In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase

Human Gene Therapy

Volumn 8, Issue 14, 1997, Pages 1637-1644

  Parker, William B ^a   King, Scott A ^a   Allan, Paula W ^a   Bennett Jr , Lee ^a   Secrist III, John A ^a   Montgomery, John A ^a   Gilbert, Karen S ^a   Waud, William R ^a   Wells, Alan H ^a   Gillespie, G Yancey ^a   Sorscher, Eric J ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

6 METHYLPURINE; ANTIMETABOLITE; DEOXYRIBOSE; FLUDARABINE; PHOSPHATE; PRODRUG; PURINE NUCLEOSIDE DERIVATIVE; PURINE NUCLEOSIDE PHOSPHORYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; DOSE RESPONSE; GENE THERAPY; GLIOMA; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TOXICITY; TUMOR CELL DESTRUCTION; TUMOR XENOGRAFT;

EID: 0031580711     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.14-1637     Document Type: Article

References (3)

1. ALLAN, P.W., S.C. SHADDIX, G.Y. GILLESPIE, L.L. BENNETT, Jr., and W.B. PARKER (1997). Mechanism of action of 6-methylpurine and 2-fluoro-adenine. Proc. Am. Assoc. Cancer Res. 38, 379.
2. ANDREANSKY, S.S., B. HE, G.Y. GILLESPIE, L. SOROCEANU, J. MARKERT, J. CHOU, B. ROIZMAN, and R.J. WHITLEY (1996). The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors. Proc. Natl. Acad. Sci. USA 93, 11313-11318.
3. BALZARINI, J., C. BOHMAN, and E. DeCLERCQ (1993). Differential mechanism of cytostatic effect of (E)-5-2-bromovinyl)-2'-deoxyuridine, 9-1(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2. J. Biol. Chem. 268, 6332-6337.