Activation of phospholipases C and D by the novel metabotropic glutamate receptor agonist tADA

Neuropharmacology

Volumn 36, Issue 2, 1997, Pages 261-263

  Klein, J ^a   Reymann, K G ^b   Riedel, G ^c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b Federal Institute of Neurobiology   (Germany)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

hippocampal slice; metabotropic glutamate receptors (mGluRs); phospholipase C; phospholipase D; trans azetidine 2,4 dicarboxylic acid (tADA)

Indexed keywords

AZETIDINE 2,4 DICARBOXYLIC ACID; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR AGONIST; GLUTAMIC ACID; INOSITOL PHOSPHATE; METABOTROPIC RECEPTOR; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; HYDROLYSIS; NEWBORN; NONHUMAN; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; RAT;

ANIMALS; AZETIDINECARBOXYLIC ACID; ENZYME ACTIVATION; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; INOSITOL PHOSPHATES; PHOSPHOLIPASE C; PHOSPHOLIPASE D; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE;

EID: 0030894147     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00174-8     Document Type: Article

References (11)

1. Boss V., Nutt K.M., Conn P.J. L-Cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Molec. Pharmacol. 45:1994;1177-1182.
2. Bruno V., Copani A., Knöpfel T., Kuhn R., Casabona G., DellÁlbani P., Condorelli D.F., Nicoletti F. Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells. Neuropharmacology. 34:1995;1089-1098.
3. Catania M.V., Landwehrmeyer G.B., Testa C.M., Standaert D.G., Penney J.B. Jr., Young A.B. Metabotropic glutamate receptors are differentially regulated during development. Neuroscience. 61:1994;481-495.
4. Favaron M., Manev R.M., Candeo P., Arban R., Gabellini N., Kozikowski A.P., Manev H. Trans-azetidine-2,4-dicarboxylic acid activates neuronal metabotropic receptors. NeuroReport. 4:1993;967-970.
5. Holler T., Cappel E., Klein J., Löffelholz K. Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats. J. Neurochem. 61:1993;1569-1572.
6. Klein J., Chalifa V., Liscovitch M., Löffelholz K. Role of phospholipase D activation in nervous system physiology and pathophysiology. J. Neurochem. 65:1995;1445-1455.
7. Knöpfel T., Sakaki J., Flor P., Baumann P., Sacaan A.I., Velicelebi G., Kuhn R., Allgeier H. Profiling of trans-azetidine-2,4-dicarboxylic acid at the human metabotropic glutamate receptors hmGluR1b, 2, 4a and 5a. Eur. J. Pharmacol. 288:1995;389-392.
8. Manahan-Vaughan D., Reiser M., Pin J.-P., Wilsch V., Bockaert J., Reymann K.G., Riedel G. Physiological and pharmacological profile of trans-azetidine-2,4-dicarboxylic acid: metabotropic glutamate receptor agonism and effects on long-term potentiation. Neuroscience. 72:1996;999-1008.
9. Pellegrini-Giampietro D.E., Torregrossa S.A., Moroni F. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br. J. Pharmacol. 118:1996;1035-1043.
10. Pin J.-P., Duvoisin R. The metabotropic glutamate receptors: structure and functions. Neuropharmacology. 34:1995;1-26.
11. Winder D.G., Smith T., Conn P.J. Pharmacological differentiation of metabotropic glutamate receptors coupled to potentiation of cyclic adenosine monophosphate responses and phosphoinositide hydrolysis. J. Pharmacol. Exp. Ther. 266:1993;518-525.