Sequence requirements for plasmid nuclear import

Experimental Cell Research

Volumn 253, Issue 2, 1999, Pages 713-722

  Dean, David A ^a   Dean, Brenda S ^a   Muller, Susanne ^b   Smith, Louis C ^b  

^a UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

^b Urigen Pharmaceuticals Inc   (United States)

Author keywords

Enhancer; Gene expression; Gene therapy; Nuclear import; Plasmid delivery

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIVISION; CELL NUCLEUS MEMBRANE; INTRACELLULAR TRANSPORT; MONKEY; NONHUMAN; PLASMID; PRIORITY JOURNAL; SIMIAN VIRUS 40; VIRUS CELL INTERACTION;

EID: 0033572896     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4716     Document Type: Article

References (36)

1. Zabner J., Fasbender A. J., Moninger T., Poellinger K. A., Welsh M. J. Cellular and molecular barriers to gene transfer by a cationic lipid. J. Biol. Chem. 270:1995;18997-19007.
2. Dean D. A. Import of plasmid DNA into the nucleus is sequence specific. Exp. Cell Res. 230:1997;293-302.
3. Hirt B. Selective extraction of polyoma DNA from infected mouse cell cultures. J. Mol. Biol. 26:1967;365-369.
4. DeLucia A. L., Deb S., Partin K., Tegtmeyer P. Functional interactions of the simian virus 40 core origin of replication with flanking regulatory sequences. J. Virol. 57:1986;138-144.
5. Tooze J. Molecular Biology of Tumor Viruses. 1980;Cold Spring Harbor Laboratory, Cold Spring Habor.
6. Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A., Struhl K. Current Protocols in Molecular Biology. 1994;Wiley, New York.
7. Dean D. A., Li P. L., Lee L. M., Kasamatsu H. Essential role of the Vp2 and Vp3 DNA-binding domain in SV40 morphogenesis. J. Virol. 69:1995;1115-1121.
8. Graessman M., Graessman A. Microinjection of tissue culture cells using glass microcapillaries: Methods. Celis J. E., Graessmann A., Loyter A. Microinjection and Organelle Transplantation Techniques: Methods and Applications. 1986;3-37 Academic Press, London.
9. Deb S., Tsui S., Koff A., DeLucia A. L., Parsons R., Tegtmeyer P. The T-antigen-binding domain of the simian virus 40 core origin of replication. J. Virol. 61:1987;2143-2149.
10. Hartikka J., Sawdey M., Cornefert-Jensen F., Margalith M., Barnhart K., Nolasco M., Vahlsing H. L., Meek J., Marquet M., Hobart P., Norman J., Manthorpe M. An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum. Gene Ther. 7:1996;1205-1217.
11. Manthorpe M., Cornefert-Jensen F., Hartikka J., Felgner J., Rundell A., Margalith M., Dwarki V. Gene therapy by intramuscular injection of plasmid DNA: Studies on firefly luciferase gene expression in mice. Hum. Gene Ther. 4:1993;419-431.
12. Capecchi M. R. High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell. 22:1980;479-488.
13. Labat-Moleur F., Steffan A. M., Brisson C., Perron H., Feugeas O., Furstenberger P., Oberling F., Brambilla E., Behr J. P. An electron microscopy study into the mechanism of gene transfer with lipopolyamines. Gene Ther. 3:1996;1010-1017.
14. Pollard H., Remy J. S., Loussouarn G., Demolombe S., Behr J. P., Escande D. Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells. J. Biol. Chem. 273:1998;7507-7511.
15. Graessman M., Menne J., Liebler M., Graeber I., Graessman A. Helper activity for gene expression, a novel function of the SV40 enhancer. Nucleic Acids Res. 17:1989;6603-6612.
16. Nigg E. A. Nucleocytoplasmic transport: Signals, mechanisms and regulation. Nature. 386:1997;779-787.
17. Wilson G. L., Dean B. S., Wang G., Dean D. A. Nuclear import of plasmid DNA in digitonin-permeabilized cells requires both cytoplasmic factors and specific DNA sequences. J. Biol. Chem. 274:1999;22025-22032.
18. Mitchell P. J., Wang C., Tjian R. Positive and negative regulation of transcription in vivo: Enhancer binding protein AP-2 is inhibited by SV40 T antigen. Cell. 50:1987;847-861.
19. Dynan W. S., Chervitz S. A. Characterization of a minimal simian virus 40 late promoter: Enhancer elements in the 72-base-pair repeat not required. J. Virol. 63:1989;1420-1427.
20. Wingender E., Kel A. E., Kel O. V., Karas H., Heinemeyer T., Dietze P., Knueppel R., Romaschenko A. G., Kolchanov N. A. TRANSFAC, TRRD and COMPEL: Towards a federated database system on transcriptional regulation. Nucleic Acids Res. 25:1997;265-268.
21. Nelson J. A., Gnann J. W. Jr., Ghazal P. Regulation and tissue-specific expression of human cytomegalovirus. Curr. Top. Microbiol. Immunol. 154:1990;75-100.
22. Vacik J., Dean B. S., Zimmer W. E., Dean D. A. Cell-specific nuclear import of plasmid DNA. Gene Ther. 6:1999;1006-1014.
23. Langle-Rouault F., Patzel V., Benavente A., Taillez M., Silvestre N., Bompard A., Sczakiel G., Jacobs E., Rittner K. Up to 100-fold increase of apparent gene expression in the presence of Epstein-Barr virus oriP sequences and EBNA1: Implications of the nuclear import of plasmids. J. Virol. 72:1998;6181-6185.
24. Sebestyén M. G., Ludtke J. L., Bassik M. C., Zhang G., Budker V., Lukhtanov E. A., Hagstrom J. E., Wolff J. A. DNA vector chemistry: The covalent attachment of signal peptides to plasmid DNA. Nat. Biotech. 16:1998;80-85.
25. Collas P., Husebye H., Alestrom P. The nuclear localization sequence of the SV40 T antigen promotes transgene uptake and expression in zebrafish embryo nuclei. Transgenic Res. 5:1996;451-458.
26. Collas P., Alestrom P. Nuclear localization signal of SV40 T antigen directs import of plasmid DNA into sea urchin male pronuclei in vitro. Mol. Reprod. Dev. 45:1996;431-438.
27. Collas P., Alestrom P. Rapid targeting of plasmid DNA to zebrafish embryo nuclei by the nuclear localization signal of SV40 T antigen. Mol. Mar. Biol. Biotechnol. 6:1997;48-58.
28. Collas P., Alestrom P. Nuclear localization signals: A driving force for nuclear transport of plasmid DNA in zebrafish. Biochem. Cell Biol. 75:1997;633-640.
29. Zanta M. A., Belguise-Valladier P., Behr J. P. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc. Natl. Acad. Sci. USA. 96:1999;91-96.
30. Kaneda Y., Iwai K., Uchida T. Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science. 243:1989;375-378.
31. Bottger M., Zaitsev S. V., Otto A., Haberland A., Vorob'ev V. I. Acid nuclear extracts as mediators of gene transfer and expression. Biochim. Biophys. Acta. 1395:1998;78-87.
32. Hagstrom J. E., Sebestyen M. G., Budker V., Ludtke J. J., Fritz J. D., Wolff J. A. Complexes of non-cationic liposomes and histone H1 mediate efficient transfection of DNA without encapsulation. Biochim. Biophys. Acta. 1284:1996;47-55.
33. Dowty M. E., Williams P., Zhang G., Hagstrom J. E., Wolff J. A. Plasmid DNA entry into postmitotic nuclei of primary rat myotubes. Proc. Natl. Acad. Sci. USA. 92:1995;4572-4576.
34. Escriou V., Ciolina C., Lacroix F., Byk G., Scherman D., Wils P. Cationic lipid-mediated gene transfer: Effect of serum on cellular uptake and intracellular fate of lipopolyamine/DNA complexes. Biochim. Biophys. Acta. 1368:1998;276-288.
35. Lusky M., Botchan M. Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences. Nature. 293:1981;79-81.
36. Cole C. N. Polyomavirinae: The viruses and their replication. Fields B. N., Knipe D. M., Howley P. M., Chanock R. M., Melnick J. L., Monath T. P., Roizman B., Staus S. E. Virology. 1996;1997-2043 Raven Press, New York.