Effect of albumin and polyanion on the structure of DNA complexes with polycation containing hydrophilic nonionic block

Bioconjugate Chemistry

Volumn 10, Issue 5, 1999, Pages 764-772

  Oupický, David ^a   Koňák, Čestmír ^a   Dash, Philip R ^b   Seymour, Leonard W ^b   Ulbrich, Karel ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BLOCK COPOLYMERS; GENE TRANSFER; HYDROPHILICITY; LIGHT SCATTERING; MOLECULAR WEIGHT; POLYELECTROLYTES; SOLUTIONS;

ASSEMBLING SYSTEMS; BLOCK CO POLYMERS; DNA COMPLEX; HYDROPHILICS; IONIC COMPLEX; LOW MOLECULAR WEIGHT; NONIONIC; POLYANIONS; POLYCATIONS; SELF-ASSEMBLING;

DNA;

EID: 0344378203     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc990007+     Document Type: Article

References (20)

1. Seymour, L. W., Kataoka, K., and Kabanov, A. V. (1998) Cationic block copolymers as self-assembling vectors for gene delivery. In Self-assembling Complexes for Gene Delivery: From Laboratory to Clinical Trials (K. V. Kabanov, P. L. Felgner, and L. W. Seymour, Eds.) pp 219-239, John Wiley & Sons, New York.
2. Wolfert, M. A., Schacht, E. H., Toncheva, V., Ulbrich, K., Nazarova, O., and Seymour, L. W. (1996) Characterization of vectors for gene therapy formed by self-assembly of DNA with synthetic block copolymers. Hum. Gene Ther. 7, 2123-2133.
3. Dash, P. R., Toncheva, V., Schacht, E. H., and Seymour, L. W. (1997) Synthetic polymers for vectorial delivery of DNA: characterization of polymer-DNA complexes by photon correlation spectroscopy and stability to nuclease degradation and disruption by polyanions in vitro. J. Controlled Release 48, 269-276.
4. Katayose, S., and Kataoka, K. (1997) Water-Soluble Polyion Complex Associates of DNA and Poly(ethylene glycol)-Poly-(L-lysine) Block Copolymer. Bioconjugate Chem. 8, 702-707.
5. Kabanov, A. V., Vinogradov, S. V., Suzdaltseva, Y. G., and Alakhov, V. Y. (1995) Water-Soluble Block Polycations as Carriers for Oligonucleotide Delivery. Bioconjugate Chem. 6, 639-643.
6. Koňák, Č., Mrkvičková, L., Nazarova, O., Ulbrich, K., and Seymour, L. W. (1998) Formation of DNA complexes with diblock copolymers of poly(N-(2-hydroxypropyl) methacrylamide) and polycations. Supramol. Sci. 5, 67-74.
7. Toncheva, V., Wolfert, M. A., Dash, P. R., Oupický, D., Ulbrich, K., Seymour, L. W., and Schacht, E. H. (1998) Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine) grafted with hydrophilic polymers. Biochim. Biophys. Acta 1380, 354-368.
8. Oupický, D., Koňák, Č., and Ulbrich, K. (1998) DNA Complexes with Block and Graft Copolymers of N-(2-Hydroxypropyl)methacrylamide and 2-(Trimethylammonio)ethyl methacrylate. J. Biomater. Sci., Polym. Ed. (in press).
9. Oupický, D., Koňák, Č., and Ulbrich, K. (1999) Preparation of DNA Complexes with Diblock Copolymers of Poly[N-(2-Hydroxypropyl)methacrylamide] and Polycations. Mater. Sci. Eng. C (in press).
10. Wolfert, M. A., and Seymour, L. W. (1996) Atomic Force Microscopy of the influence of the molecular weight of poly-(L-lysine) on the size of polyelectrolyte complexes formed with DNA. Gene Ther. 3, 269-273.
11. Chion, H. C., Tangco, M. V., Levine, S. M., Robertson, D., Karmisk, L., Wu, C. H., and Wu, G. Y. (1994) Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoproteins-polylysine carriers. Nucleic Acids Res. 22, 5439-5446.
12. Oja, C. D., Semple, S. C., Chonn, A., and Cullis, P. R. (1996) Influence of dose on liposome clearance: critical role of blood proteins. Biochim. Biophys. Acta 1281, 31-37.
13. Dash, P. R. (1998) The Development of Polymer-based Synthetic Vectors for Use in Gene Therapy. Ph.D. Thesis, University of Birmingham.
14. Lasic, D. D., and Needham, D. (1995) The "stealth" liposome: A prototypical biomaterial. Chem. Rev. 95, 2601-2628.
15. Moghimi, S. M. (1995) Mechanisms regulating body distribution of nanospheres conditioned with pluronic and tetronic block copolymers. Adv. Drug Delivery Rev. 16, 183-193.
16. Manning, G. S. (1969) Limiting laws and counterion condensation in polyelectrolyte solutions. I. Colligative properties. J. Chem. Phys. 51, 924-938.
17. Wolfert, M. A. Self-assembling systems based on synthetic polymers for gene delivery. (1998) Ph.D. Thesis, University of Birmingham.
18. Bakeev, K. N., Izumrudov, V. A., Kuchanov, S. I., Zezin, A. B., and Kabanov, V. A. (1992) Kinetics and Mechanism of Interpolyelectrolyte Exchange and Addition Reactions. Macromolecules 25, 4249-4254.
19. Takakura, Y., and Hashida, M. (1998) Pharmacokinetics of macromolecules and synthetic gene delivery systems. In Self-assembling complexes for gene delivery: From laboratory to clinical trial (A. V. Kabanov, P. L. Felgner, and L. W. Seymour, Eds.), pp 295-306, John Wiley & Sons, New York.
20. Lasic, D. D. (1997) Recent developments in medical applications of liposomes: sterically stabilized liposomes in cancer therapy and gene delivery in vivo. J. Controlled Release 48, 203-222.