Mutagenesis and modeling of the GABA(B) receptor extracellular domain support a Venus flytrap mechanism for ligand binding

Journal of Biological Chemistry

Volumn 274, Issue 19, 1999, Pages 13362-13369

  Galvez, Thierry ^a   Parmentier, Marie Laure ^a   Joly, Cécile ^a   Malitschek, Barbara ^b   Kaupmann, Klemens ^b   Kuhn, Rainer ^b   Bittiger, Helmut ^b   Froestl, Wolfgang ^b   Bettler, Bernhard ^b   Pin, Jean Philippe ^a  

^a CNRS UPR 9023   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; LIGAND; RADIOACTIVE IODINE;

AMINO ACID SEQUENCE; ARTICLE; EXTRACELLULAR MATRIX; HYDROGEN BOND; NONHUMAN; PLANT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN STABILITY; RECEPTOR DENSITY; SITE DIRECTED MUTAGENESIS; THERMOSTABILITY; ANIMAL; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; PROTEIN BINDING; PROTEIN FOLDING; RADIOASSAY; RAT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; HUMANS; IODINE RADIOISOTOPES; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-B; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0033531793     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.19.13362     Document Type: Article

References (44)

1. Nakanishi, S. (1992) Science 258, 597-603
2. Conn, P., and Pin, J.-P. (1997) Annu. Reu. Pharmacol. Toxicol. 37, 205-237
3. Brown, E. M., Gamba, G., Riccardi, D., Lombardi, M., Butters, R., Kifor, O., Sun, A., Hediger, M. A., Lytton, J., and Hebert, S. C. (1993) Nature 366, 575-580
4. Herrada, G., and Dulac, C. (1997) Cell 90, 763-773
5. Ryba, N., and Tirindelli, R. (1997) Neuron 19, 371-379
6. Matsunami, H., and Buck, L. B. (1997) Cell 90, 775-784
7. O'Hara, P. J., Sheppard, P. O., Thøgersen, H., Venezia, D., Haldeman, B. A., McGrane, V., Houamed, K. M., Thomsen, C., Gilbert, T. L., and Mulvihill, E. R. (1993) Neuron 11, 41-52
8. Takahashi, K., Tsuchida, K., Tanabe, Y., Masu, M., and Nakanishi, S. (1993) J. Biol. Chem. 268, 19341-19345
9. Tones, M. A., Bendali, H., Flor, P. J., Knopfel, T., and Kuhn, R. (1995) Neuroreport 7, 117-120
10. Parmentier, M.-L., Joly, C., Restituito, S., Bockaert, J., Grau, Y., and Pin, J.-P. (1998) Mol. Pharmacol. 53, 778-786
11. Okamoto, T., Sekiyama, N., Otsu, M., Shimada, Y., Sato, A., Nakanishi, S., and Jingami, H. (1998) J. Biol. Chem. 273, 13089-13096
12. Francesconi, A., and Duvoisin, R. M. (1998) J. Biol. Chem. 273, 5615-5624
13. Pin, J.-P., Joly, C., Heinemann, S. F., and Bockaert, J. (1994) EMBO J. 13, 342-348
14. Gomeza, J., Joly, C., Kuhn, R., Knöpfel, T., Bockaert, J., and Pin, J.-P. (1996) J. Biol. Chem. 271, 2199-2205
15. Mao, B., Pear, M. R., McCammon, J. A., and Quiocho, F. A. (1982) J. Biol. Chem. 257, 1131-1133
16. Quiocho, F. A. (1990) Philos. Trans. R. Soc. Lond. B Biol. Sci. 326, 341-351
17. Pin, J.-P., and Bockaert, J. (1995) Curr. Opin. Neurol. 5, 342-349
18. Kuryatov, A., Laube, B., Betz, H., and Kuhse, J. (1994) Neuron 12, 1291-1300
19. Stern-Bach, Y., Bettler, B., Hartley, M., Sheppard, P. O., O'Hara, P. J., and Heinemann, S. F. (1994) Neuron 13, 1345-1357
20. Paas, Y., Eisenstein, M., Medevielle, F., Teichberg, V. I., and Devillers-Thiéry, A. (1996) Neuron 17, 979-990
21. Kuusinen, A., Arvola, M., and Keinänen, K. (1995) EMBO J. 14, 6327-6332
22. Mano, I., Lamed, Y., and Teichberg, V. I. (1996) J. Biol. Chem. 271, 15299-15302
23. Kaupmann, K., Huggel, K., Heid, J., Flor, P. J., Bischoff, S., Mickel, S. J., McMaster, G., Angst, C., Bittiger, H., Froestl, W., and Bettler, B. (1997) Nature 386, 239-246
24. Froestl, W., Mickel, S. J., Hall, R. G., von Sprecher, G., Strub, D., Baumann, P. A., Brugger, F., Gentsch, C., Jaekel, J., Olpe, H.-R., Rihs, G., Vassout, A., Waldmeier, P. C., and Bittiger, H. (1995) J. Med. Chem. 38, 3297-3312
25. Bittiger, H., Froestl, W., Mickel, S. J., and Olpe, H.-R. (1993) Trends Pharmacol. Sci. 14, 391-394
26. Malitschek, B., Ruegg, D., Heid, J., Kaupmann, K., Bittiger, H., Froestl, W., Bettler, B., and Kuhn, R. (1998) Mol. Cell. Neurosci. 12, 56-64
27. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
28. Callebaut, I., Labesse, G., Durand, P., Poupon, A., Canard, L., Chomilier, J., Henrissat, B., and Mornon, J. (1997) Cell Mol. Life Sci. 53, 621-645
29. Luthy, R., Bowie, J. U., and Eisenberg, D. (1992) Nature 356, 83-85
30. Sali, A., and Blundell, T. (1993) J. Mol. Biol. 234, 779-815
31. Gomeza, J., Mary, S., Brabet, I., Parmentier, M.-L., Restituito, S., Bockaert, J., and Pin, J.-P. (1996) Mol. Pharmacol. 50, 923-930
32. Mary, S., Gomeza, J., Prézeau, L., Bockaert, J., and Pin, J.-P. (1998) J. Biol. Chem. 273, 425-432
33. Wiles, A. P., Shaw, G., Bright, J., Perczel, A., Campbell, I. D., and Barlow, P. N. (1997) J. Mol. Biol. 272, 253-265
34. Reid, K. B., and Day, A. J. (1989) Immunol. Today 10, 177-180
35. Hawrot, E., Xiao, Y., Shi, Q.-I., Norman, D., Kirkitadze, M., and Barlow, P. N. (1998) FEBS Lett. 432, 103-108
36. Sack, J. S., Saper, M. A., and Quiocho, F. A. (1989) J. Mol. Biol. 206, 171-191
37. Sack, J. S., Trakhanov, S. D., Tsigannik, I. H., and Quiocho, F. A. (1989) J. Mol. Biol. 206, 193-207
38. Kubo, Y., Miyashita, T., and Murata, Y. (1998) Science 279, 1722-1725
39. Oh, B.-H., Kang, C.-H., De Bondt, H., Kim, S.-H., Nikaido, K., Joshi, A. K., and Ames, G. F.-L. (1994) J. Biol. Chem. 269, 4135-4143
40. Wolf, A., Shaw, E. W., Nikaido, K., and Ames, G. F.-L. (1994) J. Biol. Chem. 269, 23051-23058
41. Wolf, A., Shaw, E. W., Oh, B.-H., De Bondt, H., Joshi, A. K., and Ames, G. F.-L. (1995) J. Biol. Chem. 270, 16097-16106
42. Walmsley, A. R., Shaw, J. G., and Kelly, D. J. (1992) Biochemistry 31, 11175-11181
43. Olah, G. A., Trakhanov, S. D., Trewhella, J., and Quiocho, F. A. (1993) J. Biol. Chem. 268, 16241-16247
44. Wolf, A., Lee, K. C., Kirsch, J. F., and Ames, G. F.-L. (1996) J. Biol. Chem. 271, 21243-21250