Complex involvement of pertussis toxin-sensitive G proteins in the regulation of type 1α metabotropic glutamate receptor signaling in baby hamster kidney cells

Molecular Pharmacology

Volumn 58, Issue 2, 2000, Pages 352-360

  Hermans, Emmanuel ^a,b   Saunders, Ruth ^a   Selkirk, Julie V ^a   Mistry, Rajendra ^a   Nahorski, Stefan R ^a   Challiss, R A John ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMIC ACID; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; INOSITOL PHOSPHATE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; QUISQUALIC ACID; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION;

EID: 0033933726     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.2.352     Document Type: Article

References (36)

1. 35S]GTPgammaS binding. Br J Pharmacol 121:1203-1209.
2. 35S]GTP gamma S and Galpha-specific immunoprecipitation. Br J Pharmacol 125:24.
3. Alaluf S, Mulvihill ER and McIlhinney RA (1995) Rapid agonist mediated phosphorylation of the metabotropic glutamate receptor 1α by protein kinase C in permanently transfected BHK cells. FEBS Lett 367:301-305.
4. Aramori I and Nakanishi S (1992) Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluR1, in transfected CHO cells. Neuron 8:757-765.
5. Arthur JM, Collinsworth GP, Gettys TW, Quarles LD and Raymond JR (1997) Specific coupling of a cation-sensing receptor to G protein alpha-subunits in MDCK cells. Am J Physiol. 273:F129-F135.
6. Blayney LM, Gapper PW and Newby AC (1996) Phospholipase C isoforms in vascular smooth muscle and their regulation by G-proteins. Br J Pharmacol 118:1003-1011.
7. Burford NT, Tolbert LM and Sadee W (1998) Specific G protein activation and mu-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. Eur J Pharmacol 342:123-126.
8. Carruthers AM, Challiss RAJ, Mistry R, Saunders R, Thomsen C and Nahorski SR (1997) Enhanced type 1alpha metabotropic glutamate receptor-stimulated phosphoinositide signaling after pertussis toxin treatment. Mol Pharmacol 52:406-414.
9. Challiss RAJ, Jenkinson R, Mistry R, Batty IH and Nahorski SR (1993) Assessment of neuronal phosphoinositide turnover and its disruption by lithium. Neuroprotocols 3:135-144.
10. Conn PJ and Pin JP (1997) Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 37:205-237.
11. Dickenson JM and Hill SJ (1998) Involvement of G-protein betagamma subunits in coupling the adenosine A1 receptor to phospholipase C in transfected CHO cells. Eur J Pharmacol 355:85-93.
12. Ferraguti F, Baldani GB, Corsi M, Nakanishi S and Corti C (1999) Activation of the extracellular signal-regulated kinase 2 by metabotropic glutamate receptors. Eur J Neurosci 11:2073-2082.
13. Houamed KM, Kuijper JL, Gilbert TL, Haldeman BA, O'Hara PJ, Mulvihill ER, Almers W and Hagen FS (1991) Cloning, expression, and gene structure of a G protein-coupled glutamate receptor from rat brain. Science (Wash DC) 252:1318-1321.
14. Joly C, Gomeza J, Brabet I, Curry K, Bockaert J and Pin JP (1995) Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: Comparison with mGluR1. J Neurosci 15:3970-3981.
15. 2+ channels. Neuron 22:819-829.
16. Kasahara J and Sugiyama H (1994) Inositol phospholipid metabolism in Xenopus oocytes mediated by endogenous G(o) and Gi proteins. FEBS Lett 355:41-44.
17. Katz A, Wu D and Simon MI (1992) Subunits beta gamma of heterotrimeric G protein activate beta 2 isoform of phospholipase C. Nature (Lond) 360:686-689.
18. Lang J, Nishimoto I, Okamoto T, Regazzi R, Kiraly C, Weller U and Wollheim CB (1995) Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits EMBO J 14:3635-3644.
19. Lin HC, Duncan JA, Kozasa T and Gilman AG (1998) Sequestration of the G protein beta gamma subunit complex inhibits receptor-mediated endocytosis. Proc Natl Acad Sci USA 95:5057-5060.
20. Litosch I (1996) G-protein inhibition of phospholipase C-beta 1 in membranes: Role of G-protein beta gamma subunits. Biochem J 319:173-178.
21. Luján R, Nusaer Z, Roberts JD, Shigemoto R and Somogyi P (1996) Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. Eur J Neurosci 8:1488-1500.
22. Masu M, Tanabe Y, Tsuchida K, Shigemoto R and Nakanishi S (1991) Sequence and expression of a metabotropic glutamate receptor. Nature (Lond) 349:760-765.
23. Mattera R, Hayek S, Summers BA and Grove DL (1998) Agonist-specific alterations in receptor-phospholipase coupling following inactivation of Gi2alpha gene. Biochem J 332:263-271.
24. 2+ channels via multiple signal transduction pathways in HEK 293 cells. J Neurophysiol 79:379-391.
25. Mody N, Hermans E, Nahorski SR and Challiss RAJ (1999) Inhibition of N-linked glycosylation of the human type 1 alpha metabotropic glutamate receptor by tunicamycin: effects on cell-surface receptor expression and function. Neuropharmacolcgy 38:1485-1492.
26. Nurnberg B and Ahnert HG (1996) Potential roles of heterotrimeric G proteins of the endomembrane system. FEBS Lett 389:61-65.
27. Pickering DS, Thomsen C, Suzdak PD, Fletcher EJ, Robitaille R, Salter MW, MacDonald JF, Huang XP and Hampson DR (1993) A comparison of two alternatively spliced forms of a metabotropic glutamate receptor coupled to phosphoinositide turnover. J Neurochem 81:85-92.
28. 2+ on type 1alpha metabotropic glutamate receptor-mediated signalling. Neuropharmacology 37:273-276.
29. Stowell JN and Craig AM (1999) Axon/dendrite targeting of metabotropic glutamate receptors by their cytoplasmic carboxy-terminal domains. Neuron 22:525-536.
30. Sunahara RK, Dessauer CW and Gilman AG (1996) Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol 36:461-480.
31. Thomsen C (1996) Metabotropic glutamate receptor subtype 1A activates adenylate cyclase when expressed in baby hamster kidney cells. Prog Neuropsychopharmacol Biol Psychiatry 20:709-726.
32. Thomsen C, Mulvihill ER, Haldeman B, Pickering DS, Hampson DR and Suzdak PD (1993) A pharmacological characterization of the mGluR1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line. Brain Res 619:22-28.
33. Tobin AB (1997) Phosphorylation of phospholipase C-coupled receptors. Pharmacol Ther 75:135-151.
34. Tobin AB and Nahorski SR (1993) Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation. J Biol Chem 268:9817-9823.
35. Watkins DC, Moxham CM, Morris AJ and Malbon CC (1994) Suppression of Gi alpha 2 enhances phospholipase C signalling. Biochem J 299:593-596.
36. Woo JS, Inoue CN, Hanaoka K, Schwiebert EM, Guggino SE and Guggino WB (1998) Adenylyl cyclase is involved in desensitization and recovery of ATP-stimulated Cl-secretion in MDCK cells. Am J Physiol 274:C371-C378.