Extracellular calcium sensing and extracellular calcium signaling

Physiological Reviews

Volumn 81, Issue 1, 2001, Pages 239-297

  Brown, Edward M ^a   Macleod, R John ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM SENSING RECEPTOR; ION CHANNEL;

APOPTOSIS; BONE CELL; CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL FUNCTION; EXTRACELLULAR CALCIUM; EXTRACELLULAR FLUID; GENE INACTIVATION; GENE MUTATION; HORMONAL REGULATION; HORMONE RELEASE; ION TRANSPORT; KIDNEY FUNCTION; KNOCKOUT GENE; PARATHYROID CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW;

EID: 0035138842     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.2001.81.1.239     Document Type: Review

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269. Caveolae, transmembrane signalling and cellular transformation
270. Localization of familial benign hypercalcemia, Oklahoma variant (FBHOk), to chromosome 19q13
271. Depolarizing response of rat parathyroid cells to divalent cations
272. Changes of extracellular calcium concentration induced by application of excitatory amino acids in the human neocortex in vitro
273. 2+-sensing protein
274. A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily
275. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
276. Possible different mechanism between amyloid-beta (25-35)- and substance P-induced chemotaxis of murine microglia
277. Stimulation of cell proliferation by calcium and a calcimimetic compound
278. Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin
279. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
280. Megalin (gp330) is an endocytic receptor for thyroglobulin on cultured Fisher rat thyroid cells
281. Calciferols; actions and deficiencies in actions
282. The hypocalciuric or benign variant of familial hypercalcemia: Clinical and biochemical features in fifteen kindreds
283. Maximal urine-concentrating ability: Familial hypocalciuric hypercalcemia versus typical primary hyperparathyroidism
284. Expression of the renal calcium-sensing receptor is reduced in rats with experimental chronic renal insufficiency
285. Divalent cations modulate PTH-dependent 3′,5′-cyclic adenosine monophosphate production in renal proximal tubular cells
286. Reduced expression of the renal calcium-sensing receptor in rats with experimental chronic renal insufficiency
287. A multigene family encoding a diverse array of putative pheromone receptors in mammals
288. 2+-dependent arachidonic acid liberation in collagen-stimulated rabbit platelets
289. 2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells
290. Calcium regulation of normal human mammary epithelial cell growth in culture
291. Functional calcium-sensing receptor expression in ovarian surface epithelial cells
292. Functional calcium-sensing receptors in rat fibroblasts are required for activation of SRC kinase and mitogen-activated protein kinase in response to extracellular calcium
293. Bone marrow calcium in cancer of prostate and bladder
294. 2+ in bovine parathyroid cells
295. Regulation of parathyroid hormone-related protein production by a squamous carcinoma cell line in vitro
296. Spontaneous oscillations of intracellular calcium in single bovine parathyroid cells may be associated with the inhibition of parathyroid-hormone secretion
297. 2+-sensing receptor messenger ribonucleic acid and protein
298. Binding and endocytosis of proteins mediated by epithelial gp330
299. Magnesium transport in prokaryotes
300. 2+] subcompartments in intact HeLa cells
301. Calcium in normal human gastric juice. A four-component model with speculation on the relation of calcium to pepsin secretion
302. Coupling of exogenous receptors to phospholipase C in Xenopus oocytes through pertussis toxin-sensitive and -insensitive pathways. Cross-talk through heterotrimeric G-proteins
303. Role of hexose monophosphate shunt in parathyroid hormone secretion
304. The calcium signal for Balb/MK keratinocyte terminal differentiation induces sustained alterations in phosphoinositide metabolism without detectable protein kinase-C activation
305. 2+ channels
306. 2+-induced relaxation
307. i cotransport
308. i)-cotransport
309. i-cotransport
310. 2+-sensing receptor in Fugu
311. Molecular diversity of glutamate receptors and implications for brain function
312. Metabotropic glutamate receptors: Synaptic transmission, modulation, and plasticity
313. 3 in the parathyroid gland in vivo
314. Rapid communication: Bovine calcium-sensing receptor gene resides on bovine chromosome 1
315. 2+ in bovine parathyroid cells by external divalent cations
316. 2+ receptor-dependent regulation of cellular functions
317. Calcium receptors as novel drug targets
318. Stimulation of parathyroid hormone secretion by a small molecule antagonist of the calcium receptor
319. 2+ and the regulation of secretion in parathyroid cells
320. Calcimimetics with potent and selective activity on the parathyroid calcium receptor
321. The Bcl-2 family and cell death regulation
322. The calcium loading of secretory granules. A possible key event in stimulus-secretion coupling
323. Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective microelectrode
324. Inhibition of PTH secretion by interleukin-1 beta in bovine parathyroid glands in vitro is associated with an up-regulation of the calcium-sensing receptor mRNA
325. The vitamin D endocrine system: Steroid metabolism, hormone, receptors, and biological response (calcium binding proteins)
326. 2+-sensing function of parathyroid cells in vitro and in hyperparathyroidism
327. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation
328. Receptors for the 5-oxo class of eicosanoids in neutrophils
329. Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand
330. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
331. Conserved mechanism of negative gene regulation by extracellular calcium. Parathyroid hormone gene versus atrial natriuretic polypeptide gene
332. A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium
333. Megalin is an endocytic receptor for insulin
334. 2+ concentration
335. Endocrinology of calcium metabolism in amphibians, with emphasis on the evolution of hypercalcemic regulation in tetrapods
336. Developmental changes in the mechanisms of duodenal calcium transport in the rat
337. Effect of Ca intake on saturable and nonsaturable components of duodenal Ca transport
338. Duodenal and ileal calcium absorption in the rat and effects of vitamin D
339. Bone and plasma calcium homeostasis
340. Clinical disorders of calcium, phosphorus and magnesium metabolism
341. Caveolae and caveolins
342. Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells
343. Calcium-sensing receptor mutations in familial benign hypercalcemia and neonatal hyperparathyroidism
344. A familial syndrome of hypocalcemia with hypercalciuria due to mutations in the calcium-sensing receptor
345. Molecular cloning and characterization of a channel-like transporter mediating intestinal calcium absorption
346. Mechanism of malignant hypercalcemia in carcinoma of the breast
347. Mechanisms for fast intercellular communication within single islet of Langerhans
348. i cotransporter
349. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism
350. Structural and functional aspects of calcium homeostasis in eukaryotic cells
351. Calcium regulation of growth and differentiation of normal human keratinocytes: Modulation of differentiation competence by stages of growth and extracellular calcium
352. Role of calcium channels in parathyroid hormone secretion
353. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism
354. Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype
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358. Effect of hypercalcemia on renal tubular handling of calcium and magnesium
359. Effect of hypercalcemia on renal tubular handling of calcium and magnesium
360. Intraluminal and contraluminal magnesium on magnesium and calcium transfer in the rat nephron
361. The physiology of renal magnesium handling
362. A distinct cation-sensing mechanism in MC3T3-E1 osteoblasts functionally related to the calcium receptor
363. Cation-sensing receptors in bone: A novel paradigm for regulating bone remodeling?
364. Aluminum-induced DNA synthesis in osteoblasts: Mediation by a G-protein coupled cation sensing mechanism
365. Identification of a novel calcium-sensing receptor related gene localized to mouse chromosome 7
366. Sodium and ionic strength sensing by the calcium receptor
367. 2+-sensing receptor: A target for polyamines
368. Functional expression of the parathyroid cell calcium receptor in Xenopus oocytes
369. Protein kinase C modulates hormone secretion regulated by extracellular polycations in bovine parathyroid cells
370. Regulation of bone formation
371. Regulation of bone formation (second of two parts)
372. Effect of phosphate, calcium, and magnesium on bone resorption and bone formation in tissue culture
373. Expression of the calcium-sensing receptor in pancreatic islet B-cells
374. Expression of the calcium-sensing receptor on human antral gastrin cells in culture
375. Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction
376. The carboxyl terminus of the human calcium receptor. Requirements for cell-surface expression and signal transduction
377. 2+ receptor
378. Effects of calcium deficiency on chondrocyte hypertrophy and type X collagen expression in chick embryonic sternum
379. 2+/polyvalent cation-sensing protein in rat kidney
380. 2+-sensing receptor and PTH/PTHrP receptor in rat kidney
381. Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor
382. 2+ receptor of the parathyroid cell
383. 2+ sensing of normal and adenomatous parathyroid cells
384. Ionized calcium in body fluids
385. Role of PTHrP in fetal and neonatal physiology
386. Pharmacological comparison of bovine parathyroid, human parathyroid, and rat kidney calcium receptors expressed in HEK 293 cells
387. 3
388. Localization of calcium receptor mRNA in the adult rat central nervous system by in situ hybridization
389. Metabotropic glutamate receptor 5 is a disulfide-linked dimer
390. Expression of calcium-sensing receptor and characterization of intracellular signaling in human pituitary adenomas
391. 2+-sensing receptor expression in functionally active, long-term human parathyroid cell cultures
392. Calcium sensing receptor: Molecular cloning in rat and localization to nerve terminals
393. 2+-sensing receptor
394. 3 in the regulation of preproparathyroid hormone and vitamin D receptor messenger ribonucleic acid in avian parathyroids
395. Direct regulation by calcium of cytoplasmic messenger ribonucleic acid coding for preproparathyroid hormone in isolated bovine parathyroid cells
396. 2+-sensing receptor in normal human gastric mucous epithelial cells
397. A new multigene family of putative pheromone receptors
398. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family
399. Extracellular calcium-sensing receptor (CaR) expression and its potential role in parathyroid hormone-related peptide (PTHrP) secretion in the H-500 rat Leydig cell model of humoral hypercalcemia of malignancy
400. Vasopressin-elicited water and urea permeabilities are altered in IMCD in hypercalcemic rats
401. Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressin-elicited water permeability in rat kidney inner medullary collecting duct
402. 2+-induced calcitonin secretion
403. Crowded little caves: Structure and function of caveolae
404. 3+
405. 2+ receptor is highly sensitive to activation by transition metal cations
406. 2+ release
407. Crystallographic evidence for a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis
408. 2+ mobilization in bovine parathyroid cells
409. High calcium and other divalent cations increase inositol trisphosphate in bovine parathyroid cells
410. 2+-sensing receptor coupled to release of intracellular calcium stores
411. Receptor (norepinephrine), P-site (2′,5′dideoxyadenosine), and calcium-mediated inhibition of prostaglandin and forskolin-activated cAMP generating systems in human platelets
412. Microlectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
413. New insights into the regulation of parathyroid hormone synthesis and secretion in chronic renal failure
414. Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism
415. Subfornical organ lesions reduce intravenous angiotensin-induced drinking
416. Dietary calcium intake as a mitigating factor in colon cancer
417. Aluminum is a weak agonist for the calcium-sensing receptor
418. The extracellular calcium-sensing receptor on human beta-cells negatively modulates insulin secretion
419. Mineral metabolism
420. Familial benign hypocalciuric hypercalcemia - From the clinic to the calcium sensor
421. Effects of high calcium concentration on the functions and interactions of osteoblastic cells and monocytes and on the formation of osteoclast-like cells
422. The renal diluting and concentrating mechanism in hypercalcemia
423. Complexity and diversity of mammalian adenylyl cyclases
424. Calcium and magnesium: Renal handling and disorders of metabolism
425. Thyroid transcription factor 1 is calcium modulated and coordinately regulates genes involved in calcium homeostasis in C cells
426. Inhibitory guanosine triphosphate-binding protein-mediated regulation of vasopressin action in isolated single medullary tubules of mouse kidney
427. A novel putative neuropeptide receptor expressed in neural tissue, including sensory epithelia
428. Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria
429. Acidification of serotonin-containing secretory vesicles induced by a plasma membrane calcium receptor
430. Regulation of parathyroid hormone secretion in vitro: Quantitative aspects of calcium and magnesium ion control
431. 2+ spiking
432. The response of parathyroid hormone to specific changes in either ionized calcium, ionized magnesium, or protein-bound calcium in humans
433. Voluntary intake of calcium and other minerals by rats
434. Linkage studies in a kindred from Oklahoma, with familial benign (hypocalciuric) hypercalcaemia (FBH) and developmental elevations in serum parathyroid hormone levels, indicate a third locus for FBH
435. Effects of a calcium receptor activator on the cellular response to calcium in human keratinocytes
436. Receptor-tyrosine-kinase and Gbeta and gamma-mediated MAP kinase activation by a common signalling pathway
437. Mitogenic signaling via G protein-coupled receptors
438. Expression of G protein alpha-subunits in bovine parathyroid
439. New pathophysiological mechanisms for hyperthyroidism
440. + channels is blunted in CaR gene-deficient mouse neurons
441. 2+-sensing receptors in dispersed bovine parathyroid cells
442. 2+ in the synaptic cleft
443. Divergent influences of calcium ions on releasing factor-stimulated anterior pituitary hormone secretion in normal man
444. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency
445. Molecular cloning and cDNA sequence analysis of coho salmon stanniocalcin
446. Studies on the regulation and characterization of plasma stanniocalcin in rainbow trout
447. Human squamouscell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: Calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation
448. + channels in rat TAL
449. + channels in the TAL
450. 2+ receptor in rat arteries
451. Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations in vitro
452. Vitamin D and intestinal calcium transport: Facts, speculations and hypotheses
453. 3 by calcium in the parathyroidectomized, parathyroid hormone-replete rat
454. Heterodimerization is required for the formation of a functional GABA(B) receptor
455. Calcium as differentiator and killer-colon cells
456. The GABA-A receptor gene family: New targets for therapeutic intervention
457. Calcium sensing properties of the GABA(B) receptor
458. Interactive cellular modulation of chondrogenic differentiation in vitro by subpopulations of chick embryonic calvarial cells
459. 2+)-sensing receptor (CAR): Roles in cell signaling and control of diverse cellular functions
460. 2+ on the function of ST2 cells
461. 2+)-sensing receptor and its agonists stimulate chemotaxis and proliferation of MC3T3-E1 cells
462. 2+ on the function of J774 cells
463. 2+)-sensing receptor in the clonal osteoblast-like cell lines, UMR-106 and SAOS-2
464. 2+)-sensing receptor in human peripheral blood monocytes
465. Hypocalcemia increases and hypercalcemia decreases the steady state level of parathyroid hormone messenger RNA in the rat
466. 2+ from hair cell stereocilia
467. 2+-sensing receptor mRNAs along the rat nephron
468. 2+-permeable channels through calcium-sensing receptors
469. 2+-sensing receptor gene
470. 2+-sensing receptor agonists of nonselective cation channels in rat hippocampal neurons
471. 2+-sensing receptor (CAR) activate nonselective cation channels in HEK293 cells stably transfected with the human CaR
472. 2+-sensing receptor agonists activate nonselective cation conductance in freshly isolated rat osteoclasts
473. Emerging insights into the role of calcium ions in osteoclast regulation
474. "Calcium-activated" intracellular calcium elevation: A novel mechanism of osteoclast regulation
475. Divalent cations mimic the inhibitory effect of extracellular ionised calcium on bone resorption by isolated rat osteoclasts: Further evidence for a "calcium receptor"
476. Evidence that a ryanodine receptor triggers signal transduction in the osteoclast
477. 2+ sensing
478. Identification and molecular characterization of m3 muscarinic receptor dimers
479. Evidence for a "calcium-sensing" receptor in C-cells