Progress toward the structure and therapeutic use of the hairpin ribozyme

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 4, 1997, Pages 403-411

  Earnshaw, David J ^a   Gait, Michael J ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; FUNCTIONAL GROUP; RIBOZYME;

ANTIVIRAL ACTIVITY; CHEMICAL REACTION; ENZYME ACTIVITY; GENE THERAPY; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RNA CLEAVAGE; RNA CONFORMATION; RNA STRUCTURE; STRUCTURE ACTIVITY RELATION;

EID: 0030803639     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.403     Document Type: Review

References (7)

1. ANDERSON, P., MONFORTE, J., TRITZ, R., NESBITT, S., HEARST, J., and HAMPEL, A. (1994). Mutagenesis of the hairpin ribozyme. Nucleic Acids Res. 22, 1096-1100.
2. BERZAL-HERRANZ, A., JOSEPH, S., and BURKE, J.M. (1992). In vitro selection of active hairpin ribozymes by sequential RNA-catalyzed cleavage and ligation reactions. Genes Dev. 6, 129-134.
3. BERZAL-HERRANZ, A., JOSEPH, S., CHOWRIRA, B.M., BUTCHER, S.E., and BURKE, J.M. (1993). Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme. EMBO J. 12, 2567-2574.
4. BURKE, J.M. (1994). The hairpin ribozyme. In: Nucleic Acids and Molecular Biology. F. Eckstein and D.M.J. Lilley, eds. (Springer-Verlag, Berlin), pp. 105-118.
5. BURKE, J.M. (1996). Hairpin ribozyme: Current status and future prospects. Biochem. Soc. Trans. 24, 608-615.
6. BUTCHER, S.E., and BURKE, J.M. (1994a). A photo-cross-linkable tertiary structure motif found in functionally distinct RNA molecules is essential for catalytic function of the hairpin ribozyme. Biochemistry 33, 992-999.
7. YU, M., POESCHLA, E., YAMADA, O., DEGRANDIS, P., LEAVITT, M.C., HEUSCH, M., YEES, J.-K., WONG-STAAL, F., and HAMPEL, A. (1995b). In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1. Virology 206, 381-386.