Triggered intracellular activation of disulfide crosslinked polyelectrolyte gene delivery complexes with extended systemic circulation in vivo

Gene Therapy

Volumn 8, Issue 9, 2001, Pages 713-724

  Oupicki D ^a,b   Carlisle, R C ^a   Seymour, L W ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

Author keywords

Disulfide bonds; In vivo; Pharmacokinetics; Polyelectrolyte exchange; Polyplexes; Steric stabilization

Indexed keywords

AMINE; CHLOROQUINE; DISULFIDE; DNA; MACROGOL; POLYASPARTIC ACID; POLYELECTROLYTE; POLYLYSINE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CONTROLLED STUDY; COVALENT BOND; CYTOPLASM; DNA CLEAVAGE; DNA CROSS LINKING; DNA VECTOR; ENDOSOME; FIBROBLAST; GENE ACTIVITY; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC STABILITY; GENETIC TRANSFECTION; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MELANOMA CELL; MOLECULAR STABILITY; MOUSE; MOUSE STRAIN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; RAT; REDUCTION; SOLUBILITY; SURFACE CHARGE; SYSTEMIC CIRCULATION; TRANSGENE; XENOPUS;

ANIMALS; CROSS-LINKING REAGENTS; DISULFIDES; DNA; ELECTROLYTES; FEMALE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; LIVER; MICE; MICE, INBRED BALB C; MICROINJECTIONS; POLYETHYLENE GLYCOLS; POLYLYSINE; SODIUM CHLORIDE; SOLUBILITY; TISSUE DISTRIBUTION; TRANSCRIPTION, GENETIC; XENOPUS;

ANIMALIA; MURINAE;

EID: 0034986834     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301446     Document Type: Article

References (19)

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2. Decreased binding to proteins and cells of polymeric gene delivery vectors surface modified with a multivalent hydrophilic polymer and retargeting through attachment of transferrin
3. Interactions between macromolecules in solution and intermacromolecular complexes
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12. Vector unpacking as a potential barrier for receptor-mediated polyplex gene delivery
13. An electron microscopy study into the mechanism of gene transfer with lipopolyamines
14. The reduction of the positive charges of polylysine by partial gluconoylation increases the transfection efficiency of polylysine/DNA complexes
15. Environment-sensitive stabilization of core-shell structured polyion complex micelle by reversible cross-linking of the core through disulfide bond
16. A potent new class of reductively activated peptide gene delivery agents
17. Low molecular weight disulfide cross-linking peptides as nonviral gene delivery carriers
18. An improved 2, 4, 6-trinitrobenzenesulfonic acid method for the determination of amines
19. N-(2-hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose receptor: Pharmacokinetics in DBA2 mice