The fate of poly(2-dimethyl amino ethyl)methacrylate-based polyplexes after intravenous administration

International Journal of Pharmaceutics

Volumn 214, Issue 1-2, 2001, Pages 99-101

  Verbaan, F J ^a   Oussoren, C ^a   Van Dam, I M ^a   Takakura, Y ^b   Hashida, M ^b   Crommelin, D J A ^a   Hennink, W E ^a   Storm, G ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Albumin; Distribution; Erythrocytes; Hemagglutination; Poly(2 dimethyl amino ethyl)methacrylate; Transfection; Zeta potentials

Indexed keywords

ALBUMIN; CATION; MACROGOL; METHACRYLIC ACID DERIVATIVE; POLY(2 DIMETHYLAMINOETHYL)METHACRYLATE; POLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG STRUCTURE; DRUG UPTAKE; ELECTRICITY; ERYTHROCYTE; FEMALE; GENE EXPRESSION PROFILING; GENE TARGETING; GENETIC TRANSFECTION; HEMAGGLUTINATION; LUNG; LUNG CAPILLARY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; TURBIDITY; ZETA POTENTIAL;

ANIMALS; DNA; DRUG CARRIERS; FEMALE; INJECTIONS, INTRAVENOUS; LUNG; METHACRYLATES; MICE; MICE, INBRED BALB C; NYLONS; TRANSFECTION;

EID: 0035910871     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00642-6     Document Type: Conference Paper

References (4)

1. Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles
2. Gene delivery systems: Bridging the gap between recombinant viruses and artificial vectors
3. Relation between transfection efficiency and cytotoxicity of poly(2-dimethylamino)ethyl methacrylate)/plasmid complexes
4. Effects of physicochemical characteristics of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes on cellular association and internalization