors of this study describe the finding that RAG1 and RAG2, purified from insect cells that were baculovirus transfected, are sufficient to carry out the cleavage steps of V(D)J recombination.
    • McBlane JF, Gent DCV, Ramsden DA, Romeo C, Cuomo CA, Gellert M, Oettinger MA. Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. of outstanding interest Cell. 83:1995;387-395 The authors of this study describe the finding that RAG1 and RAG2, purified from insect cells that were baculovirus transfected, are sufficient to carry out the cleavage steps of V(D)J recombination.
    • (1995) Cell , vol.83 , pp. 387-395
    • McBlane, J.F.1    Gent, D.C.V.2    Ramsden, D.A.3    Romeo, C.4    Cuomo, C.A.5    Gellert, M.6    Oettinger, M.A.7
  • 5
    • 0030009253 scopus 로고    scopus 로고
    • The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination
    • Van Gent DC, Ramsden DA, Gellert M. The RAG1 and RAG2 proteins establish the 12/23 rule in V(D)J recombination. Cell. 85:1996;107-113.
    • (1996) Cell , vol.85 , pp. 107-113
    • Van Gent, D.C.1    Ramsden, D.A.2    Gellert, M.3
  • 6
    • 0028048275 scopus 로고
    • The mechanism of V(D)J joining: Lessons from molecular, immunological, comparative analyses
    • Lewis SM. The mechanism of V(D)J joining: lessons from molecular, immunological, comparative analyses. Adv Immunol. 56:1994;127-150.
    • (1994) Adv Immunol , vol.56 , pp. 127-150
    • Lewis, S.M.1
  • 7
    • 0027183403 scopus 로고
    • Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination
    • Gerstein RM, Lieber MR. Extent to which homology can constrain coding exon junctional diversity in V(D)J recombination. Nature. 363:1993;625-627.
    • (1993) Nature , vol.363 , pp. 625-627
    • Gerstein, R.M.1    Lieber, M.R.2
  • 8
    • 0025335392 scopus 로고
    • H joining: Implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation
    • H joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation. EMBO J. 9:1990;2133-2140.
    • (1990) EMBO J , vol.9 , pp. 2133-2140
    • Gu, H.1    Förster, I.2    Rajewsky, K.3
  • 9
    • 0020663062 scopus 로고
    • A severe combined immunodeficiency mutation in the mouse
    • Bosma GC, Custer RP, Bosma MJ. A severe combined immunodeficiency mutation in the mouse. Nature. 301:1993;527-530.
    • (1993) Nature , vol.301 , pp. 527-530
    • Bosma, G.C.1    Custer, R.P.2    Bosma, M.J.3
  • 11
    • 0023801238 scopus 로고
    • The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination
    • Lieber MR, Hesse JE, Lewis S, Bosma GC, Rosenberg N, Mizuuchi K, Bosma MJ, Gellert M. The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination. Cell. 55:1988;7-16.
    • (1988) Cell , vol.55 , pp. 7-16
    • Lieber, M.R.1    Hesse, J.E.2    Lewis, S.3    Bosma, G.C.4    Rosenberg, N.5    Mizuuchi, K.6    Bosma, M.J.7    Gellert, M.8
  • 13
    • 0026792892 scopus 로고
    • V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in SCID mouse thymocytes
    • Roth DB, Menetski JP, Nakajima P, Bosma MJ, Gellert M. V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in SCID mouse thymocytes. Cell. 70:1992;983-991.
    • (1992) Cell , vol.70 , pp. 983-991
    • Roth, D.B.1    Menetski, J.P.2    Nakajima, P.3    Bosma, M.J.4    Gellert, M.5
  • 14
    • 0025011134 scopus 로고
    • The scid mutation in mice causes a general defect in DNA repair
    • Fulop GM, Phillips RA. The scid mutation in mice causes a general defect in DNA repair. Nature. 347:1990;479-482.
    • (1990) Nature , vol.347 , pp. 479-482
    • Fulop, G.M.1    Phillips, R.A.2
  • 16
    • 0026071588 scopus 로고
    • Scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair
    • Biedermann KA, Sun J, Giaccia AJ, Tosto TM, Brown JM. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci. 88:1991;1394-1397.
    • (1991) Proc Natl Acad Sci , vol.88 , pp. 1394-1397
    • Biedermann, K.A.1    Sun, J.2    Giaccia, A.J.3    Tosto, T.M.4    Brown, J.M.5
  • 17
    • 0029111784 scopus 로고
    • Gene for the catalytic subunit of the human DNA-a ctivated protein kinase maps to the site of the XRCC 7 gene on chromosome 8
    • of special interest. The authors of this report describe the identification of the human chromosome to which the DNA-PK gene maps. This pericentric region of Chromosone 8 is the region which other studies have shown complement the murine scid phenotype. This provided important evidence that DNA-PK is the murine SCID factor.
    • Sipley JC, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW. Gene for the catalytic subunit of the human DNA-a ctivated protein kinase maps to the site of the XRCC 7 gene on chromosome 8. of special interest Proc Natl Acad Sci USA. 92:1995;7515-7519 The authors of this report describe the identification of the human chromosome to which the DNA-PK gene maps. This pericentric region of Chromosone 8 is the region which other studies have shown complement the murine scid phenotype. This provided important evidence that DNA-PK is the murine SCID factor.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7515-7519
    • Sipley, J.C.1    Menninger, J.C.2    Hartley, K.O.3    Ward, D.C.4    Jackson, S.P.5    Anderson, C.W.6
  • 18
    • 0028784516 scopus 로고
    • Gene for the catalytic subunit of mouse DNA-PK maps to the scid locus
    • of special interest. In this study, the human DNA-PK cDNA is used as a probe to determine the location of the murine counterpart. The authors map the gene to the chromosomal location where the murine scid phenotype had previously been mapped.
    • Miller RD, Hogg J, Ozaki J, Gell J, Jackson SP, Riblet R. Gene for the catalytic subunit of mouse DNA-PK maps to the scid locus. of special interest Proc Natl Acad Sci USA. 92:1995;10792-10795 In this study, the human DNA-PK cDNA is used as a probe to determine the location of the murine counterpart. The authors map the gene to the chromosomal location where the murine scid phenotype had previously been mapped.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10792-10795
    • Miller, R.D.1    Hogg, J.2    Ozaki, J.3    Gell, J.4    Jackson, S.P.5    Riblet, R.6
  • 20
    • 0028902932 scopus 로고
    • Loss of the catalytic subunit of DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells
    • Peterson SR, Kurimasa A, Oshimura M, Dynan WS, Bradbury EM, Chen DJ. Loss of the catalytic subunit of DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells. Proc Natl Acad Sci USA. 92:1995;3171-3174.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3171-3174
    • Peterson, S.R.1    Kurimasa, A.2    Oshimura, M.3    Dynan, W.S.4    Bradbury, E.M.5    Chen, D.J.6
  • 21
    • 0029788520 scopus 로고    scopus 로고
    • Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse
    • Blunt T, Gell D, Fox M, Taccioli G, Lehman A, Jackson S, Jeggo PA. Identification of a nonsense mutation in the carboxy-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse. Proc Natl Acad Sci USA. 93:1996;10285-10290.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 10285-10290
    • Blunt, T.1    Gell, D.2    Fox, M.3    Taccioli, G.4    Lehman, A.5    Jackson, S.6    Jeggo, P.A.7
  • 22
    • 0029791450 scopus 로고    scopus 로고
    • Biochemical and genetic defects in DNA-dependent protein kinase in murine scid lymphocytes
    • Danska JS, Holland DP, Mariathasan S, Williams KM, Guidos CJ. Biochemical and genetic defects in DNA-dependent protein kinase in murine scid lymphocytes. Mol Cell Biol. 16:1996;5507-5517.
    • (1996) Mol Cell Biol , vol.16 , pp. 5507-5517
    • Danska, J.S.1    Holland, D.P.2    Mariathasan, S.3    Williams, K.M.4    Guidos, C.J.5
  • 24
    • 0029156599 scopus 로고
    • DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
    • of outstanding interest. This paper reports the sequence of the human DNA-PK gene, allowing it to be identified as a member of the PI3 kinase family. There is a 31 amino acid segment missing from the middle of the kinase domain in this version of the sequence. The authors of [23] report the corrected sequence of the carboxy-terminal 100 kDa, which includes the kinase domain.
    • Hartley KO, Gell D, Smith GCM, Zhang H, Divecha N, Lees-Miller SP, Anderson CW, Jackson SP. DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. of outstanding interest Cell. 82:1995;849-856 This paper reports the sequence of the human DNA-PK gene, allowing it to be identified as a member of the PI3 kinase family. There is a 31 amino acid segment missing from the middle of the kinase domain in this version of the sequence. The authors of [23] report the corrected sequence of the carboxy-terminal 100 kDa, which includes the kinase domain.
    • (1995) Cell , vol.82 , pp. 849-856
    • Hartley, K.O.1    Gell, D.2    Smith, G.C.M.3    Zhang, H.4    Divecha, N.5    Lees-Miller, S.P.6    Anderson, C.W.7    Jackson, S.P.8
  • 25
    • 0028856331 scopus 로고
    • When is a lipid kinase not a lipid kinase? When it is a protein kinase
    • Hunter T. When is a lipid kinase not a lipid kinase? When it is a protein kinase. Cell. 83:1995;1-4.
    • (1995) Cell , vol.83 , pp. 1-4
    • Hunter, T.1
  • 26
    • 0029127643 scopus 로고
    • ATM-related genes: What do they tell us about functions of the human gene?
    • Zakian VA. ATM-related genes: what do they tell us about functions of the human gene? Cell. 82:1995;685-687.
    • (1995) Cell , vol.82 , pp. 685-687
    • Zakian, V.A.1
  • 28
    • 0025224761 scopus 로고
    • Human cells contain a DNA-activated protein kinase that phosphorylates SV40 T antigen, mouse p53, and the human Ku autoantigen
    • Lees-Miller SP, Chen Y-R, Anderson CW. Human cells contain a DNA-activated protein kinase that phosphorylates SV40 T antigen, mouse p53, and the human Ku autoantigen. Mol Cell Biol. 10:1990;6472-6481.
    • (1990) Mol Cell Biol , vol.10 , pp. 6472-6481
    • Lees-Miller, S.P.1    Chen, Y.-R.2    Anderson, C.W.3
  • 29
    • 0029143646 scopus 로고
    • Scid cells are deficient in Ku and replication protein A phosphorylation by DNA-PK
    • of special interest. A description of the only in vivo phosphorylation defects known at present in DNA-PK mutants, namely RP-A, and Ku. It will be important to determine whether these or other proteins are the key phosphorylation targets.
    • Boubnov N, Weaver DT. scid cells are deficient in Ku and replication protein A phosphorylation by DNA-PK. of special interest Mol Cell Biol. 15:1995;5700-5706 A description of the only in vivo phosphorylation defects known at present in DNA-PK mutants, namely RP-A, and Ku. It will be important to determine whether these or other proteins are the key phosphorylation targets.
    • (1995) Mol Cell Biol , vol.15 , pp. 5700-5706
    • Boubnov, N.1    Weaver, D.T.2
  • 30
    • 0030009738 scopus 로고    scopus 로고
    • The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
    • of outstanding interest. The authors show that DNA-PK may undergo autophosphorylation itself, resulting in the loss of DNA dependent protein kinase activity.
    • Chan DW, Lees-Miller SP. The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit. of outstanding interest J Biol Chem. 271:1996;8936-8941 The authors show that DNA-PK may undergo autophosphorylation itself, resulting in the loss of DNA dependent protein kinase activity.
    • (1996) J Biol Chem , vol.271 , pp. 8936-8941
    • Chan, D.W.1    Lees-Miller, S.P.2
  • 31
    • 0025368957 scopus 로고
    • Studies on mammalian mutants defective in rejoining double-strand breaks in DNA
    • Jeggo PA. Studies on mammalian mutants defective in rejoining double-strand breaks in DNA. Mutat Res. 239:1990;1-16.
    • (1990) Mutat Res , vol.239 , pp. 1-16
    • Jeggo, P.A.1
  • 32
    • 0022827675 scopus 로고
    • Mechanism of interaction between Ku protein and DNA
    • Mimori T, Hardin JA. Mechanism of interaction between Ku protein and DNA. J Biol Chem. 261:1986;10375-10379.
    • (1986) J Biol Chem , vol.261 , pp. 10375-10379
    • Mimori, T.1    Hardin, J.A.2
  • 33
    • 0029954821 scopus 로고    scopus 로고
    • Mutations in two Ku homologs define a DNA end-joining repair pathway in S. cerevisiae
    • of outstanding interest. This work extends the study of DNA and joining to yeast and shows that knockout of yeast Ku reduces DNA end joining markedly.
    • Milne GT, Jin S, Shannon KB, Weaver DT. Mutations in two Ku homologs define a DNA end-joining repair pathway in S. cerevisiae. of outstanding interest Mol Cell Biol. 16:1996;4189-4198 This work extends the study of DNA and joining to yeast and shows that knockout of yeast Ku reduces DNA end joining markedly.
    • (1996) Mol Cell Biol , vol.16 , pp. 4189-4198
    • Milne, G.T.1    Jin, S.2    Shannon, K.B.3    Weaver, D.T.4
  • 34
    • 0024356877 scopus 로고
    • HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
    • DeVries E, Van Driel W, Bergsma WG, Arnberg AC, Van der Vlient PC. HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol. 208:1989;65-78.
    • (1989) J Mol Biol , vol.208 , pp. 65-78
    • Devries, E.1    Van Driel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    Van Der Vlient, P.C.5
  • 35
    • 0026045833 scopus 로고
    • Analysis of the mechanism of interaction of simian Ku with DNA
    • Paillard S, Strauss F. Analysis of the mechanism of interaction of simian Ku with DNA. Nucleic Acids Res. 19:1991;5619-5624.
    • (1991) Nucleic Acids Res , vol.19 , pp. 5619-5624
    • Paillard, S.1    Strauss, F.2
  • 36
    • 0027397867 scopus 로고
    • The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen
    • Gottlieb T, Jackson SP. The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell. 72:1993;131-142.
    • (1993) Cell , vol.72 , pp. 131-142
    • Gottlieb, T.1    Jackson, S.P.2
  • 37
    • 0028897304 scopus 로고
    • DNA-dependent protein kinase activity is absent in xrs-6 cells: Implications for site-specific recombination and DNA double-strand break repair
    • Finnie NJ, Gottlieb T, Blunt T, Jeggo P, Jackson SP. DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair. Proc Natl Acad Sci USA. 92:1995;320-324.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 320-324
    • Finnie, N.J.1    Gottlieb, T.2    Blunt, T.3    Jeggo, P.4    Jackson, S.P.5
  • 39
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • of outstanding interest. This study describes the knockout of Ku86, causing both the loss of signal and coding joint formation. Nevertheless, blunt signal ends and hairpinned coding ends are preserved.
    • Zhu C, Bogue MA, Lim D-S, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. of outstanding interest Cell. 86:1996;379-389 This study describes the knockout of Ku86, causing both the loss of signal and coding joint formation. Nevertheless, blunt signal ends and hairpinned coding ends are preserved.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.-S.3    Hasty, P.4    Roth, D.B.5
  • 40
    • 0028112944 scopus 로고
    • Restoration of X-ray resistance and V(D)J recombination in mutant mammalian cells by Ku
    • Smider V, Rathmell WK, Lieber M, Chu G. Restoration of X-ray resistance and V(D)J recombination in mutant mammalian cells by Ku. Science. 266:1994;288-291.
    • (1994) Science , vol.266 , pp. 288-291
    • Smider, V.1    Rathmell, W.K.2    Lieber, M.3    Chu, G.4
  • 42
    • 0029778191 scopus 로고    scopus 로고
    • Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
    • of outstanding interest. The knockout of Ku86 is described with similar findings to [39].
    • Nussenzweig A, Chen C, Sores VDC, Sanchez M, Sokol K, Nussenzweig MC, Li GC. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. of outstanding interest Nature. 382:1996;551-555 The knockout of Ku86 is described with similar findings to [39].
    • (1996) Nature , vol.382 , pp. 551-555
    • Nussenzweig, A.1    Chen, C.2    Sores, V.D.C.3    Sanchez, M.4    Sokol, K.5    Nussenzweig, M.C.6    Li, G.C.7
  • 43
    • 0029740571 scopus 로고    scopus 로고
    • Protein - protein and protein - DNA interaction regions within the DNA end binding protein Ku70-Ku86
    • Wu X, Lieber MR. Protein - protein and protein - DNA interaction regions within the DNA end binding protein Ku70-Ku86. Mol Cell Biol. 16:1996;5186-5193.
    • (1996) Mol Cell Biol , vol.16 , pp. 5186-5193
    • Wu, X.1    Lieber, M.R.2
  • 44
    • 0027246193 scopus 로고
    • Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II
    • Dvir A, Stein LY, Calore BL, Dynan WS. Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II. J Biol Chem. 268:1993;10440-10447.
    • (1993) J Biol Chem , vol.268 , pp. 10440-10447
    • Dvir, A.1    Stein, L.Y.2    Calore, B.L.3    Dynan, W.S.4
  • 45
    • 0028607553 scopus 로고
    • The DNA-activated protein kinase is required for the phosphorylation of replication protein A during SV40 DNA replication
    • Brush G, Anderson CW, Kelly TJ. The DNA-activated protein kinase is required for the phosphorylation of replication protein A during SV40 DNA replication. Proc Natl Acad Sci USA. 91:1994;12520-12524.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12520-12524
    • Brush, G.1    Anderson, C.W.2    Kelly, T.J.3
  • 46
    • 0030419898 scopus 로고    scopus 로고
    • Role of the Ku autoantigen in V(D)J recombination and double-strand break repair
    • R. Jessberger, Lieber M.R. Heidelberg: Springer-Verlag
    • Chu G. Role of the Ku autoantigen in V(D)J recombination and double-strand break repair. Jessberger R, Lieber MR. Molecular Analysis of DNA Rearrangements in the Immune System. 1996;113-132 Springer-Verlag, Heidelberg.
    • (1996) Molecular Analysis of DNA Rearrangements in the Immune System , pp. 113-132
    • Chu, G.1
  • 47
    • 0028906827 scopus 로고
    • The scid factor on human chromosome 8 restores both V(D)J recombination and double-strand break repair
    • Komatsu K, Kubota N, Gallo ML, Okumura Y, Lieber MR. The scid factor on human chromosome 8 restores both V(D)J recombination and double-strand break repair. Cancer Res. 55:1995;1774-1779.
    • (1995) Cancer Res , vol.55 , pp. 1774-1779
    • Komatsu, K.1    Kubota, N.2    Gallo, M.L.3    Okumura, Y.4    Lieber, M.R.5
  • 48
    • 0021712508 scopus 로고
    • X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand rejoining
    • Kemp L, Sedgwick S, Jeggo P. X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand rejoining. Mutat Res. 132:1984;189-196.
    • (1984) Mutat Res , vol.132 , pp. 189-196
    • Kemp, L.1    Sedgwick, S.2    Jeggo, P.3
  • 49
    • 0028801363 scopus 로고
    • Formation and resolution of double-strand break intermediates in V(D)J rearrangement
    • Ramsden DA, Gellert M. Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev. 9:1995;2409-2420.
    • (1995) Genes Dev , vol.9 , pp. 2409-2420
    • Ramsden, D.A.1    Gellert, M.2
  • 51
    • 0028141785 scopus 로고
    • DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen
    • Cao QP, Pitt S, Leszyk J, Baril EF. DNA-dependent ATPase from HeLa cells is related to human Ku autoantigen. Biochemistry. 33:1994;8548-8557.
    • (1994) Biochemistry , vol.33 , pp. 8548-8557
    • Cao, Q.P.1    Pitt, S.2    Leszyk, J.3    Baril, E.F.4
  • 52
    • 0029988716 scopus 로고    scopus 로고
    • Sequence-specific DNA binding by Ku autoantigen and its effects on transcription
    • of outstanding interest. Here, the binding of Ku to sites on circular DNA is documented. One possible unification of this data with the end-binding data is that these internal sites take on a non-B DNA configuration (cruciform, among other possibilities); or Ku may simply have two different binding modes.
    • Giffin W, Torrance H, Rodda DJ, Prefontaine GG, Pope L, Hache RJG. Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. of outstanding interest Nature. 380:1996;265-268 Here, the binding of Ku to sites on circular DNA is documented. One possible unification of this data with the end-binding data is that these internal sites take on a non-B DNA configuration (cruciform, among other possibilities); or Ku may simply have two different binding modes.
    • (1996) Nature , vol.380 , pp. 265-268
    • Giffin, W.1    Torrance, H.2    Rodda, D.J.3    Prefontaine, G.G.4    Pope, L.5    Hache, R.J.G.6
  • 53
    • 0021024317 scopus 로고
    • X-ray induced breakage and rejoining of human interphase chromosomes
    • Cornforth MN, Bedford JS. X-ray induced breakage and rejoining of human interphase chromosomes. Science. 222:1983;1141-1143.
    • (1983) Science , vol.222 , pp. 1141-1143
    • Cornforth, M.N.1    Bedford, J.S.2
  • 54
    • 0030067159 scopus 로고    scopus 로고
    • Induction of repair of chromosome aberrations in scid cells measured by premature chromosome condensation
    • of special interest. The authors of this report demonstrate that DNA-PK is not required for joining some chromosome breaks.
    • Evans JW, Liu XF, Kirchgessner CU, Brown JM. Induction of repair of chromosome aberrations in scid cells measured by premature chromosome condensation. of special interest Radiat Res. 145:1996;39-46 The authors of this report demonstrate that DNA-PK is not required for joining some chromosome breaks.
    • (1996) Radiat Res , vol.145 , pp. 39-46
    • Evans, J.W.1    Liu, X.F.2    Kirchgessner, C.U.3    Brown, J.M.4
  • 55
    • 0026663777 scopus 로고
    • Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells
    • Pandita TK, Hittelman WN. Initial chromosome damage but not DNA damage is greater in ataxia telangiectasia cells. Radiat Res. 130:1992;94-103.
    • (1992) Radiat Res , vol.130 , pp. 94-103
    • Pandita, T.K.1    Hittelman, W.N.2
  • 57
    • 0030021296 scopus 로고    scopus 로고
    • The recognition of DNA damage
    • Jackson SP. The recognition of DNA damage. Curr Opin Genet Dev. 6:1996;19-25.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 19-25
    • Jackson, S.P.1
  • 58
    • 0027304013 scopus 로고
    • V(D)J recombination in ataxiatelangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder
    • Hsieh CL, Arlett CF, Lieber MR. V(D)J recombination in ataxiatelangiectasia, Bloom's syndrome, and a DNA ligase I-associated immunodeficiency disorder. J Biol Chem. 268:1993;20105-20109.
    • (1993) J Biol Chem , vol.268 , pp. 20105-20109
    • Hsieh, C.L.1    Arlett, C.F.2    Lieber, M.R.3
  • 59
    • 0027953084 scopus 로고
    • Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes
    • Petrini J, Donovan JW, Dimare C, Weaver DT. Normal V(D)J coding junction formation in DNA ligase I deficiency syndromes. J Immunol. 152:1994;176-183.
    • (1994) J Immunol , vol.152 , pp. 176-183
    • Petrini, J.1    Donovan, J.W.2    Dimare, C.3    Weaver, D.T.4
  • 60
    • 0342928162 scopus 로고    scopus 로고
    • The identification and characterization of mammalian proteins involved in the rejoining of DNA double - strand breaks in vitro
    • in press
    • Johnson AP, Fairman MP. The identification and characterization of mammalian proteins involved in the rejoining of DNA double - strand breaks in vitro. Mutat Res. 1997;. in press.
    • (1997) Mutat Res
    • Johnson, A.P.1    Fairman, M.P.2
  • 61
    • 0028921338 scopus 로고
    • A modified single-strand annealing model best explains the joining of DNA double-strand breaks in mammalian cells and cell extracts
    • Nicolas AL, Munz PL, Young CSH. A modified single-strand annealing model best explains the joining of DNA double-strand breaks in mammalian cells and cell extracts. Nucleic Acids Res. 23:1995;1036-1043.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1036-1043
    • Nicolas, A.L.1    Munz, P.L.2    Young, C.S.H.3
  • 62
    • 0020585842 scopus 로고
    • Isolation of cell-cycle dependent γ-ray sensitive Chinese hamster ovary cells
    • Stamato TD, Weinstein R, Giaccia A, Mackenzie L. Isolation of cell-cycle dependent γ-ray sensitive Chinese hamster ovary cells. Somat Cell Mol Genet. 9:1983;165-173.
    • (1983) Somat Cell Mol Genet , vol.9 , pp. 165-173
    • Stamato, T.D.1    Weinstein, R.2    Giaccia, A.3    Mackenzie, L.4
  • 63
    • 0029585872 scopus 로고    scopus 로고
    • The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
    • of outstanding interest. Isolation of the XRCC4 gene using a V(D)J recombination selection. The function of XRCC4, however, is not suggested by its sequence.
    • Li Z, Otevrel T, Gao Y, Cheng H-L, Seed B, Stamato TD, Taccioli GE, Alt FW. The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. of outstanding interest Cell. 83:1996;1079-1089 Isolation of the XRCC4 gene using a V(D)J recombination selection. The function of XRCC4, however, is not suggested by its sequence.
    • (1996) Cell , vol.83 , pp. 1079-1089
    • Li, Z.1    Otevrel, T.2    Gao, Y.3    Cheng, H.-L.4    Seed, B.5    Stamato, T.D.6    Taccioli, G.E.7    Alt, F.W.8
  • 65
    • 0025020278 scopus 로고
    • Intermediates of recombination during mating type switching in S. cerevisiae
    • White CI, Haber JE. Intermediates of recombination during mating type switching in S. cerevisiae. EMBO J. 9:1990;663-674.
    • (1990) EMBO J , vol.9 , pp. 663-674
    • White, C.I.1    Haber, J.E.2
  • 66
    • 0029328551 scopus 로고
    • In vivo biochemistry: Physical monitoring of recombination induced by site-specific endonucleases
    • of special interest. A review of double-strand break repair from the viewpoint of yeast genetics (including a more balanced discussion of homologous versus non-homologous recombination than space constraints have permitted here).
    • Haber JE. In vivo biochemistry: physical monitoring of recombination induced by site-specific endonucleases. of special interest Bioessays. 17:1995;609-620 A review of double-strand break repair from the viewpoint of yeast genetics (including a more balanced discussion of homologous versus non-homologous recombination than space constraints have permitted here).
    • (1995) Bioessays , vol.17 , pp. 609-620
    • Haber, J.E.1
  • 67
    • 0027410476 scopus 로고
    • V(D)J recombination: Signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites
    • Sheehan KM, Lieber MR. V(D)J recombination: signal and coding joint resolution are uncoupled and depend on parallel synapsis of the sites. Mol Cell Biol. 13:1993;1363-1370.
    • (1993) Mol Cell Biol , vol.13 , pp. 1363-1370
    • Sheehan, K.M.1    Lieber, M.R.2
  • 68
    • 0028958942 scopus 로고
    • Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
    • Zhu C, Roth DB. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity. 2:1995;101-112.
    • (1995) Immunity , vol.2 , pp. 101-112
    • Zhu, C.1    Roth, D.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.