Structural, signalling and regulatory properties of the group I metabotropic glutamate receptors: Prototypic family C G-protein-coupled receptors

Biochemical Journal

Volumn 359, Issue 3, 2001, Pages 465-484

  Hermans, E ^a   Challiss, R A J ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Homer proteins; Protein kinase C; Receptor desensitization; Receptor phosphorylation; Signal transduction

Indexed keywords

BIOLOGICAL MEMBRANES; BRAIN; CALCIUM; CLONING;

METABOTROPIC GLUTAMATE RECEPTOR;

PROTEINS;

CALCIUM SENSING RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; PROTEIN KINASE C;

ALTERNATIVE RNA SPLICING; GLYCOSYLATION; MOLECULAR CLONING; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; RECEPTOR GENE; REVIEW; SECOND MESSENGER; SIGNAL TRANSDUCTION;

ANIMALS; CATIONS, DIVALENT; GTP-BINDING PROTEINS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEUROGLIA; NEURONS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, METABOTROPIC GLUTAMATE; SIGNAL TRANSDUCTION;

EID: 0035504328     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3590465     Document Type: Review

References (246)

1. The glutamate receptor ion channels
2. Glutamate stimulates inositol phosphate formation in striatal neurones
3. Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: Developmental changes and interaction with alpha 1-adrenoceptors
4. A new type of glutamate receptor linked to inositol phospholipid metabolism
5. Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain
6. Sequence and expression of a metabotropic glutamate receptor
7. Pharmacology and functions of metabotropic glutamate receptors
8. Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice
9. Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
10. Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1
11. Selective abolition of the NMDA component of long-term potentiation in mice lacking mGluR5
12. Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
13. mGluR1 in cerebellar Purkinje cells essential for tong-term depression, synapse elimination, and motor coordination
14. Metabotropic G-protein-coupled glutamate receptors as therapeutic targets
15. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
16. New perspectives for the development of selective metabotropic glutamate receptor ligands
17. The 'ABC' of GABA receptors: A brief review
18. Extracellular calcium sensing and extracellular calcium signaling
19. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution
20. A new multigene family of putative pheromone receptors
21. Molecular tinkering of G protein-coupled receptors: An evolutionary success
22. Homology model of the closed, functionally active, form of the amino terminal domain of mGluR1
23. Molecular determinants of metabotropic glutamate receptor signaling
24. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
25. Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination
26. The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain
27. The N-terminal domain of gamma-aminobutyric acid (B) receptors is sufficient to specify agonist and antagonist binding
28. The agonist-binding domain of the calcium-sensing receptor is located at the amino-terminal domain
29. 2+ receptors
30. Atomic structure and specificity of bacterial periplasmic receptors for active transport and chemotaxis: Variation of common themes
31. Homology modeling of metabotropic glutamate receptors (mGluRs): Structural motifs affecting binding modes and pharmacological profile of mGluR1 agonists and competitive antagonists
32. The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity
33. Cloning and stable expression of the mGluR1b subtype of human metabotropic receptors and pharmacological comparison with the mGluR5a subtype
34. Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses
35. Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor
36. Expression and purification of the extracellular ligand binding region of metabotropic glutamate receptor subtype 1
37. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor
38. Mutagenesis and modeling of the GABAB receptor extracellular domain support: A venus flytrap mechanism for ligand binding
39. Constraints on proper folding of the amino terminal domains of group iii metabotropic glutamate receptors
40. 2+ receptor cysteine-rich domain - Analysis of function of mutant and chimeric receptors
41. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
42. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
43. Characterization of metabotropic glutamate receptors in rat C6 glioma cells
44. Autoradiographic visualization of group III metabotropic glutamate receptors using [3H]-L-2-amino-4-phosphonobutyrate
45. Characterization of (2S,2′R,3′R)-2-(2′,3′-[3H]-dicarboxycyclopropyl) glycine binding in rat brain
46. In vitro binding characteristics of a new selective group II metabotropic glutamate receptor radioligand, [3H]LY354740, in rat brain
47. Direct radiolabeling by [H-3]quisqualic acid of group I metabotropic glutamate receptor in rat brain synaptic membranes
48. Leucine/isoleucine/valine-binding protein contracts upon binding of ligand
49. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding
50. How the protease thrombin talks to cells
51. Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor
52. BAY36-7620: A potent non-competitive mGlu1 receptor antagonist with inverse agonist activity
53. 2-Methyl-6-(phenylethynyl)pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
54. Characterization of [H-3]quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections
55. The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan [b]chromen-1 alphacarboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate receptors
56. Interaction of CPCCOEt with a chimeric mGlu(1b) and calcium sensing receptor
57. 2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568
58. Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor - Constitutive activity and inverse agonism in a family C G-protein-coupled receptor
59. The metabotropic glutamate receptor (MGR): Pharmacology and subcellular location
60. A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line
61. Inverse agonism at G protein-coupled receptors: (patho)physiological relevance and implications for drug discovery
62. Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity
63. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer
64. Cloning and characterization of a bifunctional metabotropic receptor activated by both extracellular calcium and glutamate
65. Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways
66. 2+-sensing function of the metabotropic glutamate receptors
67. 2+ on type 1 alpha metabotropic glutamate receptor-mediated signalling
68. 2+ sensitivity of mGluR1alpha associated with persistent glutamate response in transfected CHO cells
69. Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors
70. 2+ activates phospholipase C
71. Calcium sensing properties of the GABA(B) receptor
72. 2+ requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: Involvement of serine 269 of the GABA(B)R1 subunit
73. 2+ in single cells
74. High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus
75. A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR1 alpha metabotropic glutamate receptors
76. Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1 alpha by protein kinase C in permanently transfected BHK cells
77. Characterization of two alternatively spliced forms of a metabotropic glutamate receptor in the central nervous system of the rat
78. Metabotropic glutamate receptor 5 is a disulfide-linked dimer
79. Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1alpha
80. 2+ receptor: Effects on cell surface expression, dimerization and signal transduction
81. Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys → Ser mutations at Cys101 and Cys236
82. Cryptic dimer interface and domain organization of the extracellular region of metabotropic glutamate receptor subtype 1
83. Covalent and noncovalent interactions mediate metabotropic glutamate receptor mGlu(5) dimerization
84. Structural and functional aspects of G protein-coupled receptor oligomerization
85. Dimerization of the delta opioid receptor: Implication for a role in receptor internalization
86. G-protein-coupled receptor heterodimerization modulates receptor function
87. Metabotropic glutamate receptors dimers
88. Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors
89. 2+ receptor
90. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2
91. GABA(B)-receptor subtypes assemble into functional heteromeric complexes
92. Heterodimerization is required for the formation of a functional GABA(B) receptor
93. Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes
94. Inhibition of N-linked glycosylation of the human type 1 alpha metabotropic glutamate receptor by tunicamycin: Effects on cell-surface receptor expression and function
95. 2+ signalling in an inducible cell expression system
96. Effects of varying the expression level of recombinant human mGlu1alpha receptors on the pharmacological properties of agonists and antagonists
97. Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells
98. Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells
99. Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1 alpha metabotropic glutamate receptor signaling in baby hamster kidney cells
100. Role of the second and third intracellular loops of metabotropic glutamate receptors in mediating dual signal transduction activation
101. The G protein-coupling profile of metabotropic glutamate receptors, as determined with exogenous G proteins, is independent of their ligand recognition domain
102. Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro
103. Functional coupling of human metabotropic glutamate receptor hmGlu1d: Comparison to splice variants hmGlu1a and -1b
104. Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: Comparison with mGluR1
105. The rat mGlu1d receptor splice variant shares functional properties with the other short isoforms of mGlu1 receptor
106. 2+ signal transduction
107. Metabotropic glutamate receptor mGluR5 in astrocytes: Pharmacological properties and agonist regulation
108. Inositol phospholipid metabolism in Xenopus oocytes mediated by endogenous G(o) and Gi proteins
109. A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover
110. Cell type-specific differences in the coupling of recombinant mGlu1 alpha receptors to endogenous G protein sub-populations
111. Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes
112. Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment
113. Pharmacological characterization of type 1alpha metabotropic glutamate receptor-stimulated [35S]-GTPgammaS binding
114. 2+ channels
115. 2+ channels via multiple signal transduction pathways in HEK 293 cells
116. Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors
117. 2+ channels involves multiple receptor subtypes in cortical neurons
118. + channel, GIRK, in Xenopus oocytes
119. Emerging roles for RGS proteins in cell signalling
120. Regulator of G protein signalling: Novel multifunctional drug targets
121. Regulators of G-protein signaling (RGS) proteins: Region-specific expression of nine subtypes in rat brain
122. RGS4 inhibits signaling by group I metabotropic glutamate receptors
123. Metabotropic excitatory amino acid receptor activation stimulates phospholipase D in hippocampal slices
124. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus
125. Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA
126. Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes
127. Activation of phospholipase D by metabotropic glutamate receptor agonists in rat cerebrocortical synaptosomes
128. Antagonist pharmacology of metabotropic glutamate receptors coupled to phospholipase D activation in adult rat hippocampus: Focus on (2R,1′S,2′R,3′S)-2-(2′-carboxy-3′- phenylcyclopropyl)glycine versus 3,5-dihydroxyphenylglycine
129. Functional coupling between ryanodine receptors and L-type calcium channels in neurons
130. 2+ stores and ion channels in neurons
131. 2+ from the same store in cultured DRG neurones
132. 2+ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture
133. Characterization of the metabotropic glutamate receptors mediating phospholipase 6 activation and calcium release in cerebellar granule cells: Calcium-dependence of the phospholipase C response
134. Switch from facilitation to inhibition of excitatory synaptic transmission by group I mGluR desensitization
135. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors
136. A cluster of basic residues in the carboxyl-terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C
137. The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G-proteins
138. Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors
139. The metabotropic glutamate receptors: Their second intracellular loop plays a critical role in the G-protein coupling specificity
140. The metabotropic glutamate receptors: Structure and functions
141. Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain
142. Molecular determinants of metabotropic glutamate receptor 1B trafficking
143. The expression of two splice variants of metabotropic glutamate receptor subtype 5 in the rat brain and neuronal cells during development
144. Bidirectional regulation of neurite elaboration by alternatively spliced metabotropic glutamate receptor 5 (mGluR5) isoforms
145. Heptahelical receptor signaling: Beyond the G protein paradigm
146. G-protein-independent signaling by G-protein-coupled receptors
147. G-protein-independent signaling mediated by metabotropic glutamate receptors
148. Direct binding of activated c-Src to the beta(3)-adrenergic receptor is required for MAP kinase activation
149. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization
150. Beta-arrestin-dependent formation of beta(2) adrenergic receptor Src protein kinase complexes
151. Beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2
152. Phosphorylation of mitogen-activated protein kinase in cultured rat cortical glia by stimulation of metabotropic glutamate receptors
153. Glutamate-stimulated activation of DNA synthesis via mitogen-activated protein kinase in primary astrocytes: Involvement of protein kinase C and related adhesion focal tyrosine kinase
154. Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice
155. Agonist-induced internalisation of the metabotropic glutamate receptor 1a is arrestin- and dynamin-dependent
156. Rapid internalization and surface expression of a functional, fluorescently tagged G-protein-coupled glutamate receptor
157. Postsynaptic organization and regulation of excitatory synapses
158. Agonist-induced functional desensitization of the mu-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein
159. PKC phosphorylation of a conserved serine residue in the C-terminus of group III metabotropic glutamate receptors inhibits calmodulin binding
160. Heteromultimerization and NMDA receptor-clustering activity of chapsyn-110, a member of the PSD-95 family of proteins
161. Cytoskeletal dynamics in dendritic spines: Direct modulation by glutamate receptors?
162. GRIP: A synaptic PDZ domain-containing protein that interacts with AMPA receptors
163. SAP90 binds and clusters kainate receptors causing incomplete desensitization
164. Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus
165. Homer: A protein that selectively binds metabotropic glutamate receptors
166. Novel members of the Vesl/Homer family of PDZ proteins that bind metabotropic glutamate receptors
167. Molecular characterisation of two structurally distinct groups of human Homers, generated by extensive alternative splicing
168. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
169. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
170. Involvement of unique leucine-zipper motif of PSD-Zip45 (Homer 1c/vesl-1L) in group 1 metabotropic glutamate receptor clustering
171. Co-expression of metabotropic glutamate receptor type 1alpha with homer-1a/Vesl-1S increases the cell surface expression of the receptor
172. Homer 1b regulates the trafficking of group I metabotropic glutamate receptors
173. Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1 alpha: Evidence for an anchoring function
174. Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by Homer1 proteins and neuronal excitation
175. Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
176. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
177. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
178. Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels
179. The scaffold protein, Homer1b/c, regulates axon pathfinding in the central nervous system in vivo
180. Excitatory synapses - Glutamate receptors put in their place
181. The role of receptor kinases and arrestins in G protein-coupled receptor regulation
182. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
183. Desensitization of metabotropic glutamate receptors in neuronal cultures
184. Mechanisms underlying developmental changes in the expression of metabotropic glutamate receptors in cultured cerebellar granule cells: Homologous desensitization and interactive effects involving N-methyl-o-aspartate receptors
185. Inhibition of the phospholipase C-linked metabotropic glutamate receptor by 2-amino-3-phosphonopropionate is dependent on extracellular calcium
186. Phorbol esters attenuate glutamate-stimulated inositol phospholipid hydrolysis in neuronal cultures
187. Role of protein kinase C phosphorylation in rapid desensitization of metabotropic glutamate receptor 5
188. Control of calcium oscillations by phosphorylation of metabotropic glutamate receptors
189. The metabotropic glutamate receptor mGluR5 induces calcium oscillations in cultured astrocytes via protein kinase C phosphorylation
190. Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations
191. 2+ oscillations and waves by oscillating translocation and activation of protein kinase C
192. Diversity of calcium signaling by metabotropic glutamate receptors
193. Spatial-temporal patterning of metabotropic glutamate receptor-mediated inositol 1,4,5-trisphosphate, calcium, and protein kinase C oscillations: Protein kinase C-dependent receptor phosphorylation is not required
194. Calcium oscillations increase the efficiency and specificity of gene expression
195. 2+ spike frequency can optimize gene expression
196. 2+](i) oscillation frequency regulates agonist-stimulated NF-kappa B transcriptional activity
197. Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
198. Calmodulin binding to G protein-coupling domain of opioid receptors
199. Binding of calmodulin to the D-2-dopamine receptor reduces receptor signaling by arresting the G protein activation switch
200. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
201. 2+ pathway by phosphorylation of the receptor-G protein-coupling domain
202. Rapid desensitization of the metabotropic glutamate receptor that facilitates glutamate release in rat cerebrocortical nerve terminals
203. Glutamate mediates an inhibitory postsynaptic potential in dopamine neurons
204. Functional regulation of metabotropic glutamate receptor type 1c: A role for phosphorylation in the desensitization of the receptor
205. G protein coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death
206. The G-protein-coupled receptor kinase GRK4 mediates homologous desensitization of metabotropic glutamate receptor 1
207. Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells
208. Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders
209. NMDA receptor stimulation and brain-derived neurotrophic factor upregulate Homer 1a mRNA via the mitogen-activated protein kinase cascade in cultured cerebellar granule cells
210. Differential subcellular localization of mGluR1a and mGluR5 in the rat and monkey substantia nigra
211. 3-sensitive stores evoked by synaptic activation of mGluRs paired with backpropagating action potentials
212. 2+ signaling in rat hippocampal neurons
213. Calcium on the up: Supralinear calcium signaling in central neurons
214. Activation of the G protein Gq/11 through tyrosine phosphorylation of the alpha subunit
215. Group I mGluRs coupled to G proteins are regulated by tyrosine kinase in dopamine neurons of the rat midbrain
216. Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways
217. Cloning of novel splice variants of mouse mGluR1
218. Identification, cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA1
219. Expression of a novel splice variant of human mGluR1 in the cerebellum
220. Cys-140 is critical for metabotropic glutamate receptor-1 dimerization
221. In vitro translation and membrane topology of rat recombinant mGluR1 alpha
222. Palmitoylation of metabotropic glutamate receptor subtype 4 but not 1 alpha expressed in permanently transfected BHK cells
223. Cloning and expression of a human metabotropic glutamate receptor 1 alpha: Enhanced coupling on co-transfection with a glutamate transporter
224. A family of metabotropic glutamate receptors
225. HmGlu1d, a novel splice variant of the human type I metabotropic glutamate receptor
226. Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5
227. Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5
228. A variant of metabotropic glutamate receptor subtype 5: An evolutionally conserved insertion with no termination codon
229. Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2
230. Molecular characterization and localization of human metabotropic glutamate receptor type 3
231. Group III human metabotropic glutamate receptors 4, 7 and 8: Molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells
232. Cloning and characterization of a metabotropic glutamate receptor, mGluR4b
233. The whole nucleoside sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6
234. Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate
235. Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS
236. Cloning and expression of a new member of the L-2-amino-4-phosphonobutyric acid-sensitive class of metabotropic glutamate receptors
237. Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction
238. A novel splice variant of a metabotropic glutamate receptor, human mGluR7b
239. Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8
240. Cloning and expression of rat metabotropic glutamate receptor 8 reveals a distinct pharmacological profile
241. Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8
242. Different levels of receptor expression as a new procedure to estimate agonist affinity constant. Application to the metabotropic receptors
243. Cupidin, an isoform of Homer/Vesl, interacts with the actin cytoskeleton and activated rho family small GTPases and is expressed in developing mouse cerebellar granule cells
244. Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: Evidence for a direct interaction with tubulin
245. Metabotropic glutamate receptor type 1 alpha and tubulin assemble into dynamic interacting complexes
246. Immunocytochemical localization of metabotropic glutamate receptor type 1 alpha and tubulin in rat brain