Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7

Gene Therapy

Volumn 4, Issue 5, 1997, Pages 419-425

  Rubin, J ^a   Galanis, E ^a   Pitot, H C ^a   Richardson, R L ^a   Burch, P A ^a   Charboneau, J W ^a   Reading, C C ^a   Lewis, B D ^a   Stahl, S ^b   Akporiaye, E T ^c   Harris, D T ^c  

^a MAYO CLINIC   (United States)

^b VICAL INC   (United States)

^c UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Colorectal carcinoma; Gene therapy; HLA B7; Immunotherapy; Lipid vector

Indexed keywords

ALLOVECTIN 7; BETA 2 MICROGLOBULIN; HLA B7 ANTIGEN; LIPID; LIPOSOME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CLINICAL ARTICLE; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA TRANSFECTION; DRUG EFFICACY; DRUG FORMULATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; GENE THERAPY; GENE TRANSFER; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOTHERAPY; INTRATUMORAL DRUG ADMINISTRATION; LIVER BIOPSY; LIVER INJURY; LIVER METASTASIS; LYMPHOCYTE ACTIVATION; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR VOLUME; ULTRASOUND;

EID: 8244224532     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3300396     Document Type: Article

References (24)

1. Funa K, Gazdar AF, Minna JD, Linnoila RI. Paucity of beta 2-microglobulin expression on small cell lung cancer, bronchial carcinoids and certain other neuroendocrine tumors. Lab Invest 1986; 55: 186-193.
2. Garrido F, Gabrera T, Lopez-Nevok MA, Ruiz-Cabello F. HLA class I antigens in human tumors Adv Cancer Res 1995; 67: 155-195.
3. Schmidt W, Leben L, Atfield G, Festenstein H. Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross virus-induced leukemia in BALB K. Immunogenetics 1981; 14: 323-339.
4. Ostrand-Rosenberg S. Rejection of mouse sarcoma cells after transfection of MHC class II genes. J Immunol 1990; 144: 4068-4071.
5. Plautz GE et al. Immunotherapy of malignancy by in vivo gene transfer into tumors. Proc Natl Acad Sci USA 1993; 90: 4332-4333.
6. Nabel EG et al. Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther 1993; 3: 649-656.
7. Nabel EG et al. Recombinant gene expression in vivo within endothelial cells of the arterial wall. Science 1989; 244: 1342-1344.
8. Nabel GJ et al. Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci USA 1993; 90: 11307-11311.
9. Momberg F, Koch S. Selective loss of β2-microglobulin mRNA in human colon carcinoma. J Exp Med 1989; 169: 309-314.
10. Parker SE et al. Cancer gene therapy using plasmid DNA: safety evaluation in rodents and non-human primates. Hum Gene Ther 1995; 6: 575-590.
11. Lew D et al. Cancer gene therapy using plasmid DNA: pharmacokinetic study of DNA following injection in mice. Hum Gene Ther 1995; 6: 553-564.
12. Rosenberg S. Immunotherapy and gene therapy of cancer. Karnofsky Memorial Lecture. J Clin Oncol 1992; 10: 180-199.
13. Barth RJ Jr et al. Unique murine tumor associated antigens identified by tumor infiltrating lymphocytes. J Immunol 1990; 144: 1531-1537.
14. + tumor infiltrating lymphocytes. J Exp Med 1991; 173: 647-658.
15. Barth RJ et al. Identification of unique murine tumor associated antigens by tumor infiltrating lymphocytes using tumor specific secretion of interferon-gamma and tumor necrosis factor. J Immunol Meth 1991; 140: 269-279.
16. Darrow TL, Slingluff CL, Seigler HF. The role of class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes: evidence for shared tumor antigens. J Immunol 1989; 142: 3329-3335.
17. Rosenberg SA et al. Gene therapy of patients with advanced cancer using tumor infiltration lymphocytes transduced with the gene coding for tumor necrosis factor. Hum Gene Ther 1992; 3: 57-73.
18. Fearon ER et al. Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 1990; 60: 397-403.
19. Norman JA et al. Preclinical pharmacokinetics, manufacturing, and safety studies supporting a multicenter cancer gene therapy trial. Hum Gene Ther 1995; 6: 549-550.
20. Vogelzang NJ et al. Clinical experience in phase I and phase II testing of direct intratumoral administration with allovectin-7: a gene-based immunotherapeutic agent. Proc Am Soc Clin Oncol 1996; 15: 235.
21. Gorman C, Padmanabhan R, Howeard BH. High efficiency DNA-mediated transformation of primate cells. Science 1983; 221: 551-553.
22. Horn NA, Meek JA, Budahazi G, Marquet M. Cancer gene therapy using plasmid DNA: purification of DNA for human clinical trials. Hum Gene Ther 1995; 6: 565-573.
23. Grogan T et al. Kinetic-mode, automated double-labelled immunohistochemistry and in situ hybridization in diagnostic pathology Adv Pathol Lab Med 1995; 8: 99-118.
24. Harris DT, LoCascio J, Bensencon FJ. Analysis of the alloreactive capacity of human umbilical cord blood: implications for graft-versus-host disease. Bone Marrow Transplant 1994; 14: 545-553.