Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments

Pharmaceutical Research

Volumn 19, Issue 2, 2002, Pages 140-146

  Merdan, T ^a,b   Kunath, K ^a   Fischer, D ^a   Kopecek, J ^b   Kissel, T ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Intracellular processing; Living cell confocal microscopy; Lysosomal escape; Polyethylenimine

Indexed keywords

BAFILOMYCIN A1; NUCLEIC ACID; POLYETHYLENEIMINE; POLYMER; RIBOZYME;

ARTICLE; CELL NUCLEUS; COMPLEX FORMATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DEVICE; ENDOSOME; GENE DELIVERY SYSTEM; HUMAN; HUMAN CELL; LYSOSOME; PLASMID; PRIORITY JOURNAL; SECRETORY VESICLE;

ANIMALS; ANTI-BACTERIAL AGENTS; CARBOXYLIC ACIDS; ENZYME INHIBITORS; HUMANS; LUCIFERASES; MACROLIDES; MICROSCOPY, CONFOCAL; MOLECULAR WEIGHT; PLASMIDS; POLYETHYLENEIMINE; PROTON-TRANSLOCATING ATPASES; RNA, CATALYTIC; SPECTROMETRY, FLUORESCENCE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036179935     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014212630566     Document Type: Article

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